{"id":"https://openalex.org/W3018216396","doi":"https://doi.org/10.1016/j.omtn.2020.04.006","title":"Definition of miRNA Signatures of Nodal Metastasis in LCa: miR-449a Targets Notch Genes and Suppresses Cell Migration and Invasion","display_name":"Definition of miRNA Signatures of Nodal Metastasis in LCa: miR-449a Targets Notch Genes and Suppresses Cell Migration and Invasion","publication_year":2020,"publication_date":"2020-04-22","ids":{"openalex":"https://openalex.org/W3018216396","doi":"https://doi.org/10.1016/j.omtn.2020.04.006","mag":"3018216396","pmid":"https://pubmed.ncbi.nlm.nih.gov/32402942","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7218231"},"language":"en","primary_location":{"id":"doi:10.1016/j.omtn.2020.04.006","doi":"https://doi.org/10.1016/j.omtn.2020.04.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2020.04.006","pdf_url":"http://www.cell.com/article/S2162253120301141/pdf","source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Nucleic Acids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2162253120301141/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109372228","display_name":"Hiromichi Kawasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210134940","display_name":"Wakunaga (Japan)","ror":"https://ror.org/04ae5ch43","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210134940"]}],"countries":["IT","JP"],"is_corresponding":false,"raw_author_name":"Hiromichi Kawasaki","raw_affiliation_strings":["Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy; Drug Discovery Laboratory, Wakunaga Pharmaceutical, Hiroshima, Japan","Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","Drug Discovery Laboratory, Wakunaga Pharmaceutical, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy; Drug Discovery Laboratory, Wakunaga Pharmaceutical, Hiroshima, Japan","institution_ids":["https://openalex.org/I197809005","https://openalex.org/I4210134940"]},{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Drug Discovery Laboratory, Wakunaga Pharmaceutical, Hiroshima, Japan","institution_ids":["https://openalex.org/I4210134940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001134032","display_name":"Takashi Takeuchi","orcid":"https://orcid.org/0000-0001-9308-1302","observed_orcids":["https://orcid.org/0000-0001-9308-1302"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210134940","display_name":"Wakunaga (Japan)","ror":"https://ror.org/04ae5ch43","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210134940"]}],"countries":["IT","JP"],"is_corresponding":false,"raw_author_name":"Takashi Takeuchi","raw_affiliation_strings":["Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy; Molecular Diagnostics Division, Wakunaga Pharmaceutical, Hiroshima, Japan","Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","Molecular Diagnostics Division, Wakunaga Pharmaceutical, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy; Molecular Diagnostics Division, Wakunaga Pharmaceutical, Hiroshima, Japan","institution_ids":["https://openalex.org/I197809005","https://openalex.org/I4210134940"]},{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Molecular Diagnostics Division, Wakunaga Pharmaceutical, Hiroshima, Japan","institution_ids":["https://openalex.org/I4210134940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003063866","display_name":"Filippo Ricciardiello","orcid":"https://orcid.org/0000-0001-7235-2804","observed_orcids":["https://orcid.org/0000-0001-7235-2804"]},"institutions":[{"id":"https://openalex.org/I4210087768","display_name":"Ospedale Antonio Cardarelli","ror":"https://ror.org/003hhqx84","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087768"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Ricciardiello","raw_affiliation_strings":["Ear, Nose, and Throat Unit, AORN \"Antonio Cardarelli,\" Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ear, Nose, and Throat Unit, AORN \"Antonio Cardarelli,\" Naples, Italy","institution_ids":["https://openalex.org/I4210087768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040277868","display_name":"Angela Lombardi","orcid":"https://orcid.org/0000-0001-5421-9970","observed_orcids":["https://orcid.org/0000-0001-5421-9970","https://orcid.org/0000-0002-8978-1653"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angela Lombardi","raw_affiliation_strings":["Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049635189","display_name":"Elia Mario Biganzoli","orcid":"https://orcid.org/0000-0003-1202-5873","observed_orcids":["https://orcid.org/0000-0003-1202-5873"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elia Biganzoli","raw_affiliation_strings":["Unit of Medical Statistics, Biometry and