{"id":"https://openalex.org/W3018899273","doi":null,"title":"On Aging, Behavior and the Role of PA28\u03b1\u03b2 in Protein Homeostasis","display_name":"On Aging, Behavior and the Role of PA28\u03b1\u03b2 in Protein Homeostasis","publication_year":2020,"publication_date":"2020-04-23","ids":{"openalex":"https://openalex.org/W3018899273","mag":"3018899273"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/63276","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/63276","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022125870","display_name":"Julia Adel\u00f6f","orcid":"https://orcid.org/0000-0003-0924-3394","observed_orcids":["https://orcid.org/0000-0003-0924-3394"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Julia Adel\u00f6f","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0924-3394","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022125870"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.03550000116229057,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunoproteasome","display_name":"immunoproteasome","score":0.7639999985694885},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/chaperone-like-function","display_name":"chaperone-like function","score":0.7789999842643738},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6859999895095825},{"id":"https://openalex.org/keywords/cognitive-behavior","display_name":"cognitive behavior","score":0.7039999961853027},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.9490000009536743},{"id":"https://openalex.org/keywords/exploratory-activity","display_name":"exploratory activity","score":0.875},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8159999847412109},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8740000128746033},{"id":"https://openalex.org/keywords/proteinopathies","display_name":"proteinopathies","score":0.9259999990463257},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.3763824701309204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29528412222862244},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2564684748649597}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/63276","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/63276","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:3018899273","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/handle/2077/63276","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1495756776","https://openalex.org/W1947552193","https://openalex.org/W1972049578","https://openalex.org/W1975396085","https://openalex.org/W1978310063","https://openalex.org/W2023095530","https://openalex.org/W2092279282","https://openalex.org/W2110561490","https://openalex.org/W2149050070","https://openalex.org/W2168047782","https://openalex.org/W2901231347","https://openalex.org/W2901694253","https://openalex.org/W2937474370"],"related_works":["https://openalex.org/W3137194929","https://openalex.org/W2900382336","https://openalex.org/W6977613006","https://openalex.org/W6902219953","https://openalex.org/W6902232704","https://openalex.org/W7116963417","https://openalex.org/W6902216013","https://openalex.org/W4316464528","https://openalex.org/W2899118224","https://openalex.org/W4407541556"],"abstract_inverted_index":{"As":[0],"life":[1],"expectancy":[2],"increases,":[3],"understanding":[4],"challenges":[5],"related":[6],"to":[7,69,110],"the":[8,71,86,130],"processes":[9],"of":[10,23,43,74,88,92,136,146,170,181,189],"aging":[11,128],"are":[12],"more":[13],"relevant":[14],"than":[15],"ever.":[16],"Common":[17],"age-related":[18],"diseases":[19],"progress":[20],"as":[21,115,124],"consequences":[22],"accumulative":[24],"protein":[25,28,44,150,183],"damage":[26,45],"and":[27,38,56,64,76,79,118,123,165,172],"aggregates.":[29],"PA28\u03b1\u03b2":[30,60,75,93,147,171,190],"has":[31],"previously":[32,143],"demonstrated":[33,95],"protective":[34],"effects":[35,81,175],"against":[36],"proteinopathy":[37],"is":[39,94],"involved":[40],"in":[41,47,100,120,127,148,156,163,191],"removal":[42],"early":[46],"mammalian":[48],"embryonic":[49],"development.":[50],"In":[51],"this":[52],"thesis":[53],"project,":[54],"female":[55],"male":[57],"mice":[58,104],"overexpressing":[59,105],"have":[61,140],"been":[62],"followed":[63],"analyzed":[65],"throughout":[66],"their":[67],"lifespan":[68],"investigate":[70],"molecular":[72,179],"function":[73,91,108],"what":[77],"physiological":[78],"behavioral":[80,134,161],"its":[82,173],"overexpression":[83],"induces.":[84],"\\n\\nHerein,":[85],"finding":[87],"a":[89,132,142,186],"chaperone-like":[90],"by":[96],"enhanced":[97,111],"aggregation":[98],"prevention":[99],"hippocampal":[101],"extracts":[102],"from":[103],"PA28\u03b1\u03b2.":[106],"This":[107],"correlates":[109],"cognitive":[112,154,174],"capacities":[113],"represented":[114],"improved":[116],"learning":[117],"memory":[119],"young":[121,164],"adults":[122],"exploratory":[125],"activity":[126],"mice,":[129,157],"latter":[131],"strong":[133],"marker":[135],"aging.":[137],"Thus,":[138],"we":[139],"found":[141],"unprecedented":[144],"role":[145,169],"neuronal":[149,168],"homeostasis,":[151],"which":[152],"improves":[153],"behavior":[155],"but":[158],"with":[159,177],"altered":[160],"outcomes":[162],"old":[166],"mice.\\n\\nThe":[167],"combined":[176],"PA28\u03b1\u03b2\u2019s":[178],"mechanism":[180],"preventing":[182],"aggregation,":[184],"highlight":[185],"therapeutical":[187],"potential":[188],"combating":[192],"proteinopathies,":[193],"especially":[194],"neurodegenerative":[195],"diseases.":[196]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2020-05-01T00:00:00"}
