{"id":"https://openalex.org/W3017581786","doi":"https://doi.org/10.1016/j.heliyon.2020.e03813","title":"HPLC-MS/MS coupled with equilibrium dialysis method for quantification of free drug concentration of pazopanib in plasma","display_name":"HPLC-MS/MS coupled with equilibrium dialysis method for quantification of free drug concentration of pazopanib in plasma","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3017581786","doi":"https://doi.org/10.1016/j.heliyon.2020.e03813","mag":"3017581786","pmid":"https://pubmed.ncbi.nlm.nih.gov/32373731","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7191207"},"language":"en","primary_location":{"id":"doi:10.1016/j.heliyon.2020.e03813","doi":"https://doi.org/10.1016/j.heliyon.2020.e03813","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2020.e03813","pdf_url":"http://www.cell.com/article/S2405844020306587/pdf","source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2405844020306587/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050068120","display_name":"Yi Long Toh","orcid":"https://orcid.org/0000-0003-2997-555X","observed_orcids":["https://orcid.org/0000-0003-2997-555X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yi Long Toh","raw_affiliation_strings":["Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore"],"raw_orcid":"https://orcid.org/0000-0003-2997-555X","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110357579","display_name":"Yi Pang","orcid":"https://orcid.org/0009-0007-5655-5688","observed_orcids":["https://orcid.org/0009-0007-5655-5688"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yi Yun Pang","raw_affiliation_strings":["Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110574102","display_name":"Maung Shwe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Maung Shwe","raw_affiliation_strings":["Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore","Oncology Pharmacy, National Cancer Centre Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Oncology Pharmacy, National Cancer Centre Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037495975","display_name":"Ravindran Kanesvaran","orcid":"https://orcid.org/0000-0002-2351-881X","observed_orcids":["https://orcid.org/0000-0002-2351-881X"]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ravindran Kanesvaran","raw_affiliation_strings":["Division of Medical Oncology, National Cancer Centre Singapore, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-2351-881X","affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, National Cancer Centre Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007311021","display_name":"Chee\u2010Keong Toh","orcid":"https://orcid.org/0000-0002-5691-6144","observed_orcids":["https://orcid.org/0000-0002-5691-6144"]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chee Keong Toh","raw_affiliation_strings":["Division of Medical Oncology, National Cancer Centre Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, National Cancer Centre Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060981830","display_name":"Alexandre Chan","orcid":"https://orcid.org/0000-0003-4391-4219","observed_orcids":["https://orcid.org/0000-0003-4391-4219"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Alexandre Chan","raw_affiliation_strings":["Department of Clinical Pharmacy Practice, University of California, Irvine, USA","Oncology Pharmacy, National Cancer Centre Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy Practice, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Oncology Pharmacy, National Cancer Centre Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080867207","display_name":"Han Kiat Ho","orcid":"https://orcid.org/0000-0003-0614-3048","observed_orcids":["https://orcid.org/0000-0003-0614-3048"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Han Kiat Ho","raw_affiliation_strings":["Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5080867207"],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":{"value":1750,"currency":"USD","value_usd":1750},"apc_paid":{"value":1750,"currency":"USD","value_usd":1750},"fwci":0.7898,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.60865908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"4","first_page":"e03813","last_page":"e03813"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.06920000165700912,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pazopanib","display_name":"pazopanib","score":1.0},{"id":"https://openalex.org/keywords/free-drug-concentration","display_name":"free drug concentration","score":0.9129999876022339},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"plasma protein binding","score":0.8939999938011169},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.6100000143051147},{"id":"https://openalex.org/keywords/equilibrium-dialysis","display_name":"equilibrium dialysis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/unbound-fraction","display_name":"unbound fraction","score":0.7919999957084656},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/drug-exposure-monitoring","display_name":"drug exposure monitoring","score":0.6380000114440918},{"id":"https://openalex.org/keywords/plasma-pharmacokinetics","display_name":"plasma pharmacokinetics","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2778439243","wikidata":"https://www.wikidata.org/wiki/Q7157043","display_name":"Pazopanib","level":4,"score":0.8812334537506104},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7896376252174377},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6895004510879517},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6403518915176392},{"id":"https://openalex.org/C2781233306","wikidata":"https://www.wikidata.org/wiki/Q5500236","display_name":"Free fraction","level":3,"score":0.6342962384223938},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5482977628707886},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.4887840449810028},{"id":"https://openalex.org/C23531484","wikidata":"https://www.wikidata.org/wiki/Q3196863","display_name":"Calibration