{"id":"https://openalex.org/W3019606932","doi":"https://doi.org/10.1016/j.bonr.2020.100267","title":"Rebound-associated vertebral fractures may occur in sequential time points following denosumab discontinuation: need for prompt treatment re-initiation","display_name":"Rebound-associated vertebral fractures may occur in sequential time points following denosumab discontinuation: need for prompt treatment re-initiation","publication_year":2020,"publication_date":"2020-04-22","ids":{"openalex":"https://openalex.org/W3019606932","doi":"https://doi.org/10.1016/j.bonr.2020.100267","mag":"3019606932","pmid":"https://pubmed.ncbi.nlm.nih.gov/32373677","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7191536"},"language":"en","primary_location":{"id":"doi:10.1016/j.bonr.2020.100267","doi":"https://doi.org/10.1016/j.bonr.2020.100267","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bonr.2020.100267","pdf_url":null,"source":{"id":"https://openalex.org/S2764541639","display_name":"Bone Reports","issn_l":"2352-1872","issn":["2352-1872"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.bonr.2020.100267","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027646905","display_name":"Athanasios D. Anastasilakis","orcid":"https://orcid.org/0000-0002-9624-6296","observed_orcids":["https://orcid.org/0000-0002-9624-6296"]},"institutions":[{"id":"https://openalex.org/I4210119702","display_name":"424 General Military Hospital","ror":"https://ror.org/02cpzy455","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210119702"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Athanasios D. Anastasilakis","raw_affiliation_strings":["Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0002-9624-6296","affiliations":[{"raw_affiliation_string":"Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210119702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079914575","display_name":"Gerasimos Evangelatos","orcid":"https://orcid.org/0000-0003-3822-3093","observed_orcids":["https://orcid.org/0000-0003-3822-3093"]},"institutions":[{"id":"https://openalex.org/I4210106119","display_name":"NIMTS Hospital","ror":"https://ror.org/00y1kmp77","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210106119"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Gerasimos Evangelatos","raw_affiliation_strings":["Department of Rheumatology, 417 \"NIMTS\", Army Shared Fund Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, 417 \"NIMTS\", Army Shared Fund Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210106119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039430897","display_name":"Polyzois Makras","orcid":"https://orcid.org/0000-0002-3231-3357","observed_orcids":["https://orcid.org/0000-0002-3231-3357"]},"institutions":[{"id":"https://openalex.org/I2802113776","display_name":"Hellenic Air Force","ror":"https://ror.org/044xk2674","country_code":"GR","type":"government","lineage":["https://openalex.org/I2802113776"]},{"id":"https://openalex.org/I4210102619","display_name":"Hellenic Airforce General Hospital","ror":"https://ror.org/0169n7f49","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210102619"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Polyzois Makras","raw_affiliation_strings":["Department of Endocrinology and Diabetes, 251 Hellenic Air Force & VA General Hospital, Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0002-3231-3357","affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes, 251 Hellenic Air Force & VA General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I2802113776","https://openalex.org/I4210102619"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058747002","display_name":"Alexios Iliopoulos","orcid":"https://orcid.org/0000-0001-7107-1664","observed_orcids":["https://orcid.org/0000-0001-7107-1664"]},"institutions":[{"id":"https://openalex.org/I4210106119","display_name":"NIMTS Hospital","ror":"https://ror.org/00y1kmp77","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210106119"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Alexios Iliopoulos","raw_affiliation_strings":["Department of Rheumatology, 417 \"NIMTS\", Army Shared Fund Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, 417 \"NIMTS\", Army Shared Fund Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210106119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5027646905"],"corresponding_institution_ids":["https://openalex.org/I4210119702"],"apc_list":{"value":1450,"currency":"USD","value_usd":1450},"apc_paid":{"value":1450,"currency":"USD","value_usd":1450},"fwci":5.9829,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.97057997,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"12","issue":null,"first_page":"100267","last_page":"100267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/denosumab-discontinuation","display_name":"denosumab discontinuation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/multiple-vertebral-fractures","display_name":"multiple vertebral