{"id":"https://openalex.org/W3019429779","doi":"https://doi.org/10.3389/fphar.2020.00467","title":"Dissecting the Epigenetic Changes Induced by Non-Antipsychotic Mood Stabilizers on Schizophrenia and Affective Disorders: A Systematic Review","display_name":"Dissecting the Epigenetic Changes Induced by Non-Antipsychotic Mood Stabilizers on Schizophrenia and Affective Disorders: A Systematic Review","publication_year":2020,"publication_date":"2020-04-22","ids":{"openalex":"https://openalex.org/W3019429779","doi":"https://doi.org/10.3389/fphar.2020.00467","mag":"3019429779","pmid":"https://pubmed.ncbi.nlm.nih.gov/32390836","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7189731"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2020.00467","doi":"https://doi.org/10.3389/fphar.2020.00467","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2020.00467","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2020.00467/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2020.00467/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076427138","display_name":"Manuel Gardea\u2010Resendez","orcid":"https://orcid.org/0000-0002-9825-8792","observed_orcids":["https://orcid.org/0000-0002-9825-8792"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Manuel Gardea-Resendez","raw_affiliation_strings":["Department of Psychiatry, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, M\u00e9xico","Department of Psychiatry, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, M\u00e9xico","institution_ids":["https://openalex.org/I169046204"]},{"raw_affiliation_string":"Department of Psychiatry, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, M\u00e9xico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007402109","display_name":"Mehmet Utku K\u00fc\u00e7\u00fcker","orcid":"https://orcid.org/0000-0002-3508-5935","observed_orcids":["https://orcid.org/0000-0002-3508-5935"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehmet Utku Kucuker","raw_affiliation_strings":["Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, United States","Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015727111","display_name":"Caren Jacquetta Blacker","orcid":"https://orcid.org/0000-0003-3510-0696","observed_orcids":["https://orcid.org/0000-0003-3510-0696"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caren J. Blacker","raw_affiliation_strings":["Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, United States","Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042266009","display_name":"Ada Man\u2010Choi Ho","orcid":"https://orcid.org/0000-0003-4989-8782","observed_orcids":["https://orcid.org/0000-0003-4989-8782"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ada M.-C. Ho","raw_affiliation_strings":["Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, United States","Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058499524","display_name":"Paul E. Croarkin","orcid":"https://orcid.org/0000-0001-6843-6503","observed_orcids":["https://orcid.org/0000-0001-6843-6503"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul E. Croarkin","raw_affiliation_strings":["Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, United States","Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029433360","display_name":"Mark A. Frye","orcid":"https://orcid.org/0000-0001-6997-4215","observed_orcids":["https://orcid.org/0000-0001-6997-4215"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Frye","raw_affiliation_strings":["Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, United States","Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106171858","display_name":"Marin Veldi\u0107","orcid":"https://orcid.org/0000-0002-7651-9197","observed_orcids":["https://orcid.org/0000-0002-7651-9197"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marin Veldic","raw_affiliation_strings":["Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, United States","Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, United States","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5106171858"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.4328,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.44020239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":null,"first_page":"467","last_page":"467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.13680000603199005,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.10260000079870224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.8769999742507935},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9929999709129333},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9980000257492065},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9800000190734863},{"id":"https://openalex.org/keywords/lithium","display_name":"lithium","score":1.0},{"id":"https://openalex.org/keywords/lamotrigine","display_name":"lamotrigine","score":1.0},{"id":"https://openalex.org/keywords/carbamazepine","display_name":"carbamazepine","score":1.0},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.9679999947547913},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7792452573776245},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.6561185717582703},{"id":"https://openalex.org/C2778802184","wikidata":"https://www.wikidata.org/wiki/Q410346","display_name":"Lamotrigine","level":3,"score":0.6340086460113525},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.6064963936805725},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.6030087471008301},{"id":"https://openalex.org/C2777134132","wikidata":"https://www.wikidata.org/wiki/Q188638","display_name":"Mood