{"id":"https://openalex.org/W30188281","doi":null,"title":"MUTAGENIC POTENTIAL OF TELOMERIC REPEATS AND THE ROLE OF WERNER SYNDROME HELICASE PROTEIN IN FACILITATING TELOMERIC DNA REPLICATION","display_name":"MUTAGENIC POTENTIAL OF TELOMERIC REPEATS AND THE ROLE OF WERNER SYNDROME HELICASE PROTEIN IN FACILITATING TELOMERIC DNA REPLICATION","publication_year":2011,"publication_date":"2011-06-29","ids":{"openalex":"https://openalex.org/W30188281","mag":"30188281"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:6803","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/6803/1/Rama_Damerla_Thesis1.pdf","pdf_url":"https://d-scholarship.pitt.edu/6803/1/Rama_Damerla_Thesis1.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046241020","display_name":"Rama Rao Damerla","orcid":"https://orcid.org/0000-0001-6815-0097","observed_orcids":["https://orcid.org/0000-0001-6815-0097"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rama Rao Damerla","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6815-0097","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046241020"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.09969999641180038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomeric-repeats","display_name":"telomeric repeats","score":0.8629999756813049},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"mutagenesis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/g-quadruplex","display_name":"G-quadruplex","score":0.9089999794960022},{"id":"https://openalex.org/keywords/werner-syndrome","display_name":"Werner syndrome","score":0.9369999766349792},{"id":"https://openalex.org/keywords/wrn-helicase","display_name":"WRN helicase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/recq-helicase","display_name":"RecQ helicase","score":0.8389999866485596},{"id":"https://openalex.org/keywords/telomere-replication","display_name":"telomere replication","score":0.8240000009536743},{"id":"https://openalex.org/keywords/telomere-loss","display_name":"telomere loss","score":0.6610000133514404},{"id":"https://openalex.org/keywords/replication-fork-stalling","display_name":"replication fork stalling","score":0.6669999957084656},{"id":"https://openalex.org/keywords/shuttle-vector","display_name":"shuttle vector","score":0.5839999914169312},{"id":"https://openalex.org/keywords/mutant-frequency","display_name":"mutant frequency","score":0.5740000009536743},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.6100000143051147},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.8115333914756775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7498623728752136},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6501345634460449},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.5579909086227417},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5315333008766174},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.511916995048523},{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.5078325867652893},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5043851137161255},{"id":"https://openalex.org/C2780751114","wikidata":"https://www.wikidata.org/wiki/Q7302254","display_name":"RecQ helicase","level":5,"score":0.4641977548599243},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43344953656196594},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.4295847713947296},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.41139280796051025},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3265230655670166},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22504234313964844},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.08332684636116028}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:6803","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/6803/1/Rama_Damerla_Thesis1.pdf","pdf_url":"https://d-scholarship.pitt.edu/6803/1/Rama_Damerla_Thesis1.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:30188281","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/6803/1/Rama_Damerla_Thesis1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":210,"referenced_works":["https://openalex.org/W5604228","https://openalex.org/W1487697828","https://openalex.org/W1538603370","https://openalex.org/W1543207966","https://openalex.org/W1545080826","https://openalex.org/W1560288504","https://openalex.org/W1590326214","https://openalex.org/W1590561480","https://openalex.org/W1804841424","https://openalex.org/W1829553711","https://openalex.org/W1912524364","https://openalex.org/W1964529737","https://openalex.org/W1965493201","https://openalex.org/W1968558368","https://openalex.org/W1969578702","https://openalex.org/W1970018793","https://openalex.org/W1970891016","https://openalex.org/W1972655555","https://openalex.org/W1975817860","https://openalex.org/W1976145400","https://openalex.org/W1976334693","https://openalex.org/W1977642897","https://openalex.org/W1978014307","https://openalex.org/W1978916795","https://openalex.org/W1979015046","https://openalex.org/W1979496143","https://openalex.org/W1980480427","https://openalex.org/W1981358003","https://openalex.org/W1981922425","https://openalex.org/W1982056967","https