Bioinformatics \"Giulio A. Maccacaro,\" Department of Clinical Sciences and Community Health & DSRC, University of Milan Campus Cascina Rosa, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Medical Statistics, Biometry and Bioinformatics \"Giulio A. Maccacaro,\" Department of Clinical Sciences and Community Health & DSRC, University of Milan Campus Cascina Rosa, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054181142","display_name":"Marco Fornili","orcid":"https://orcid.org/0000-0002-5713-3926","observed_orcids":["https://orcid.org/0000-0002-5713-3926"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Fornili","raw_affiliation_strings":["Unit of Medical Statistics, Biometry and Bioinformatics \"Giulio A. Maccacaro,\" Department of Clinical Sciences and Community Health & DSRC, University of Milan Campus Cascina Rosa, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Medical Statistics, Biometry and Bioinformatics \"Giulio A. Maccacaro,\" Department of Clinical Sciences and Community Health & DSRC, University of Milan Campus Cascina Rosa, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064895346","display_name":"Davide De Bortoli","orcid":"https://orcid.org/0000-0001-9648-0763","observed_orcids":["https://orcid.org/0000-0001-9648-0763"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide De Bortoli","raw_affiliation_strings":["Unit of Medical Statistics, Biometry and Bioinformatics \"Giulio A. Maccacaro,\" Department of Clinical Sciences and Community Health & DSRC, University of Milan Campus Cascina Rosa, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Medical Statistics, Biometry and Bioinformatics \"Giulio A. Maccacaro,\" Department of Clinical Sciences and Community Health & DSRC, University of Milan Campus Cascina Rosa, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038934034","display_name":"Massimo Mesolella","orcid":"https://orcid.org/0000-0002-5081-1552","observed_orcids":["https://orcid.org/0000-0002-5081-1552","https://orcid.org/0000-0001-5278-6998"]},"institutions":[{"id":"https://openalex.org/I4210087768","display_name":"Ospedale Antonio Cardarelli","ror":"https://ror.org/003hhqx84","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087768"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Mesolella","raw_affiliation_strings":["Ear, Nose, and Throat Unit, AORN \"Antonio Cardarelli,\" Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ear, Nose, and Throat Unit, AORN \"Antonio Cardarelli,\" Naples, Italy","institution_ids":["https://openalex.org/I4210087768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090301927","display_name":"Alessia Maria Cossu","orcid":"https://orcid.org/0000-0003-2646-1254","observed_orcids":["https://orcid.org/0000-0003-2646-1254"]},"institutions":[{"id":"https://openalex.org/I4210115745","display_name":"Biogem","ror":"https://ror.org/01ymr5447","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I2801626668","https://openalex.org/I4210115745"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessia Maria Cossu","raw_affiliation_strings":["IRGS, Biogem, Molecular Oncology and Precision Medicine Laboratory, Via Camporeale, 83031 Ariano Irpino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRGS, Biogem, Molecular Oncology and Precision Medicine Laboratory, Via Camporeale, 83031 Ariano Irpino, Italy","institution_ids":["https://openalex.org/I4210115745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055023849","display_name":"Marianna Scrima","orcid":"https://orcid.org/0000-0003-4636-7695","observed_orcids":["https://orcid.org/0000-0003-4636-7695"]},"institutions":[{"id":"https://openalex.org/I4210115745","display_name":"Biogem","ror":"https://ror.org/01ymr5447","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I2801626668","https://openalex.org/I4210115745"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marianna Scrima","raw_affiliation_strings":["IRGS, Biogem, Molecular Oncology and Precision Medicine Laboratory, Via Camporeale, 83031 Ariano Irpino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRGS, Biogem, Molecular Oncology and Precision Medicine Laboratory, Via Camporeale, 83031 Ariano Irpino, Italy","institution_ids":["https://openalex.org/I4210115745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009442516","display_name":"Rosanna Capasso","orcid":"https://orcid.org/0000-0002-4938-1567","observed_orcids":["https://orcid.org/0000-0002-4938-1567"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosanna Capasso","raw_affiliation_strings":["Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060282315","display_name":"Michela