{"id":"https://openalex.org/W3020188209","doi":"https://doi.org/10.1017/s0007114520002913","title":"The rationale for a multi-step therapeutic approach based on antivirals, drugs and nutrients with immunomodulatory activity in patients with coronavirus-SARS2-induced disease of different severities","display_name":"The rationale for a multi-step therapeutic approach based on antivirals, drugs and nutrients with immunomodulatory activity in patients with coronavirus-SARS2-induced disease of different severities","publication_year":2020,"publication_date":"2020-07-24","ids":{"openalex":"https://openalex.org/W3020188209","doi":"https://doi.org/10.1017/s0007114520002913","mag":"3020188209","pmid":"https://pubmed.ncbi.nlm.nih.gov/32703328","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7431858"},"language":"en","primary_location":{"id":"doi:10.1017/s0007114520002913","doi":"https://doi.org/10.1017/s0007114520002913","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114520002913","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/78752A759F395D9FD23DF3DD0306E45D/S0007114520002913a.pdf/div-class-title-the-rationale-for-a-multi-step-therapeutic-approach-based-on-antivirals-drugs-and-nutrients-with-immunomodulatory-activity-in-patients-with-coronavirus-sars2-induced-disease-of-different-severities-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/78752A759F395D9FD23DF3DD0306E45D/S0007114520002913a.pdf/div-class-title-the-rationale-for-a-multi-step-therapeutic-approach-based-on-antivirals-drugs-and-nutrients-with-immunomodulatory-activity-in-patients-with-coronavirus-sars2-induced-disease-of-different-severities-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007849093","display_name":"Sirio Fiorino","orcid":"https://orcid.org/0000-0001-5755-2197","observed_orcids":["https://orcid.org/0000-0001-5755-2197"]},"institutions":[{"id":"https://openalex.org/I4210098325","display_name":"Ospedale Maggiore Carlo Alberto Pizzardi","ror":"https://ror.org/010tmdc88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210098325","https://openalex.org/I4210119117","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210119117","display_name":"Azienda USL di Bologna","ror":"https://ror.org/02mby1820","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210119117"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Sirio Fiorino","raw_affiliation_strings":["Medicine Department, Internal Medicine Unit C, Maggiore Hospital Azienda USL, 40100 Bologna, Italy","Medicine Department, Internal Medicine Unit, Budrio Hospital Azienda USL, Budrio, 40054 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Department, Internal Medicine Unit C, Maggiore Hospital Azienda USL, 40100 Bologna, Italy","institution_ids":["https://openalex.org/I4210098325","https://openalex.org/I4210119117"]},{"raw_affiliation_string":"Medicine Department, Internal Medicine Unit, Budrio Hospital Azienda USL, Budrio, 40054 Bologna, Italy","institution_ids":["https://openalex.org/I4210119117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077485905","display_name":"Maddalena Zippi","orcid":"https://orcid.org/0000-0001-5876-3199","observed_orcids":["https://orcid.org/0000-0001-5876-3199"]},"institutions":[{"id":"https://openalex.org/I4210134461","display_name":"Ospedale Sandro Pertini","ror":"https://ror.org/03hj7dq77","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210134461"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maddalena Zippi","raw_affiliation_strings":["Gastroenterology and Hepatology Department, Unit of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, 00100 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Hepatology Department, Unit of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, 00100 Rome, Italy","institution_ids":["https://openalex.org/I4210134461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101456408","display_name":"Claudio Giuseppe Gallo","orcid":"https://orcid.org/0000-0002-4037-8185","observed_orcids":["https://orcid.org/0000-0002-4037-8185"]},"institutions":[{"id":"https://openalex.org/I4210119117","display_name":"Azienda USL di Bologna","ror":"https://ror.org/02mby1820","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210119117"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Gallo","raw_affiliation_strings":["Medicine Department, Internal Medicine Unit, Budrio Hospital Azienda USL, Budrio, 40054 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Department, Internal Medicine Unit, Budrio Hospital Azienda USL, Budrio, 40054 Bologna, Italy","institution_ids":["https://openalex.org/I4210119117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010701198","display_name":"Debora