{"id":"https://openalex.org/W3017991765","doi":"https://doi.org/10.1016/j.bioorg.2020.103879","title":"Synthesis, in vitro and in silico screening of 2-amino-4-aryl-6-(phenylthio) pyridine-3,5-dicarbonitriles as novel \u03b1-glucosidase inhibitors","display_name":"Synthesis, in vitro and in silico screening of 2-amino-4-aryl-6-(phenylthio) pyridine-3,5-dicarbonitriles as novel \u03b1-glucosidase inhibitors","publication_year":2020,"publication_date":"2020-04-24","ids":{"openalex":"https://openalex.org/W3017991765","doi":"https://doi.org/10.1016/j.bioorg.2020.103879","mag":"3017991765","pmid":"https://pubmed.ncbi.nlm.nih.gov/32413625"},"language":"en","primary_location":{"id":"doi:10.1016/j.bioorg.2020.103879","doi":"https://doi.org/10.1016/j.bioorg.2020.103879","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2020.103879","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100676956","display_name":"Muhammad Fawad Ali","orcid":"https://orcid.org/0000-0002-2339-2364","observed_orcids":["https://orcid.org/0000-0002-2339-2364"]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]},{"id":"https://openalex.org/I4210121526","display_name":"International Center for Chemical and Biological Sciences","ror":"https://ror.org/024ghrf67","country_code":"PK","type":"facility","lineage":["https://openalex.org/I4210121526"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Ali","raw_affiliation_strings":["H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan","institution_ids":["https://openalex.org/I193670377","https://openalex.org/I4210121526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100702511","display_name":"Khalid Mohammed Khan","orcid":"https://orcid.org/0000-0001-8337-4021","observed_orcids":["https://orcid.org/0000-0001-8337-4021","https://orcid.org/0009-0009-9276-2929"]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]},{"id":"https://openalex.org/I292192723","display_name":"Pakistan Academy of Sciences","ror":"https://ror.org/05gb9dv72","country_code":"PK","type":"government","lineage":["https://openalex.org/I292192723"]},{"id":"https://openalex.org/I4210121526","display_name":"International Center for Chemical and Biological Sciences","ror":"https://ror.org/024ghrf67","country_code":"PK","type":"facility","lineage":["https://openalex.org/I4210121526"]},{"id":"https://openalex.org/I76571253","display_name":"Imam Abdulrahman Bin Faisal University","ror":"https://ror.org/038cy8j79","country_code":"SA","type":"education","lineage":["https://openalex.org/I76571253"]}],"countries":["PK","SA"],"is_corresponding":true,"raw_author_name":"Khalid Mohammed Khan","raw_affiliation_strings":["H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Pakistan Academy of Sciences, 3-Constitution Avenue G-5/2, Islamabad, Pakistan; Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia. Electronic address: khalid.khan@iccs.edu","Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia","H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan","Pakistan Academy of Sciences, 3-Constitution Avenue G-5/2, Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Pakistan Academy of Sciences, 3-Constitution Avenue G-5/2, Islamabad, Pakistan; Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia. Electronic address: khalid.khan@iccs.edu","institution_ids":["https://openalex.org/I193670377","https://openalex.org/I292192723","https://openalex.org/I4210121526","https://openalex.org/I76571253"]},{"raw_affiliation_string":"Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia","institution_ids":["https://openalex.org/I76571253"]},{"raw_affiliation_string":"H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan","institution_ids":["https://openalex.org/I193670377","https://openalex.org/I4210121526"]},{"raw_affiliation_string":"Pakistan Academy of Sciences, 3-Constitution Avenue G-5/2, Islamabad, Pakistan","institution_ids":["https://openalex.org/I292192723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100690240","display_name":"Mohammad Reza Mahdavi","orcid":"https://orcid.org/0000-0002-8007-2543","observed_orcids":["https://orcid.org/0000-0002-8007-2543","https://orcid.org/0000-0002-4171-7310","https://orcid.org/0000-0003-2591-8750","https://orcid.org/0000-0003-0256-3352"]},"institutions":[{"id":"https://openalex.org/I4403928377","display_name":"Endocrine & Metabolism Research Institute","ror":"https://ror.org/0281zft76","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928377","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Mahdavi","raw_affiliation_strings":["Endocrinology & Metabolism Research Institute (EMRI), Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology & Metabolism Research Institute (EMRI), Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928377","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071421225","display_name":"Abdul Jabbar","orcid":"https://orcid.org/0000-0001-8888-0046","observed_orcids":["https://orcid.org/0000-0001-8888-0046"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Abdul Jabbar","raw_affiliation_strings":["Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020890131","display_name":"Shahbaz Shamim","orcid":"https://orcid.org/0000-0002-0539-9845","observed_orcids":["https://orcid.org/0000-0002-0539-9845"]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]},{"id":"https://openalex.org/I4210121526","display_name":"International Center for Chemical and Biological Sciences","ror":"https://ror.org/024ghrf67","country_code":"PK","type":"facility","lineage":["https://openalex.org/I4210121526"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Shahbaz Shamim","raw_affiliation_strings":["H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan","institution_ids":["https://openalex.org/I193670377","https://openalex.org/I4210121526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001517819","display_name":"Uzma Salar","orcid":"https://orcid.org/0000-0003-1871-9112","observed_orcids":["https://orcid.org/0000-0003-1871-9112"]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]},{"id":"https://openalex.org/I4210121526","display_name":"International Center for Chemical and Biological Sciences","ror":"https://ror.org/024ghrf67","country_code":"PK","type":"facility","lineage":["https://openalex.org/I4210121526"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Uzma Salar","raw_affiliation_strings":["Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan","institution_ids":["https://openalex.org/I193670377","https://openalex.org/I4210121526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023610691","display_name":"Muhammad Taha","orcid":"https://orcid.org/0000-0003-3047-9289","observed_orcids":["https://orcid.org/0000-0003-3047-9289"]},"institutions":[{"id":"https://openalex.org/I76571253","display_name":"Imam Abdulrahman Bin Faisal