{"id":"https://openalex.org/W3017645447","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.09695","title":"The Relation between Immune Cell Mitochondrial Respiration and Brachial Artery Pulse Pressure in Humans","display_name":"The Relation between Immune Cell Mitochondrial Respiration and Brachial Artery Pulse Pressure in Humans","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3017645447","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.09695","mag":"3017645447"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2020.34.s1.09695","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.09695","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.09695","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044634393","display_name":"Theodore M. DeConne","orcid":"https://orcid.org/0000-0002-9704-6499","observed_orcids":["https://orcid.org/0000-0002-9704-6499"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore M. DeConne","raw_affiliation_strings":["University of Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070322386","display_name":"Eric R. Mu\u00f1oz","orcid":"https://orcid.org/0000-0003-0010-7513","observed_orcids":["https://orcid.org/0000-0003-0010-7513"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric R. Mu\u00f1oz","raw_affiliation_strings":["University of Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073559526","display_name":"Faria Sanjana","orcid":"https://orcid.org/0000-0001-6529-6680","observed_orcids":["https://orcid.org/0000-0001-6529-6680"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faria Sanjana","raw_affiliation_strings":["University of Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105470625","display_name":"Joshua C. Hobson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua C. Hobson","raw_affiliation_strings":["University of Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036205151","display_name":"Christopher R. Martens","orcid":"https://orcid.org/0000-0003-0578-2948","observed_orcids":["https://orcid.org/0000-0003-0578-2948"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher R. Martens","raw_affiliation_strings":["University of Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I86501945"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"S1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.36820000410079956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.8489999771118164},{"id":"https://openalex.org/keywords/brachial-pulse-pressure","display_name":"brachial pulse pressure","score":0.8420000076293945},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9470000267028809},{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":0.8500000238418579},{"id":"https://openalex.org/keywords/arterial-aging","display_name":"arterial aging","score":0.6399999856948853},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.6579999923706055},{"id":"https://openalex.org/keywords/maximal-respiration","display_name":"maximal respiration","score":0.656000018119812},{"id":"https://openalex.org/keywords/spare-respiratory-capacity","display_name":"spare respiratory capacity","score":0.9649999737739563},{"id":"https://openalex.org/keywords/coupling-efficiency","display_name":"coupling efficiency","score":0.8980000019073486},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6759999990463257},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7260000109672546},{"id":"https://openalex.org/keywords/healthy-adults","display_name":"healthy adults","score":0.8180000185966492},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.3799999952316284},{"id":"https://openalex.org/keywords/oxygen-consumption-rate","display_name":"oxygen consumption rate","score":0.6639999747276306},{"id":"https://openalex.org/keywords/fccp","display_name":"FCCP","score":0.8809999823570251},{"id":"https://openalex.org/keywords/oligomycin","display_name":"oligomycin","score":0.9779999852180481}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5675473809242249},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.5459643006324768},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5333051085472107},{"id":"https://openalex.org/C2779134199","wikidata":"https://www.wikidata.org/wiki/Q1076381","display_name":"Oligomycin","level":4,"score":0.49291062355041504},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4641749858856201},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46408388018608093},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.45523619651794434},{"id":"https://openalex.org/C17140001","wikidata":"https://www.wikidata.org/wiki/Q1759415","display_name":"Pulse