{"id":"https://openalex.org/W3018943500","doi":"https://doi.org/10.3389/fncel.2020.00090","title":"Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases","display_name":"Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases","publication_year":2020,"publication_date":"2020-04-24","ids":{"openalex":"https://openalex.org/W3018943500","doi":"https://doi.org/10.3389/fncel.2020.00090","mag":"3018943500","pmid":"https://pubmed.ncbi.nlm.nih.gov/32390802","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7194075"},"language":"en","primary_location":{"id":"doi:10.3389/fncel.2020.00090","doi":"https://doi.org/10.3389/fncel.2020.00090","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2020.00090","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2020.00090/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3018943500"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fncel.2020.00090/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057692103","display_name":"Adam Armada\u2010Moreira","orcid":"https://orcid.org/0000-0002-1598-5784","observed_orcids":["https://orcid.org/0000-0002-1598-5784"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["DK","PT"],"is_corresponding":false,"raw_author_name":"Adam Armada-Moreira","raw_affiliation_strings":["Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]},{"raw_affiliation_string":"Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076574729","display_name":"Joana I. Gomes","orcid":"https://orcid.org/0000-0001-7761-1983","observed_orcids":["https://orcid.org/0000-0001-7761-1983"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana I. Gomes","raw_affiliation_strings":["Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000568778","display_name":"Carolina Campos Pina","orcid":"https://orcid.org/0000-0003-0105-2198","observed_orcids":["https://orcid.org/0000-0003-0105-2198"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carolina Campos Pina","raw_affiliation_strings":["Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072607910","display_name":"Oksana K. Savchak","orcid":"https://orcid.org/0000-0003-0448-5343","observed_orcids":["https://orcid.org/0000-0003-0448-5343"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Oksana K. Savchak","raw_affiliation_strings":["Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013341958","display_name":"Joana Gon\u00e7alves\u2010Ribeiro","orcid":"https://orcid.org/0000-0002-5194-6512","observed_orcids":["https://orcid.org/0000-0002-5194-6512"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Gon\u00e7alves-Ribeiro","raw_affiliation_strings":["Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091606743","display_name":"N\u00e1dia Rei","orcid":"https://orcid.org/0000-0003-0131-0126","observed_orcids":["https://orcid.org/0000-0003-0131-0126"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"N\u00e1dia Rei","raw_affiliation_strings":["Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025498024","display_name":"Sara Pinto","orcid":"https://orcid.org/0000-0002-9785-8956","observed_orcids":["https://orcid.org/0000-0002-9785-8956"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sara Pinto","raw_affiliation_strings":["Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066443951","display_name":"Tatiana P. Morais","orcid":"https://orcid.org/0000-0002-7486-9409","observed_orcids":["https://orcid.org/0000-0002-7486-9409"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tatiana P. Morais","raw_affiliation_strings":["Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063410837","display_name":"Robertta Silva Martins","orcid":"https://orcid.org/0000-0002-7177-7226","observed_orcids":["https://orcid.org/0000-0002-7177-7226"]},"institutions":[{"id":"https://openalex.org/I161127581","display_name":"Universidade Federal Fluminense","ror":"https://ror.org/02rjhbb08","country_code":"BR","type":"education","lineage":["https://openalex.org/I161127581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Robertta Silva Martins","raw_affiliation_strings":["Laborat\u00f3rio de Neurofarmacologia, Instituto Biom\u00e9dico, Universidade Federal Fluminense, Niter\u00f3i, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Neurofarmacologia, Instituto