{"id":"https://openalex.org/W3020552003","doi":"https://doi.org/10.37897/rjn.2019.3.5","title":"17beta estradiol ameliorates neuroinflammation driven neuropathic pain in chronic constriction injury \u2013 induced peripheral neuropathy in rats","display_name":"17beta estradiol ameliorates neuroinflammation driven neuropathic pain in chronic constriction injury \u2013 induced peripheral neuropathy in rats","publication_year":2019,"publication_date":"2019-09-30","ids":{"openalex":"https://openalex.org/W3020552003","doi":"https://doi.org/10.37897/rjn.2019.3.5","mag":"3020552003"},"language":"en","primary_location":{"id":"doi:10.37897/rjn.2019.3.5","doi":"https://doi.org/10.37897/rjn.2019.3.5","is_oa":true,"landing_page_url":"https://doi.org/10.37897/rjn.2019.3.5","pdf_url":"https://doi.org/10.37897/rjn.2019.3.5","source":{"id":"https://openalex.org/S4210231381","display_name":"Romanian Journal of Neurology","issn_l":"1843-8148","issn":["1843-8148","2069-6094"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Journal of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.37897/rjn.2019.3.5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056357487","display_name":"Nafissa Telailia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108754898","display_name":"Badji Mokhtar-Annaba University","ror":"https://ror.org/03sf55932","country_code":"DZ","type":"education","lineage":["https://openalex.org/I108754898"]}],"countries":["DZ"],"is_corresponding":true,"raw_author_name":"Nafissa Telailia","raw_affiliation_strings":["Environmental Biomonitoring Laboratory, Department of Biology, Faculty of Sciences, Badji Mokhtar University, Annaba, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Biomonitoring Laboratory, Department of Biology, Faculty of Sciences, Badji Mokhtar University, Annaba, Algeria","institution_ids":["https://openalex.org/I108754898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055865606","display_name":"Hac\u00e8ne Frih","orcid":"https://orcid.org/0000-0002-2357-2090","observed_orcids":["https://orcid.org/0000-0002-2357-2090"]},"institutions":[{"id":"https://openalex.org/I108754898","display_name":"Badji Mokhtar-Annaba University","ror":"https://ror.org/03sf55932","country_code":"DZ","type":"education","lineage":["https://openalex.org/I108754898"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Hac\u00e8ne Frih","raw_affiliation_strings":["Environmental Biomonitoring Laboratory, Department of Biology, Faculty of Sciences, Badji Mokhtar University, Annaba, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Biomonitoring Laboratory, Department of Biology, Faculty of Sciences, Badji Mokhtar University, Annaba, Algeria","institution_ids":["https://openalex.org/I108754898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011983078","display_name":"Sylvain Fisson","orcid":"https://orcid.org/0000-0002-0057-363X","observed_orcids":["https://orcid.org/0000-0002-0057-363X","https://orcid.org/0009-0006-3740-3825"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210127167","display_name":"Genethon (France)","ror":"https://ror.org/03fj96t64","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210127167"]},{"id":"https://openalex.org/I88467170","display_name":"Universit\u00e9 d'\u00c9vry Val-d'Essonne","ror":"https://ror.org/00e96v939","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954","https://openalex.org/I88467170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvain Fisson","raw_affiliation_strings":["Genethon, Evry, France","INSERM, UMR_S951, Evry, France","University of Evry Val d'Essonne, UMRS 951, Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genethon, Evry, France","institution_ids":["https://openalex.org/I4210127167"]},{"raw_affiliation_string":"INSERM, UMR_S951, Evry, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"University of Evry Val d'Essonne, UMRS 951, Evry, France","institution_ids":["https://openalex.org/I88467170"]}]},{"author_position":"middle","author":{"id":null,"display_name":"INSERM, UMR_S951, Evry, France","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"INSERM, UMR_S951, Evry, France","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Genethon, Evry, France","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Genethon, Evry, France","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5056357487"],"corresponding_institution_ids":["https://openalex.org/I108754898"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26330817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"3","first_page":"127","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9160000085830688},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9509999752044678},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/chronic-constriction-injury","display_name":"chronic constriction injury","score":0.9710000157356262},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.7360000014305115},{"id":"https://openalex.org/keywords/antineutrophil-cytoplasmic-antibodies","display_name":"antineutrophil cytoplasmic antibodies","score":0.9470000267028809},{"id":"https://openalex.org/keywords/allodynia","display_name":"allodynia","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.8339999914169312},{"id":"https://openalex.org/keywords/sex-differences-in-pain","display_name":"sex differences in pain","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.9346479177474976},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8579447865486145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7842592000961304},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.6462725400924683},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.6103532314300537},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5541554689407349},{"id":"https://openalex.org/C2776880756","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Peripheral nerve injury","level":3,"score":0.540547788143158},{"id":"https://openalex.org/C2775991916","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Nerve