Falco","orcid":"https://orcid.org/0000-0003-4513-8639","observed_orcids":["https://orcid.org/0000-0003-4513-8639"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michela Falco","raw_affiliation_strings":["Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032860019","display_name":"Giovanni Motta","orcid":"https://orcid.org/0000-0003-4570-4899","observed_orcids":["https://orcid.org/0000-0003-4570-4899"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Motta","raw_affiliation_strings":["Department of Mental and Physical Health and Preventive Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mental and Physical Health and Preventive Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082188975","display_name":"Gaetano Motta","orcid":"https://orcid.org/0000-0001-7899-5691","observed_orcids":["https://orcid.org/0000-0001-7899-5691"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gaetano Motta","raw_affiliation_strings":["Department of Mental and Physical Health and Preventive Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mental and Physical Health and Preventive Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069912395","display_name":"Domenico Testa","orcid":"https://orcid.org/0000-0001-7176-3652","observed_orcids":["https://orcid.org/0000-0001-7176-3652"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Testa","raw_affiliation_strings":["Department of Mental and Physical Health and Preventive Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mental and Physical Health and Preventive Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070717233","display_name":"Stefania De Luca","orcid":"https://orcid.org/0000-0002-4607-529X","observed_orcids":["https://orcid.org/0000-0002-4607-529X"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania De Luca","raw_affiliation_strings":["Department of Mental and Physical Health and Preventive Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mental and Physical Health and Preventive Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062506504","display_name":"Flavia Oliva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087768","display_name":"Ospedale Antonio Cardarelli","ror":"https://ror.org/003hhqx84","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087768"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Flavia Oliva","raw_affiliation_strings":["Ear, Nose, and Throat Unit, AORN \"Antonio Cardarelli,\" Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ear, Nose, and Throat Unit, AORN \"Antonio Cardarelli,\" Naples, Italy","institution_ids":["https://openalex.org/I4210087768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042155637","display_name":"Teresa Abate","orcid":"https://orcid.org/0009-0005-5417-9995","observed_orcids":["https://orcid.org/0009-0005-5417-9995"]},"institutions":[{"id":"https://openalex.org/I4210087768","display_name":"Ospedale Antonio Cardarelli","ror":"https://ror.org/003hhqx84","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087768"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Teresa Abate","raw_affiliation_strings":["Ear, Nose, and Throat Unit, AORN \"Antonio Cardarelli,\" Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ear, Nose, and Throat Unit, AORN \"Antonio Cardarelli,\" Naples, Italy","institution_ids":["https://openalex.org/I4210087768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083804414","display_name":"Salvatore Mazzone","orcid":"https://orcid.org/0000-0002-7468-8675","observed_orcids":["https://orcid.org/0000-0002-7468-8675"]},"institutions":[{"id":"https://openalex.org/I4210087768","display_name":"Ospedale Antonio Cardarelli","ror":"https://ror.org/003hhqx84","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087768"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Salvatore Mazzone","raw_affiliation_strings":["Ear, Nose, and Throat Unit, AORN \"Antonio Cardarelli,\" Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ear, Nose, and Throat Unit, AORN \"Antonio Cardarelli,\" Naples, Italy","institution_ids":["https://openalex.org/I4210087768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023630762","display_name":"Gabriella Misso","orcid":"https://orcid.org/0000-0002-7787-2531","observed_orcids":["https://orcid.org/0000-0002-7787-2531"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gabriella Misso","raw_affiliation_strings":["Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy. Electronic address: gabriella.misso@unicampania.it","Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy. Electronic address: gabriella.misso@unicampania.it","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073891277","display_name":"Michele