{"id":"https://openalex.org/W302115605","doi":null,"title":"Thyroglobulin: current status in differentiated thyroid carcinoma (review).","display_name":"Thyroglobulin: current status in differentiated thyroid carcinoma (review).","publication_year":2006,"publication_date":"2006-06-01","ids":{"openalex":"https://openalex.org/W302115605","mag":"302115605","pmid":"https://pubmed.ncbi.nlm.nih.gov/17100547"},"language":"en","primary_location":{"id":"pmid:17100547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17100547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine regulations","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059538246","display_name":"Krishnamachar Harish","orcid":"https://orcid.org/0000-0003-0751-5296","observed_orcids":["https://orcid.org/0000-0003-0751-5296"]},"institutions":[{"id":"https://openalex.org/I4210134671","display_name":"M.S. Ramaiah Medical College","ror":"https://ror.org/03j554d90","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210134671"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"K Harish","raw_affiliation_strings":["Department of Surgical Oncology, MS Ramaiah Medical College & Hospital, Bangalore, India. drkhari@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, MS Ramaiah Medical College & Hospital, Bangalore, India. drkhari@yahoo.com","institution_ids":["https://openalex.org/I4210134671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5059538246"],"corresponding_institution_ids":["https://openalex.org/I4210134671"],"apc_list":null,"apc_paid":null,"fwci":1.2683,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.79718853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"40","issue":"2","first_page":"53","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroglobulin","display_name":"thyroglobulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/differentiated-thyroid-cancer","display_name":"differentiated thyroid cancer","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7609999775886536},{"id":"https://openalex.org/keywords/anti-thyroglobulin-antibodies","display_name":"thyroglobulin antibodies","score":0.8619999885559082},{"id":"https://openalex.org/keywords/radioactive-iodine-therapy","display_name":"radioiodine therapy","score":0.6959999799728394},{"id":"https://openalex.org/keywords/thyroid-cancer-recurrence","display_name":"recurrent thyroid cancer","score":0.42100000381469727},{"id":"https://openalex.org/keywords/metastasis-detection","display_name":"metastasis detection","score":0.8190000057220459},{"id":"https://openalex.org/keywords/thyroxine-suppression","display_name":"thyroxine suppression","score":0.5120000243186951},{"id":"https://openalex.org/keywords/tsh-stimulation","display_name":"TSH stimulation","score":0.628000020980835},{"id":"https://openalex.org/keywords/thyroglobulin-mrna","display_name":"thyroglobulin mRNA","score":0.8339999914169312},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C2778835679","wikidata":"https://www.wikidata.org/wiki/Q412228","display_name":"Thyroglobulin","level":3,"score":0.8654211759567261},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.7940801382064819},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.764219343662262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7472578287124634},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6312950849533081},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.5590004324913025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.465364933013916},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.45923101902008057},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4552936851978302},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4432443082332611},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.441056489944458},{"id":"https://openalex.org/C50181227","wikidata":"https://www.wikidata.org/wiki/Q1943709","display_name":"Anti-thyroid autoantibodies","level":4,"score":0.43332916498184204},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.42505791783332825},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4180130362510681},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39434149861335754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16616541147232056}],"mesh":[{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013954","descriptor_name":"Thyroglobulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013954","descriptor_name":"Thyroglobulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013954","descriptor_name":"Thyroglobulin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:17100547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17100547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine regulations","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":119,"referenced_works":["https://openalex.org/W20955532","https://openalex.org/W145132618","https://openalex.org/W1589691155","https://openalex.org/W1607026867","https://openalex.org/W1717738413","https://openalex.org/W1881730789","https://openalex.org/W1890276828","https://openalex.org/W1896286430","https://openalex.org/W1925802749","https://openalex.org/W1963972106","https://openalex.org/W1964618826","https://openalex.org/W1966715409","https://openalex.org/W1967553326","https://openalex.org/W1967582707","https://openalex.org/W1968467130","https://openalex.org/W1968883645","https://openalex.org/W1971286227","https://openalex.org/W1977572076","https://openalex.org/W1978675244","https://openalex.org/W1979200290","https://openalex.org/W1979420670","https://openalex.org/W1980122494","https://openalex.org/W