injury","level":2,"score":0.5002801418304443},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.49440979957580566},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.44037455320358276},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.41885966062545776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40562325716018677},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33306795358657837},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.22901633381843567},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.12018370628356934},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11595621705055237},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.08855801820755005},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.07365602254867554}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.37897/rjn.2019.3.5","doi":"https://doi.org/10.37897/rjn.2019.3.5","is_oa":true,"landing_page_url":"https://doi.org/10.37897/rjn.2019.3.5","pdf_url":"https://doi.org/10.37897/rjn.2019.3.5","source":{"id":"https://openalex.org/S4210231381","display_name":"Romanian Journal of Neurology","issn_l":"1843-8148","issn":["1843-8148","2069-6094"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Journal of Neurology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:b765857f11e547d0b59c2df62c110238","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b765857f11e547d0b59c2df62c110238","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Romanian Journal of Neurology, Vol 18, Iss 3, Pp 127-136 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.37897/rjn.2019.3.5","doi":"https://doi.org/10.37897/rjn.2019.3.5","is_oa":true,"landing_page_url":"https://doi.org/10.37897/rjn.2019.3.5","pdf_url":"https://doi.org/10.37897/rjn.2019.3.5","source":{"id":"https://openalex.org/S4210231381","display_name":"Romanian Journal of Neurology","issn_l":"1843-8148","issn":["1843-8148","2069-6094"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Journal of Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3020552003.pdf","grobid_xml":"https://content.openalex.org/works/W3020552003.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W60700377","https://openalex.org/W1484225284","https://openalex.org/W1565081346","https://openalex.org/W1968618759","https://openalex.org/W1988868629","https://openalex.org/W1990738990","https://openalex.org/W2000492372","https://openalex.org/W2006763945","https://openalex.org/W2014781140","https://openalex.org/W2017679057","https://openalex.org/W2018901856","https://openalex.org/W2022061294","https://openalex.org/W2023559607","https://openalex.org/W2024374556","https://openalex.org/W2031816147","https://openalex.org/W2034949619","https://openalex.org/W2069932050","https://openalex.org/W2071936063","https://openalex.org/W2074564840","https://openalex.org/W2076219528","https://openalex.org/W2114930069","https://openalex.org/W2128692107","https://openalex.org/W2145340623","https://openalex.org/W2151019621","https://openalex.org/W2154507501","https://openalex.org/W2160764996","https://openalex.org/W2302151110","https://openalex.org/W2475808935","https://openalex.org/W2663787016","https://openalex.org/W2764017426","https://openalex.org/W2770429776","https://openalex.org/W3014176206","https://openalex.org/W4256732573","https://openalex.org/W4379179521","https://openalex.org/W6653424282"],"related_works":["https://openalex.org/W2554423814","https://openalex.org/W2986437494","https://openalex.org/W2224283033","https://openalex.org/W2597630571","https://openalex.org/W2803072989","https://openalex.org/W1984744514","https://openalex.org/W2048807171","https://openalex.org/W3106850511","https://openalex.org/W2975797131","https://openalex.org/W2188578600"],"abstract_inverted_index":{"17beta":[0,74,187],"estradiol":[1,75,107,126,188],"ameliorates":[2],"neuroinflammation":[3,36,87],"driven":[4,88],"neuropathic":[5,38,89,101,104,133],"pain":[6,48,55,63,90,134],"in":[7,13,86,159],"chronic":[8,128,163],"constriction":[9,129],"injuryinduced":[10],"peripheral":[11,20,28,194],"neuropathy":[12],"rats":[14,94],"AbstrAct":[15],"background.Accumulating":[16],"evidence":[17],"illustrates":[18],"that":[19,42,62,186],"nerve":[21,195],"injuries":[22],"ac-tivate":[23],"glial":[24],"components":[25],"of":[26,47,123,171,183],"the":[27,45,80,117,168,175,180],"and":[29,37,66,103,111,140,156,166],"central":[30],"cellular":[31],"circuitry":[32],"which":[33],"contributes":[34],"to":[35,78],"pain.Epidemiological":[39],"surveys":[40],"suggest":[41],"for":[43],"women":[44],"prevalence":[46],"increases":[49],"with":[50,52],"age":[51],"more":[53],"frequent":[54],"than":[56],"men.Recently,":[57],"several":[58],"studies":[59],"have":[60],"found":[61],"generation,":[64],"transmission":[65],"modulation":[67],"are":[68],"under":[69],"hormonal":[70],"regulation.To":[71],"this":[72],"end,":[73],"was":[76],"used":[77],"investigate":[79],"modulatory":[81],"actions":[82],"on":[83,193],"nociceptive":[84],"thresholds":[85],"conditions.Methods.Adult":[91],"female":[92],"Wistar":[93],"were":[95],"divided":[96],"into":[97],"four":[98],"groups:":[99],"Ovariectomised":[100],"untreated":[102],"17":[105,124],"beta":[106,125],"treated":[108,115,160],"groups.sham":[109],"operated":[110],"intact":[112],"control":[113],"groups.results.In":[114],"rats,":[116],"results":[118],"validate":[119],"an":[120,148],"anti-inflammatory":[121],"action":[122,150],"against":[127],"injury":[130,165,196],"(CCI)":[131],"induced":[132],"by":[135,151,173],"attenuat-ing":[136],"complement":[137],"C3":[138],"fractions":[139],"anti-neutrophil":[141],"cytoplasmic":[142],"auto-antibodies":[143],"(ANCAs)":[144],"intensity":[145],"plasma":[146],"level,":[147],"anti-nociceptive":[149],"attenuating":[152],"ipsilateral,":[153],"con-trolateral":[154],"allodynia":[155],"hyperalgesia":[157],"developed":[158],"animals":[161],"after":[162],"con-striction":[164],"at":[167,179],"last":[169,181],"day":[170,182],"treatment":[172],"increasing":[174],"tail":[176],"flick":[177],"latency":[178],"treatment.conclusions.We":[184],"conclude":[185],"might":[189],"exhibit":[190],"beneficial":[191],"effects":[192],"consequences.":[197]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-05-01T00:00:00"}