Biom\u00e9dico, Universidade Federal Fluminense, Niter\u00f3i, Brazil","institution_ids":["https://openalex.org/I161127581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044403672","display_name":"Filipa F. Ribeiro","orcid":"https://orcid.org/0000-0002-4006-7328","observed_orcids":["https://orcid.org/0000-0002-4006-7328","https://orcid.org/0000-0003-1673-0537"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Filipa F. Ribeiro","raw_affiliation_strings":["Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021255614","display_name":"Ana Maria Sebasti\u00e3o","orcid":"https://orcid.org/0000-0001-9030-6115","observed_orcids":["https://orcid.org/0000-0001-9030-6115"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana M. Sebasti\u00e3o","raw_affiliation_strings":["Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017639601","display_name":"Vincenzo Crunelli","orcid":"https://orcid.org/0000-0001-7154-9752","observed_orcids":["https://orcid.org/0000-0001-7154-9752"]},"institutions":[{"id":"https://openalex.org/I197854408","display_name":"University of Malta","ror":"https://ror.org/03a62bv60","country_code":"MT","type":"education","lineage":["https://openalex.org/I197854408"]},{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB","MT"],"is_corresponding":false,"raw_author_name":"Vincenzo Crunelli","raw_affiliation_strings":["Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta","Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta","institution_ids":["https://openalex.org/I197854408"]},{"raw_affiliation_string":"Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027568151","display_name":"Sandra Henriques Vaz","orcid":"https://orcid.org/0000-0003-4258-9397","observed_orcids":["https://orcid.org/0000-0003-4258-9397"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Sandra H. Vaz","raw_affiliation_strings":["Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5027568151"],"corresponding_institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":4.0493,"has_fulltext":true,"cited_by_count":346,"citation_normalized_percentile":{"value":0.96906637,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"14","issue":null,"first_page":"90","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.6690000295639038},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.902999997138977},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.890999972820282},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8539999723434448},{"id":"https://openalex.org/keywords/glutamate-glutamine-cycle","display_name":"glutamate-glutamine cycle","score":0.9470000267028809},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.8730000257492065},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6890000104904175},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.968999981880188},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9909999966621399},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.5820000171661377},{"id":"https://openalex.org/keywords/glutamate-clearance","display_name":"glutamate clearance","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.7971521615982056},{"id":"https://openalex.org/C186379835","wikidata":"https://www.wikidata.org/wiki/Q253276","display_name":"Mile","level":2,"score":0.7172107696533203},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6462956070899963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29910778999328613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23257863521575928},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.19435349106788635},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.1156603991985321},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07177957892417908},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.3389/fncel.2020.00090","doi":"https://doi.org/10.3389/fncel.2020.00090","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2020.00090","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2020.00090/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},{"id":"pmid:32390802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32390802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7194075","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7194075/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Neurosci","raw_type":"Text"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:131779","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/131779/1/fncel-14-00090.