curve","level":3,"score":0.48401448130607605},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4661508798599243},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.37365081906318665},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31580501794815063},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.2520824074745178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1897093653678894},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15839987993240356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07334685325622559},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.0},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1016/j.heliyon.2020.e03813","doi":"https://doi.org/10.1016/j.heliyon.2020.e03813","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2020.e03813","pdf_url":"http://www.cell.com/article/S2405844020306587/pdf","source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7191207","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7191207","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Text"},{"id":"pmid:32373731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32373731","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/196752","doi":null,"is_oa":true,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/196752","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus OA2020","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:69bb65283f324c49a522cec2018c0de6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/69bb65283f324c49a522cec2018c0de6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon, Vol 6, Iss 4, Pp e03813- (2020)","raw_type":"article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/145356","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10356/145356","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt6t48k1zg","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6t48k1zg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon, vol 6, iss 4","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6t48k1zg","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6t48k1zg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon, vol 6, iss 4","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.heliyon.2020.e03813","doi":"https://doi.org/10.1016/j.heliyon.2020.e03813","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2020.e03813","pdf_url":"http://www.cell.com/article/S2405844020306587/pdf","source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3997369388","display_name":null,"funder_award_id":"R148-000-295-114","funder_id":"https://openalex.org/F4320320698","funder_display_name":"National University of Singapore"},{"id":"https://openalex.org/G4263787607","display_name":null,"funder_award_id":"R148-000-272-114","funder_id":"https://openalex.org/F4320320698","funder_display_name":"National University of Singapore"}],"funders":[{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3017581786.pdf","grobid_xml":"https://content.openalex.org/works/W3017581786.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1980262752","https://openalex.org/W1985320798","https://openalex.org/W1991487663","https://openalex.org/W2004362238","https://openalex.org/W2027519910","https://openalex.org/W2052683946","https://openalex.org/W2064041774","https://openalex.org/W2065902287","https://openalex.org/W2074340815","https://openalex.org/W2095771928","https://openalex.org/W2114487470","https://openalex.org/W2114860228","https://openalex.org/W2129504479","https://openalex.org/W2154490581","https://openalex.org/W2240208529","https://openalex.org/W2336274690","https://openalex.org/W2426673991","https://openalex.org/W2500897030","https://openalex.org/W2586120609","https://openalex.org/W2589662306","https://openalex.org/W2612144746","https://openalex.org/W2735362862","https://openalex.org/W2744391674","https://openalex.org/W2767976665","https://openalex.org/W2792630544","https://openalex.org/W2897982776","https://openalex.org/W2973845707","https://openalex.org/W4250850018"],"related_works":["https://openalex.org/W3196682437","https://openalex.org/W2240208529","https://openalex.org/W2780720231","https://openalex.org/W4250850018","https://openalex.org/W1991487663","https://openalex.org/W7218827167","https://openalex.org/W2146693250","https://openalex.org/W2193906887","https://openalex.org/W2030231059","https://openalex.org/W2731626019"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,27,100,120],"selective":[2],"occurrence":[3],"of":[4,9,18,72,108,115,117,142,163,173],"hepatotoxicity":[5],"observed":[6,145],"with":[7,40,57,91,111,151],"use":[8],"pazopanib":[10,143,174],"may":[11,167],"be":[12,168],"attributed":[13],"to":[14,31,80,87],"its":[15],"high":[16],"level":[17],"plasma":[19,164],"protein":[20],"binding":[21],"and":[22,66,122,125],"low":[23],"hepatic":[24],"extraction":[25],"ratio.":[26],"primary":[28],"objective":[29],"was":[30],"investigate":[32],"changes":[33],"in":[34,60,76,146,176],"free":[35,73,165],"drug":[36],"concentration":[37,75],"amongst":[38],"patients":[39,147],"varying":[41],"albumin":[42,155],"concentrations.":[43,156],"METHODS:":[44],"A":[45],"HPLC-MS/MS":[46],"method":[47],"using":[48],"C18":[49],"column":[50],"(4.6":[51],"\u00d7":[52],"150":[53],"mm,":[54],"5":[55,118],"\u03bcm)":[56],"ESI":[58],"source":[59],"positive":[61],"mode":[62],"had":[63],"been":[64],"developed":[65,160],"validated":[67],"for":[68],"the":[69,106,159],"quantitative":[70],"determination":[71],"pazaopanib":[74],"human":[77],"plasma.":[78],"Prior":[79],"sample":[81],"preparation,":[82],"patient":[83],"samples":[84],"were":[85,103,127,144],"subjected":[86],"6-hour":[88],"equilibrium":[89],"dialysis":[90],"molecular":[92],"weight":[93],"cut-off":[94],"set":[95],"at":[96,133],"8000":[97],"Da.":[98],"RESULTS:":[99],"calibration":[101],"curves":[102],"linear":[104],"over":[105],"range":[107],"5-1000":[109],"ng/mL,":[110],"a":[112],"lower":[113,152],"limit":[114],"quantification":[116],"ng/mL.":[119],"intra-day":[121],"inter-day":[123],"precisions":[124],"accuracies":[126],"all":[128],"within":[129],"\u00b1":[130],"15":[131],"%,":[132],"3":[134],"different":[135],"quality":[136],"controls.":[137],"Higher":[138],"median":[139],"fraction":[140],"unbound":[141],"(n":[148],"=":[149],"17)":[150],"than":[153],"normal":[154],"CONCLUSION:":[157],"With":[158],"assay,":[161],"monitoring":[162],"concentrations":[166],"evaluated":[169],"as":[170],"an":[171],"indicator":[172],"exposure":[175],"patients.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2020-05-01T00:00:00"}
