{"id":"https://openalex.org/W3019304","doi":null,"title":"Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension.","display_name":"Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension.","publication_year":1990,"publication_date":"1990-06-01","ids":{"openalex":"https://openalex.org/W3019304","mag":"3019304","pmid":"https://pubmed.ncbi.nlm.nih.gov/1972963"},"language":"en","primary_location":{"id":"pmid:1972963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1972963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of human hypertension","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"P Singer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Singer","raw_affiliation_strings":["Central Institute for Cardiovascular Research, Academy of Sciences, Berlin-Buch, GDR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Institute for Cardiovascular Research, Academy of Sciences, Berlin-Buch, GDR","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000151943","display_name":"Waltraud Jaeger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Jaeger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"I Berger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Berger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076330238","display_name":"H Barleben","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Barleben","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108636168","display_name":"M. Wirth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Wirth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064404796","display_name":"Elisabeth Richter-Heinrich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Richter-Heinrich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108435227","display_name":"Siegfried Voigt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Voigt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034290583","display_name":"Wolfgang G\u00f6dicke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W G\u00f6dicke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2325,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.93747683,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"3","first_page":"227","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10909","display_name":"Edible Oils Quality and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9419999718666077},{"id":"https://openalex.org/keywords/dietary-fatty-acids","display_name":"dietary fatty acids","score":0.7429999709129333},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":0.7720000147819519},{"id":"https://openalex.org/keywords/linoleic-acid","display_name":"linoleic acid","score":1.0},{"id":"https://openalex.org/keywords/alpha-linolenic-acid","display_name":"alpha-linolenic acid","score":1.0},{"id":"https://openalex.org/keywords/olive-oil","display_name":"olive oil","score":0.890999972820282},{"id":"https://openalex.org/keywords/sunflower-oil","display_name":"sunflower oil","score":0.9229999780654907},{"id":"https://openalex.org/keywords/linseed-oil","display_name":"linseed oil","score":0.9890000224113464},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.9139999747276306},{"id":"https://openalex.org/keywords/lipoproteins","display_name":"lipoproteins","score":0.8360000252723694},{"id":"https://openalex.org/keywords/eicosanoid-precursors","display_name":"eicosanoid precursors","score":0.8859999775886536},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.9819999933242798},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":1.0},{"id":"https://openalex.org/keywords/cholesteryl-esters","display_name":"cholesterol esters","score":0.8389999866485596},{"id":"https://openalex.org/keywords/serum-triglycerides","display_name":"serum triglycerides","score":0.8610000014305115},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.6449999809265137},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.7540000081062317},{"id":"https://openalex.org/keywords/ldl-hdl-ratio","display_name":"LDL/HDL ratio","score":0.7509999871253967},{"id":"https://openalex.org/keywords/lcat","display_name":"lecithin:cholesterol acyltransferase","score":0.8489999771118164},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.8130000233650208},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.7649571299552917},{"id":"https://openalex.org/C2780809830","wikidata":"https://www.wikidata.org/wiki/Q407426","display_name":"Linoleic acid","level":3,"score":0.7261006236076355},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.6699749231338501},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6196194291114807},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5817196369171143},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5747220516204834},{"id":"https://openalex.org/C2778717857","wikidata":"https://www.wikidata.org/wiki/Q818405","display_name":"Linseed