://openalex.org/W1982199027","https://openalex.org/W1982306759","https://openalex.org/W1983127291","https://openalex.org/W1983673827","https://openalex.org/W1984166927","https://openalex.org/W1985910710","https://openalex.org/W1986108211","https://openalex.org/W1987516656","https://openalex.org/W1987603976","https://openalex.org/W1990507848","https://openalex.org/W1991019568","https://openalex.org/W1993031232","https://openalex.org/W1995004577","https://openalex.org/W1996423479","https://openalex.org/W1996831741","https://openalex.org/W1998000773","https://openalex.org/W1998129814","https://openalex.org/W1999247982","https://openalex.org/W2003411878","https://openalex.org/W2003636889","https://openalex.org/W2003745942","https://openalex.org/W2004314923","https://openalex.org/W2005576986","https://openalex.org/W2006322108","https://openalex.org/W2008669260","https://openalex.org/W2009374460","https://openalex.org/W2009581739","https://openalex.org/W2010203380","https://openalex.org/W2010882280","https://openalex.org/W2011037268","https://openalex.org/W2013851878","https://openalex.org/W2013988118","https://openalex.org/W2014013625","https://openalex.org/W2015221134","https://openalex.org/W2016594530","https://openalex.org/W2021489383","https://openalex.org/W2023167598","https://openalex.org/W2025350653","https://openalex.org/W2025880317","https://openalex.org/W2026370504","https://openalex.org/W2026766143","https://openalex.org/W2027779909","https://openalex.org/W2028345897","https://openalex.org/W2032407757","https://openalex.org/W2033332310","https://openalex.org/W2033418849","https://openalex.org/W2035389897","https://openalex.org/W2036301524","https://openalex.org/W2036639619","https://openalex.org/W2037236933","https://openalex.org/W2037480531","https://openalex.org/W2037703099","https://openalex.org/W2038661569","https://openalex.org/W2039154667","https://openalex.org/W2042076400","https://openalex.org/W2044485780","https://openalex.org/W2045464664","https://openalex.org/W2046916766","https://openalex.org/W2048366793","https://openalex.org/W2050228381","https://openalex.org/W2055132002","https://openalex.org/W2055237449","https://openalex.org/W2056047802","https://openalex.org/W2056595058","https://openalex.org/W2058197513","https://openalex.org/W2058792468","https://openalex.org/W2059501883","https://openalex.org/W2060017837","https://openalex.org/W2060955969","https://openalex.org/W2062724831","https://openalex.org/W2063070639","https://openalex.org/W2064310741","https://openalex.org/W2064387695","https://openalex.org/W2066253067","https://openalex.org/W2068341767","https://openalex.org/W2071918742","https://openalex.org/W2072744580","https://openalex.org/W2073204556","https://openalex.org/W2075006474","https://openalex.org/W2075593502","https://openalex.org/W2075808770","https://openalex.org/W2076127482","https://openalex.org/W2076926674","https://openalex.org/W2078042856","https://openalex.org/W2078786713","https://openalex.org/W2079752269","https://openalex.org/W2079768304","https://openalex.org/W2080032853","https://openalex.org/W2080661557","https://openalex.org/W2080792646","https://openalex.org/W2082947047","https://openalex.org/W2084017895","https://openalex.org/W2084712319","https://openalex.org/W2086095857","https://openalex.org/W2086401125","https://openalex.org/W2086992094","https://openalex.org/W2087011288","https://openalex.org/W2087831639","https://openalex.org/W2088848743","https://openalex.org/W2088880824","https://openalex.org/W2088926897","https://openalex.org/W2089041372","https://openalex.org/W2092476887","https://openalex.org/W2093624810","https://openalex.org/W2094556673","https://openalex.org/W2095787428","https://openalex.org/W2098085059","https://openalex.org/W2098951211","https://openalex.org/W2099198402","https://openalex.org/W2100440853","https://openalex.org/W2102212065","https://openalex.org/W2102839588","https://openalex.org/W2104114743","https://openalex.org/W2105144878","https://openalex.org/W2106996266","https://openalex.org/W2107665433","https://openalex.org/W2108482850","https://openalex.org/W2108862848","https://openalex.org/W2109229110","https://openalex.org/W2110522968","https://openalex.org/W2110761051","https://openalex.org/W2113168077","https://openalex.org/W2113194569","https://openalex.org/W2113558017","https://openalex.org/W2117413664","https://openalex.org/W2117529453","https://openalex.org/W2119457036","https://openalex.org/W2119707666","https://openalex.org/W2119762097","https://openalex.org/W2122740168","https://openalex.org/W2125250665","https://openalex.org/W2126595071","https://openalex.org/W2127014693","https://openalex.org/W2128856714","https://openalex.org/W2129031151","https://openalex.org/W2130937335","https://openalex.org/W2132695846","https://openalex.org/W2137832223","https://openalex.org/W2138222569","https://openalex.org/W2138398263","https://openalex.org/W2140262230","https://openalex.org/W2141280535","https://openalex.org/W2141436536","https://openalex.org/W2141853045","https://openalex.org/W2142611898","https://openalex.org/W2145952889","https://openalex.org/W2147