{"id":"https://openalex.org/W3020006997","doi":"https://doi.org/10.3389/fonc.2020.00530","title":"Perineural Invasion and Postoperative Adjuvant Chemotherapy Efficacy in Patients With Gastric Cancer","display_name":"Perineural Invasion and Postoperative Adjuvant Chemotherapy Efficacy in Patients With Gastric Cancer","publication_year":2020,"publication_date":"2020-04-21","ids":{"openalex":"https://openalex.org/W3020006997","doi":"https://doi.org/10.3389/fonc.2020.00530","mag":"3020006997","pmid":"https://pubmed.ncbi.nlm.nih.gov/32373527","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7186485"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2020.00530","doi":"https://doi.org/10.3389/fonc.2020.00530","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2020.00530","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2020.00530/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2020.00530/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080982649","display_name":"Tao Qing","orcid":"https://orcid.org/0000-0001-6610-0301","observed_orcids":["https://orcid.org/0000-0001-6610-0301"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Tao","raw_affiliation_strings":["Department of Medical Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wen Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Zhu","raw_affiliation_strings":["Department of Medical Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101785910","display_name":"Xiaohui Zhao","orcid":"https://orcid.org/0000-0001-8052-3570","observed_orcids":["https://orcid.org/0000-0001-8052-3570"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Zhao","raw_affiliation_strings":["Department of Pathology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Affiliated Hospital of Jiangsu University, Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100617721","display_name":"Mei Li","orcid":"https://orcid.org/0000-0002-8830-5209","observed_orcids":["https://orcid.org/0000-0002-8830-5209"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei Li","raw_affiliation_strings":["Department of Pathology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Affiliated Hospital of Jiangsu University, Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074904959","display_name":"Yongqian Shu","orcid":"https://orcid.org/0000-0003-2103-0877","observed_orcids":["https://orcid.org/0000-0003-2103-0877","https://orcid.org/0000-0002-3034-685X","https://orcid.org/0000-0002-6683-4249","https://orcid.org/0000-0003-2099-4260","https://orcid.org/0000-0002-4684-2540"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongqian Shu","raw_affiliation_strings":["Department of Medical Oncology, Jiangsu Province Hospital, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Jiangsu Province Hospital, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101578018","display_name":"Deqiang Wang","orcid":"https://orcid.org/0000-0002-8411-312X","observed_orcids":["https://orcid.org/0000-0002-8411-312X","https://orcid.org/0009-0009-8349-9372"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Deqiang Wang","raw_affiliation_strings":["Department of Medical Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100707521","display_name":"Xiaoqin Li","orcid":"https://orcid.org/0000-0003-3762-9817","observed_orcids":["https://orcid.org/0000-0003-3762-9817"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoqin Li","raw_affiliation_strings":["Department of Medical Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100707521","https://openalex.org/A5101578018"],"corresponding_institution_ids":["https://openalex.org/I4210111628"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.5851,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.8503463,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":null,"first_page":"530","last_page":"530"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.8659999966621399},{"id":"https://openalex.org/keywords/perineural-invasion","display_name":"perineural invasion","score":1.0},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9789999723434448},{"id":"https://openalex.org/keywords/fluoropyrimidine","display_name":"fluoropyrimidine","score":0.8899999856948853},{"id":"https://openalex.org/keywords/chemotherapy-response-prediction","display_name":"chemotherapy response prediction","score":0.6340000033378601},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.984000027179718},{"id":"https://openalex.org/keywords/ero1a","display_name":"ERO1A","score":0.949999988079071},{"id":"https://openalex.org/keywords/thymidylate-synthase","display_name":"thymidylate synthase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/s100-protein","display_name":"S-100 protein","score":0.6600000262260437},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.628000020980835},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8489999771118164},{"id":"https://openalex.org/keywords/radical-resection","display_name":"radical resection","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8289052844047546},{"id":"https://openalex.org/C2777154038","wikidata":"https://www.wikidata.org/wiki/Q7168585","display_name":"Perineural invasion","level":3,"score":0.7844218015670776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6895878314971924},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6726173758506775},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6212355494499207},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5405551195144653},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5246565341949463},{"id":"https://openalex.org/C123321153","wikidata":"https://www.wikidata.org/wiki/Q22676802","display_name":"Thymidylate synthase","level":4,"score":0.5135343074798584},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5088129639625549},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5034160017967224},{"id":"https://openalex.org/C3018227240","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant