{"id":"https://openalex.org/W3021683282","doi":null,"title":"Unravelling The Role Of Androgens In Polycystic Ovary Syndrome","display_name":"Unravelling The Role Of Androgens In Polycystic Ovary Syndrome","publication_year":2017,"publication_date":"2017-09-20","ids":{"openalex":"https://openalex.org/W3021683282","mag":"3021683282"},"language":"en","primary_location":{"id":"pmh:oai:ses.library.usyd.edu.au:2123/18129","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2123/18129","pdf_url":null,"source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000222559","display_name":"Aim\u00e9e Sarah Lee Caldwell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Aim\u00e9e Sarah Lee Caldwell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5000222559"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.9120000004768372},{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":0.8330000042915344},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.8659999966621399},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8529999852180481},{"id":"https://openalex.org/keywords/prenatal-androgen-exposure","display_name":"prenatal androgen exposure","score":0.9079999923706055},{"id":"https://openalex.org/keywords/letrozole","display_name":"letrozole","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":0.9160000085830688},{"id":"https://openalex.org/keywords/aromatase-inhibition","display_name":"aromatase inhibition","score":0.7549999952316284},{"id":"https://openalex.org/keywords/pcos-pathogenesis","display_name":"PCOS pathogenesis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.3149999976158142},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.3179999887943268},{"id":"https://openalex.org/keywords/insulin-sensitivity-index","display_name":"insulin sensitivity index","score":0.3310000002384186}],"concepts":[{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.7995368242263794},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.5010182857513428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3980320990085602},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3840622007846832},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3274588882923126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32468903064727783},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31426239013671875},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ses.library.usyd.edu.au:2123/18129","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2123/18129","pdf_url":null,"source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:3021683282","doi":null,"is_oa":false,"landing_page_url":"https://ses.library.usyd.edu.au/bitstream/2123/18129/2/caldwell_asl_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2084300141","https://openalex.org/W3217131835","https://openalex.org/W2158039367","https://openalex.org/W3013027351","https://openalex.org/W2335370634","https://openalex.org/W2002113485","https://openalex.org/W2000075793","https://openalex.org/W2109487808","https://openalex.org/W2587739710","https://openalex.org/W2914893853"],"abstract_inverted_index":{"Polycystic":[0,942],"Ovary":[1,943],"Syndrome":[2,944],"(PCOS)":[3],"is":[4,24,59,580,784],"a":[5,27,164,180,206,301,320,339,375,469,609,688,804,808,814,839,867,889],"multifaceted":[6],"hormonal":[7],"disorder":[8],"which":[9,344,830,837],"affects":[10,838],"5-15%":[11],"of":[12,29,45,57,64,75,91,100,106,113,122,139,146,163,166,182,195,201,228,272,284,297,303,323,349,361,370,380,392,414,425,450,454,523,543,566,572,585,616,623,635,653,677,687,690,707,718,729,772,791,807,811,816,842,853,858,882,896,906,916,922,939,952,955],"reproductive-aged":[13],"women":[14,843],"worldwide.":[15,844],"While":[16],"classically":[17],"recognised":[18],"as":[19,67,76,518,520,924],"an":[20,42,785,925],"ovarian":[21,926],"disorder,":[22],"PCOS":[23,114,141,174,257,372,381,419,430,432,486,551,573,586,607,624,655,812,859,883],"associated":[25,172,255],"with":[26,173,209,256,260,484,608,750],"variety":[28,689],"reproductive,":[30,