Sifo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119117","display_name":"Azienda USL di Bologna","ror":"https://ror.org/02mby1820","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210119117"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Debora Sifo","raw_affiliation_strings":["Medicine Department, Internal Medicine Unit, Budrio Hospital Azienda USL, Budrio, 40054 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Department, Internal Medicine Unit, Budrio Hospital Azienda USL, Budrio, 40054 Bologna, Italy","institution_ids":["https://openalex.org/I4210119117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075541848","display_name":"Sergio Sabbatani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sergio Sabbatani","raw_affiliation_strings":["Gastroenterology and Hepatology Department, Infective Disease Unit, Policlinico S. Orsola-Malpighi, University of Bologna, 40100 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Hepatology Department, Infective Disease Unit, Policlinico S. Orsola-Malpighi, University of Bologna, 40100 Bologna, Italy","institution_ids":["https://openalex.org/I4210097083","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051980640","display_name":"Roberto Manfredi","orcid":"https://orcid.org/0000-0001-9022-9893","observed_orcids":["https://orcid.org/0000-0001-9022-9893"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Manfredi","raw_affiliation_strings":["Gastroenterology and Hepatology Department, Infective Disease Unit, Policlinico S. Orsola-Malpighi, University of Bologna, 40100 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Hepatology Department, Infective Disease Unit, Policlinico S. Orsola-Malpighi, University of Bologna, 40100 Bologna, Italy","institution_ids":["https://openalex.org/I4210097083","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085771710","display_name":"Edoardo Rasciti","orcid":"https://orcid.org/0000-0002-1281-4015","observed_orcids":["https://orcid.org/0000-0002-1281-4015"]},"institutions":[{"id":"https://openalex.org/I4210123082","display_name":"Ospedale per gli Infermi","ror":"https://ror.org/033mjf763","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123082"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Edoardo Rasciti","raw_affiliation_strings":["Unit of Radiodiagnostics, Ospedale degli Infermi, 48018 Faenza, AUSL Romagna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Radiodiagnostics, Ospedale degli Infermi, 48018 Faenza, AUSL Romagna, Italy","institution_ids":["https://openalex.org/I4210123082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060402035","display_name":"Leonardo Rasciti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119117","display_name":"Azienda USL di Bologna","ror":"https://ror.org/02mby1820","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210119117"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Leonardo Rasciti","raw_affiliation_strings":["Medicine Department, Internal Medicine Unit, Budrio Hospital Azienda USL, Budrio, 40054 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Department, Internal Medicine Unit, Budrio Hospital Azienda USL, Budrio, 40054 Bologna, Italy","institution_ids":["https://openalex.org/I4210119117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017491241","display_name":"Enrico Giampieri","orcid":"https://orcid.org/0000-0003-2269-2338","observed_orcids":["https://orcid.org/0000-0003-2269-2338"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Giampieri","raw_affiliation_strings":["Experimental, Diagnostic and Specialty Medicine Department, University of Bologna, 40100 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental, Diagnostic and Specialty Medicine Department, University of Bologna, 40100 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059757384","display_name":"Ivan Corazza","orcid":"https://orcid.org/0000-0003-2078-1978","observed_orcids":["https://orcid.org/0000-0003-2078-1978"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ivan Corazza","raw_affiliation_strings":["Experimental, Diagnostic and Specialty Medicine Department, University of Bologna, 40100 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental, Diagnostic and Specialty Medicine Department, University of Bologna, 40100 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025566124","display_name":"Paolo Leandri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098325","display_name":"Ospedale Maggiore Carlo Alberto