{"id":"https://openalex.org/W3021606396","doi":"https://doi.org/10.2967/jnumed.119.238998","title":"Receptor-Targeted Photodynamic Therapy of Glucagon-Like Peptide 1 Receptor\u2013Positive Lesions","display_name":"Receptor-Targeted Photodynamic Therapy of Glucagon-Like Peptide 1 Receptor\u2013Positive Lesions","publication_year":2020,"publication_date":"2020-05-08","ids":{"openalex":"https://openalex.org/W3021606396","doi":"https://doi.org/10.2967/jnumed.119.238998","mag":"3021606396","pmid":"https://pubmed.ncbi.nlm.nih.gov/32385165","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8679620"},"language":"en","primary_location":{"id":"doi:10.2967/jnumed.119.238998","doi":"https://doi.org/10.2967/jnumed.119.238998","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.119.238998","pdf_url":"https://jnm.snmjournals.org/content/jnumed/61/11/1588.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jnm.snmjournals.org/content/jnumed/61/11/1588.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075989352","display_name":"Marti Boss","orcid":"https://orcid.org/0000-0002-5837-1803","observed_orcids":["https://orcid.org/0000-0002-5837-1803"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Marti Boss","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands marti.boss@radboudumc.nl","Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands marti.boss@radboudumc.nl","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110760638","display_name":"Desir\u00e9e L. Bos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Desiree Bos","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089453603","display_name":"Cathelijne Frielink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Cathelijne Frielink","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050468895","display_name":"Gerwin W. Sandker","orcid":"https://orcid.org/0000-0002-0997-5440","observed_orcids":["https://orcid.org/0000-0002-0997-5440"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerwin Sandker","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062002798","display_name":"Patricia Bronkhorst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Patricia Bronkhorst","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031779188","display_name":"Sanne A. M. van Lith","orcid":"https://orcid.org/0000-0001-8584-2546","observed_orcids":["https://orcid.org/0000-0001-8584-2546"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sanne A.M. van Lith","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066889322","display_name":"Maarten Brom","orcid":"https://orcid.org/0000-0001-5755-1477","observed_orcids":["https://orcid.org/0000-0001-5755-1477"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maarten Brom","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064948355","display_name":"Mijke Buitinga","orcid":"https://orcid.org/0000-0002-4202-2473","observed_orcids":["https://orcid.org/0000-0002-4202-2473"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mijke Buitinga","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042300545","display_name":"Martin Gotthardt","orcid":"https://orcid.org/0000-0002-6537-7744","observed_orcids":["https://orcid.org/0000-0002-6537-7744"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martin Gotthardt","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075989352"],"corresponding_institution_ids":["https://openalex.org/I2802934949"],"apc_list":null,"apc_paid":null,"fwci":1.687,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.86380879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"61","issue":"11","first_page":"1588","last_page":"1593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-1-receptor","display_name":"GLP-1 receptor","score":0.984000027179718},{"id":"https://openalex.org/keywords/hyperinsulinemic-hypoglycemia","display_name":"hyperinsulinemic hypoglycemia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/insulinoma","display_name":"insulinoma","score":0.824999988079071},{"id":"https://openalex.org/keywords/congenital-hyperinsulinism","display_name":"congenital hyperinsulinism","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nesidioblastosis","display_name":"nesidioblastosis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.47200000286102295},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.7369999885559082},{"id":"https://openalex.org/keywords/minimally-invasive-therapy","display_name":"minimally invasive therapy","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.691613495349884},{"id":"https://openalex.org/C2775858560","wikidata":"https://www.wikidata.org/wiki/Q11612732","display_name":"Hyperinsulinemic hypoglycemia","level":4,"score":0.6113728880882263},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5720390677452087},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5457479357719421},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.48487409949302673},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.482652485370636},{"id":"https://openalex.org/C2780053029","wikidata":"https://www.wikidata.org/wiki/Q1501239","display_name":"Insulinoma","level":3,"score":0.4723152816295624},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4718891382217407},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.426975280046463},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.4174032211303711},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34761929512023926},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.33216822147369385},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.2606413662433624},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2529956102371216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20783939957618713},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.12770900130271912},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10650277137756348},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077270","descriptor_name":"Exenatide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077270","descriptor_name":"Exenatide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017646","descriptor_name":"Organosilicon Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017646","descriptor_name":"Organosilicon Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D044903","descriptor_name":"Congenital Hyperinsulinism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046768","descriptor_name":"Nesidioblastosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2967/jnumed.119.238998","doi":"https://doi.org/10.2967/jnumed.119.238998","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.119.238998","pdf_url":"https://jnm.snmjournals.org/content/jnumed/61/11/1588.