167,304,817],"endocrine":[31,168,236,305,818],"and":[32,41,50,70,111,134,137,169,197,235,266,306,337,438,494,502,510,514,537,574,643,692,702,743,762,819,914,945],"metabolic":[33,170,243,282,307,693,820],"features":[34,254,676,720,771,881],"including":[35,491,695],"ovulatory":[36,495],"dysfunction,":[37],"infertility,":[38],"hyperandrogenism,":[39],"obesity,":[40],"increased":[43],"risk":[44],"type":[46],"2":[47],"diabetes":[48],"mellitus":[49],"cardiovascular":[51],"disease.":[52],"The":[53,120,149,351,793],"most":[54],"consistently":[55],"present":[56],"these":[58,371,455,617,929],"hyperandrogenism":[60,101],"\u2013":[61],"supraphysiological":[62],"levels":[63],"androgens":[65,80,107,557,854,940],"such":[66,870],"testosterone":[68],"(T)":[69],"dihydrotestosterone":[71],"(DHT).":[72],"Typically":[73],"thought":[74,921],"male":[77],"steroid":[78],"hormones,":[79],"have":[81,848,900,931],"been":[82,384],"shown":[83,849],"to":[84,117,126,240,292,327,345,357,386,401,409,422,460,466,472,499,555,582,597,660,769,802,831,879,892],"play":[85],"important":[86,786],"role":[87,105,728,938],"in":[88,108,143,175,246,313,334,343,367,418,420,435,497,531,569,606,664,710,721,733,741,767,788,829,866,884,888,911,941],"the":[89,97,104,109,128,135,140,159,186,212,242,273,287,330,347,359,368,393,411,415,423,429,474,480,540,544,564,570,591,602,613,629,651,654,685,716,727,789,800,826,851,856,863,885,894,902,912,937,950],"maintenance":[90],"normal":[92],"female":[93],"reproductive":[94,234,489,691],"function.":[95],"Despite":[96],"high":[98],"prevalence":[99],"amongst":[102],"patients,":[103],"etiology":[110],"pathogenesis":[112,348,717,857],"has":[115,824],"yet":[116],"be":[118],"determined.":[119],"aim":[121],"this":[123,154,399,626,797,833,956],"work":[124,155,823],"was":[125,433,682],"unravel":[127],"association":[129],"between":[130],"excess":[131,293,556,756],"androgen":[132,189,203,363,439,604,757,864,897,909],"exposure":[133,204,291,326,659,758],"development":[136,369,571,652,686,790,951],"advancement":[138],"phenotype":[142,333,656],"mouse":[144,178,378,809],"model":[145,181,342,379,408,622,810,828],"androgen-induced":[147],"PCOS.":[148,247,285,315,350,678,773,792],"first":[150,160,801],"study":[151,317,346,353,562,593,627,775,832,891],"contained":[152,795],"within":[153,796],"(Chapter":[156,354,594],"Three)":[157],"provides":[158,338,776],"comprehensive":[161,805],"characterization":[162],"range":[165],"traits":[171,308,552,694],"four":[176],"distinct":[177],"models:":[179],"prenatal":[183,407,559,588,666],"androgenisation":[184,231],"utilising":[185],"potent":[187],"non-aromatizable":[188],"DHT":[190,298,328,445,529,878],"administered":[191,446],"during":[192,558],"days":[193,223,448,464],"16-18":[194,449],"gestation,":[196],"three":[198],"diverse":[199],"models":[200],"postnatal":[202,290,325,621],"employing":[205],"long-term":[207,324],"treatment":[208,249,259,277,321,530],"either":[210],"DHT,":[211],"proandrogen":[213],"dehydroepiandrosterone":[214],"(DHEA),":[215],"or":[216],"letrozole":[217,261,276],"(an":[218],"aromatase":[219],"inhibitor)":[220],"for":[221,462,539,684,877,949],"90":[222],"beginning":[224],"at":[225],"3":[226],"weeks":[227],"age.":[229],"Prenatal":[230],"produced":[232,262,300],"some":[233,267],"traits,":[237],"but":[238],"failed":[239],"induce":[241],"abnormalities":[244,490],"seen":[245,312],"DHEA":[248],"did":[250,278,547,713],"not":[251,270,279,548,714,763],"reproduce":[252,280,880],"any":[253,281,550],"while":[258],"few":[263],"PCOS-like":[264,332,719],"characteristics":[265],"aberrant":[268,492],"changes":[269],"typical":[271],"syndrome.":[274],"Additionally,":[275,845],"attributes":[283],"On":[286],"other":[288],"hand,":[289],"androgen,":[294],"by":[295,528,587,658],"way":[296],"treatment,":[299],"breadth":[302,815],"that":[309,319,576,755,779,850,871],"mimic":[310],"those":[311],"human":[314],"This":[316,561,774,822],"revealed":[318,575,754,901],"regime":[322],"reproduced":[329],"strongest":[331],"our":[335,405,620,665,846],"mice":[336,403,443