Pizzardi","ror":"https://ror.org/010tmdc88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210098325","https://openalex.org/I4210119117","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210119117","display_name":"Azienda USL di Bologna","ror":"https://ror.org/02mby1820","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210119117"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Leandri","raw_affiliation_strings":["Medicine Department, Internal Medicine Unit C, Maggiore Hospital Azienda USL, 40100 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Department, Internal Medicine Unit C, Maggiore Hospital Azienda USL, 40100 Bologna, Italy","institution_ids":["https://openalex.org/I4210098325","https://openalex.org/I4210119117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049212835","display_name":"Dario de Biase","orcid":"https://orcid.org/0000-0002-0609-8817","observed_orcids":["https://orcid.org/0000-0002-0609-8817"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Dario de Biase","raw_affiliation_strings":["Department of Pharmacy and Biotechnology, University of Bologna, 40100 Bologna, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0609-8817","affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Biotechnology, University of Bologna, 40100 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5007849093"],"corresponding_institution_ids":["https://openalex.org/I4210098325","https://openalex.org/I4210119117"],"apc_list":{"value":3070,"currency":"USD","value_usd":3070},"apc_paid":{"value":3070,"currency":"USD","value_usd":3070},"fwci":0.4764,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.79264243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"125","issue":"3","first_page":"275","last_page":"293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.2345000058412552,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sars-cov","display_name":"SARS-CoV","score":0.8309999704360962},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.8529999852180481},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.6480000019073486},{"id":"https://openalex.org/keywords/vitamin-a","display_name":"vitamin A","score":0.8709999918937683},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":1.0},{"id":"https://openalex.org/keywords/cytokine-release-syndrome","display_name":"cytokine release syndrome","score":0.9300000071525574},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.5230000019073486},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.7310000061988831},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.5139999985694885},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7377034425735474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.663149356842041},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.6161863803863525},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.5883589386940002},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5882366895675659},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.5648974776268005},{"id":"https://openalex.org/C2779673711","wikidata":"https://www.wikidata.org/wiki/Q2633267","display_name":"Atypical pneumonia","level":3,"score":0.5222542881965637},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5193087458610535},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.4844510555267334},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.47817355394363403},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.46924591064453125},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.4411349892616272},{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.42508915066719055},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.4179835617542267},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3757742643356323},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.347398966550827},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.33524054288864136},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.33293938636779785},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11460083723068237},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067011","descriptor_name":"Severe Acute Malnutrition","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000067011","descriptor_name":"Severe Acute