disorders","level":3,"score":0.5626325011253357},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.552886962890625},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5298566222190857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48020991683006287},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.47368124127388},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.47101935744285583},{"id":"https://openalex.org/C2779253243","wikidata":"https://www.wikidata.org/wiki/Q410412","display_name":"Carbamazepine","level":3,"score":0.46768051385879517},{"id":"https://openalex.org/C2780550438","wikidata":"https://www.wikidata.org/wiki/Q2622367","display_name":"Mood stabilizer","level":4,"score":0.46160948276519775},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4242496192455292},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.33147257566452026},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3314554691314697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2075575590133667},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.18046945333480835},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16165131330490112},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.13208502531051636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11639440059661865},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09410232305526733}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fphar.2020.00467","doi":"https://doi.org/10.3389/fphar.2020.00467","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2020.00467","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2020.00467/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7189731","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7189731","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:32390836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32390836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Systematic Review"},{"id":"pmh:oai:eprints.uanl.mx:29700","doi":null,"is_oa":false,"landing_page_url":"http://eprints.uanl.mx/29700/7/29700.pdf","pdf_url":"http://eprints.uanl.mx/29700/7/29700.pdf","source":{"id":"https://openalex.org/S4306400994","display_name":"El Repositorio Academico Digital de la UANL (Universidad Aut\u00f3noma de Nuevo Le\u00f3n)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169046204","host_organization_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","host_organization_lineage":["https://openalex.org/I169046204"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:7763ff99fad54427aeff64bf8c3ef778","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7763ff99fad54427aeff64bf8c3ef778","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 11 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2020.00467","doi":"https://doi.org/10.3389/fphar.2020.00467","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2020.00467","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2020.00467/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[{"id":"https://openalex.org/G5127234948","display_name":"Glutamatergic and GABAergic Biomarkers in rTMS for Adolescent Depression","funder_award_id":"R01MH113700","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3019429779.pdf","grobid_xml":"https://content.openalex.org/works/W3019429779.grobid-xml"},"referenced_works_count":118,"referenced_works":["https://openalex.org/W831838120","https://openalex.org/W900740758","https://openalex.org/W1579231583","https://openalex.org/W1965171314","https://openalex.org/W1965798496","https://openalex.org/W1966605094","https://openalex.org/W1966959753","https://openalex.org/W1971334707","https://openalex.org/W1973675690","https://openalex.org/W1973753081","https://openalex.org/W1974849634","https://openalex.org/W1976157209","https://openalex.org/W1976626368","https://openalex.org/W1978480599","https://openalex.org/W1978714931","https://openalex.org/W1989328589","https://openalex.org/W1992369317","https://openalex.org/W1994759068","https://openalex.org/W1994958608","https://openalex.org/W2000855271","https://openalex.org/W2001552899","https://openalex.org/W2001555806","https://openalex.org/W2007487855","https://openalex.org/W2009200655","https://openalex.org/W2013368811","https://openalex.org/W2014874816","https://openalex.org/W2024486446","https://openalex.org/W2024560618","https://openalex.org/W2026504919","https://openalex.org/W2028774417","https://openalex.org/W2030260775","https://openalex.org/W2030754304","https://openalex.org/W2034753731","https://openalex.org/W2039547082","https://openalex.org/W2041438934","https://openalex.org/W2048395906","https://openalex.org/W2055188488","https://openalex.org/W2055190268","https://openalex.org/W2059097951","https://openalex.org/W2062534208","https://openalex.org/W2063963078","https://openalex.org/W2080657904","https://openalex.org/W2081512274","https://openalex.org/W2083020792","https://openalex.org/W2083595600","https://openalex.org/W2084160423","https://openalex.org/W2088831976","https://openalex.org/W2091023632","https://openalex.org/W2098234705","https://openalex.org/W2098249941","https://openalex.org/W2098622411","https://openalex.org/W2102728571","https://openalex.org/W2103127225","https://openalex.org/W2103612899","https://openalex.org/W2105058919","https://openalex.org/W2113386261","https://openalex.org/W2117347068","https://openalex.org/W2117691193","https://openalex.org/W2124600242","https://