{"id":"https://openalex.org/W3017730185","doi":"https://doi.org/10.1038/s41419-020-2485-1","title":"LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis","display_name":"LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis","publication_year":2020,"publication_date":"2020-04-24","ids":{"openalex":"https://openalex.org/W3017730185","doi":"https://doi.org/10.1038/s41419-020-2485-1","mag":"3017730185","pmid":"https://pubmed.ncbi.nlm.nih.gov/32332718","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7181648"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-020-2485-1","doi":"https://doi.org/10.1038/s41419-020-2485-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-020-2485-1","pdf_url":"https://www.nature.com/articles/s41419-020-2485-1.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-020-2485-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039495897","display_name":"Yifei Shen","orcid":"https://orcid.org/0000-0002-1401-7183","observed_orcids":["https://orcid.org/0000-0002-1401-7183"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifei Shen","raw_affiliation_strings":["Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Shanghai Tongji University, 200120, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Shanghai Tongji University, 200120, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073291175","display_name":"Jingwen Xu","orcid":"https://orcid.org/0000-0002-2451-8037","observed_orcids":["https://orcid.org/0000-0002-2451-8037"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingwen Xu","raw_affiliation_strings":["Department of Nutrition, Changzhou No.2 People's Hospital, Nanjing Medical University, 213003, Changzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Changzhou No.2 People's Hospital, Nanjing Medical University, 213003, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020883407","display_name":"Xiaohui Pan","orcid":"https://orcid.org/0000-0002-8424-260X","observed_orcids":["https://orcid.org/0000-0002-8424-260X"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Pan","raw_affiliation_strings":["Department of Orthopedics, Changzhou No.2 People's Hospital, Nanjing Medical University, 213003, Changzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changzhou No.2 People's Hospital, Nanjing Medical University, 213003, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102725461","display_name":"Yunkun Zhang","orcid":"https://orcid.org/0009-0008-6095-1840","observed_orcids":["https://orcid.org/0009-0008-6095-1840"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunkun Zhang","raw_affiliation_strings":["Department of Orthopedics, Changzhou No.2 People's Hospital, Nanjing Medical University, 213003, Changzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changzhou No.2 People's Hospital, Nanjing Medical University, 213003, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090599155","display_name":"Yiping Weng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiping Weng","raw_affiliation_strings":["Department of Orthopedics, Changzhou No.2 People's Hospital, Nanjing Medical University, 213003, Changzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changzhou No.2 People's Hospital, Nanjing Medical University, 213003, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044721016","display_name":"Dong Zhou","orcid":"https://orcid.org/0000-0001-9514-3116","observed_orcids":["https://orcid.org/0000-0001-9514-3116"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dong Zhou","raw_affiliation_strings":["Department of Orthopedics, Changzhou No.2 People's Hospital, Nanjing Medical University, 213003, Changzhou, Jiangsu, China. zhoudong1012@163.com","Department of Orthopedics, Wuqia People's Hospital, 845450, Xinjiang, China. zhoudong1012@163.com","Department of Orthopedics, Changzhou No.2 People's Hospital, Nanjing Medical University, 213003, Changzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changzhou No.2 People's Hospital, Nanjing Medical University, 213003, Changzhou, Jiangsu, China. zhoudong1012@163.com","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Orthopedics, Wuqia People's Hospital, 845450, Xinjiang, China. zhoudong1012@163.com","institution_ids":[]},{"raw_affiliation_string":"Department of Orthopedics, Changzhou No.2 People's Hospital, Nanjing Medical University, 213003, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044004958","display_name":"Shisheng He","orcid":"https://orcid.org/0000-0001-7796-1510","observed_orcids":["https://orcid.org/0000-0001-7796-1510"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shisheng He","raw_affiliation_strings":["Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Shanghai Tongji University, 200120, Shanghai, China. tjhss7418@tongji.edu.cn","Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Shanghai Tongji University, 200120, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Shanghai Tongji University, 200120, Shanghai, China. tjhss7418@tongji.edu.cn","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]},{"raw_affiliation_string":"Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Shanghai Tongji University, 200120, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5044004958","https://openalex.org/A5044721016"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741","https://openalex.org/I4210151861","https://openalex.org/I83519826"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":9.2587,"has_fulltext":true,"cited_by_count":151,"citation_normalized_percentile":{"value":0.99109587,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"11","issue":"4","first_page":"278","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kcnq1ot1","display_name":"KCNQ1OT1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mir-34c-5p","display_name":"miR-34c-5p","score":0.9789999723434448},{"id":"https://openalex.org/keywords/aldolase-a","display_name":"aldolase A","score":0.9739999771118164},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.8690000176429749},{"id":"https://openalex.org/keywords/aerobic-glycolysis","display_name":"aerobic glycolysis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.9890000224113464},{"id":"https://openalex.org/keywords/glucose-metabolism-reprogramming","display_name":"glucose metabolism reprogramming","score":0.7799999713897705},{"id":"https://openalex.org/keywords/competing-endogenous-rna","display_name":"competing endogenous RNA","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/3-utr-targeting","display_name":"3' UTR