Malnutrition","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014815","descriptor_name":"Vitamins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014815","descriptor_name":"Vitamins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1017/s0007114520002913","doi":"https://doi.org/10.1017/s0007114520002913","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114520002913","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/78752A759F395D9FD23DF3DD0306E45D/S0007114520002913a.pdf/div-class-title-the-rationale-for-a-multi-step-therapeutic-approach-based-on-antivirals-drugs-and-nutrients-with-immunomodulatory-activity-in-patients-with-coronavirus-sars2-induced-disease-of-different-severities-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},{"id":"pmid:32703328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32703328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7431858","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7431858/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Nutr","raw_type":"Text"},{"id":"mag:3125597781","doi":null,"is_oa":false,"landing_page_url":"https://www.preprints.org/manuscript/202004.0406/v1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:cris.unibo.it:11585/770293","doi":null,"is_oa":true,"landing_page_url":"https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/rationale-for-a-multistep-therapeutic-approach-based-on-antivirals-drugs-and-nutrients-with-immunomodulatory-activity-in-patients-with-coronavirussars2induced-disease-of-different-severity/78752A759F395D9FD23DF3DD0306E45D","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1017/s0007114520002913","doi":"https://doi.org/10.1017/s0007114520002913","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114520002913","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/78752A759F395D9FD23DF3DD0306E45D/S0007114520002913a.pdf/div-class-title-the-rationale-for-a-multi-step-therapeutic-approach-based-on-antivirals-drugs-and-nutrients-with-immunomodulatory-activity-in-patients-with-coronavirus-sars2-induced-disease-of-different-severities-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323553","display_name":"Universit\u00e0 di Bologna","ror":"https://ror.org/01111rn36"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3020188209.pdf","grobid_xml":"https://content.openalex.org/works/W3020188209.grobid-xml"},"referenced_works_count":122,"referenced_works":["https://openalex.org/W31599967","https://openalex.org/W89358359","https://openalex.org/W130920184","https://openalex.org/W261295809","https://openalex.org/W1495456524","https://openalex.org/W1527086897","https://openalex.org/W1542375433","https://openalex.org/W1565157642","https://openalex.org/W1566776722","https://openalex.org/W1582148465","https://openalex.org/W1859742880","https://openalex.org/W1954783160","https://openalex.org/W1964641978","https://openalex.org/W1964891568","https://openalex.org/W1965737875","https://openalex.org/W1971884054","https://openalex.org/W1973152075","https://openalex.org/W1975280933","https://openalex.org/W1980564318","https://openalex.org/W1983937216","https://openalex.org/W1984570356","https://openalex.org/W1987847924","https://openalex.org/W1995717418","https://openalex.org/W2000423251","https://openalex.org/W2001975441","https://openalex.org/W2006955905","https://openalex.org/W2007770728","https://openalex.org/W2009080092","https://openalex.org/W2010733432","https://openalex.org/W2010917880","https://openalex.org/W2017394237","https://openalex.org/W2025835729","https://openalex.org/W2026216011","https://openalex.org/W2027203404","https://openalex.org/W2028764252","https://openalex.org/W2032473124","https://openalex.org/W2035742661","https://openalex.org/W2055007053","https://openalex.org/W2060845714","https://openalex.org/W2062993199","https://openalex.org/W2070463916","https://openalex.org/W2075530183","https://openalex.org/W2092616294","https://openalex.org/W2093852073","https://openalex.org/W2096343073","https://openalex.org/W2099129294","https://openalex.org/W2102792873","https://openalex.org/W2119739932","https://openalex.org/W2120801007","https://openalex.org/W2122743894","https://openalex.org/W2123093300","https://openalex.org/W2128698112","https://openalex.org/W2129542667","https://openalex.org/W2134266729","https://openalex.org/W2137836062","https://openalex.org/W2140388343","https://openalex.org/W2141845531","https://openalex.org/W2143033228","https://openalex.org/W2147390979","https://openalex.org/W2147720216","https://openalex.org/W2154348937","https://openalex.org/W2156273941","https://openalex.org/W2158574195","https://openalex.org/W2162815224","https://openalex.org/W2165275185","https://openalex.org/W2295770513","https://openalex.org/W2341786551","https://openalex.org/W2416727941","https://openalex.org/W2473144702","https://openalex.org/W2528573856","https://openalex.org/W2549708057","https://openalex.org/W2566510183","https://openalex.org/W2572357090","https://openalex.org/W2610792835","https://openalex.org/W2620241325","https://openalex.org/W2623