{"id":"https://openalex.org/W3018875409","doi":"https://doi.org/10.1111/jphp.13282","title":"Pharmacokinetic, bioavailability and tissue distribution study of astilbin in rats","display_name":"Pharmacokinetic, bioavailability and tissue distribution study of astilbin in rats","publication_year":2020,"publication_date":"2020-04-28","ids":{"openalex":"https://openalex.org/W3018875409","doi":"https://doi.org/10.1111/jphp.13282","mag":"3018875409","pmid":"https://pubmed.ncbi.nlm.nih.gov/32346882"},"language":"en","primary_location":{"id":"doi:10.1111/jphp.13282","doi":"https://doi.org/10.1111/jphp.13282","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jphp.13282","pdf_url":null,"source":{"id":"https://openalex.org/S118304455","display_name":"Journal of Pharmacy and Pharmacology","issn_l":"0022-3573","issn":["0022-3573","2042-7158"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy and Pharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3018875409"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050152496","display_name":"Meiyun Shi","orcid":"https://orcid.org/0000-0003-0755-5642","observed_orcids":["https://orcid.org/0000-0003-0755-5642"]},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Meiyun Shi","raw_affiliation_strings":["School of Life and Pharmaceutical Sciences, Dalian University of Technology , Panjin,","School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life and Pharmaceutical Sciences, Dalian University of Technology , Panjin,","institution_ids":["https://openalex.org/I27357992"]},{"raw_affiliation_string":"School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066989187","display_name":"Mengyao Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyao Xu","raw_affiliation_strings":["School of Life and Pharmaceutical Sciences, Dalian University of Technology , Panjin,","School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life and Pharmaceutical Sciences, Dalian University of Technology , Panjin,","institution_ids":["https://openalex.org/I27357992"]},{"raw_affiliation_string":"School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100761397","display_name":"Lei Yin","orcid":"https://orcid.org/0000-0002-8068-5999","observed_orcids":["https://orcid.org/0000-0002-8068-5999"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Yin","raw_affiliation_strings":["Clinical laboratory, The First Hospital of Jilin University , Changchun,","Clinical laboratory, The First Hospital of Jilin University, Changchun, China"],"raw_orcid":"https://orcid.org/0000-0002-8068-5999","affiliations":[{"raw_affiliation_string":"Clinical laboratory, The First Hospital of Jilin University , Changchun,","institution_ids":["https://openalex.org/I4210125137"]},{"raw_affiliation_string":"Clinical laboratory, The First Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210125137"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050152496","https://openalex.org/A5100761397"],"corresponding_institution_ids":["https://openalex.org/I27357992","https://openalex.org/I4210125137"],"apc_list":{"value":2200,"currency":"GBP","value_usd":3300},"apc_paid":null,"fwci":0.9537,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.69335861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"72","issue":"8","first_page":"1061","last_page":"1071"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.15029999613761902,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.05429999902844429,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astilbin","display_name":"astilbin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.9990000128746033},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.906000018119812},{"id":"https://openalex.org/keywords/plasma-half-life","display_name":"plasma half-life","score":0.8050000071525574},{"id":"https://openalex.org/keywords/oral-absorption","display_name":"oral absorption","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.9047544002532959},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8602385520935059},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.7093949913978577},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7086290121078491},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.4939597249031067},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45656618475914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4180663824081421},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.05300009250640869},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044948","descriptor_name":"Flavonols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D044948","descriptor_name":"Flavonols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/jphp.13282","doi":"https://doi.org/10.1111/jphp.13282","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jphp.13282","pdf_url":null,"source":{"id":"https://openalex.org/S118304455","display_name":"Journal