{"id":"https://openalex.org/W3020983124","doi":"https://doi.org/10.1186/s12944-020-01257-z","title":"Association of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: a Mendelian randomization analysis","display_name":"Association of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: a Mendelian randomization analysis","publication_year":2020,"publication_date":"2020-05-08","ids":{"openalex":"https://openalex.org/W3020983124","doi":"https://doi.org/10.1186/s12944-020-01257-z","mag":"3020983124","pmid":"https://pubmed.ncbi.nlm.nih.gov/32384904","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7206776"},"language":"en","primary_location":{"id":"doi:10.1186/s12944-020-01257-z","doi":"https://doi.org/10.1186/s12944-020-01257-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12944-020-01257-z","pdf_url":"https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-020-01257-z","source":{"id":"https://openalex.org/S188748365","display_name":"Lipids in Health and Disease","issn_l":"1476-511X","issn":["1476-511X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids in Health and Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-020-01257-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055087045","display_name":"Zhenhuang Zhuang","orcid":"https://orcid.org/0000-0001-9150-3081","observed_orcids":["https://orcid.org/0000-0001-9150-3081"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenhuang Zhuang","raw_affiliation_strings":["Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024534066","display_name":"Meng Qiu Gao","orcid":"https://orcid.org/0000-0001-6941-0284","observed_orcids":["https://orcid.org/0000-0001-6941-0284"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Gao","raw_affiliation_strings":["Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112956969","display_name":"Ruotong Yang","orcid":"https://orcid.org/0009-0005-3829-8943","observed_orcids":["https://orcid.org/0009-0005-3829-8943"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruotong Yang","raw_affiliation_strings":["Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084384992","display_name":"Nan Li","orcid":"https://orcid.org/0000-0002-2932-9649","observed_orcids":["https://orcid.org/0000-0002-2932-9649"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4405272564","display_name":"National Health Commission of the People's Republic of China","ror":"https://ror.org/04bdenw41","country_code":"CN","type":"government","lineage":["https://openalex.org/I4405272564"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Li","raw_affiliation_strings":["Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China","Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Bejing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Bejing, 100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4405272564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100413271","display_name":"Zhonghua Liu","orcid":"https://orcid.org/0000-0003-3048-9823","observed_orcids":["https://orcid.org/0000-0003-3048-9823","https://orcid.org/0009-0001-0313-2506"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Zhonghua Liu","raw_affiliation_strings":["Department of Statistics and Actuarial Science, The University of Hong Kong, Pok Fu Lam, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics and Actuarial Science, The University of Hong Kong, Pok Fu Lam, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102157669","display_name":"Weihua Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weihua Cao","raw_affiliation_strings":["Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China. caoweihua60@163.com","Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China. caoweihua60@163.com","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076740728","display_name":"Tao Huang","orcid":"https://orcid.org/0000-0002-0328-1368","observed_orcids":["https://orcid.org/0000-0002-0328-1368","https://orcid.org/0009-0001-7340-1652","https://orcid.org/0000-0002-6554-2463"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tao Huang","raw_affiliation_strings":["Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China. huangtaotao@pku.edu.cn","Department of Global Health, School of Public Health, Peking University, Bejing, 100191, China. huangtaotao@pku.edu.cn","Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Bejing, 100191, China. huangtaotao@pku.edu.cn","Department of Global Health, School of Public Health, Peking University, Bejing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Bejing, 100191, China. huangtaotao@pku.edu.cn","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Global Health, School of Public Health, Peking University, Bejing, 100191, China. huangtaotao@pku.edu.cn","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Bejing, 100191, China. huangtaotao@pku.edu.cn","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Global Health, School of Public Health, Peking University, Bejing, 100191, China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5076740728","https://openalex.org/A5102157669"],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":{"value":2170,"currency":"USD","value_usd":2170},"apc_paid":{"value":2170,"currency":"USD","value_usd":2170},"fwci":9.96,"has_fulltext":true,"cited_by_count":106,"citation_normalized_percentile":{"value":0.98713155,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"19","issue":"1","first_page":"86","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.13819999992847443,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.08760000020265579,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9789999723434448},{"id":"https://openalex.org/keywords/sedentary-behavior","display_name":"sedentary