Caraglia","orcid":"https://orcid.org/0000-0003-2408-6091","observed_orcids":["https://orcid.org/0000-0003-2408-6091"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210115745","display_name":"Biogem","ror":"https://ror.org/01ymr5447","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I2801626668","https://openalex.org/I4210115745"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Michele Caraglia","raw_affiliation_strings":["Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy; IRGS, Biogem, Molecular Oncology and Precision Medicine Laboratory, Via Camporeale, 83031 Ariano Irpino, Italy. Electronic address: michele.caraglia@unicampania.it","Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","IRGS, Biogem, Molecular Oncology and Precision Medicine Laboratory, Via Camporeale, 83031 Ariano Irpino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy; IRGS, Biogem, Molecular Oncology and Precision Medicine Laboratory, Via Camporeale, 83031 Ariano Irpino, Italy. Electronic address: michele.caraglia@unicampania.it","institution_ids":["https://openalex.org/I197809005","https://openalex.org/I4210115745"]},{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \"Luigi Vanvitelli,\" Naples, Italy","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"IRGS, Biogem, Molecular Oncology and Precision Medicine Laboratory, Via Camporeale, 83031 Ariano Irpino, Italy","institution_ids":["https://openalex.org/I4210115745"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5023630762","https://openalex.org/A5073891277"],"corresponding_institution_ids":["https://openalex.org/I197809005","https://openalex.org/I4210115745"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.8846,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.86232065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"20","issue":null,"first_page":"711","last_page":"724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mir-449a","display_name":"miR-449a","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mir-133b","display_name":"miR-133b","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.8080000281333923},{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/notch2","display_name":"Notch2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.875},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.8759999871253967},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8618448972702026},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.630905270576477},{"id":"https://openalex.org/C83330619","wikidata":"https://www.wikidata.org/wiki/Q21124872","display_name":"NODAL","level":2,"score":0.6157543659210205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5609012842178345},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5452322959899902},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5114666223526001},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.492343544960022},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.46755990386009216},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34866422414779663},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26983392238616943},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19112589955329895}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.omtn.2020.04.006","doi":"https://doi.org/10.1016/j.omtn.2020.04.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2020.04.006","pdf_url":"http://www.cell.com/article/S2162253120301141/pdf","source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Nucleic Acids","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7218231","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7218231","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Nucleic Acids","raw_type":"Text"},{"id":"pmid:32402942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32402942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Nucleic acids","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/1133560","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11568/1133560","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:846c744f593a40159c688d38225c6a45","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/846c744f593a40159c688d38225c6a45","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Therapy: Nucleic Acids, Vol 20, Iss , Pp 711-724 (2020)","raw_type":"article"},{"id":"pmh:oai:iris.unicampania.it:11591/428171","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11591/428171","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.omtn.2020.04.006","doi":"https://doi.org/10.1016/j.omtn.2020.04.