chemotherapy","level":4,"score":0.4260207414627075},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.424790620803833},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.20410680770874023},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.07561305165290833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06729045510292053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2020.00530","doi":"https://doi.org/10.3389/fonc.2020.00530","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2020.00530","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2020.00530/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmid:32373527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32373527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7186485","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7186485/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:31b48085a31f4ea1bc8a70167346ff08","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/31b48085a31f4ea1bc8a70167346ff08","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 10 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2020.00530","doi":"https://doi.org/10.3389/fonc.2020.00530","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2020.00530","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2020.00530/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4922392974","display_name":null,"funder_award_id":"81672896","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320327797","display_name":"Science and Technology Planning Social Development Project of Zhenjiang City","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3020006997.pdf","grobid_xml":"https://content.openalex.org/works/W3020006997.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1532654778","https://openalex.org/W1590524909","https://openalex.org/W1767508090","https://openalex.org/W1841705709","https://openalex.org/W1902808781","https://openalex.org/W1966684718","https://openalex.org/W2016052287","https://openalex.org/W2024903578","https://openalex.org/W2030430663","https://openalex.org/W2049397238","https://openalex.org/W2060311941","https://openalex.org/W2060717502","https://openalex.org/W2084116712","https://openalex.org/W2091935484","https://openalex.org/W2107907529","https://openalex.org/W2272984102","https://openalex.org/W2323442346","https://openalex.org/W2514972769","https://openalex.org/W2519577242","https://openalex.org/W2562440474","https://openalex.org/W2605993275","https://openalex.org/W2617439368","https://openalex.org/W2735063286","https://openalex.org/W2737082469","https://openalex.org/W2737578400","https://openalex.org/W2767760804","https://openalex.org/W2800160157","https://openalex.org/W2801785519","https://openalex.org/W2884209526","https://openalex.org/W2899801782","https://openalex.org/W2906016781","https://openalex.org/W2912546405","https://openalex.org/W2920600229","https://openalex.org/W2936946217","https://openalex.org/W2946890704","https://openalex.org/W2966797106","https://openalex.org/W2982276024"],"related_works":["https://openalex.org/W2048923944","https://openalex.org/W1981308639","https://openalex.org/W6912394886","https://openalex.org/W2999780489","https://openalex.org/W6958258086","https://openalex.org/W2053509924","https://openalex.org/W3014088711","https://openalex.org/W2010300709","https://openalex.org/W3001852452","https://openalex.org/W2386983091"],"abstract_inverted_index":{"Purpose:":[0],"There":[1],"is":[2,22,263],"currently":[3],"a":[4,127,249],"lack":[5],"of":[6,25,28,45,63,78,108,207,221],"validated":[7],"predictors":[8],"for":[9,182,256],"adjuvant":[10,65,87,176,238,257],"chemotherapy":[11,48,66,88,149,177,239],"efficacy":[12,49,62],"in":[13,52,67,159,163,186,189,215,227,241,260],"patients":[14,68,188,242],"with":[15,69,82,100,243],"gastric":[16],"cancer":[17],"(GC).":[18],"Perineural":[19],"invasion":[20,27],"(PNI)":[21],"the":[23,29,43,56,61,210],"process":[24],"neoplastic":[26],"nerves,":[30],"accompanied":[31],"by":[32,113,136,170],"tumor":[33],"microenvironment":[34],"(TME)":[35],"changes.":[36],"TME":[37],"can":[38],"determine":[39],"treatment":[40],"outcome":[41],"while":[42],"impact":[44],"PNI":[46,59,97,234,246],"on":[47,118],"remains":[50],"unknown":[51],"GC.":[53,71,245],"We":[54],"investigated":[55],"association":[57],"between":[58],"and":[60,106,126,144,155,184,203,223],"postoperative":[64],"resected":[70,244],"Methods:":[72],"Patients":[73],"who":[74],"underwent":[75],"radical":[76],"resection":[77],"stage":[79],"IB-III":[80],"GC":[81],"or":[83,218],"without":[84],"fluoropyrimidine":[85],"(FU)-based":[86],"were":[89,111,134,196,200],"retrospectively":[90],"selected":[91,109],"from":[92],"two":[93],"separate":[94],"patient":[95,254],"cohorts.":[96,191],"was":[98,167,178],"confirmed":[99],"S100":[101],"immunohistochemistry":[102],"(IHC).":[103],"Tumor":[104],"hypoxia":[105,123],"activity":[107],"pathways":[110,211],"quantified":[112],"mRNA-based":[114],"signature":[115],"scoring":[116],"based":[117],"publicly":[119],"available":[120],"data.":[121],"A":[122],"biomarker,":[124,130],"ERO1A,":[125],"FU":[128,216],"resistance":[129],"thymidylate":[131],"synthase":[132],"(TS),":[133],"assessed":[135],"IHC,":[137],"respectively.":[138,147],"Results:":[139],"Two":[140],"cohorts":[141],"included":[142],"223":[143],"599":[145],"patients,":[146,165],"Adjuvant":[148],"significantly":[150,225],"improved":[151],"overall":[152],"survival":[153,157],"(OS)":[154],"disease-free":[156],"(DFS)":[158],"PNI-positive":[160,187,201,228],"but":[161],"not":[162,168],"PNI-negative":[164,194,231],"which":[166],"impacted":[169],"stages.":[171],"Multivariate":[172],"models":[173],"showed":[174],"that":[175,212],"an":[179],"independent":[180],"predictor":[181],"OS":[183],"DFS":[185],"both":[190],"For":[192],"TME,":[193],"tumors":[195],"more":[197],"hypoxic":[198],"than":[199],"tumors,":[202],"displayed":[204],"relative":[205],"up-regulation":[206],"signaling":[208],"along":[209],"are":[213],"important":[214],"metabolism":[217],"resistance.":[219],"Expressions":[220],"ERO1A":[222],"TS":[224],"decreased":[226],"compared":[229],"to":[230,252],"tumors.":[232],"Conclusions:":[233],"might":[235,247],"help":[236],"predict":[237],"benefit":[240],"be":[248],"convenient":[250],"marker":[251],"improve":[253],"selection":[255],"chemotherapy.":[258],"Validation":[259],"prospective":[261],"studies":[262],"required.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-05-01T00:00:00"}