765162","https://openalex.org/W2149718327","https://openalex.org/W2150490516","https://openalex.org/W2152365110","https://openalex.org/W2152472623","https://openalex.org/W2152700122","https://openalex.org/W2152760906","https://openalex.org/W2154093655","https://openalex.org/W2154731205","https://openalex.org/W2155001149","https://openalex.org/W2155096684","https://openalex.org/W2155437022","https://openalex.org/W2156778003","https://openalex.org/W2158737337","https://openalex.org/W2159349156","https://openalex.org/W2160618567","https://openalex.org/W2161232591","https://openalex.org/W2162110004","https://openalex.org/W2162569387","https://openalex.org/W2163819508","https://openalex.org/W2164011916","https://openalex.org/W2164255791","https://openalex.org/W2164389045","https://openalex.org/W2165019352","https://openalex.org/W2166514049","https://openalex.org/W2167230638","https://openalex.org/W2168236235","https://openalex.org/W2168986282","https://openalex.org/W2171818443","https://openalex.org/W2171830519","https://openalex.org/W2172118596","https://openalex.org/W2331470031","https://openalex.org/W3187658540","https://openalex.org/W7095856360"],"related_works":["https://openalex.org/W2151888603","https://openalex.org/W101202856","https://openalex.org/W2094556673","https://openalex.org/W2265283765","https://openalex.org/W4211240305","https://openalex.org/W1968558368","https://openalex.org/W2624791552","https://openalex.org/W4389024402","https://openalex.org/W6908186118","https://openalex.org/W2034145167"],"abstract_inverted_index":{"Chromosome":[0],"termini":[1],"form":[2,154],"nucleoprotein":[3],"structures":[4,45,63],"called":[5,46],"telomeres":[6,39,313],"that":[7,34,128,153,191,273,336],"consist":[8],"of":[9,12,38,66,134,183,212,234,296,344],"tandem":[10],"repeats":[11,88,107,208,302],"TTAGGG":[13],"DNA":[14,44,59,62,69,73,120,137,158,204,213,290,299],"sequences":[15,152],"(mammals)":[16],"and":[17,28,57,77,95,110,199,258,306,325],"telomeric":[18,58,87,106,130,151,161,207,219,257,269,284],"proteins.":[19],"Telomeres":[20],"play":[21],"a":[22,218],"critical":[23],"role":[24],"in":[25,75,83,98,132,144,171,210,225,237,277,280,292,303],"cell":[26],"survival":[27],"genomic":[29],"stability.":[30,60],"Biochemical":[31],"studies":[32],"showed":[33],"the":[35,125,172,184,262,268,342],"G-rich":[36,129],"strand":[37],"can":[40],"fold":[41,117],"into":[42,89,118],"secondary":[43],"G-quadruplexes":[47],"(G4-DNA),":[48],"which":[49,178],"are":[50,64,78,140,287,314],"thought":[51],"to":[52,80,103,113,116,195,202],"impact":[53],"telomere":[54,167,301,339],"length":[55],"regulation":[56],"G4":[61,119,136,157,203],"capable":[65],"interfering":[67],"with":[68,217,283,316,341],"synthesis":[70,291],"by":[71,181,206],"blocking":[72],"polymerases":[74],"vitro":[76],"proposed":[79],"hinder":[81],"replication":[82,143,196],"vivo.":[84],"We":[85,122,189,271,286],"cloned":[86],"reporter":[90],"cassettes":[91],"on":[92],"shuttle":[93,235,243,281],"vectors":[94,216,236,260,282],"replicated":[96,224],"them":[97],"normal":[99,145,238],"human":[100,146,160],"somatic":[101],"cells":[102,227,239,250],"determine":[104],"if":[105],"induce":[108,163],"mutations":[109],"deletions":[111,211],"due":[112,201],"their":[114,135],"ability":[115,139],"structures.":[121],"demonstrated":[123,272],"for":[124,231,255,267],"first":[126],"time":[127],"repeats,":[131],"spite":[133],"forming":[138],"stable":[141,156],"upon":[142],"cells.":[147,308],"In":[148],"contrast,":[149],"ciliate":[150],"more":[155,164],"than":[159],"sequences,":[162],"mutations.":[165],"Stochastic":[166],"loss":[168,182,340],"is":[169,179,275],"seen":[170],"premature":[173,326],"aging":[174,327],"disorder":[175],"Werner":[176],"Syndrome,":[177],"caused":[180],"RecQ":[185],"helicase":[186],"protein":[187],"WRN.":[188,232],"hypothesized":[190],"WRN":[192,248,274,304],"deficiency":[193],"leads":[194],"fork":[197],"stalling":[198],"collapse":[200],"formed":[205],"resulting":[209],"sequence.":[214],"Shuttle":[215],"or":[220,229,346],"control":[221,259],"sequence":[222],"were":[223],"U2OS":[226],"deficient":[228,307],"proficient":[230,305],"Replication":[233],"did":[240],"not":[241],"influence":[242],"vector":[244],"mutant":[245,253],"frequencies,":[246],"while":[247],"depleted":[249],"exhibited":[251],"elevated":[252],"frequencies":[254],"both":[256],"but":[261],"increase":[263],"was":[264],"significantly":[265],"higher":[266],"vector.":[270],"involved":[276],"suppressing":[278],"mutagenesis":[279],"sequences.":[285],"also":[288],"testing":[289],"plasmids":[293],"through":[294],"regions":[295],"single":[297],"stranded":[298],"containing":[300],"Public":[309],"health":[310],"significance:":[311],"Shortened":[312],"associated":[315],"age":[317],"related":[318],"diseases":[319],"such":[320],"as":[321],"heart":[322],"disease,":[323],"cancer":[324],"disorders.":[328],"These":[329],"assays":[330],"will":[331],"help":[332],"us":[333],"investigate":[334],"factors":[335],"cause":[337],"accelerated":[338],"goal":[343],"preventing":[345],"delaying":[347],"disease.":[348]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}