behavior","score":0.8980000019073486},{"id":"https://openalex.org/keywords/sleep-duration","display_name":"sleep duration","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8220000267028809},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9660000205039978},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":1.0},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":1.0},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.8859999775886536},{"id":"https://openalex.org/keywords/high-intensity-exercise","display_name":"high-intensity exercise","score":0.8159999847412109},{"id":"https://openalex.org/keywords/moderate-to-vigorous-physical-activity","display_name":"moderate-to-vigorous physical activity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/causal-effects","display_name":"causal effects","score":0.48899999260902405},{"id":"https://openalex.org/keywords/genetic-tools","display_name":"genetic instruments","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9527256488800049},{"id":"https://openalex.org/C22894154","wikidata":"https://www.wikidata.org/wiki/Q15483409","display_name":"Lipidology","level":3,"score":0.7932431101799011},{"id":"https://openalex.org/C148257392","wikidata":"https://www.wikidata.org/wiki/Q2358629","display_name":"Clinical nutrition","level":2,"score":0.763595461845398},{"id":"https://openalex.org/C382228","wikidata":"https://www.wikidata.org/wiki/Q849994","display_name":"Clinical chemistry","level":2,"score":0.6097831130027771},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.5245124101638794},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.5090200901031494},{"id":"https://openalex.org/C2778996325","wikidata":"https://www.wikidata.org/wiki/Q422201","display_name":"Actigraphy","level":3,"score":0.5015265941619873},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46438702940940857},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45165008306503296},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.44832485914230347},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3337523639202118},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3199284076690674},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2785850167274475},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21269911527633667},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.17416417598724365},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.1465756595134735},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.12790101766586304},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09559562802314758},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D057185","descriptor_name":"Sedentary Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12944-020-01257-z","doi":"https://doi.org/10.1186/s12944-020-01257-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12944-020-01257-z","pdf_url":"https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-020-01257-z","source":{"id":"https://openalex.org/S188748365","display_name":"Lipids in Health and Disease","issn_l":"1476-511X","issn":["1476-511X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids in Health and Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7206776","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7206776","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids Health Dis","raw_type":"Text"},{"id":"pmid:32384904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32384904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids in health and disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4075326d35e74544a16e6be37d339560","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4075326d35e74544a16e6be37d339560","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-11 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12944-020-01257-z","doi":"https://doi.org/10.1186/s12944-020-01257-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12944-020-01257-z","pdf_url":"https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-020-01257-z","source":{"id":"https://openalex.org/S188748365","display_name":"Lipids in Health and Disease","issn_l":"1476-511X","issn":["1476-511X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids in Health and Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323378","display_name":"Beijing Technology and Business University","ror":"https://ror.org/013e0zm98"},{"id":"https://openalex.org/F4320324787","display_name":"Peking University","ror":"https://ror.org/02v51f717"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3020983124.pdf","grobid_xml":"https://content.openalex.org/works/W3020983124.