{"id":"https://openalex.org/W3018540468","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06876","title":"Blocking Store\u2010Operated Ca 2+ Entry to Protect Cardiomyocytes from Epirubicin\u2010Induced Toxicity","display_name":"Blocking Store\u2010Operated Ca 2+ Entry to Protect Cardiomyocytes from Epirubicin\u2010Induced Toxicity","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3018540468","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06876","mag":"3018540468"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2020.34.s1.06876","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06876","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.06876","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101457215","display_name":"Xian Liu","orcid":"https://orcid.org/0000-0002-8715-658X","observed_orcids":["https://orcid.org/0000-0002-8715-658X"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xian Liu","raw_affiliation_strings":["University of Texas at Arlington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Arlington","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100714644","display_name":"Yan Chang","orcid":"https://orcid.org/0000-0001-5846-8819","observed_orcids":["https://orcid.org/0000-0001-5846-8819"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Chang","raw_affiliation_strings":["University of Texas at Arlington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Arlington","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038326431","display_name":"Sangyong Choi","orcid":"https://orcid.org/0000-0001-6316-7068","observed_orcids":["https://orcid.org/0000-0001-6316-7068"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sangyong Choi","raw_affiliation_strings":["University of Texas at Arlington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Arlington","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025549159","display_name":"Zui Pan","orcid":"https://orcid.org/0000-0003-4105-901X","observed_orcids":["https://orcid.org/0000-0003-4105-901X"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zui Pan","raw_affiliation_strings":["University of Texas at Arlington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Arlington","institution_ids":["https://openalex.org/I189196454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I189196454"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"S1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epirubicin","display_name":"epirubicin","score":0.9399999976158142},{"id":"https://openalex.org/keywords/anthracycline-induced-cardiotoxicity","display_name":"anthracycline cardiotoxicity","score":0.9190000295639038},{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.9520000219345093},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8970000147819519},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/orai1","display_name":"Orai1","score":0.8669999837875366},{"id":"https://openalex.org/keywords/orai3","display_name":"Orai3","score":0.972000002861023},{"id":"https://openalex.org/keywords/stromal-interaction-molecule-1","display_name":"STIM1","score":1.0},{"id":"https://openalex.org/keywords/intracellular-calcium-homeostasis","display_name":"intracellular calcium homeostasis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/thapsigargin","display_name":"thapsigargin","score":0.6629999876022339},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8199999928474426},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.6600000262260437},{"id":"https://openalex.org/keywords/hl-1-cells","display_name":"HL-1 cells","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2780835546","wikidata":"https://www.wikidata.org/wiki/Q425122","display_name":"Epirubicin","level":4,"score":0.7314693927764893},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.616684079170227},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5575515031814575},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5340297222137451},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5082394480705261},{"id":"https://openalex.org/C2777146706","wikidata":"https://www.wikidata.org/wiki/Q3981006","display_name":"Thapsigargin","level":3,"score":0.45358824729919434},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37817737460136414},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3585778772830963},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3581348955631256},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.335873544216156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28346168994903564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20009082555770874},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17911666631698608},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2020.34.s1.06876","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06876","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.06