{"id":"https://openalex.org/W3018964265","doi":null,"title":"Neurofilament light chain and MRI volume parameters as markers of neurodegeneration in multiple sclerosis.","display_name":"Neurofilament light chain and MRI volume parameters as markers of neurodegeneration in multiple sclerosis.","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3018964265","mag":"3018964265","pmid":"https://pubmed.ncbi.nlm.nih.gov/32338853"},"language":"en","primary_location":{"id":"pmid:32338853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32338853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058690895","display_name":"Pavol Filippi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Pavol Filippi","raw_affiliation_strings":["1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061936365","display_name":"Veronika Vestenicka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Veronika Vestenick\u00e1","raw_affiliation_strings":["1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070874269","display_name":"Pavel \u0160iarnik","orcid":"https://orcid.org/0000-0002-2589-6363","observed_orcids":["https://orcid.org/0000-0002-2589-6363","https://orcid.org/0000-0001-6388-6273"]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Pavel Siarnik","raw_affiliation_strings":["1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017186834","display_name":"Monika Siv\u00e1kov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Monika Sivakova","raw_affiliation_strings":["1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003633654","display_name":"Daniela \u010cop\u00edkov\u00e1\u2010Cudr\u00e1kov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Daniela \u010cop\u00edkov\u00e1-Cudr\u00e1kov\u00e1","raw_affiliation_strings":["1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070124068","display_name":"V. Belan","orcid":"https://orcid.org/0000-0001-9208-4034","observed_orcids":["https://orcid.org/0000-0001-9208-4034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V\u00ed\u0165azoslav Belan","raw_affiliation_strings":["Dr. Magnet - Kram\u00e1re, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Magnet - Kram\u00e1re, Bratislava, Slovakia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040407785","display_name":"Jozef Hanes","orcid":"https://orcid.org/0000-0001-5427-2042","observed_orcids":["https://orcid.org/0000-0001-5427-2042"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210145572","display_name":"Institute of Neuroimmunology of the Slovak Academy of Sciences","ror":"https://ror.org/05c516317","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210145572"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Jozef Hanes","raw_affiliation_strings":["Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210145572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108592550","display_name":"Michal Nov\u00e1k","orcid":"https://orcid.org/0000-0003-2384-8533","observed_orcids":["https://orcid.org/0000-0003-2384-8533"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210145572","display_name":"Institute of Neuroimmunology of the Slovak Academy of Sciences","ror":"https://ror.org/05c516317","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210145572"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Michal Nov\u00e1k","raw_affiliation_strings":["Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210145572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065973448","display_name":"Branislav Koll\u00e1r","orcid":"https://orcid.org/0000-0002-7016-6992","observed_orcids":["https://orcid.org/0000-0002-7016-6992"]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Branislav Kollar","raw_affiliation_strings":["1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114376553","display_name":"Peter Tur\u010d\u00e1ni","orcid":"https://orcid.org/0000-0002-4868-6836","observed_orcids":["https://orcid.org/0000-0002-4868-6836"]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Peter Turcani","raw_affiliation_strings":["1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3973,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82082545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"41","issue":"1","first_page":"17","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurofilament-light-chain","display_name":"neurofilament light chain","score":1.0},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neurodegeneration-markers","display_name":"neurodegeneration biomarkers","score":0.8949999809265137},{"id":"https://openalex.org/keywords/brain-atrophy","display_name":"brain atrophy","score":0.9470000267028809},{"id":"https://openalex.org/keywords/expanded-disability-status-scale","display_name":"Expanded Disability Status Scale","score":0.8140000104904175},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.8029999732971191},{"id":"https://openalex.org/keywords/mri-lesion-load","display_name":"MRI