{"id":"https://openalex.org/W3020711697","doi":"https://doi.org/10.1021/acs.jmedchem.0c00203","title":"Structure\u2013Activity Analysis of Cyclic Multicomponent Lipopeptide Self-Adjuvanting Vaccine Candidates Presenting Group A Streptococcus Antigens","display_name":"Structure\u2013Activity Analysis of Cyclic Multicomponent Lipopeptide Self-Adjuvanting Vaccine Candidates Presenting Group A Streptococcus Antigens","publication_year":2020,"publication_date":"2020-04-29","ids":{"openalex":"https://openalex.org/W3020711697","doi":"https://doi.org/10.1021/acs.jmedchem.0c00203","mag":"3020711697","pmid":"https://pubmed.ncbi.nlm.nih.gov/32347723"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.0c00203","doi":"https://doi.org/10.1021/acs.jmedchem.0c00203","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.0c00203","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075967182","display_name":"Harrison Y. R. Madge","orcid":"https://orcid.org/0000-0002-8116-5194","observed_orcids":["https://orcid.org/0000-0002-8116-5194"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Harrison Y. R. Madge","raw_affiliation_strings":["School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058044147","display_name":"Hansa Sharma","orcid":"https://orcid.org/0000-0003-3282-4859","observed_orcids":["https://orcid.org/0000-0003-3282-4859"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hansa Sharma","raw_affiliation_strings":["School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051605057","display_name":"Waleed M. Hussein","orcid":"https://orcid.org/0000-0001-5392-1880","observed_orcids":["https://orcid.org/0000-0001-5392-1880"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Waleed M. Hussein","raw_affiliation_strings":["School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046282420","display_name":"Zeinab G. Khalil","orcid":"https://orcid.org/0000-0002-9285-1720","observed_orcids":["https://orcid.org/0000-0002-9285-1720"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Zeinab G. Khalil","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021696238","display_name":"Robert J. Capon","orcid":"https://orcid.org/0000-0002-8341-7754","observed_orcids":["https://orcid.org/0000-0002-8341-7754"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robert J. Capon","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia"],"raw_orcid":"https://orcid.org/0000-0002-8341-7754","affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008581557","display_name":"Istv\u00e1n T\u00f3th","orcid":"https://orcid.org/0000-0002-4572-397X","observed_orcids":["https://orcid.org/0000-0002-4572-397X","https://orcid.org/0000-0002-6771-4388"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Istvan Toth","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia","School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia","School of Pharmacy, The University of Queensland, Brisbane 4072, Australia"],"raw_orcid":"https://orcid.org/0000-0002-4572-397X","affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"School of Pharmacy, The University of Queensland, Brisbane 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075359638","display_name":"Rachel J. Stephenson","orcid":"https://orcid.org/0000-0001-6424-7502","observed_orcids":["https://orcid.org/0000-0001-6424-7502"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Rachel J. Stephenson","raw_affiliation_strings":["School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia"],"raw_orcid":"https://orcid.org/0000-0001-6424-7502","affiliations":[{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075359638"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.0245,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.69095677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"63","issue":"10","first_page":"5387","last_page":"5397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.20010000467300415,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.12809999287128448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-pyogenes","display_name":"Streptococcus pyogenes","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cyclic-lipopeptides","display_name":"cyclic lipopeptides","score":0.6629999876022339},{"id":"https://openalex.org/keywords/self-adjuvanting-vaccine","display_name":"self-adjuvanting vaccine","score":0.9679999947547913},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8690000176429749},{"id":"https://openalex.org/keywords/b-cell-epitopes","display_name":"B-cell epitopes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/t-helper-epitopes","display_name":"T-helper epitopes","score":0.8880000114440918},{"id":"https://openalex.org/keywords/opsonization","display_name":"opsonization","score":0.6359999775886536},{"id":"https://openalex.org/keywords/rheumatic-heart-disease","display_name":"rheumatic heart disease","score":0.9169999957084656},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.5199999809265137},{"id":"https://openalex.org/keywords/cyclic-peptides","display_name":"cyclic peptides","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C2777425210","wikidata":"https://www.wikidata.org/wiki/Q2903964","display_name":"Lipopeptide","level":3,"score":0.9400812387466431},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.8251082897186279},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7625138759613037},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6853811144828796},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6392092704772949},{"id":"https://openalex.org/C2778276568","wikidata":"https://www.wikidata.org/wiki/Q190161","display_name":"Streptococcus","level":3,"score":0.5722699761390686},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.559186577796936},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5528841614723206},{"id":"https://openalex.org/C2779306812","wikidata":"https://www.wikidata.org/wiki/Q131271","display_name":"Streptococcus