,456,483,669],"robust":[340],"animal":[341],"second":[352],"Four)":[355],"aimed":[356,596],"explore":[358],"involvement":[360],"genomic":[362,781],"receptor":[364,440,865],"(AR)-mediated":[365],"actions":[366,605,898],"traits.":[373],"As":[374,663],"prenatally":[376],"androgenised":[377],"had":[382],"previously":[383,903],"reported":[385],"exhibit":[387],"impaired":[388,475],"neuroendocrine":[389,412,780,908],"hypothalamic":[390,521],"feedback":[391,478,517],"hypothalamic-pituitary-gonadal":[394],"(HPG)":[395],"axis,":[396],"we":[397,899],"took":[398],"opportunity":[400],"utilise":[402],"from":[404,673,747],"own":[406],"investigate":[410,473,893],"regulation":[413],"HPG":[416],"axis":[417],"addition":[421,498],"effects":[424,630,852],"AR":[426,545,567,578,636,647,680,708,731,765,782],"inactivation":[427,542,648],"on":[428,447,479,601,611,650,855],"phenotype.":[431],"induced":[434,657],"wild-type":[436],"(WT)":[437],"knockout":[441,641],"(ARKO)":[442],"using":[444],"gestation.":[451],"A":[452],"subset":[453],"were":[457,526,670,738],"also":[458],"exposed":[459,554],"17\u03b2-estradiol":[461],"7":[463],"prior":[465],"collection,":[467],"via":[468,862],"subdermal":[470],"implant,":[471],"estradiol":[476],"negative":[477,516],"hypothalamus.":[481],"WT":[482,532,742,752],"DHT-induced":[485,675],"displayed":[487],"several":[488,524],"cycling":[493],"dysfunction":[496],"adipocyte":[500],"hypertrophy":[501],"hepatic":[503],"steatosis.":[504],"However,":[505],"diestrus":[506],"serum":[507],"luteinising":[508],"hormone":[509],"follicle":[511],"stimulating":[512],"hormone,":[513],"estradiol-induced":[515],"well":[519],"expression":[522],"neuropeptides":[525],"unaffected":[527],"mice.":[533,723,745],"Mice":[534],"both":[535,936],"homozygous":[536],"heterozygous":[538],"global":[541,633],"(ARKO),":[546,638],"display":[549],"when":[553],"life.":[560],"showed":[563],"importance":[565,905],"signalling":[568,637,709,732,766],"even":[577],"haplosufficiency":[579],"adequate":[581],"prevent":[583],"induction":[584],"hyperandrogenism.":[589],"Finally,":[590,887],"third":[592],"Five)":[595],"shed":[598],"further":[599,725],"light":[600],"AR-mediated":[603],"focus":[610],"identifying":[612],"tissue-specific":[614],"targets":[615,948],"actions.":[618],"Employing":[619],"induction,":[625],"investigates":[628],"of:":[631],"1)":[632],"loss":[634,706],"2)":[639],"neuronal":[640],"(NeurARKO)":[642],"3)":[644],"granulosa":[645,711],"cell-specific":[646],"(GCARKO)":[649],"exogenous":[661],"DHT.":[662],"model,":[667],"ARKO":[668,744,748],"fully":[671],"protected":[672],"all":[674],"Neuron-specific":[679],"signaling":[681,783],"required":[683,876],"classic":[696],"polycystic":[697],"ovaries,":[698],"dysfunctional":[699],"ovulation,":[700],"obesity":[701],"dyslipidemia.":[703],"In":[704],"contrast,":[705],"cells":[712],"impede":[715],"GCARKO":[722],"To":[724],"examine":[726],"extra-ovarian":[730,907],"PCOS,":[734,917],"reciprocal":[735],"ovary":[736],"transplants":[737],"carried":[739],"out":[740],"Results":[746],"hosts":[749],"transplanted":[751],"ovaries":[753],"requires":[759],"functional":[760,873],"extra-ovarian,":[761],"intra-ovarian,":[764],"order":[768],"produce":[770],"strong":[777],"evidence":[778],"mediator":[787],"studies":[794,930],"thesis":[798],"are":[799,860,875],"provide":[803],"analysis":[806],"encompassing":[813],"features.":[821],"identified":[825],"optimal":[827],"complex,":[834],"multifactorial":[835],"condition":[836],"significant":[840],"number":[841],"results":[847],"mediated":[861],"dose-dependent":[868],"manner":[869],"two":[872],"copies":[874],"mouse.":[886],"crucial":[890],"locus":[895],"overlooked":[904],"action":[910],"origins":[913],"progression":[915],"despite":[918],"it":[919],"being":[920],"primarily":[923],"disorder.":[927,957],"Overall,":[928],"provided":[932],"valuable":[933],"insights":[934],"into":[935],"potential":[946],"new":[947],"mechanism-based":[953],"treatments":[954]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2020-05-13T00:00:00"}