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/131779/1/fncel-14-00090.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:iris.unimore.it:11380/1375205","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11380/1375205","pdf_url":"https://iris.unimore.it/bitstream/11380/1375205/2/fncel-14-00090.pdf","source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:57e1911ba2a4443e9afa0e7b04684a6c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/57e1911ba2a4443e9afa0e7b04684a6c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular Neuroscience, Vol 14 (2020)","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:openaire/20af0d5b-805d-4d6a-ae43-2bf5f5c3be9d","doi":null,"is_oa":true,"landing_page_url":"https://www.scopus.com/pages/publications/85084365299","pdf_url":null,"source":{"id":"https://openalex.org/S4306400063","display_name":"Scopus (Elsevier)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Armada-Moreira, A, Gomes, J I, Pina, C C, Savchak, O K, Gon\u00e7alves-Ribeiro, J, Rei, N, Pinto, S, Morais, T P, Martins, R S, Ribeiro, F F, Sebasti\u00e3o, A M, Crunelli, V & Vaz, S H 2020, 'Going the Extra (Synaptic) Mile : Excitotoxicity as the Road Toward Neurodegenerative Diseases', Frontiers in Cellular Neuroscience, vol. 14, 90. https://doi.org/10.3389/fncel.2020.00090","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:repositorio.ulisboa.pt:10451/50245","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/50245","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.3389/fncel.2020.00090","doi":"https://doi.org/10.3389/fncel.2020.00090","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2020.00090","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2020.00090/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1949695853","display_name":"Astrossomas: Astr\u00f3citos Artificiais como reguladores da comunica\u00e7\u00e3o neuronal","funder_award_id":"PTDC/BTM-SAL/32147/2017","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2981442677","display_name":null,"funder_award_id":"UID/ BIM /50005/2019","funder_id":"https://openalex.org/F4320323642","funder_display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5425662812","display_name":"Astrosomes: a novel approach for the regulation of neuronal communication\"","funder_award_id":"PD/BD/114278/2016","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5454278309","display_name":null,"funder_award_id":"/2017","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6520154620","display_name":"Training, Research and Raising of Public Awareness in Cell Biology and Pathology of Neuroglia","funder_award_id":"722053","funder_id":"https://openalex.org/F4320338337","funder_display_name":"H2020 Marie Sk\u0142odowska-Curie Actions"},{"id":"https://openalex.org/G6602794862","display_name":null,"funder_award_id":"PTDC/BTM-SAL/32147/2017, PD/BD/114278/2016, IMM/CT/35-2018, PD/BD/150342/2019, SFRH/BD/147277/2019, UID/BIM/50005/2019","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G8608397601","display_name":"Training, Research and Raising of Public Awareness in Cell Biology and Pathology of Neuroglia","funder_award_id":"722053","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8696638714","display_name":"Instituto de Medicina Molecular - IMM","funder_award_id":"UID/BIM/50005/2019","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320323642","display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior","ror":"https://ror.org/045b9pr88"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320338337","display_name":"H2020 Marie Sk\u0142odowska-Curie