openalex.org/W2127821690","https://openalex.org/W2132107205","https://openalex.org/W2139852368","https://openalex.org/W2141017448","https://openalex.org/W2141220522","https://openalex.org/W2143681905","https://openalex.org/W2144570173","https://openalex.org/W2145611567","https://openalex.org/W2146526204","https://openalex.org/W2148160168","https://openalex.org/W2148657832","https://openalex.org/W2149646285","https://openalex.org/W2156305088","https://openalex.org/W2158747282","https://openalex.org/W2161297645","https://openalex.org/W2168942809","https://openalex.org/W2168951683","https://openalex.org/W2169205464","https://openalex.org/W2196598555","https://openalex.org/W2266871031","https://openalex.org/W2282574978","https://openalex.org/W2282980633","https://openalex.org/W2289386451","https://openalex.org/W2305402881","https://openalex.org/W2317270251","https://openalex.org/W2320983896","https://openalex.org/W2339030503","https://openalex.org/W2340552375","https://openalex.org/W2463708289","https://openalex.org/W2474604030","https://openalex.org/W2504918311","https://openalex.org/W2515414411","https://openalex.org/W2531435844","https://openalex.org/W2554616527","https://openalex.org/W2560438049","https://openalex.org/W2563385753","https://openalex.org/W2575397726","https://openalex.org/W2611270005","https://openalex.org/W2668113664","https://openalex.org/W2744138357","https://openalex.org/W2767286342","https://openalex.org/W2779081898","https://openalex.org/W2790033034","https://openalex.org/W2792027821","https://openalex.org/W2799463622","https://openalex.org/W2888147011","https://openalex.org/W2895275448","https://openalex.org/W2899958179","https://openalex.org/W2900830044","https://openalex.org/W2901760616","https://openalex.org/W2906222762","https://openalex.org/W2938384580","https://openalex.org/W2943344359","https://openalex.org/W2963036768","https://openalex.org/W3200596333","https://openalex.org/W4211013640","https://openalex.org/W4211263234","https://openalex.org/W4234860686","https://openalex.org/W6766170628"],"related_works":["https://openalex.org/W3111867040","https://openalex.org/W2769700318","https://openalex.org/W2141017448","https://openalex.org/W2474604030","https://openalex.org/W7151752720","https://openalex.org/W2773901898","https://openalex.org/W2013456521","https://openalex.org/W2282980633","https://openalex.org/W2954974272","https://openalex.org/W900740758"],"abstract_inverted_index":{"BACKGROUND:":[0],"evidence":[1],"suggest":[2],"that":[3,21],"mood":[4,17,63,102,224],"stabilizers":[5,64,225],"can":[6],"potentially":[7],"reverse":[8],"epigenetic":[9,31,58,106,169,219],"deregulations":[10],"found":[11,165],"in":[12,70,157,226],"patients":[13,77,227],"with":[14,78,197,228],"schizophrenia":[15],"or":[16,76,82,133],"disorders":[18,231],"through":[19,171],"mechanisms":[20],"are":[22],"not":[23],"yet":[24],"fully":[25],"understood.":[26],"However,":[27],"their":[28],"activity":[29],"on":[30,203],"processes":[32],"has":[33],"made":[34],"them":[35],"a":[36,45,120,128,150],"research":[37],"target":[38,241],"for":[39,53,90,117,146],"therapeutic":[40],"approaches.":[41],"METHODS:":[42],"We":[43],"conducted":[44],"comprehensive":[46],"literature":[47,183],"search":[48],"of":[49,93,131,152,201,216,244],"PubMed":[50],"and":[51,68,97,109,124,140,149,162,177,184,191,248],"EMBASE":[52],"studies":[54,202],"investigating":[55],"the":[56,91,95,158,198,217,242],"specific":[57,218],"changes":[59,107,170,220],"induced":[60,221],"by":[61,222],"non-antipsychotic":[62],"(valproate,":[65],"lithium,":[66],"lamotrigine,":[67],"carbamazepine)":[69],"animal":[71],"models,":[72],"human":[73],"cell":[74],"lines,":[75],"schizophrenia,":[79],"bipolar":[80],"disorder,":[81],"major":[83,229],"depressive":[84],"disorder.":[85,112],"Each":[86],"paper":[87],"was":[88,115,181],"reviewed":[89],"nature":[92],"research,":[94],"species":[96],"tissue":[98],"examined,":[99],"sample":[100,210],"size,":[101],"stabilizer,":[103],"targeted":[104],"gene,":[105],"found,":[108],"associated":[110,195],"psychiatric":[111,230],"Every":[113],"article":[114],"appraised":[116],"quality":[118,129],"using":[119],"modified":[121],"published":[122],"process":[123],"those":[125],"who":[126],"met":[127],"score":[130],"moderate":[132],"high":[134],"were":[135,144,155,164,207],"included.":[136],"RESULTS:":[137],"title,":[138],"abstract":[139],"keywords;":[141],"129":[142],"records":[143],"selected":[145],"full-text":[147],"screening":[148],"remaining":[151],"38":[153],"articles":[154],"included":[156],"qualitative":[159],"synthesis.":[160],"Valproate":[161],"lithium":[163],"to":[166,189],"induce":[167],"broader":[168],"different":[172],"mechanisms,":[173],"mainly":[174],"DNA":[175],"demethylation":[176],"histones":[178],"acetylation.":[179],"There":[180],"less":[182],"hence":[185],"smaller":[186],"effects":[187],"attributable":[188],"lamotrigine":[190],"carbamazepine":[192],"could":[193],"be":[194],"overall":[196],"small":[199],"number":[200],"these":[204],"agents.":[205],"Findings":[206],"congruent":[208],"across":[209],"types.":[211],"CONCLUSIONS:":[212],"An":[213],"advanced":[214],"understanding":[215],"classic":[223],"will":[232],"facilitate":[233],"personalized":[234],"interventions.":[235],"Further":[236],"related":[237],"drug":[238],"discovery":[239],"should":[240],"induction":[243],"selective":[245],"chromatin":[246],"remodeling":[247],"gene-specific":[249],"expression":[250],"effects.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2020-05-01T00:00:00"}