393404","https://openalex.org/W2738344725","https://openalex.org/W2785081607","https://openalex.org/W2786983345","https://openalex.org/W2790014151","https://openalex.org/W2790127336","https://openalex.org/W2835891577","https://openalex.org/W2890638701","https://openalex.org/W2901868709","https://openalex.org/W2904288329","https://openalex.org/W2905076420","https://openalex.org/W2911326189","https://openalex.org/W2952676828","https://openalex.org/W2956084665","https://openalex.org/W2962953360","https://openalex.org/W2976098783","https://openalex.org/W2976383068","https://openalex.org/W2996155896","https://openalex.org/W2999364275","https://openalex.org/W2999722173","https://openalex.org/W3001827567","https://openalex.org/W3001897055","https://openalex.org/W3003464757","https://openalex.org/W3004114601","https://openalex.org/W3004318991","https://openalex.org/W3004499272","https://openalex.org/W3004894342","https://openalex.org/W3009446530","https://openalex.org/W3009828946","https://openalex.org/W3009992310","https://openalex.org/W3010441732","https://openalex.org/W3010588272","https://openalex.org/W3011201358","https://openalex.org/W3012169665","https://openalex.org/W3016489853","https://openalex.org/W3017680297","https://openalex.org/W3018517500","https://openalex.org/W3020992950","https://openalex.org/W3020993161","https://openalex.org/W3028659908","https://openalex.org/W3031739230","https://openalex.org/W4206751571","https://openalex.org/W6603642136","https://openalex.org/W6605264662","https://openalex.org/W6629673125","https://openalex.org/W6681948851","https://openalex.org/W6774699271"],"related_works":["https://openalex.org/W4390082969","https://openalex.org/W3092477106","https://openalex.org/W3163322206","https://openalex.org/W4224283693","https://openalex.org/W6949988264","https://openalex.org/W3168647978","https://openalex.org/W3092498418","https://openalex.org/W4210399629","https://openalex.org/W4200134020","https://openalex.org/W3125597781"],"abstract_inverted_index":{"In":[0],"December":[1],"2019,":[2],"a":[3,20,118],"novel":[4],"human-infecting":[5],"coronavirus,":[6],"named":[7],"Severe":[8],"Acute":[9],"Respiratory":[10],"Syndrome":[11],"Corona":[12],"Virus":[13],"2":[14],"(SARS-CoV-2),":[15],"was":[16,121],"recognised":[17],"to":[18,56,87,123],"cause":[19],"pneumonia":[21],"epidemic":[22,38],"outbreak":[23],"with":[24,132,182],"different":[25],"degrees":[26],"of":[27,78,92,102,107,142,159,171,176,190,209],"severity":[28],"in":[29,33,42,130,180,201],"Wuhan,":[30],"Hubei":[31],"Province":[32],"China.":[34],"Since":[35],"then,":[36],"this":[37,58],"has":[39,45],"spread":[40],"worldwide;":[41],"Europe,":[43],"Italy":[44],"been":[46],"involved.":[47],"Effective":[48],"preventive":[49],"and":[50,71,95,144,150,152,163,175,185,199,211],"therapeutic":[51],"strategies":[52],"are":[53,73,114],"absolutely":[54],"required":[55],"block":[57],"serious":[59],"public":[60],"health":[61],"concern.":[62],"Unfortunately,":[63],"few":[64],"studies":[65],"about":[66],"SARS-CoV-2":[67,83,143,210],"concerning":[68],"its":[69,97],"immunopathogenesis":[70],"treatment":[72],"available.":[74],"On":[75],"the":[76,79,82,100,105,108,125,140,147,157,164,169,172,177,187,206],"basis":[77],"assumption":[80],"that":[81,96],"is":[84],"genetically":[85],"related":[86],"SARS-CoV":[88],"(about":[89],"82":[90],"%":[91],"genome":[93],"homology)":[94],"characteristics,":[98],"like":[99],"modality":[101],"transmission":[103],"or":[104,204],"type":[106],"immune":[109,178,213],"response":[110,179],"it":[111],"may":[112],"stimulate,":[113],"still":[115],"poorly":[116],"known,":[117],"literature":[119],"search":[120],"performed":[122],"identify":[124],"reports":[126],"assessing":[127],"these":[128],"elements":[129],"patients":[131,181],"SARS-CoV-induced":[133],"infection.":[134],"Therefore,":[135],"we":[136],"have":[137],"analysed:":[138],"(1)":[139],"structure":[141],"SARS-CoV;":[145],"(2)":[146],"clinical":[148],"signs":[149],"symptoms":[151],"pathogenic":[153],"mechanisms":[154],"observed":[155],"during":[156],"development":[158],"acute":[160],"respiratory":[161],"syndrome":[162],"cytokine":[165],"release":[166],"syndrome;":[167],"(3)":[168],"modification":[170],"cell":[173],"microRNome":[174],"SARS":[183],"infection;":[184],"(4)":[186],"possible":[188],"role":[189],"some":[191],"fat-soluble":[192],"compounds":[193],"(such":[194],"as":[195],"vitamins":[196],"A,":[197],"D":[198],"E)":[200],"modulating":[202],"directly":[203],"indirectly":[205],"replication":[207],"ability":[208],"host":[212],"response.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-05-01T00:00:00"}