1981246395","https://openalex.org/W1981393546","https://openalex.org/W1987229242","https://openalex.org/W1987585774","https://openalex.org/W1988314055","https://openalex.org/W1990048928","https://openalex.org/W1993041398","https://openalex.org/W1993056348","https://openalex.org/W1993218005","https://openalex.org/W1993309576","https://openalex.org/W1993691073","https://openalex.org/W1993885825","https://openalex.org/W1995385643","https://openalex.org/W1996821185","https://openalex.org/W1999319228","https://openalex.org/W2002176629","https://openalex.org/W2010122962","https://openalex.org/W2014195571","https://openalex.org/W2018223856","https://openalex.org/W2018556609","https://openalex.org/W2019014309","https://openalex.org/W2019523762","https://openalex.org/W2022202489","https://openalex.org/W2023845429","https://openalex.org/W2024296742","https://openalex.org/W2030588490","https://openalex.org/W2037916796","https://openalex.org/W2039049997","https://openalex.org/W2039754686","https://openalex.org/W2041455346","https://openalex.org/W2045243038","https://openalex.org/W2046215409","https://openalex.org/W2048413452","https://openalex.org/W2050169128","https://openalex.org/W2052158882","https://openalex.org/W2057825946","https://openalex.org/W2059689021","https://openalex.org/W2060428768","https://openalex.org/W2066476236","https://openalex.org/W2067137057","https://openalex.org/W2067303590","https://openalex.org/W2068133672","https://openalex.org/W2069482376","https://openalex.org/W2070434180","https://openalex.org/W2071027519","https://openalex.org/W2073972088","https://openalex.org/W2078521860","https://openalex.org/W2079857238","https://openalex.org/W2080188786","https://openalex.org/W2082835153","https://openalex.org/W2085144152","https://openalex.org/W2087690670","https://openalex.org/W2089608960","https://openalex.org/W2090633368","https://openalex.org/W2091923260","https://openalex.org/W2095036778","https://openalex.org/W2097610362","https://openalex.org/W2103912940","https://openalex.org/W2105773573","https://openalex.org/W2112752101","https://openalex.org/W2116670135","https://openalex.org/W2117673336","https://openalex.org/W2119680768","https://openalex.org/W2124215377","https://openalex.org/W2124524123","https://openalex.org/W2126403689","https://openalex.org/W2127409358","https://openalex.org/W2133822485","https://openalex.org/W2134480384","https://openalex.org/W2139399152","https://openalex.org/W2140526606","https://openalex.org/W2142255247","https://openalex.org/W2142563702","https://openalex.org/W2149711914","https://openalex.org/W2153859333","https://openalex.org/W2154079360","https://openalex.org/W2155384122","https://openalex.org/W2156954509","https://openalex.org/W2156955236","https://openalex.org/W2159338455","https://openalex.org/W2160254617","https://openalex.org/W2169723723","https://openalex.org/W2170967471","https://openalex.org/W2182589509","https://openalex.org/W2223712791","https://openalex.org/W2249171140","https://openalex.org/W2320378887","https://openalex.org/W2329891670","https://openalex.org/W2336907646","https://openalex.org/W2411329336","https://openalex.org/W2413153824","https://openalex.org/W2428538474","https://openalex.org/W2616027747","https://openalex.org/W2966412521","https://openalex.org/W4256151227","https://openalex.org/W4256237610","https://openalex.org/W4295202617"],"related_works":["https://openalex.org/W3032217711","https://openalex.org/W2293540483","https://openalex.org/W2137501112","https://openalex.org/W2114751292","https://openalex.org/W2384089590","https://openalex.org/W4211173975","https://openalex.org/W7158002066","https://openalex.org/W2035875115","https://openalex.org/W1967553326","https://openalex.org/W1593873170"],"abstract_inverted_index":{"Thyroglobulin":[0,143],"(Tg)":[1],"measurements":[2],"in":[3,11,44,60,107,112],"tissue":[4],"and":[5,35,52,84],"serum":[6],"play":[7],"an":[8],"important":[9,29],"role":[10,30],"the":[12,19,63,113,138],"management":[13],"of":[14,33,70,90,105,116,118,124,137],"differentiated":[15,57],"thyroid":[16,21,58,94,151],"cancers.":[17],"In":[18,121],"post":[20],"ablation":[22],"scenario,":[23],"Tg":[24,41,47,71,82,106,125],"estimation":[25,145],"plays":[26],"a":[27,49],"very":[28],"for":[31,56],"detection":[32,104],"recurrence":[34],"metastasis.":[36],"Although":[37],"there":[38],"could":[39],"be":[40],"autoantibody":[42,64],"interference":[43],"some":[45,136],"patients,":[46],"is":[48,65,72,77,110],"highly":[50],"specific":[51],"sensitive":[53],"tumor":[54,130],"marker":[55],"cancer":[59,152],"those":[61],"where":[62],"absent.":[66],"The":[67],"clinical":[68],"sensitivity":[69],"greatest":[73],"when":[74],"endogenous":[75],"TSH":[76,155],"elevated":[78],"before":[79],"radioiodine":[80,85],"imaging.":[81],"assays":[83],"scans":[86],"are":[87,101],"independent":[88],"indicators":[89],"residual":[91],"or":[92],"metastatic":[93],"cancer,":[95],"indicating":[96],"that":[97],"both":[98],"these":[99],"tests":[100],"complimentary.":[102],"Immunohistochemical":[103],"surgical":[108],"specimens":[109],"useful":[111],"differential":[114],"diagnosis":[115],"tumors":[117],"unknown":[119],"origin.":[120],"future,":[122],"measurement":[123],"mRNA":[126,147],"to":[127,134],"detect":[128],"circulating":[129],"cells":[131],"may":[132],"help":[133],"overcome":[135],"current":[139],"limitations.":[140],"Key":[141],"words:":[142],"Serum":[144],"-Antibodies":[146],"testing":[148],"-":[149],"Differentiated":[150],"Radioiodine":[153],"Thyroxine":[154],"Diagnostic":[156],"use.":[157]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}