University","ror":"https://ror.org/038cy8j79","country_code":"SA","type":"education","lineage":["https://openalex.org/I76571253"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Muhammad Taha","raw_affiliation_strings":["Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia","institution_ids":["https://openalex.org/I76571253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103152722","display_name":"Shahnaz Perveen","orcid":"https://orcid.org/0000-0002-8667-8327","observed_orcids":["https://orcid.org/0000-0002-8667-8327"]},"institutions":[{"id":"https://openalex.org/I1315513584","display_name":"Pakistan Council of Scientific & Industrial Research","ror":"https://ror.org/05vmcbf05","country_code":"PK","type":"government","lineage":["https://openalex.org/I1315513584"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Shahnaz Perveen","raw_affiliation_strings":["PCSIR Laboratories Complex, Karachi, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi 75280, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PCSIR Laboratories Complex, Karachi, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi 75280, Pakistan","institution_ids":["https://openalex.org/I1315513584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007232361","display_name":"Bagher A. Larijani","orcid":"https://orcid.org/0000-0001-5386-7597","observed_orcids":["https://orcid.org/0000-0001-5386-7597"]},"institutions":[{"id":"https://openalex.org/I4403928377","display_name":"Endocrine & Metabolism Research Institute","ror":"https://ror.org/0281zft76","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928377","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Bagher Larijani","raw_affiliation_strings":["Endocrinology & Metabolism Research Institute (EMRI), Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology & Metabolism Research Institute (EMRI), Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928377","https://openalex.org/I70640408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039784428","display_name":"Mohammad Ali Faramarzi","orcid":"https://orcid.org/0000-0002-8822-453X","observed_orcids":["https://orcid.org/0000-0002-8822-453X","https://orcid.org/0000-0003-3467-7266"]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Ali Faramarzi","raw_affiliation_strings":["Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5100702511"],"corresponding_institution_ids":["https://openalex.org/I193670377","https://openalex.org/I292192723","https://openalex.org/I4210121526","https://openalex.org/I76571253"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":4.9034,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.96060083,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"100","issue":null,"first_page":"103879","last_page":"103879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.6898999810218811,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.6898999810218811,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.2386000007390976,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibitors","display_name":"alpha-glucosidase inhibitors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9129999876022339},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.6629999876022339},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7839999794960022},{"id":"https://openalex.org/keywords/acarbose","display_name":"acarbose","score":0.7570000290870667},{"id":"https://openalex.org/keywords/ligand-binding-modes","display_name":"ligand binding modes","score":0.800000011920929},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6439999938011169},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9363143444061279},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.87650465965271},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7089370489120483},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.6808201670646667},{"id":"https://openalex.org/C2779485729","wikidata":"https://www.wikidata.org/wiki/Q210385","display_name":"Pyridine","level":2,"score":0.6427143812179565},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.550574541091919},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.45365869998931885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3611904978752136},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21537813544273376},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000586","descriptor_name":"Amination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bioorg.2020.103879","doi":"https://doi.org/10.1016/j.bioorg.2020.103879","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2020.103879","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},{"id":"pmid:32413625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32413625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/258573","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11343/258573","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G182716619","display_name":null,"funder_award_id":"5-9/PAS/440","funder_id":"https://openalex.org/F4320326343","funder_display_name":"Pakistan Academy of Sciences"}],"funders":[{"id":"https://openalex.org/F4320326343","display_name":"Pakistan Academy of Sciences","ror":"https://ror.org/05gb9dv72"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1824866388","https://openalex.org/W1927021417","https://openalex.org/W1969869157","https://openalex.org/W1980160040","https://openalex.org/W2025430410","https://openalex.org/W2025768351","https://openalex.org/W2029749250","https://openalex.org/W2051507935","https://openalex.org/W2075594789","https://openalex.org/W2083473645","https://openalex.org/W2084761995","https://openalex.org/W2090619263","https://openalex.org/W2118200955","https://openalex.org/W2118707645","https://openalex.org/W2128191049","https://openalex.org/W2137178807","https://openalex.org/W2137344325","https://openalex.org/W2150137431","https://openalex.org/W2155756814","https://openalex.org/W2163065855","https://openalex.org/W2181218334","https://openalex.org/W2273253184","https://openalex.org/W2404885798","https://openalex.org/W2517145217","https://openalex.org/W2589086895","https://openalex.org/W2591162656","https://openalex.org/W2611800660","https://openalex.org/W2723466115","https://openalex.org/W2742338598","https://openalex.org/W2792319416","https://openalex.org/W2806497803","https://openalex.org/W2811269521","https://openalex.org/W2953350797","https://openalex.org/W3197880534","https://openalex.org/W4247232252","https://openalex.org/W6800305575"],"related_works":["https://openalex.org/W2723466115","https://openalex.org/W2806497803","https://openalex.org/W1983248721","https://openalex.org/W4411919938","https://openalex.org/W3041575711","https://openalex.org/W3161535006","https://openalex.org/W2997563139","https://openalex.org/W4321243136","https://openalex.org/W3163680797","https://openalex.org/W2999423635"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-05-01T00:00:00"}