fractures","score":0.8050000071525574},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.7730000019073486},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.6579999923706055},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":0.906000018119812},{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dermatomyositis","display_name":"dermatomyositis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/connective-tissue-diseases","display_name":"connective tissue diseases","score":0.8190000057220459},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.9369491338729858},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.918742299079895},{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.9161030054092407},{"id":"https://openalex.org/C2780372218","wikidata":"https://www.wikidata.org/wiki/Q417222","display_name":"Methylprednisolone","level":2,"score":0.530817985534668},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4839651882648468},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.38178056478500366},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24725186824798584}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bonr.2020.100267","doi":"https://doi.org/10.1016/j.bonr.2020.100267","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bonr.2020.100267","pdf_url":null,"source":{"id":"https://openalex.org/S2764541639","display_name":"Bone Reports","issn_l":"2352-1872","issn":["2352-1872"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7191536","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7191536/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7191536/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Rep","raw_type":"Text"},{"id":"pmid:32373677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32373677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone reports","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:247a6d145507455685f8831bcf79ded1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/247a6d145507455685f8831bcf79ded1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bone Reports, Vol 12, Iss , Pp 100267- (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.bonr.2020.100267","doi":"https://doi.org/10.1016/j.bonr.2020.100267","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bonr.2020.100267","pdf_url":null,"source":{"id":"https://openalex.org/S2764541639","display_name":"Bone Reports","issn_l":"2352-1872","issn":["2352-1872"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3019606932.pdf","grobid_xml":"https://content.openalex.org/works/W3019606932.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W110053699","https://openalex.org/W2021748249","https://openalex.org/W2048346627","https://openalex.org/W2592545064","https://openalex.org/W2594420699","https://openalex.org/W2612475646","https://openalex.org/W2619448414","https://openalex.org/W2621525643","https://openalex.org/W2743295977","https://openalex.org/W2766957057","https://openalex.org/W2793425232","https://openalex.org/W2802834903","https://openalex.org/W2969420040","https://openalex.org/W2999036028","https://openalex.org/W3004232792","https://openalex.org/W3004428357"],"related_works":["https://openalex.org/W2805521456","https://openalex.org/W2981417974","https://openalex.org/W2999036028","https://openalex.org/W2594420699","https://openalex.org/W2220606005","https://openalex.org/W2531903877","https://openalex.org/W4402768905","https://openalex.org/W2771455692","https://openalex.org/W7124368218","https://openalex.org/W3096031914"],"abstract_inverted_index":{"Denosumab":[0],"discontinuation":[1,33,99],"has":[2],"been":[3,48],"associated":[4],"with":[5,51],"increased":[6],"risk":[7],"of":[8,17,44,61,64,109,120,143],"rebound-associated":[9,28,93,127],"multiple":[10,94],"vertebral":[11,29,37,95,128],"fractures.":[12,144],"We":[13,90],"report":[14],"the":[15,45,65,81,115],"cases":[16,112],"three":[18],"patients,":[19],"two":[20],"females":[21],"and":[22,34,80],"one":[23],"male,":[24],"who":[25,125],"had":[26,47],"manifested":[27],"fractures":[30,38,96],"after":[31,56,97],"denosumab":[32,55,98],"sustained":[35,126],"new":[36],"a":[39,140],"few":[40],"months":[41],"later.":[42],"Two":[43],"patients":[46,67,124],"previously":[49],"treated":[50],"bisphosphonates.":[52],"Patients":[53],"discontinued":[54],"2":[57],"to":[58,132],"8":[59,85],"years":[60],"treatment.":[62],"One":[63],"female":[66],"was":[68],"receiving":[69],"prednisolone":[70],"7.5":[71],"mg":[72,86],"daily":[73,87],"for":[74,88,117],"an":[75],"unspecified":[76],"connective":[77],"tissue":[78],"disorder":[79],"male":[82],"patient":[83],"methylprednisolone":[84],"dermatomyositis.":[89],"hypothesize":[91],"that":[92],"may":[100],"occur,":[101],"at":[102],"least":[103],"in":[104,123,130],"some":[105],"cases,":[106],"sequentially":[107],"instead":[108],"simultaneously.":[110],"Our":[111],"further":[113],"underpin":[114],"need":[116],"prompt":[118],"initiation":[119],"potent":[121],"antiresorptives":[122],"fractures,":[129],"order":[131],"prevent":[133],"not":[134],"only":[135],"bone":[136],"loss":[137],"but":[138],"also":[139],"second":[141],"round":[142]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-05-01T00:00:00"}