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8679620","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8679620","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Nucl Med","raw_type":"Text"},{"id":"pmid:32385165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32385165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/226801","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/226801","pdf_url":"https://repository.ubn.ru.nl/bitstream/handle/2066/226801/1/226801.pdf","source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Nuclear Medicine (1978), 61, 1588 - 1593","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/226801","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/226801","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.2967/jnumed.119.238998","doi":"https://doi.org/10.2967/jnumed.119.238998","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.119.238998","pdf_url":"https://jnm.snmjournals.org/content/jnumed/61/11/1588.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3021606396.pdf","grobid_xml":"https://content.openalex.org/works/W3021606396.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1596848781","https://openalex.org/W1909761377","https://openalex.org/W1972731321","https://openalex.org/W1976282388","https://openalex.org/W1983692618","https://openalex.org/W1997986298","https://openalex.org/W2013316743","https://openalex.org/W2038304520","https://openalex.org/W2039011000","https://openalex.org/W2042857160","https://openalex.org/W2058591402","https://openalex.org/W2061192940","https://openalex.org/W2077984066","https://openalex.org/W2080916065","https://openalex.org/W2082368169","https://openalex.org/W2088578227","https://openalex.org/W2095748322","https://openalex.org/W2102393399","https://openalex.org/W2104837713","https://openalex.org/W2106593894","https://openalex.org/W2120766385","https://openalex.org/W2125244661","https://openalex.org/W2141867295","https://openalex.org/W2300158724","https://openalex.org/W2409123916","https://openalex.org/W2751288211","https://openalex.org/W2806319700","https://openalex.org/W2942117113","https://openalex.org/W2952566998","https://openalex.org/W2999958807","https://openalex.org/W3000930612","https://openalex.org/W3003160777"],"related_works":["https://openalex.org/W2023763957","https://openalex.org/W2576191233","https://openalex.org/W3000175167","https://openalex.org/W2944026528","https://openalex.org/W3177519150","https://openalex.org/W2018816414","https://openalex.org/W2171460614","https://openalex.org/W2061192940","https://openalex.org/W3132681667","https://openalex.org/W7099759568"],"abstract_inverted_index":{"Treatment":[0],"of":[1,8,22,48,90,103,119,148,194,204,227,230],"hyperinsulinemic":[2,49,250],"hypoglycemia":[3],"is":[4,16],"challenging.":[5],"Surgical":[6],"treatment":[7,132,247],"insulinomas":[9],"and":[10,18,28,35,88,122,162,171,197],"focal":[11],"lesions":[12],"in":[13,96,98,110,156,169,179,188,219,224,237],"congenital":[14,30],"hyperinsulinism":[15,31],"invasive":[17],"carries":[19],"major":[20],"risks":[21],"morbidity.":[23],"Medication":[24],"to":[25,130,199],"treat":[26],"nesidioblastosis":[27],"diffuse":[29],"has":[32,136],"varying":[33],"efficacy":[34,87],"causes":[36],"significant":[37,153],"side":[38],"effects.":[39],"Here,":[40],"we":[41],"describe":[42],"a":[43,137,144,200,241],"novel":[44],"method":[45,248],"for":[46,140,249],"therapy":[47,58],"hyperglycemia,":[50],"highly":[51,245],"selectively":[52],"killing":[53],"\u03b2-cells":[54],"by":[55,191],"receptor-targeted":[56],"photodynamic":[57],"(rtPDT)":[59],"with":[60,83,92,100,143],"exendin-4-IRDye700DX,":[61],"targeting":[62],"the":[63,84,123,141,205,228,238],"glucagon-like":[64],"peptide":[65],"1":[66],"receptor":[67],"(GLP-1R).":[68],"Methods:":[69],"A":[70],"competitive":[71],"binding":[72],"assay":[73],"was":[74,108],"performed":[75],"using":[76,232],"Chinese":[77],"hamster":[78],"lung":[79],"(CHL)":[80],"cells":[81,99,158],"transfected":[82],"GLP-1R.":[85],"The":[86,175],"specificity":[89],"rtPDT":[91,151,184,231],"exendin-4-IRDye700DX":[93],"were":[94,128],"examined":[95],"vitro":[97,220],"different":[101],"levels":[102],"GLP-1R":[104],"expression.":[105],"Tracer":[106],"biodistribution":[107],"determined":[109],"BALB/c":[111],"nude":[112],"mice":[113,206],"bearing":[114],"subcutaneous":[115],"CHL-GLP-1R":[116,170],"xenografts.":[117],"Induction":[118],"cellular":[120,186],"damage":[121,187],"effect":[124],"on":[125],"tumor":[126],"growth":[127],"analyzed":[129],"determine":[131],"efficacy.":[133],"Results:":[134],"Exendin-4-IRDye700DX":[135],"high":[138],"affinity":[139],"GLP-1R,":[142],"half-maximal":[145],"inhibitory":[146],"concentration":[147],"6.3":[149],"nM.":[150],"caused":[152],"specific":[154,246],"phototoxicity":[155],"GLP-1R\u2013positive":[157,180],"(2.3%":[159],"\u00b1":[160,164],"0.8%":[161],"2.7%":[163],"0.3%":[165],"remaining":[166],"cell":[167],"viability":[168],"INS-1":[172],"cells,":[173],"respectively).":[174],"tracer":[176],"accumulates":[177],"dose-dependently":[178],"tumors.":[181],"In":[182],"vivo,":[183],"induces":[185],"tumors,":[189],"shown":[190],"strong":[192],"expression":[193],"cleaved":[195],"caspase-3,":[196],"leads":[198],"prolonged":[201],"median":[202],"survival":[203],"(36.5":[207],"vs.":[208],"22.5":[209],"d,":[210],"respectively;":[211],"P":[212],"<":[213],"0.05).":[214],"Conclusion:":[215],"These":[216],"data":[217],"show":[218],"as":[221,223],"well":[222],"vivo":[225],"evidence":[226],"potency":[229],"exendin-4-IRDye700DX.":[233],"This":[234],"approach":[235],"might":[236],"future":[239],"provide":[240],"new,":[242],"minimally":[243],"invasive,":[244],"hypoglycemia.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-05-13T00:00:00"}