Actions","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3018943500.pdf","grobid_xml":"https://content.openalex.org/works/W3018943500.grobid-xml"},"referenced_works_count":371,"referenced_works":["https://openalex.org/W85910470","https://openalex.org/W111736103","https://openalex.org/W113155472","https://openalex.org/W795447023","https://openalex.org/W972099853","https://openalex.org/W1499834471","https://openalex.org/W1501293323","https://openalex.org/W1505624094","https://openalex.org/W1506970858","https://openalex.org/W1519351707","https://openalex.org/W1526054140","https://openalex.org/W1530479094","https://openalex.org/W1532004838","https://openalex.org/W1533853049","https://openalex.org/W1537179351","https://openalex.org/W1558113371","https://openalex.org/W1571689838","https://openalex.org/W1592375995","https://openalex.org/W1598578622","https://openalex.org/W1602771322","https://openalex.org/W1607065540","https://openalex.org/W1641618604","https://openalex.org/W1772604871","https://openalex.org/W1776692865","https://openalex.org/W1797578063","https://openalex.org/W1876408798","https://openalex.org/W1881066497","https://openalex.org/W1918340692","https://openalex.org/W1928433275","https://openalex.org/W1930450098","https://openalex.org/W1938199221","https://openalex.org/W1948471478","https://openalex.org/W1963882244","https://openalex.org/W1965108122","https://openalex.org/W1966556202","https://openalex.org/W1967117930","https://openalex.org/W1967268953","https://openalex.org/W1968257316","https://openalex.org/W1968286122","https://openalex.org/W1968362444","https://openalex.org/W1969155399","https://openalex.org/W1969616018","https://openalex.org/W1970217675","https://openalex.org/W1971324155","https://openalex.org/W1971335269","https://openalex.org/W1971516308","https://openalex.org/W1972260106","https://openalex.org/W1972464623","https://openalex.org/W1974642350","https://openalex.org/W1974966491","https://openalex.org/W1975218333","https://openalex.org/W1976191674","https://openalex.org/W1976854136","https://openalex.org/W1976955003","https://openalex.org/W1978895733","https://openalex.org/W1978901759","https://openalex.org/W1979656924","https://openalex.org/W1979889191","https://openalex.org/W1980311878","https://openalex.org/W1980506971","https://openalex.org/W1980829307","https://openalex.org/W1983100194","https://openalex.org/W1983399491","https://openalex.org/W1983637312","https://openalex.org/W1983753007","https://openalex.org/W1984089779","https://openalex.org/W1986078216","https://openalex.org/W1986776839","https://openalex.org/W1987209784","https://openalex.org/W1987587452","https://openalex.org/W1988278010","https://openalex.org/W1989173007","https://openalex.org/W1989331957","https://openalex.org/W1989902251","https://openalex.org/W1990293508","https://openalex.org/W1994419985","https://openalex.org/W1994640389","https://openalex.org/W1994688027","https://openalex.org/W1996024251","https://openalex.org/W1996568613","https://openalex.org/W1996973828","https://openalex.org/W2000511227","https://openalex.org/W2000931014","https://openalex.org/W2001152160","https://openalex.org/W2001261203","https://openalex.org/W2001725826","https://openalex.org/W2001879021","https://openalex.org/W2001940195","https://openalex.org/W2002044194","https://openalex.org/W2002134475","https://openalex.org/W2002388929","https://openalex.org/W2003059369","https://openalex.org/W2003564912","https://openalex.org/W2004159036","https://openalex.org/W2004459001","https://openalex.org/W2005614483","https://openalex.org/W2006178657","https://openalex.org/W2006958922","https://openalex.org/W2007622668","https://openalex.org/W2008811778","https://openalex.org/W2010095445","https://openalex.org/W2010980945","https://openalex.org/W2011103525","https://openalex.org/W2011218959","https://openalex.org/W2011622901","https://openalex.org/W2013621867","https://openalex.org/W2013974620","https://openalex.org/W2013980139","https://openalex.org/W2015067348","https://openalex.org/W2016036161","https://openalex.org/W2016444389","https://openalex.org/W2016575029","https://openalex.org/W2018336630","https://openalex.org/W2018724570","https://openalex.org/W2019260835","https://openalex.org/W2019369816","https://openalex.org/W2020197694","https://openalex.org/W2020569812","https://openalex.org/W2020925798","https://openalex.org/W2022531767","https://openalex.org/W2022671065","https://openalex.org/W2022957364","https://openalex.org/W2023711347","https://openalex.org/W2025344775","https://openalex.org/W2025681573","https://openalex.org/W2026555623","https://openalex.org/W2027616