lesion burden","score":0.7149999737739563},{"id":"https://openalex.org/keywords/gray-matter-atrophy","display_name":"gray matter atrophy","score":0.746999979019165},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.837090253829956},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.8339067101478577},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7949748635292053},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6642844676971436},{"id":"https://openalex.org/C2780892749","wikidata":"https://www.wikidata.org/wiki/Q929518","display_name":"Expanded Disability Status Scale","level":3,"score":0.6630349159240723},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6243337988853455},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6201850175857544},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.5759690999984741},{"id":"https://openalex.org/C2778013878","wikidata":"https://www.wikidata.org/wiki/Q646150","display_name":"Grey matter","level":4,"score":0.5387817621231079},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5149955749511719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46736809611320496},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3518522083759308},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.3312370181083679},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.16323044896125793},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10576009750366211},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.062321215867996216},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007382","descriptor_name":"Intermediate Filaments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018154","descriptor_name":"Slovakia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:32338853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32338853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3166697652","https://openalex.org/W3129554493","https://openalex.org/W2912745240","https://openalex.org/W4320490540","https://openalex.org/W4389465100","https://openalex.org/W3158088890","https://openalex.org/W3002588492","https://openalex.org/W2885014554","https://openalex.org/W3164316479","https://openalex.org/W4388974397"],"abstract_inverted_index":{"BACKGROUND:":[0],"Neurofilament":[1],"light":[2],"chain":[3],"(NfL)":[4],"is":[5,72],"considered":[6,243],"a":[7],"major":[8],"marker":[9],"of":[10,17,43,70,77,91,101,114,158,164,168,174,180,203,208,216,246],"neurodegeneration":[11,78,247],"and":[12,25,49,52,79,111,154,162,185,197,211,213,237],"disease":[13,80,230],"activity.":[14,81,231],"Higher":[15],"levels":[16,90,196],"NfL":[18,48,71,92],"are":[19],"associated":[20],"with":[21,32,172,187,205,218,229],"worse":[22],"clinical":[23,51],"outcomes":[24],"increased":[26],"brain":[27,61,176,209],"atrophy.":[28],"In":[29,145],"treated":[30,84],"patients":[31,86,132],"Relapsing-Remitting":[33],"Multiple":[34],"Sclerosis":[35],"(RRMS),":[36],"we":[37,147],"aimed":[38],"to":[39,66],"determine":[40],"the":[41],"level":[42,69,126],"NfL,":[44],"an":[45],"association":[46,151,202,227],"between":[47,152,194],"demographic,":[50],"magnetic":[53],"resonance":[54],"imaging":[55],"(MRI)":[56],"characteristics":[57],"as":[58,60,75,244],"well":[59],"volume":[62,177,183,221,239],"parameters.":[63,222],"We":[64,189,223],"wanted":[65],"confirm":[67,226],"that":[68,235],"clinically":[73],"useful":[74],"biomarker":[76],"METHODS:":[82],"56":[83],"RRMS":[85],"were":[87,94],"enrolled.":[88],"Plasmatic":[89],"(pNfL)":[93],"measured":[95],"by":[96,105],"SIMOA\u00ae":[97],"technique.":[98],"Clinical":[99],"severity":[100],"MS":[102,131],"was":[103,117,127],"expressed":[104],"Expanded":[106],"Disability":[107],"Status":[108],"Scale":[109],"(EDSS),":[110],"volumetric":[112],"analysis":[113],"MRI":[115,155,220,238],"data":[116,233],"performed":[118],"using":[119],"Icobrain":[120],"software.":[121],"RESULTS:":[122],"The":[123],"mean":[124],"pNfL":[125,153,169,195,204,228,236],"significantly":[128,171,191],"higher":[129],"in":[130,134,248],"than":[133],"healthy":[135],"controls":[136],"(14.73":[137],"\u00b1":[138,142],"6.38":[139],"versus":[140],"6.67":[141],"3.9,":[143],"p<0.001).":[144],"patients,":[146],"did":[148,224],"not":[149,225],"find":[150],"activity,":[156],"number":[157,163],"new":[159],"T2":[160],"lesions,":[161],"enhancing":[165],"lesions.":[166],"Levels":[167],"correlated":[170],"atrophy":[173,179,210],"whole":[175],"(Wbv),":[178],"grey":[181],"matter":[182],"(Gmv),":[184],"negatively":[186],"Wbv.":[188],"found":[190],"positive":[192],"correlation":[193,215],"EDSS.":[198],"CONCLUSION:":[199],"Study":[200],"shows":[201],"Wbv,":[206],"presence":[207],"EDSS,":[212],"strong":[214],"EDSS":[217],"multiple":[219],"Our":[232],"suggest":[234],"parameters":[240],"could":[241],"be":[242],"biomarkers":[245],"MS.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-05-01T00:00:00"}