{"id":"https://openalex.org/W30199205","doi":null,"title":"Generation of a T-cell hybridoma producing a contrasuppressor factor for contact sensitivity.","display_name":"Generation of a T-cell hybridoma producing a contrasuppressor factor for contact sensitivity.","publication_year":1990,"publication_date":"1990-10-01","ids":{"openalex":"https://openalex.org/W30199205","mag":"30199205","pmid":"https://pubmed.ncbi.nlm.nih.gov/1699882","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384317"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384317","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384317","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384317","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105989182","display_name":"Alan M. Friedman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A M Friedman","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112834020","display_name":"W Ptak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Ptak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112085469","display_name":"E Brewer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Brewer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075655484","display_name":"Douglas R. Green","orcid":"https://orcid.org/0000-0002-7332-1417","observed_orcids":["https://orcid.org/0000-0002-7332-1417"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D R Green","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067503810","display_name":"Pamela Reuter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P A Reuter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109230705","display_name":"Patrick M. Flood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M Flood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1721,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.43600917,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"2","first_page":"282","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/contact-hypersensitivity","display_name":"contact hypersensitivity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/t-cell-hybridomas","display_name":"T cell hybridomas","score":0.8899999856948853},{"id":"https://openalex.org/keywords/suppressor-t-cell-factor","display_name":"suppressor T cell factor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/adoptive-transfer","display_name":"adoptive transfer","score":0.6079999804496765},{"id":"https://openalex.org/keywords/c3h-hen-mice","display_name":"C3H/HeN mice","score":0.8199999928474426},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.842767596244812},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7433299422264099},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6219966411590576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6153573989868164},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5643308162689209},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5067551732063293},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.48940983414649963},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.47105762362480164},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4642897844314575},{"id":"https://openalex.org/C2781128717","wikidata":"https://www.wikidata.org/wiki/Q1133884","display_name":"Transfer factor","level":2,"score":0.42915716767311096},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4190523326396942},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36462023854255676},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1677296757698059},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10328328609466553},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06879255175590515}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003877","descriptor_name":"Dermatitis, Contact","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013491","descriptor_name":"Suppressor Factors, Immunologic","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1384317","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384317","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:1699882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1699882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:30199205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1699882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384317","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384317","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5099999904632568}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3892057705","display_name":"IMMUNOREGULATION:  T CELLS AND THEIR PRODUCTS","funder_award_id":"5p01ca029606-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W32715354","https://openalex.org/W216590783","https://openalex.org/W1480091187","https://openalex.org/W1505837234","https://openalex.org/W1538475960","https://openalex.org/W1547158702","https://openalex.org/W1548153820","https://openalex.org/W1596131511","https://openalex.org/W1601865671","https://openalex.org/W1781355750","https://openalex.org/W1920500909","https://openalex.org/W1936641248","https://openalex.org/W1942668068","https://openalex.org/W1976351607","https://openalex.org/W1984051362","https://openalex.org/W1995911475","https://openalex.org/W2028889973","https://openalex.org/W2033277142","https://openalex.org/W2037244730","https://openalex.org/W2044220392","https://openalex.org/W2071183722","https://openalex.org/W2079471031","https://openalex.org/W2079588771","https://openalex.org/W2080052508","https://openalex.org/W2081026580","https://openalex.org/W2083923637","https://openalex.org/W2084873243","https://openalex.org/W2096303665","https://openalex.org/W2105772310","https://openalex.org/W2106875731","https://openalex.org/W2111042594","https://openalex.org/W2140985128","https://openalex.org/W2141470884","https://openalex.org/W2157587085","https://openalex.org/W2166659122","https://openalex.org/W2170256198","https://openalex.org/W2413723342"],"related_works":["https://openalex.org/W2415933127","https://openalex.org/W19945985","https://openalex.org/W1556247690","https://openalex.org/W2055136532","https://openalex.org/W1631298814","https://openalex.org/W2124766321","https://openalex.org/W2068923696","https://openalex.org/W1621822736","https://openalex.org/W20008773","https://openalex.org/W2039033625"],"abstract_inverted_index":{"C3H/HeN":[0],"mice":[1,15],"were":[2,16,26,41],"immunized":[3],"to":[4,31,47,112,140],"induce":[5],"contrasuppressor":[6,34,75,115,137],"T-cell":[7,35,54,154,173],"(Tcs)":[8],"activity,":[9],"splenic":[10],"T":[11],"cells":[12,145,163],"from":[13,122],"these":[14,66],"fused":[17],"with":[18],"the":[19,23,49,58,71,79,148,151],"BW5147":[20],"thymoma,":[21],"and":[22,78,92,109,178],"resulting":[24],"hybridomas":[25,40,174],"tested":[27],"for":[28,117,175],"their":[29,45],"ability":[30,46],"produce":[32],"a":[33,74,133,136,159],"factor":[36,55,76,116,138],"(TcsF).":[37],"Nine":[38],"TcsF-producing":[39],"preliminarily":[42],"identified":[43],"by":[44,83,143,158],"inhibit":[48],"effect":[50],"of":[51,61,65,73,132,153,162,171,182],"antigen-specific":[52,91,114],"suppressor":[53],"(TsF)":[56],"on":[57],"adoptive":[59],"transfer":[60],"contact":[62,118],"sensitivity.":[63],"One":[64],"hybrids,":[67],"AF5.C6,":[68],"was":[69],"cloned,":[70],"production":[72,121],"confirmed,":[77],"high-titred":[80],"TcsF":[81,89,106],"produced":[82,142],"this":[84],"cloned":[85],"hybrid":[86],"characterized.":[87],"Hybridoma-derived":[88],"is":[90,107,156,166],"specifically":[93],"binds":[94],"its":[95],"antigen,":[96],"but":[97],"does":[98],"not":[99],"bear":[100],"immunoglobulin":[101],"(Ig)":[102],"determinants.":[103],"Thus,":[104],"hybridoma-derived":[105],"serologically":[108],"functionally":[110],"identical":[111,139],"an":[113],"sensitivity,":[119],"whose":[120,164],"splenocyte":[123],"cell":[124],"cultures":[125],"has":[126],"previously":[127],"been":[128],"described.":[129],"The":[130,168],"generation":[131],"hybridoma":[134],"secreting":[135],"that":[141,150],"spleen":[144],"significantly":[146],"strengthens":[147],"hypothesis":[149],"phenomenon":[152],"contrasuppression":[155,183],"mediated":[157],"specific":[160],"subset":[161],"activity":[165],"contrasuppressive.":[167],"further":[169],"advantages":[170],"employing":[172],"functional,":[176],"biochemical":[177],"molecular":[179],"genetic":[180],"analyses":[181],"are":[184],"also":[185],"discussed.":[186]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