of Pharmacy and Pharmacology","issn_l":"0022-3573","issn":["0022-3573","2042-7158"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy and Pharmacology","raw_type":"journal-article"},{"id":"pmid:32346882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32346882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pharmacy and pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1514141300","display_name":null,"funder_award_id":"81703607","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1831513659","display_name":null,"funder_award_id":"20190103082JH","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G2376499184","display_name":null,"funder_award_id":"20190103082JH","funder_id":"https://openalex.org/F4320322174","funder_display_name":"People's Government of Jilin Province"},{"id":"https://openalex.org/G74521534","display_name":null,"funder_award_id":"81603182","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8834172564","display_name":null,"funder_award_id":"DUT18LK24","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W151619972","https://openalex.org/W1969491090","https://openalex.org/W1974775776","https://openalex.org/W1997881836","https://openalex.org/W2022890533","https://openalex.org/W2034089125","https://openalex.org/W2043901631","https://openalex.org/W2059577693","https://openalex.org/W2059875536","https://openalex.org/W2067690301","https://openalex.org/W2077502316","https://openalex.org/W2081690719","https://openalex.org/W2095463187","https://openalex.org/W2111727229","https://openalex.org/W2127015773","https://openalex.org/W2142051176","https://openalex.org/W2145449025","https://openalex.org/W2158001250","https://openalex.org/W2158640707","https://openalex.org/W2334759250","https://openalex.org/W2410004908","https://openalex.org/W2414737764","https://openalex.org/W2443058334","https://openalex.org/W2750548727","https://openalex.org/W2781127607","https://openalex.org/W2793282004","https://openalex.org/W2796319457","https://openalex.org/W2810310715","https://openalex.org/W2884616576","https://openalex.org/W2897634679","https://openalex.org/W2904053549","https://openalex.org/W2942650391","https://openalex.org/W2958000770","https://openalex.org/W6718330931","https://openalex.org/W6747362838"],"related_works":["https://openalex.org/W1499265491","https://openalex.org/W2137604403","https://openalex.org/W2365018914","https://openalex.org/W2334759250","https://openalex.org/W2103337793","https://openalex.org/W2029332909","https://openalex.org/W2415719384","https://openalex.org/W2958000770","https://openalex.org/W3092656432","https://openalex.org/W2418654255"],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],"The":[2,51,157],"purpose":[3],"of":[4,13,29,53,80,91,103,154,161,166,177],"this":[5],"study":[6],"is":[7,163],"to":[8,97],"reveal":[9],"the":[10,22,83,99,113,138,151,167],"pharmacokinetic":[11,68],"profiles":[12],"astilbin":[14,30,40,47,54,81,92,104,162,178],"with":[15,82],"various":[16,59],"doses":[17],"in":[18,55,179],"rats":[19,36,180],"and":[20,26,44,58,72,94,109,122,133,143,170,175],"investigate":[21],"oral":[23,32,89,100,146,158,173,184],"absolute":[24,101,159],"bioavailability":[25,102,160],"tissue":[27,60],"distribution":[28,136],"after":[31,183],"administration.":[33,147,185],"Methods":[34],"Wistar":[35],"were":[37,74,105,118],"orally":[38],"administered":[39,46],"12,":[41],"24":[42,95],"mg/kg":[43,49,96],"intravenous":[45],"6":[48],"randomly.":[50],"concentration":[52],"rat":[56],"plasma":[57,77,114],"samples":[61],"was":[62],"determined":[63],"by":[64],"LC-MS/MS":[65],"method.":[66],"Noncompartmental":[67],"parameters":[69],"including":[70],"AUC":[71],"t1/2":[73],"calculated":[75],"from":[76],"concentration\u2013time":[78],"data":[79],"DAS":[84],"3.0.":[85],"Key":[86],"findings":[87],"After":[88],"administration":[90],"12":[93],"rats,":[98],"1.16":[106],"\u00b1":[107,111,120,124],"0.695%":[108],"1.27":[110],"0.379%;":[112],"elimination":[115],"half-lives":[116],"(t1/2)":[117],"101":[119],"35.8":[121],"109":[123],"25.3":[125],"min,":[126],"respectively.":[127],"Astilbin":[128,148],"had":[129],"a":[130,134],"rapid":[131,182],"absorption":[132,174],"wide":[135],"throughout":[137],"whole":[139],"body":[140],"except":[141],"liver":[142],"fat":[144],"following":[145],"could":[149],"penetrate":[150],"blood\u2013brain":[152],"barrier":[153],"rat.":[155],"Conclusions":[156],"poor":[164],"because":[165],"low":[168],"permeability":[169],"solubility.":[171],"Both":[172],"clearance":[176],"are":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-05-01T00:00:00"}