targeting","score":0.6209999918937683},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C109156525","wikidata":"https://www.wikidata.org/wiki/Q56770304","display_name":"Warburg effect","level":4,"score":0.8866932988166809},{"id":"https://openalex.org/C60365752","wikidata":"https://www.wikidata.org/wiki/Q5156306","display_name":"Competing endogenous RNA","level":5,"score":0.8552310466766357},{"id":"https://openalex.org/C55885012","wikidata":"https://www.wikidata.org/wiki/Q4750801","display_name":"Anaerobic glycolysis","level":4,"score":0.659125804901123},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.5607283711433411},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.5319880247116089},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5263813138008118},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5101433396339417},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.460573673248291},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4562895894050598},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4387936592102051},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4267002046108246},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.41924411058425903},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3268030881881714},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13524767756462097},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13062065839767456},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.09970226883888245}],"mesh":[{"descriptor_ui":"D000082802","descriptor_name":"Warburg Effect, Oncologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41419-020-2485-1","doi":"https://doi.org/10.1038/s41419-020-2485-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-020-2485-1","pdf_url":"https://www.nature.com/articles/s41419-020-2485-1.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},{"id":"pmid:32332718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32332718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7181648","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7181648/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41419-020-2485-1","doi":"https://doi.org/10.1038/s41419-020-2485-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-020-2485-1","pdf_url":"https://www.nature.com/articles/s41419-020-2485-1.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322449","display_name":"Tongji University","ror":"https://ror.org/03rc6as71"},{"id":"https://openalex.org/F4320324291","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3017730185.pdf","grobid_xml":"https://content.openalex.org/works/W3017730185.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1551034491","https://openalex.org/W1921408704","https://openalex.org/W1965347187","https://openalex.org/W1971050035","https://openalex.org/W1990399973","https://openalex.org/W1998166655","https://openalex.org/W2005636452","https://openalex.org/W2014058353","https://openalex.org/W2022101765","https://openalex.org/W2041405844","https://openalex.org/W2095987251","https://openalex.org/W2097259163","https://openalex.org/W2109856813","https://openalex.org/W2115383660","https://openalex.org/W2117692326","https://openalex.org/W2128955892","https://openalex.org/W2130687298","https://openalex.org/W2132015542","https://openalex.org/W2141831115","https://openalex.org/W2161817637","https://openalex.org/W2163729820","https://openalex.org/W2234115940","https://openalex.org/W2262236353","https://openalex.org/W2412926120","https://openalex.org/W2503851771","https://openalex.org/W2513886106","https://openalex.org/W2558650001","https://openalex.org/W2624119497","https://openalex.org/W2625600561","https://openalex.org/W2789699341","https://openalex.org/W2809860772","https://openalex.org/W2886530178","https://openalex.org/W2888987199","https://openalex.org/W2889623518","https://openalex.org/W2897443184","https://openalex.org/W2900210632","https://openalex.org/W2900980455","https://openalex.org/W2905941774","https://openalex.org/W2917279709","https://openalex.org/W2924590194","https://openalex.org/W2925207309","https://openalex.org/W2932887409","https://openalex.org/W2954674224","https://openalex.org/W4231565327"],"related_works":["https://openalex.org/W4415848855","https://openalex.org/W2965694825","https://openalex.org/W4206886806","https://openalex.org/W3094622192","https://openalex.org/W4406228998","https://openalex.org/W4380730809","https://openalex.org/W4409078619","https://openalex.org/W2983092509","https://openalex.org/W4387515937","https://openalex.org/W3164749075"],"abstract_inverted_index":{"Metabolic":[0],"switch":[1],"from":[2],"oxidative":[3],"phosphorylation":[4],"to":[5,23,81],"aerobic":[6],"glycolysis,":[7],"which":[8,117],"is":[9,15],"also":[10],"called":[11],"the":[12,24,46,67,82,143],"Warburg":[13,47,83],"effect,":[14],"a":[16,42,109,131,148],"hallmark":[17],"of":[18,26,49,74,134,140],"osteosarcoma":[19],"(OS)":[20],"and":[21,31,71,99],"leads":[22],"enhancement":[25],"cell":[27],"chemoresistance,":[28],"growth,":[29],"metastasis,":[30],"invasion.":[32],"Emerging":[33],"evidence":[34],"indicates":[35],"that":[36,55,66,105],"long":[37],"non-coding":[38],"RNA":[39,97,100,112],"(lncRNA)":[40],"plays":[41],"crucial":[43],"role":[44,133],"in":[45,60,136,152],"effect":[48,84],"cancer":[50],"cells.":[51,76],"Here,":[52],"we":[53,103],"report":[54],"lncRNA":[56],"KCNQ1OT1":[57,68,79,106,135],"was":[58],"upregulated":[59],"OS.":[61,141],"Meanwhile,":[62],"functional":[63],"experiments":[64],"demonstrated":[65],"facilitated":[69],"proliferation":[70],"suppressed":[72],"apoptosis":[73],"OS":[75,153],"In":[77],"addition,":[78],"contributed":[80],"by":[85,114,121],"stimulating":[86],"aldolase":[87],"A":[88],"(ALDOA)":[89],"expression.":[90],"Furthermore,":[91],"using":[92],"bioinformatics":[93],"analysis,":[94],"luciferase":[95],"reporter,":[96],"immunoprecipitation,":[98],"pull-down":[101],"assay,":[102],"identified":[104,130],"functions":[107],"as":[108],"competing":[110],"endogenous":[111],"(ceRNA)":[113],"sponging":[115],"miR-34c-5p,":[116],"inhibited":[118],"ALDOA":[119],"expression":[120],"directly":[122],"targeting":[123],"its":[124],"3'UTR.":[125],"Taken":[126],"together,":[127],"these":[128],"data":[129],"key":[132],"glucose":[137],"metabolism":[138],"reprogramming":[139],"Targeting":[142],"KCNQ1OT1/miR-34c-5p/ALDOA":[144],"axis":[145],"may":[146],"be":[147],"potential":[149],"therapeutic":[150],"target":[151],"treatment.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":39},{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":35},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-05-01T00:00:00"}