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2020.04.006","pdf_url":"http://www.cell.com/article/S2162253120301141/pdf","source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Nucleic Acids","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3018216396.pdf"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1509492675","https://openalex.org/W1535136055","https://openalex.org/W1744006947","https://openalex.org/W1866072251","https://openalex.org/W1875559588","https://openalex.org/W1882000757","https://openalex.org/W1973569665","https://openalex.org/W1974249701","https://openalex.org/W1976367680","https://openalex.org/W1978575041","https://openalex.org/W1978776093","https://openalex.org/W1985029768","https://openalex.org/W1986915398","https://openalex.org/W1990261439","https://openalex.org/W1992508898","https://openalex.org/W1994094900","https://openalex.org/W2006797972","https://openalex.org/W2008945738","https://openalex.org/W2012319310","https://openalex.org/W2018343943","https://openalex.org/W2026037612","https://openalex.org/W2030120875","https://openalex.org/W2035396934","https://openalex.org/W2045604306","https://openalex.org/W2067435335","https://openalex.org/W2080232352","https://openalex.org/W2081098333","https://openalex.org/W2087832022","https://openalex.org/W2093921289","https://openalex.org/W2105666596","https://openalex.org/W2110065044","https://openalex.org/W2118016057","https://openalex.org/W2123356446","https://openalex.org/W2135810600","https://openalex.org/W2139710924","https://openalex.org/W2147014402","https://openalex.org/W2155052345","https://openalex.org/W2156839972","https://openalex.org/W2161817637","https://openalex.org/W2278136105","https://openalex.org/W2281206304","https://openalex.org/W2415096301","https://openalex.org/W2518533905","https://openalex.org/W2548728560","https://openalex.org/W2579136250","https://openalex.org/W2599587040","https://openalex.org/W2741665313","https://openalex.org/W2741708726","https://openalex.org/W2753603018","https://openalex.org/W2772722620","https://openalex.org/W2804751945","https://openalex.org/W2893427972","https://openalex.org/W2962797253"],"related_works":["https://openalex.org/W2772722620","https://openalex.org/W1986915398","https://openalex.org/W2401973874","https://openalex.org/W2465803133","https://openalex.org/W2914890586","https://openalex.org/W4391560303","https://openalex.org/W2087278673","https://openalex.org/W2063880557","https://openalex.org/W7100412444","https://openalex.org/W2607953254"],"abstract_inverted_index":{"Laryngeal":[0],"cancer":[1],"(LCa),":[2],"a":[3,12,27,83,94,188],"neoplasm":[4],"of":[5,15,23,97,128,168,175,197],"the":[6,21,33,124,135,150,166,195],"head":[7],"and":[8,45,87,106,157,164,170,187],"neck":[9],"region,":[10],"is":[11,30,39],"leading":[13],"cause":[14],"death":[16],"worldwide.":[17],"Surgical":[18],"intervention":[19],"remains":[20],"mainstay":[22],"LCa":[24,66,110,131,151,185,201],"treatment,":[25],"but":[26],"crucial":[28],"point":[29],"represented":[31],"by":[32,82,90],"possible":[34],"nodal":[35,198],"involvement.":[36],"Therefore,":[37],"it":[38],"urgently":[40],"needed":[41],"to":[42,49,103,113,134,191],"develop":[43],"biomarkers":[44,183],"therapeutic":[46],"tools":[47],"able":[48],"drive":[50],"treatment":[51,196],"approaches":[52],"for":[53,130,141,184,194],"LCa.":[54],"In":[55],"this":[56,178],"study,":[57],"we":[58,138],"investigated":[59],"deregulated":[60],"microRNAs":[61],"(miRNAs)":[62],"in":[63,100,109,143,149,159,200],"tissues":[64,111],"from":[65],"patients":[67],"with":[68],"either":[69],"lymph":[70],"node":[71],"metastases":[72,199],"(N+)":[73],"or":[74],"not":[75],"(N-).":[76],"miRNA":[77],"expression":[78,99,148],"profiling":[79],"was":[80],"performed":[81],"comprehensive":[84],"PCR":[85],"array":[86],"subsequent":[88],"validation":[89,136],"RT-qPCR.":[91],"Results":[92],"showed":[93],"significant":[95],"decrease":[96],"miR-449a":[98,140,147,193],"N+":[101],"compared":[102,112],"N-":[104],"patients,":[105],"miR-133b":[107,129],"down-modulation":[108],"paired":[114],"normal":[115],"ones.":[116],"Receiver":[117],"operating":[118],"characteristic":[119],"(ROC)":[120],"curve":[121],"analysis":[122],"revealed":[123],"potential":[125],"diagnostic":[126],"power":[127],"detection.":[132],"According":[133],"results,":[137],"selected":[139],"further":[142],"vitro":[144],"studies.":[145],"Ectopic":[146],"cell":[152,162],"line":[153],"Hep-2":[154],"inhibited":[155],"invasion":[156],"motility":[158],"vitro,":[160],"slowed":[161],"proliferation,":[163],"induced":[165],"downregulation":[167],"Notch1":[169],"Notch2":[171],"as":[172],"direct":[173],"targets":[174],"miR-449a.":[176],"Collectively,":[177],"study":[179],"provides":[180],"new":[181,189],"promising":[182],"diagnosis":[186],"opportunity":[190],"use":[192],"patients.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-05-01T00:00:00"}