725","https://openalex.org/W2028174194","https://openalex.org/W2028634940","https://openalex.org/W2029790055","https://openalex.org/W2031132507","https://openalex.org/W2031155126","https://openalex.org/W2031804766","https://openalex.org/W2033487383","https://openalex.org/W2033678540","https://openalex.org/W2033911584","https://openalex.org/W2034042784","https://openalex.org/W2035174844","https://openalex.org/W2035351488","https://openalex.org/W2035845442","https://openalex.org/W2036755018","https://openalex.org/W2036796078","https://openalex.org/W2037230855","https://openalex.org/W2038351582","https://openalex.org/W2038611992","https://openalex.org/W2039133868","https://openalex.org/W2039232566","https://openalex.org/W2039804718","https://openalex.org/W2041096053","https://openalex.org/W2043681173","https://openalex.org/W2046181551","https://openalex.org/W2048011585","https://openalex.org/W2048383480","https://openalex.org/W2048528277","https://openalex.org/W2048713890","https://openalex.org/W2048788380","https://openalex.org/W2048916015","https://openalex.org/W2049141357","https://openalex.org/W2049262684","https://openalex.org/W2049264566","https://openalex.org/W2049594669","https://openalex.org/W2049939184","https://openalex.org/W2050706464","https://openalex.org/W2051118048","https://openalex.org/W2051303822","https://openalex.org/W2051566636","https://openalex.org/W2051690270","https://openalex.org/W2051802131","https://openalex.org/W2052208005","https://openalex.org/W2052238208","https://openalex.org/W2052704430","https://openalex.org/W2053050620","https://openalex.org/W2053881838","https://openalex.org/W2055193187","https://openalex.org/W2056711573","https://openalex.org/W2056863694","https://openalex.org/W2057528850","https://openalex.org/W2057552891","https://openalex.org/W2058176457","https://openalex.org/W2060390553","https://openalex.org/W2062122785","https://openalex.org/W2062384458","https://openalex.org/W2062882490","https://openalex.org/W2063261415","https://openalex.org/W2063906832","https://openalex.org/W2064119008","https://openalex.org/W2064579827","https://openalex.org/W2065817981","https://openalex.org/W2065894198","https://openalex.org/W2066057252","https://openalex.org/W2066557327","https://openalex.org/W2066566361","https://openalex.org/W2067841051","https://openalex.org/W2069021415","https://openalex.org/W2070046033","https://openalex.org/W2070117026","https://openalex.org/W2070251027","https://openalex.org/W2070781141","https://openalex.org/W2073656988","https://openalex.org/W2073777605","https://openalex.org/W2074445711","https://openalex.org/W2074932161","https://openalex.org/W2075056521","https://openalex.org/W2078354326","https://openalex.org/W2079606432","https://openalex.org/W2080645324","https://openalex.org/W2080811912","https://openalex.org/W2081070804","https://openalex.org/W2081358044","https://openalex.org/W2081895884","https://openalex.org/W2083035386","https://openalex.org/W2083204774","https://openalex.org/W2084973310","https://openalex.org/W2085574272","https://openalex.org/W2085600559","https://openalex.org/W2087140031","https://openalex.org/W2087292928","https://openalex.org/W2088387923","https://openalex.org/W2088585211","https://openalex.org/W2089139317","https://openalex.org/W2090122364","https://openalex.org/W2090880672","https://openalex.org/W2093412414","https://openalex.org/W2093637072","https://openalex.org/W2093950888","https://openalex.org/W2094028021","https://openalex.org/W2094201176","https://openalex.org/W2094217759","https://openalex.org/W2094869269","https://openalex.org/W2095004045","https://openalex.org/W2095551590","https://openalex.org/W2097497116","https://openalex.org/W2098324936","https://openalex.org/W2099160207","https://openalex.org/W2100193366","https://openalex.org/W2100395945","https://openalex.org/W2100701004","https://openalex.org/W2101077392","https://openalex.org/W2102839882","https://openalex.org/W2103863804","https://openalex.org/W2105442740","https://openalex.org/W2106042714","https://openalex.org/W2107541051","https://openalex.org/W2109740923","https://openalex.org/W2109909801","https://openalex.org/W2110304317","https://openalex.org/W2111425451","https://openalex.org/W