{"id":"https://openalex.org/W301996367","doi":"https://doi.org/10.1023/a:1025427700337","title":"Molecular characterization of a nuclear topoisomerase II from Nicotiana tabacum that functionally complements a temperature-sensitive topoisomerase II yeast mutant","display_name":"Molecular characterization of a nuclear topoisomerase II from Nicotiana tabacum that functionally complements a temperature-sensitive topoisomerase II yeast mutant","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W301996367","doi":"https://doi.org/10.1023/a:1025427700337","mag":"301996367","pmid":"https://pubmed.ncbi.nlm.nih.gov/14558665"},"language":"en","primary_location":{"id":"doi:10.1023/a:1025427700337","doi":"https://doi.org/10.1023/a:1025427700337","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1025427700337","pdf_url":null,"source":{"id":"https://openalex.org/S189846775","display_name":"Plant Molecular Biology","issn_l":"0167-4412","issn":["0167-4412","1573-5028"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056255473","display_name":"Badri Nath Singh","orcid":"https://orcid.org/0000-0002-6100-7092","observed_orcids":["https://orcid.org/0000-0002-6100-7092"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"B.N. Singh","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110 067, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110 067, India","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033033149","display_name":"Yashwanti Mudgil","orcid":"https://orcid.org/0000-0002-0423-3499","observed_orcids":["https://orcid.org/0000-0002-0423-3499"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yashwanti Mudgil","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, 110 067, India","International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, 110 067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050631215","display_name":"Sudhir Kumar Sopory","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S.K. Sopory","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, 110 067, India","International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, 110 067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056946531","display_name":"Malireddy K. Reddy","orcid":"https://orcid.org/0000-0001-7217-5246","observed_orcids":["https://orcid.org/0000-0001-7217-5246"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"M.K. Reddy","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, 110 067, India","International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, 110 067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056946531"],"corresponding_institution_ids":["https://openalex.org/I4210142124"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.3448,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.52854754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"52","issue":"5","first_page":"1063","last_page":"1076"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topoisomerase-ii","display_name":"topoisomerase II","score":0.925000011920929},{"id":"https://openalex.org/keywords/nicotiana-tabacum","display_name":"tobacco","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.6729999780654907},{"id":"https://openalex.org/keywords/intron-structure","display_name":"intron structure","score":0.6819999814033508},{"id":"https://openalex.org/keywords/splice-junctions","display_name":"splice junctions","score":0.6729999780654907},{"id":"https://openalex.org/keywords/gene-evolution","display_name":"gene evolution","score":0.6359999775886536},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.9259999990463257},{"id":"https://openalex.org/keywords/dna-relaxation","display_name":"DNA relaxation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/dna-decatenation","display_name":"DNA decatenation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gal1-promoter","display_name":"GAL1 promoter","score":0.8109999895095825},{"id":"https://openalex.org/keywords/functional-complementation","display_name":"functional complementation","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.942163348197937},{"id":"https://openalex.org/C2781205006","wikidata":"https://www.wikidata.org/wiki/Q181095","display_name":"Nicotiana tabacum","level":3,"score":0.8540617227554321},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.7812906503677368},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.709822416305542},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5658641457557678},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43373292684555054},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3838305175304413},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3499745726585388},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3436010777950287},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.32436686754226685}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004278","descriptor_name":"DNA, Superhelical","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018744","descriptor_name":"DNA, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018744","descriptor_name":"DNA, Plant","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1025427700337","doi":"https://doi.org/10.1023/a:1025427700337","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1025427700337","pdf_url":null,"source":{"id":"https://openalex.org/S189846775","display_name":"Plant Molecular Biology","issn_l":"0167-4412","issn":["0167-4412","1573-5028"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Molecular Biology","raw_type":"journal-article"},{"id":"pmid:14558665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14558665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W139246821","https://openalex.org/W143908686","https://openalex.org/W207058667","https://openalex.org/W256672630","https://openalex.org/W976139268","https://openalex.org/W1559338540","https://openalex.org/W1649887069","https://openalex.org/W1973538970","https://openalex.org/W1976057490","https://openalex.org/W1983515719","https://openalex.org/W1983985776","https://openalex.org/W1986655847","https://openalex.org/W2001061684","https://openalex.org/W2005905056","https://openalex.org/W2013050134","https://openalex.org/W2023682312","https://openalex.org/W2031676888","https://openalex.org/W2037623448","https://openalex.org/W2043310411","https://openalex.org/W2044575603","https://openalex.org/W2056367986","https://openalex.org/W2058911936","https://openalex.org/W2074637295","https://openalex.org/W2079163603","https://openalex.org/W2083153561","https://openalex.org/W2086725260","https://openalex.org/W2087067146","https://openalex.org/W2092025094","https://openalex.org/W2105841854","https://openalex.org/W2108871842","https://openalex.org/W2123374199","https://openalex.org/W2124624490","https://openalex.org/W2128264377","https://openalex.org/W2132600317","https://openalex.org/W2143173841","https://openalex.org/W2144096494","https://openalex.org/W2160558938","https://openalex.org/W2162283352","https://openalex.org/W2163584895","https://openalex.org/W2166187656","https://openalex.org/W2218064154","https://openalex.org/W2479059126","https://openalex.org/W4234928750","https://openalex.org/W4236530034","https://openalex.org/W4242137010","https://openalex.org/W4285719527","https://openalex.org/W6721720303"],"related_works":["https://openalex.org/W4309476146","https://openalex.org/W1970285813","https://openalex.org/W2013050134","https://openalex.org/W2102715626","https://openalex.org/W2078867993","https://openalex.org/W256672630","https://openalex.org/W2010717560","https://openalex.org/W139246821","https://openalex.org/W1983622714","https://openalex.org/W2083153561"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}