pyogenes","level":4,"score":0.5515235066413879},{"id":"https://openalex.org/C2780678043","wikidata":"https://www.wikidata.org/wiki/Q743241","display_name":"Group A","level":2,"score":0.4983220100402832},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.4651167690753937},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.46385762095451355},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2862318158149719},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2202189564704895},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.20850905776023865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09643477201461792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0933273434638977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08159744739532471},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.0664113461971283},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001428","descriptor_name":"Bacterial Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001428","descriptor_name":"Bacterial Vaccines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001428","descriptor_name":"Bacterial Vaccines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013297","descriptor_name":"Streptococcus pyogenes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013297","descriptor_name":"Streptococcus pyogenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055666","descriptor_name":"Lipopeptides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D055666","descriptor_name":"Lipopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055666","descriptor_name":"Lipopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jmedchem.0c00203","doi":"https://doi.org/10.1021/acs.jmedchem.0c00203","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.0c00203","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:32347723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32347723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6033910826","display_name":"Tropical diseases: Translating discoveries into better health","funder_award_id":"1132975","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1430023774","https://openalex.org/W1559148237","https://openalex.org/W1968318850","https://openalex.org/W1980775088","https://openalex.org/W1985992806","https://openalex.org/W1994667037","https://openalex.org/W1997464207","https://openalex.org/W2022331490","https://openalex.org/W2035096211","https://openalex.org/W2050774179","https://openalex.org/W2055422378","https://openalex.org/W2062029650","https://openalex.org/W2065566578","https://openalex.org/W2067516919","https://openalex.org/W2071029587","https://openalex.org/W2073095051","https://openalex.org/W2081114763","https://openalex.org/W2096949729","https://openalex.org/W2123460554","https://openalex.org/W2136389983","https://openalex.org/W2167398285","https://openalex.org/W2216203568","https://openalex.org/W2327171017","https://openalex.org/W2418712064","https://openalex.org/W2513870508","https://openalex.org/W2517971962","https://openalex.org/W2549307002","https://openalex.org/W2579639856","https://openalex.org/W2593785799","https://openalex.org/W2633721424","https://openalex.org/W2746455801","https://openalex.org/W2809702354","https://openalex.org/W2900852496","https://openalex.org/W2910530924","https://openalex.org/W2956084568","https://openalex.org/W2980473693","https://openalex.org/W4252374612","https://openalex.org/W4313376288"],"related_works":["https://openalex.org/W4214686134","https://openalex.org/W3215343668","https://openalex.org/W4406358685","https://openalex.org/W4414113448","https://openalex.org/W4400580638","https://openalex.org/W1982111692","https://openalex.org/W2061654649","https://openalex.org/W2061692747","https://openalex.org/W53609307","https://openalex.org/W2059685308"],"abstract_inverted_index":{"(GAS)":[0],"infection":[1],"causes":[2],"a":[3,34,39,45,51,58,128,136],"range":[4],"of":[5,20,66,74,97,117,141],"life-threatening":[6],"diseases,":[7],"including":[8],"rheumatic":[9],"heart":[10],"disease.":[11],"Cyclic":[12],"peptides":[13],"offer":[14],"an":[15,85],"attractive":[16],"solution":[17],"for":[18,127,138],"presentation":[19],"short":[21],"peptide":[22,43,143],"antigens":[23,144],"due":[24],"to":[25,112,133,145],"their":[26],"stability":[27],"and":[28,50],"structurally":[29],"constrained":[30],"conformation.":[31],"We":[32],"investigated":[33],"cyclic":[35,68,130],"carrier":[36],"decapeptide":[37],"incorporating":[38],"B":[40],"cell":[41],"GAS":[42,61,120,142,147],"epitope,":[44,49],"universal":[46],"T":[47],"helper":[48],"synthetic":[52],"toll-like":[53],"receptor":[54],"2-targeting":[55],"moiety":[56],"as":[57,135],"possible":[59],"self-adjuvanting":[60,129],"vaccine.":[62],"A":[63],"structure-activity":[64],"relationship":[65],"the":[67,89,94,125,139],"lipopeptide":[69],"vaccine":[70,99],"showed":[71,124],"successful":[72],"induction":[73],"J8-specific":[75],"systemic":[76],"immunoglobulin":[77],"G":[78],"(IgG)":[79],"antibodies":[80,102],"when":[81],"administered":[82],"subcutaneously":[83],"without":[84],"additional":[86],"adjuvant.":[87],"Interestingly,":[88],"physical":[90,108],"mixture":[91,109],"control":[92,110],"induced":[93],"highest":[95],"titers":[96],"all":[98],"compounds,":[100],"with":[101,106],"from":[103],"mice":[104],"immunized":[105],"this":[107],"shown":[111],"effectively":[113],"opsonize":[114],"multiple":[115],"strains":[116],"clinically":[118],"isolated":[119],"bacteria.":[121],"This":[122],"study":[123],"capability":[126],"delivery":[131,140],"system":[132],"act":[134],"vehicle":[137],"treat":[146],"infections.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-05-01T00:00:00"}