oil","level":2,"score":0.4518125653266907},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4429299235343933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4414994716644287},{"id":"https://openalex.org/C2777686832","wikidata":"https://www.wikidata.org/wiki/Q256502","display_name":"alpha-Linolenic acid","level":5,"score":0.41548100113868713},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33913475275039673},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.33474212884902954},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.312219500541687},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.29670143127441406},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.2800512909889221},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.1743445098400116},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.04870954155921936}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005526","descriptor_name":"Food, Formulated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007862","descriptor_name":"Phosphatidylcholine-Sterol O-Acyltransferase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008041","descriptor_name":"Linoleic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008042","descriptor_name":"Linolenic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009829","descriptor_name":"Oleic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015777","descriptor_name":"Eicosanoids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017962","descriptor_name":"alpha-Linolenic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019787","descriptor_name":"Linoleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1972963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1972963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of human hypertension","raw_type":"Clinical Trial"},{"id":"mag:3019304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1972963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1963777061","https://openalex.org/W1975287303","https://openalex.org/W2799791649","https://openalex.org/W2438077792","https://openalex.org/W2001083402","https://openalex.org/W2431546667","https://openalex.org/W2053840686","https://openalex.org/W1563109854","https://openalex.org/W1994819279","https://openalex.org/W2474646640"],"abstract_inverted_index":{"Forty-four":[0],"male":[1],"in-patients":[2],"with":[3,18,172],"mild":[4,173],"essential":[5,174],"hypertension":[6],"were":[7,255],"randomly":[8],"allocated":[9],"to":[10,119,236],"three":[11],"groups":[12],"and":[13,63,71,96,113,153,157,167,199,217,241,248],"put":[14,128],"on":[15,129],"diets":[16],"supplemented":[17],"60":[19],"ml/day":[20],"of":[21,52,88,123,138,155,165,191],"olive":[22,131],"(n":[23,27,33],"=":[24,28,34],"15),":[25],"sunflowerseed":[26,48,185],"15)":[29],"or":[30],"linseed":[31,82,231],"oils":[32],"14),":[35],"respectively,":[36],"for":[37],"two":[38],"weeks":[39],"within":[40],"a":[41,120,135,150,162,188,213],"blind":[42],"study.":[43],"In":[44,104,125],"the":[45,81,126,130,184,200,225,230,242],"group":[46,127],"receiving":[47],"oil":[49],"an":[50,86],"increase":[51,87],"linoleic":[53,139,156,226],"acid":[54,90,109,115,140],"in":[55,68,75,91,101,143,170,180,234],"serum":[56,69,92,102,144,246],"lipids":[57],"could":[58],"be":[59,178],"observed,":[60],"whereas":[61,94],"arachidonic":[62,95,108,166],"eicosapentaenoic":[64,97,114,168],"acids":[65,98,159,169],"appeared":[66,116,221],"unchanged":[67,100],"triglycerides":[70,247],"even":[72],"significantly":[73,111,222,256],"lower":[74,223],"cholesterol":[76,105,198,205,240,244,250],"esters.":[77],"The":[78,146],"subjects":[79],"ingesting":[80],"oil-rich":[83,132,186,232],"diet":[84,187],"showed":[85],"alpha-linolenic":[89,158],"lipids,":[93],"remained":[99],"triglycerides.":[103,145],"esters,":[106],"however,":[107],"was":[110,141,207],"decreased":[112],"increased":[117],"only":[118,134],"low":[121,194],"level":[122],"significance.":[124],"regimen":[133],"significant":[136,189],"fall":[137],"obvious":[142],"results":[147],"might":[148],"indicate":[149],"defective":[151],"desaturation":[152],"elongation":[154],"and,":[160],"consequently,":[161],"slow":[163],"formation":[164],"patients":[171],"hypertension,":[175],"which":[176],"should":[177],"considered":[179],"dietary":[181],"studies.":[182],"After":[183,229],"decrease":[190],"total":[192,237],"cholesterol,":[193,238],"density":[195,202],"lipoprotein":[196,203],"(LDL)":[197],"LDL/high":[201],"(HDL)":[204],"ratio":[206],"found.":[208],"Systolic":[209],"blood":[210],"pressure":[211],"during":[212],"psychophysiological":[214],"stress":[215],"test":[216],"urinary":[218],"sodium":[219],"excretion":[220],"after":[224],"acid-rich":[227],"diet.":[228],"diet,":[233],"addition":[235],"LDL":[239],"LDL/HDL":[243],"ratio,":[245],"lecithin":[249],"acyl":[251],"transferase":[252],"(LCAT)":[253],"activity":[254],"depressed.(ABSTRACT":[257],"TRUNCATED":[258],"AT":[259],"250":[260],"WORDS)":[261]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
