{"id":"https://openalex.org/W3020898744","doi":"https://doi.org/10.1016/j.jalz.2006.05.1191","title":"P2\u2013351: Role of magnetization transfer imaging in early diagnosis of Alzheimer's disease","display_name":"P2\u2013351: Role of magnetization transfer imaging in early diagnosis of Alzheimer's disease","publication_year":2006,"publication_date":"2006-07-01","ids":{"openalex":"https://openalex.org/W3020898744","doi":"https://doi.org/10.1016/j.jalz.2006.05.1191","mag":"3020898744"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2006.05.1191","doi":"https://doi.org/10.1016/j.jalz.2006.05.1191","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2006.05.1191","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081740807","display_name":"Noor Jehan Kabani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Noor Jehan Kabani","raw_affiliation_strings":["Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1323843004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055634028","display_name":"Adrienne E. Dorr","orcid":"https://orcid.org/0009-0004-7628-1678","observed_orcids":["https://orcid.org/0009-0004-7628-1678"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Adrienne Dorr","raw_affiliation_strings":["Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1323843004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091593779","display_name":"John G. Sled","orcid":"https://orcid.org/0000-0002-4461-283X","observed_orcids":["https://orcid.org/0000-0002-4461-283X"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John G. Sled","raw_affiliation_strings":["Hospital for Sick Children, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Sick Children, Toronto, ON, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088503502","display_name":"Howard Mark Chertkow","orcid":"https://orcid.org/0000-0003-3749-8132","observed_orcids":["https://orcid.org/0000-0003-3749-8132"]},"institutions":[{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Howard Chertkow","raw_affiliation_strings":["Lady Davis Institute, Montreal, PQ, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lady Davis Institute, Montreal, PQ, Canada","institution_ids":["https://openalex.org/I4405267356"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081740807"],"corresponding_institution_ids":["https://openalex.org/I1323843004"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42218788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"3S_Part_11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnetization-transfer-imaging","display_name":"magnetization transfer imaging","score":0.9369999766349792},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.726482629776001},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.6367436647415161},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6123983860015869},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5631890892982483},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5555484890937805},{"id":"https://openalex.org/C144494922","wikidata":"https://www.wikidata.org/wiki/Q6547272","display_name":"Likelihood ratios in diagnostic testing","level":3,"score":0.4937761723995209},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4379972219467163},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.401418536901474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38741010427474976},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3753678798675537},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3434821665287018},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3427775502204895},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33854275941848755},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32045799493789673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2006.05.1191","doi":"https://doi.org/10.1016/j.jalz.2006.05.1191","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2006.05.1191","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2003647469","https://openalex.org/W2051899742","https://openalex.org/W2004412802","https://openalex.org/W2062168749","https://openalex.org/W2370959644","https://openalex.org/W2049512075","https://openalex.org/W44398472","https://openalex.org/W2090581690","https://openalex.org/W4387840873","https://openalex.org/W7165870613"],"abstract_inverted_index":{"Elderly":[0],"individuals":[1],"who":[2],"suffer":[3],"from":[4,96,264],"significant":[5],"memory":[6],"impairment":[7,24],"in":[8,13,93,145,218,224,261,281],"the":[9,47,57,128,136,160,163,172,200,203,226,232,267,270,282],"absence":[10],"of":[11,29,49,59,67,103,127,154,165,171,181,189,214,229,269,284],"decline":[12,39],"functional":[14],"and":[15,79,116,130,169,221],"intellectual":[16],"ability":[17],"are":[18],"classified":[19],"as":[20,156,239],"having":[21],"mild":[22],"cognitive":[23,27],"(MCI).":[25],"The":[26],"condition":[28],"such":[30],"individual":[31],"may":[32,38],"either":[33],"remain":[34],"stable":[35],"(MCIs)":[36],"or":[37,43,191,275],"further":[40],"(MCI":[41],"progressors":[42],"MCIp),":[44],"leading":[45],"to":[46,120,134,140,149,198,246],"diagnosis":[48,66],"Alzheimer's":[50],"disease":[51],"(AD).":[52],"This":[53],"research":[54],"focuses":[55],"on":[56],"use":[58],"magnetization":[60],"transfer":[61],"(MT)":[62],"imaging":[63],"for":[64,82,159,236],"early":[65],"dementia.":[68],"In":[69,98,209],"a":[70,109,142,157,240],"longitudinal":[71],"study":[72,100],"where":[73],"35":[74,104],"MCI":[75,105],"subjects":[76,185],"were":[77,193],"scanned":[78],"clinically":[80],"followed":[81],"two":[83,110,227],"years,":[84],"we":[85],"found":[86,139],"that":[87,184,256],"MT":[88],"measurement":[89,248],"was":[90,118,138,174,207,243],"more":[91,196],"reliable":[92],"differentiating":[94,225,262],"MCIp":[95,148,265],"MCIs.":[97,150],"this":[99],"10":[101],"out":[102],"developed":[106],"AD":[107],"over":[108],"year":[111],"interval.":[112],"Time":[113],"1":[114],"volumetric":[115,247],"MTR":[117,137,153,188,257,268],"used":[119],"create":[121],"receiver":[122],"operating":[123],"characteristic":[124],"(ROC)":[125],"curves":[126],"hippocampus":[129],"entorhinal":[131,161],"cortex.":[132],"Compared":[133,245],"volume,":[135],"be":[141],"better":[143,259],"parameter":[144],"discriminating":[146],"between":[147],"Using":[151],"an":[152,187,211],"31.4%":[155,190],"cut\u2013off":[158],"cortex,":[162],"accuracy":[164,223],"correct":[166],"classification,":[167],"sensitivity":[168,213],"specificity":[170,220],"measure":[173],"80%":[175,212],"each.":[176],"A":[177],"positive":[178,233],"likelihood":[179,205,234],"ratio":[180,206,235],"4":[182],"suggested":[183],"with":[186],"lower":[192],"four":[194],"times":[195],"likely":[197],"develop":[199],"disease,":[201],"whereas":[202],"negative":[204],"0.25.":[208],"contrast,":[210],"hippocampal":[215,237],"volume":[216,238],"resulted":[217],"52%":[219],"60%":[222],"sub\u2013groups":[228],"MCI.":[230],"Additionally":[231],"diagnostic":[241],"factor":[242],"1.67.":[244],"which":[249],"is":[250,273],"labor":[251],"intensive,":[252],"these":[253],"findings":[254],"show":[255],"produces":[258],"results":[260],"MCIs":[263],"whether":[266],"entire":[271],"structure":[272],"measured":[274],"only":[276],"20":[277],"randomly":[278],"selected":[279],"voxels":[280],"region":[283],"interest.":[285]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-05-13T00:00:00"}