876","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6800000071525574,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4322503843","https://openalex.org/W3174036025","https://openalex.org/W2981830889","https://openalex.org/W2346053691","https://openalex.org/W4406631617","https://openalex.org/W3161426586","https://openalex.org/W2922560968","https://openalex.org/W3088402598","https://openalex.org/W2074758391","https://openalex.org/W1998660025"],"abstract_inverted_index":{"Epirubicin":[0,331],"(EPI)":[1],"is":[2],"one":[3],"of":[4,107,149,167,185,220,245,250,314,327,370],"widely":[5],"used":[6,67],"anthracycline":[7],"chemotherapy":[8],"drugs,":[9],"yet":[10],"its":[11,15,48],"cardiotoxicity":[12,52],"severely":[13],"limits":[14],"clinical":[16],"application.":[17],"Altered":[18],"intracellular":[19,80],"Ca":[20,34,81,109,118,133],"2+":[21,35,82,110,119,134],"homeostasis":[22],"has":[23,39],"been":[24,40],"linked":[25,41],"to":[26,131,365,383],"epirubicin\u2010induced":[27,51,353],"cell":[28,59,152,259,315],"death":[29],"and":[30,45,79,96,146,171,225,241,247,297,324,336,355,377],"hypertrophy.":[31,356],"While":[32,151],"store\u2010operated":[33],"entry":[36],"(SOCE)":[37],"recently":[38],"with":[42,159,199,228,266],"cardiac":[43],"hypertrophy":[44,277,311,337],"heart":[46],"failure,":[47],"role":[49],"in":[50,68,116,156,194,257,312,338],"remains":[53],"unknown.":[54],"METHOD":[55],"HL\u20101,":[56],"a":[57,90,288],"cardiomyocyte":[58],"line":[60],"derived":[61],"from":[62,301,309,352],"adult":[63],"mouse":[64],"atria,":[65],"was":[66,73,83,123,128,138,154,232,280],"this":[69,294],"study.":[70],"Intracellular":[71],"ROS":[72,192],"measured":[74],"by":[75,85,112,140,238,343],"dihydroethidium":[76],"(DHE)":[77],"fluorescence":[78],"monitored":[84],"ratiometric":[86],"dye":[87],"Fura\u20102":[88],"on":[89],"spectrofluorometer":[91],"(excitation":[92],"\u03bb":[93,98],"=":[94,99],"350/385nm":[95],"emission":[97],"510nm;":[100],"Photon":[101],"Technology":[102],"International,":[103],"NJ).":[104],"Upon":[105],"depletion":[106],"ER":[108],"stores":[111],"10\u03bcM":[113],"thapsigargin":[114],"(TG)":[115],"0mM":[117],"extracellular":[120,126],"solution,":[121],"SOCE":[122,210,221,290,296,342],"activated":[124],"when":[125],"solution":[127],"rapidly":[129],"exchanged":[130],"2mM":[132],".":[135],"Apoptosis":[136,231],"assay":[137],"conducted":[139],"nuclei":[141],"staining,":[142],"F\u2010actin":[143,246],"phalloidin":[144],"staining":[145],"Western":[147],"Blotting":[148],"caspase\u20103.":[150],"size":[153,260,316],"compared":[155,178,198,227,265],"HL\u20101":[157,196,299,307,339,350],"cells":[158,197,269,300,308,351],"different":[160],"treatments":[161],"using":[162,179],"Image":[163],"J,":[164],"the":[165,239],"mRNA":[166],"Orai1,":[168,223],"Orai3,":[169,224],"STIM1":[170,226],"B\u2010type":[172],"natriuretic":[173],"peptide":[174],"(BNP)":[175],"were":[176],"also":[177,255,305,325],"real":[180],"time":[181],"qPCR.":[182],"RESULTS":[183],"Incubation":[184],"1uM":[186],"EPI":[187,206,235,253,283],"for":[188,375,381],"30min":[189],"induced":[190,207,334],"significant":[191],"production":[193],"cultured":[195],"vehicle":[200],"control":[201,229,268],"(10410\u00b11492":[202],"vs.":[203,212],"2762\u00b1939,":[204],"p<0.0001).":[205,275],"an":[208],"enhanced":[209],"(0.1214\u00b10.0104":[211],"0.0682\u00b10.0062,":[213],"n=32,":[214],"p=0.0008),":[215],"likely":[216],"through":[217],"increased":[218,248],"expression":[219],"components":[222],"cells.":[230],"observed":[233],"upon":[234,282],"treatment,":[236],"indicated":[237],"condensed":[240],"fragmented":[242],"nuclei,":[243],"degradation":[244],"cleavage":[249],"caspase\u20103":[251],"protein.":[252],"treatment":[254,284],"resulted":[256],"larger":[258],"(3894\u00b1120":[261],"\u03bcm":[262,271,321],"2":[263,272,322],")":[264,323],"non\u2010treated":[267],"(2452\u00b157":[270],",":[273,319],"n=581,":[274],"The":[276],"marker":[278],"BNP":[279,328],"up\u2010regulated":[281],"as":[285],"well.":[286],"BTP\u20102,":[287],"known":[289],"blocker,":[291],"could":[292,345],"block":[293],"EPI\u2010induced":[295,302,310],"rescue":[298,349],"apoptosis.":[303],"BTP\u20102":[304,344],"prevented":[306],"terms":[313],"(see":[317],"Figure":[318,386],"2548\u00b169":[320],"reduction":[326],"expression.":[329],"CONCLUSION":[330],"upregulated":[332],"SOCE,":[333],"apoptosis":[335,354],"cardiomyocytes.":[340],"Blocking":[341],"at":[346,372],"least":[347],"partially":[348],"Support":[357],"or":[358],"Funding":[359],"Information":[360],"(1)":[361],"NIH":[362],"S10":[363],"OD025230":[364],"Dr.":[366],"Zui":[367],"Pan(2)":[368],"University":[369],"Texas":[371],"Arlington":[373],"Center":[374],"Research":[376],"Scholarship":[378],"Pilot":[379],"Grant":[380],"Trainee":[382],"Xian":[384],"Liu":[385],"1":[387]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2020-05-01T00:00:00"}