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1988988771","https://openalex.org/W2027855458","https://openalex.org/W2038542855","https://openalex.org/W2073995775","https://openalex.org/W2080422716","https://openalex.org/W2081910621","https://openalex.org/W2090383555","https://openalex.org/W2100117695","https://openalex.org/W2128485372","https://openalex.org/W2135065189","https://openalex.org/W2144215489","https://openalex.org/W2152370758","https://openalex.org/W2153118028","https://openalex.org/W2198604009","https://openalex.org/W2206631438","https://openalex.org/W2232953978","https://openalex.org/W2238851414","https://openalex.org/W2320228217","https://openalex.org/W2322742466","https://openalex.org/W2408720990","https://openalex.org/W2439882308","https://openalex.org/W2520017930","https://openalex.org/W2555637497","https://openalex.org/W2564640632","https://openalex.org/W2582295014","https://openalex.org/W2591018678","https://openalex.org/W2591152589","https://openalex.org/W2596490879","https://openalex.org/W2617356362","https://openalex.org/W2624378293","https://openalex.org/W2624802280","https://openalex.org/W2750848836","https://openalex.org/W2754465935","https://openalex.org/W2758276259","https://openalex.org/W2766736132","https://openalex.org/W2767409895","https://openalex.org/W2768238915","https://openalex.org/W2779260763","https://openalex.org/W2784351705","https://openalex.org/W2786619822","https://openalex.org/W2791021113","https://openalex.org/W2791783341","https://openalex.org/W2793007799","https://openalex.org/W2807749226","https://openalex.org/W2884916011","https://openalex.org/W2887420502","https://openalex.org/W2903445830","https://openalex.org/W2905863102","https://openalex.org/W2913696992","https://openalex.org/W2972151766"],"related_works":["https://openalex.org/W6920742773","https://openalex.org/W3140097256","https://openalex.org/W3202069842","https://openalex.org/W7134135000","https://openalex.org/W7154306746","https://openalex.org/W4409119434","https://openalex.org/W4414193650","https://openalex.org/W4402633351","https://openalex.org/W7161776861","https://openalex.org/W3017303542"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Observational":[2],"studies":[3],"have":[4],"shown":[5],"that":[6,196,274],"moderate-to-vigorous":[7],"physical":[8,12,46,82,244,286],"activity":[9,13,245,287],"(MVPA),":[10],"vigorous":[11,197],"(VPA),":[14],"sedentary":[15,48,84,173,221],"behaviours,":[16,49,85],"and":[17,26,50,62,86,96,108,158,172,182,203,226,257],"sleep":[18,51,87,170],"duration":[19,52,88,171,219],"were":[20],"associated":[21,80],"with":[22,53,81,146,180,223,289],"cardiovascular":[23,224],"diseases":[24],"(CVDs)":[25],"lipid":[27,63,97,184,227],"levels.":[28,64,98,185,228],"However,":[29,165,208],"whether":[30],"such":[31,275],"observations":[32],"reflect":[33],"causality":[34],"remain":[35],"largely":[36],"unknown.":[37],"We":[38,66],"aimed":[39],"to":[40,89,213,247,261,296,317],"investigate":[41],"the":[42,91,112,133,190,253,266,283,298],"causal":[43,92,215],"associations":[44,141,179,216],"of":[45,103,114,142,201,217,233,269,282,285,292],"activity,":[47,83],"coronary":[54],"artery":[55],"disease":[56],"(CAD),":[57],"myocardial":[58],"infarction":[59],"(MI),":[60],"stroke":[61,181],"Methods":[65],"conducted":[67],"a":[68,301],"Mendelian":[69],"randomization":[70],"(MR)":[71],"study":[72,100,235],"using":[73],"genetic":[74],"variants":[75],"as":[76],"instruments":[77],"which":[78,308],"are":[79],"examine":[90],"effects":[93],"on":[94,242,305],"CVDs":[95,293,306],"This":[99],"included":[101],"analyses":[102],"4":[104],"potentially":[105],"modifiable":[106],"factors":[107],"7":[109],"outcomes.":[110],"Thus,":[111],"threshold":[113],"statistical":[115],"significance":[116],"is":[117,294],"P":[118,155,162],"=":[119,156,163],"1.8":[120],"\u00d7":[121,126],"10":[122],"\u2212":[123],"3":[124],"(0.05/4":[125],"7)":[127],"after":[128],"Bonferroni":[129],"correction.":[130],"Results":[131],"In":[132],"present":[134],"study,":[135],"there":[136,209],"was":[137,210],"suggestive":[138,194],"evidence":[139,195,212],"for":[140,300],"genetically":[143,166],"predicted":[144,167],"VPA":[145],"CAD":[147,202],"(odds":[148],"ratio,":[149],"0.65;":[150],"95%":[151],"confidence":[152],"intervals,":[153],"0.47\u20130.90;":[154],"0.009)":[157],"MI":[159],"(0.74;":[160],"0.59\u20130.93;":[161],"0.010).":[164],"VPA,":[168],"MVPA,":[169],"behaviours":[174,222],"did":[175,236],"not":[176,206,237],"show":[177],"significant":[178,249],"any":[183],"Conclusions":[186],"Our":[187],"findings":[188,232,254],"from":[189],"MR":[191],"approach":[192,304],"provided":[193],"exercise":[198],"decreased":[199],"risk":[200,225],"MI,":[204],"but":[205],"stroke.":[207],"no":[211],"support":[214],"MVPA,sleep":[218],"or":[220],"Translational":[229],"perspective":[230],"The":[231],"this":[234],"point":[238],"out":[239],"specific":[240],"recommendations":[241],"increasing":[243,265],"required":[246],"deliver":[248],"health":[250,259],"benefits.":[251],"Nevertheless,":[252],"allowed":[255],"clinicians":[256],"public":[258],"practitioners":[260],"provide":[262,297],"advice":[263,276],"about":[264],"total":[267],"amount":[268],"excising":[270],"time":[271],"by":[272],"demonstrating":[273],"can":[277,309],"be":[278,310],"effective.":[279],"Reliable":[280],"assessment":[281],"association":[284],"levels":[288],"different":[290],"subtypes":[291],"needed":[295],"basis":[299],"comprehensive":[302],"clinical":[303],"prevention,":[307],"achieved":[311],"through":[312],"lifestyle":[313],"interventions":[314],"in":[315],"addition":[316],"drug":[318],"therapy.":[319]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":31},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2020-05-13T00:00:00"}