2112384117","https://openalex.org/W2112696881","https://openalex.org/W2116394679","https://openalex.org/W2116447221","https://openalex.org/W2116635659","https://openalex.org/W2118153193","https://openalex.org/W2118756235","https://openalex.org/W2119774379","https://openalex.org/W2119983609","https://openalex.org/W2120392057","https://openalex.org/W2120764696","https://openalex.org/W2121726351","https://openalex.org/W2124729399","https://openalex.org/W2124955411","https://openalex.org/W2127234248","https://openalex.org/W2127744856","https://openalex.org/W2128223061","https://openalex.org/W2128744963","https://openalex.org/W2131347780","https://openalex.org/W2131729915","https://openalex.org/W2132380031","https://openalex.org/W2132949150","https://openalex.org/W2133569747","https://openalex.org/W2133607725","https://openalex.org/W2133751687","https://openalex.org/W2133994038","https://openalex.org/W2134279094","https://openalex.org/W2134333026","https://openalex.org/W2136637275","https://openalex.org/W2137420165","https://openalex.org/W2137491003","https://openalex.org/W2139748951","https://openalex.org/W2139826497","https://openalex.org/W2143742981","https://openalex.org/W2144118537","https://openalex.org/W2144328020","https://openalex.org/W2144341669","https://openalex.org/W2144561709","https://openalex.org/W2145345810","https://openalex.org/W2147250720","https://openalex.org/W2150999725","https://openalex.org/W2151927746","https://openalex.org/W2157526951","https://openalex.org/W2157527374","https://openalex.org/W2158059993","https://openalex.org/W2160412383","https://openalex.org/W2160644313","https://openalex.org/W2163334026","https://openalex.org/W2164485496","https://openalex.org/W2165543962","https://openalex.org/W2167886264","https://openalex.org/W2168063913","https://openalex.org/W2168203604","https://openalex.org/W2169149767","https://openalex.org/W2169995490","https://openalex.org/W2177909750","https://openalex.org/W2179495678","https://openalex.org/W2180309778","https://openalex.org/W2180941170","https://openalex.org/W2186898572","https://openalex.org/W2189806591","https://openalex.org/W2202641067","https://openalex.org/W2254514199","https://openalex.org/W2284741714","https://openalex.org/W2312098387","https://openalex.org/W2312354603","https://openalex.org/W2322504897","https://openalex.org/W2329057544","https://openalex.org/W2346726077","https://openalex.org/W2373055082","https://openalex.org/W2418451530","https://openalex.org/W2460819002","https://openalex.org/W2473702520","https://openalex.org/W2504385670","https://openalex.org/W2509007372","https://openalex.org/W2522811111","https://openalex.org/W2528596420","https://openalex.org/W2529838225","https://openalex.org/W2531811404","https://openalex.org/W2557155892","https://openalex.org/W2562104027","https://openalex.org/W2564814346","https://openalex.org/W2593595447","https://openalex.org/W2594072479","https://openalex.org/W2594644573","https://openalex.org/W2613809978","https://openalex.org/W2615003101","https://openalex.org/W2619641984","https://openalex.org/W2625308621","https://openalex.org/W2708431081","https://openalex.org/W2734983874","https://openalex.org/W2736052154","https://openalex.org/W2754326783","https://openalex.org/W2756063862","https://openalex.org/W2762432001","https://openalex.org/W2785267239","https://openalex.org/W2791141811","https://openalex.org/W2792811901","https://openalex.org/W2793296647","https://openalex.org/W2804828410","https://openalex.org/W2806992211","https://openalex.org/W2810762414","https://openalex.org/W2842183226","https://openalex.org/W2884945321","https://openalex.org/W2913548861","https://openalex.org/W2913609543","https://openalex.org/W2945912901","https://openalex.org/W2947172512","https://openalex.org/W2949257592","https://openalex.org/W2952014905","https://openalex.org/W2954290075","https://openalex.org/W2954464051","https://openalex.org/W2963519984","https://openalex.org/W2964831451","https://openalex.org/W2972753038","https://openalex.org/W2984262886","https://openalex.org/W4210979710","https://openalex.org/W4211157318","https://openalex.org/W4238711740","https://openalex.org/W4245157692","https://openalex.org/W4249569300","https://openalex.