pressure","level":3,"score":0.44890210032463074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4322534203529358},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37379032373428345},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.22894766926765442},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14651423692703247},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2020.34.s1.09695","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.09695","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.09695","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7125917177","https://openalex.org/W4210629105","https://openalex.org/W4391630666","https://openalex.org/W3005128316","https://openalex.org/W4296798981","https://openalex.org/W2890512067","https://openalex.org/W2953542129","https://openalex.org/W4414242426","https://openalex.org/W3176332504","https://openalex.org/W7056387618"],"abstract_inverted_index":{"Elevated":[0],"pulse":[1,351],"pressure":[2],"(PP)":[3],"occurs":[4],"with":[5,32,72,105,284,314],"advancing":[6],"age":[7,123],"due":[8],"to":[9,37,174,216,236,258,345],"stiffening":[10],"of":[11,54,83,112,207,229],"the":[12,38,81,157,190,214,232,336],"elastic":[13],"arteries":[14],"and":[15,34,48,172,202,210,247,270,324,367],"is":[16,69,93,251,256],"an":[17,161,181,227,237,342],"important":[18,52,343],"risk":[19,73,347],"factor":[20],"for":[21,75,278],"cardiovascular":[22,88],"disease":[23],"(CVD),":[24],"even":[25],"among":[26],"normotensive":[27],"adults.":[28],"Mitochondrial":[29],"function":[30,86,89,100,177,269],"declines":[31],"aging":[33],"may":[35,340],"contribute":[36],"increase":[39],"in":[40,63,77,90,143,154,156,350,364],"PP":[41,146,271,280,310],"through":[42,348],"a":[43],"mechanism":[44],"involving":[45],"oxidative":[46,365],"stress":[47,366],"chronic":[49],"inflammation;":[50],"two":[51],"hallmarks":[53],"arterial":[55],"aging.":[56],"Emerging":[57],"evidence":[58],"indicates":[59],"that":[60,98,335],"mitochondrial":[61,85,99,176,268,338],"respiration":[62,219,339],"peripheral":[64],"blood":[65,127],"mononuclear":[66],"cells":[67],"(PBMCs)":[68],"negatively":[70,103],"associated":[71,104,283,313],"factors":[74],"CVD":[76,114,346],"heart":[78],"failure;":[79],"however,":[80],"role":[82],"impaired":[84,337],"on":[87],"healthy":[91,109],"adults":[92,110],"not":[94,282],"known.":[95],"We":[96],"hypothesized":[97],"would":[101],"be":[102,341],"brachial":[106,150],"PP.":[107],"Twenty\u2010two":[108],"free":[111],"overt":[113],"(12":[115],"M/10":[116],"F;":[117],"age:":[118],"56":[119],"\u00b1":[120,131,133,138],"21":[121],"years;":[122,126],"range:":[124],"22\u201378":[125],"pressure,":[128],"BP:":[129],"123":[130],"15/72":[132],"10":[134],"mmHg;":[135],"PP:":[136],"51":[137],"11":[139],"mmHg)":[140],"were":[141,166,262,272],"included":[142,189],"this":[144],"analysis.":[145],"was":[147,281,311],"determined":[148],"from":[149],"artery":[151],"BP":[152,163],"assessed":[153],"triplicate":[155],"non\u2010dominant":[158],"arm":[159],"using":[160,180,274],"automated":[162],"monitor.":[164],"PBMCs":[165],"isolated":[167],"by":[168,178,362],"density":[169],"dependent":[170],"centrifugation":[171],"used":[173],"assess":[175],"respirometry":[179],"Agilent":[182],"Seahorse":[183],"XFp":[184],"Analyzer.":[185],"Primary":[186],"outcome":[187],"measures":[188],"oxygen":[191,242],"consumption":[192,243],"rate":[193],"(OCR)":[194],"at":[195],"baseline":[196],"(basal":[197],"respiration;":[198],"BASE":[199,259,285],"RESP":[200,221,260,286,316],")":[201],"following":[203],"three":[204],"serial":[205],"injections":[206],"oligomycin,":[208],"FCCP":[209],"rotenone/antimycin":[211],"A":[212],"into":[213],"respirometer":[215],"determine":[217],"maximal":[218],"(MAX":[220],").":[222],"Spare":[223],"respiratory":[224],"capacity":[225],"(SRC),":[226],"indicator":[228],"how":[230,252],"well":[231,253],"cell":[233],"can":[234],"respond":[235],"increased":[238],"energetic":[239],"demand,":[240],"ATP\u2010linked":[241],"(ATP":[244],"O2":[245,255,302],"),":[246],"coupling":[248,292],"efficiency,":[249],"which":[250],"ATP":[254,301],"matched":[257],",":[261],"also":[263],"measured.":[264],"The":[265],"associations":[266,359],"between":[267],"analyzed":[273],"multi\u2010linear":[275],"regressions":[276],"correcting":[277],"age.":[279],"(p=0.89,":[287],"R":[288,295,304,318,328],"2":[289,296,305,319,329],"=0.10,":[290],"\u03b2=0.01),":[291],"efficiency":[293],"(p=0.20,":[294],"=0.18,":[297],"\u03b2=":[298,307,321],"\u22128.5),":[299],"or":[300,371],"(p=0.33,":[303],"=0.15,":[306],"\u22120.10).":[308],"However,":[309],"inversely":[312],"MAX":[315],"(p=0.05,":[317],"=0.28,":[320],"\u2212":[322],"0.03)":[323],"SRC":[325],"(PP;":[326],"p=0.02,":[327],"=0.33,":[330],"\u03b2=\u22120.04).":[331],"These":[332],"data":[333],"suggest":[334],"contributor":[344],"increases":[349,363],"pressure.":[352],"Future":[353],"studies":[354],"should":[355],"explore":[356],"whether":[357],"these":[358],"are":[360],"mediated":[361],"inflammatory":[368],"cytokines.":[369],"Support":[370],"Funding":[372,374],"Information":[373],"Sources:":[375],"P20GM113125,":[376],"K01AG054731":[377]},"counts_by_year":[],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2020-05-01T00:00:00"}