org/W4300539464","https://openalex.org/W4406057195","https://openalex.org/W6681928647"],"related_works":["https://openalex.org/W2005614483","https://openalex.org/W4410481920","https://openalex.org/W1971324155","https://openalex.org/W131783756","https://openalex.org/W111663151","https://openalex.org/W4247791532","https://openalex.org/W3000717029","https://openalex.org/W2082879602","https://openalex.org/W2050279035","https://openalex.org/W3023525242"],"abstract_inverted_index":{"Excitotoxicity":[0],"is":[1,51,70,141,270],"a":[2,24,123,198,271,280],"phenomenon":[3],"that":[4,28,90,143,183,255,268],"describes":[5],"the":[6,15,32,43,60,65,76,84,115,144,151,176,202,231,259,266,289,296,301],"toxic":[7],"actions":[8],"of":[9,20,26,34,62,101,106,125,147,154,173,178,192,204,228,233,252,261,300],"excitatory":[10],"neurotransmitters,":[11],"primarily":[12],"glutamate,":[13],"where":[14,288],"exacerbated":[16],"or":[17],"prolonged":[18],"activation":[19,146],"glutamate":[21,63,73,96,102,107],"receptors":[22,112],"starts":[23],"cascade":[25],"neurotoxicity":[27],"ultimately":[29],"leads":[30,159],"to":[31,160,186,248,258],"loss":[33],"neuronal":[35,134,187],"function":[36,48],"and":[37,49,79,97,104,136,158,216,226,236,244,277],"cell":[38],"death.":[39],"In":[40,218],"this":[41,219],"process,":[42],"shift":[44],"between":[45],"normal":[46],"physiological":[47],"excitotoxicity":[50,92,118,196,235,269],"largely":[52],"controlled":[53],"by":[54],"astrocytes":[55],"since":[56],"they":[57],"can":[58,119,285],"control":[59,69],"levels":[61],"on":[64,240,283],"synaptic":[66,77],"cleft.":[67],"This":[68],"achieved":[71],"through":[72,83],"clearance":[74],"from":[75],"cleft":[78],"its":[80,237],"underlying":[81,297],"recycling":[82],"glutamate-glutamine":[85],"cycle.":[86],"The":[87],"molecular":[88],"mechanism":[89,200],"triggers":[91],"involves":[93],"alterations":[94],"in":[95,150,201,274],"calcium":[98,155,174],"metabolism,":[99],"dysfunction":[100],"transporters,":[103],"malfunction":[105],"receptors,":[108],"particularly":[109],"N-methyl-D-aspartic":[110],"acid":[111],"(NMDAR).":[113],"On":[114],"other":[116,126,278],"hand,":[117],"be":[120,286],"regarded":[121],"as":[122,130,197],"consequence":[124],"cellular":[127,298],"phenomena,":[128],"such":[129],"mitochondrial":[131,165],"dysfunction,":[132,166],"physical":[133],"damage,":[135],"oxidative":[137],"stress.":[138],"Regardless,":[139],"it":[140],"known":[142],"excessive":[145],"NMDAR":[148],"results":[149],"sustained":[152],"influx":[153],"into":[156],"neurons":[157],"several":[161,241],"deleterious":[162],"consequences,":[163],"including":[164,208],"reactive":[167],"oxygen":[168],"species":[169],"(ROS)":[170],"overproduction,":[171],"impairment":[172],"buffering,":[175],"release":[177],"pro-apoptotic":[179],"factors,":[180],"among":[181],"others,":[182],"inevitably":[184],"contribute":[185],"loss.":[188],"A":[189],"large":[190],"body":[191],"evidence":[193],"implicates":[194],"NMDAR-mediated":[195,234],"central":[199],"pathogenesis":[203],"many":[205],"neurodegenerative":[206,242,275],"diseases,":[207],"amyotrophic":[209],"lateral":[210],"sclerosis":[211],"(ALS),":[212],"Alzheimer's":[213],"disease":[214],"(AD),":[215],"epilepsy.":[217],"review":[220],"article,":[221],"we":[222],"explore":[223],"different":[224],"causes":[225],"consequences":[227],"excitotoxicity,":[229],"discuss":[230],"involvement":[232],"downstream":[238],"effects":[239],"disorders,":[243,279],"identify":[245],"possible":[246],"strategies":[247],"study":[249],"new":[250,262,281],"aspects":[251],"these":[253],"diseases":[254,276],"may":[256],"lead":[257],"discovery":[260],"therapeutic":[263],"approaches.":[264],"With":[265],"understanding":[267],"common":[272],"denominator":[273],"perspective":[282],"therapy":[284],"considered,":[287],"targets":[290],"are":[291],"not":[292],"specific":[293],"symptoms,":[294],"but":[295],"phenomena":[299],"disease.":[302]},"counts_by_year":[{"year":2026,"cited_by_count":61},{"year":2025,"cited_by_count":66},{"year":2024,"cited_by_count":71},{"year":2023,"cited_by_count":43},{"year":2022,"cited_by_count":62},{"year":2021,"cited_by_count":38},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2020-05-01T00:00:00"}