{"id":"https://openalex.org/W3017380760","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06458","title":"Inorganic Nitrate Supplementation Blunts Vasoconstrictor Responsiveness During Exercise in Patients with Type 2 Diabetes","display_name":"Inorganic Nitrate Supplementation Blunts Vasoconstrictor Responsiveness During Exercise in Patients with Type 2 Diabetes","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3017380760","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06458","mag":"3017380760"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2020.34.s1.06458","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06458","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.06458","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023677104","display_name":"Josh Bock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josh Bock","raw_affiliation_strings":["University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101464255","display_name":"William Edward Hughes","orcid":"https://orcid.org/0000-0002-7580-9213","observed_orcids":["https://orcid.org/0000-0002-7580-9213","https://orcid.org/0000-0003-2064-4834"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Hughes","raw_affiliation_strings":["University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054758021","display_name":"Kenichi Ueda","orcid":"https://orcid.org/0000-0002-4559-4581","observed_orcids":["https://orcid.org/0000-0002-4559-4581"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenichi Ueda","raw_affiliation_strings":["University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084137343","display_name":"Andrew J. Feider","orcid":"https://orcid.org/0000-0002-7620-6537","observed_orcids":["https://orcid.org/0000-0002-7620-6537"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Feider","raw_affiliation_strings":["University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007769262","display_name":"Satoshi Hanada","orcid":"https://orcid.org/0000-0002-6205-3146","observed_orcids":["https://orcid.org/0000-0002-6205-3146"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satoshi Hanada","raw_affiliation_strings":["University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054111868","display_name":"Darren P. Casey","orcid":"https://orcid.org/0000-0003-4564-8604","observed_orcids":["https://orcid.org/0000-0003-4564-8604"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darren Casey","raw_affiliation_strings":["University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"S1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.09189999848604202,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inorganic-nitrate-supplementation","display_name":"inorganic nitrate supplementation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9079999923706055},{"id":"https://openalex.org/keywords/vasoconstrictor-responsiveness","display_name":"vasoconstrictor responsiveness","score":0.8640000224113464},{"id":"https://openalex.org/keywords/sympatholysis","display_name":"sympatholysis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/alpha1-adrenergic-receptors","display_name":"alpha1-adrenoceptors","score":0.7680000066757202},{"id":"https://openalex.org/keywords/alpha2-adrenergic-receptors","display_name":"alpha2-adrenoceptors","score":1.0},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.8709999918937683},{"id":"https://openalex.org/keywords/forearm-blood-flow","display_name":"forearm blood flow","score":0.7450000047683716},{"id":"https://openalex.org/keywords/vascular-conductance","display_name":"vascular conductance","score":0.8410000205039978},{"id":"https://openalex.org/keywords/handgrip-exercise","display_name":"handgrip exercise","score":0.8840000033378601},{"id":"https://openalex.org/keywords/phenylephrine","display_name":"phenylephrine","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.6984493732452393},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.677741527557373},{"id":"https://openalex.org/C2777604165","wikidata":"https://www.wikidata.org/wiki/Q503643","display_name":"Brachial artery","level":3,"score":0.5806567668914795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5746805667877197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5420985221862793},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4620897173881531},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.43557208776474},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3595288395881653},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35575127601623535},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.32920172810554504}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2020.34.s1.06458","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06458","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.06458","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3208439766","https://openalex.org/W3048922745","https://openalex.org/W4308059655","https://openalex.org/W3187450022","https://openalex.org/W4283832177","https://openalex.org/W3080443686","https://openalex.org/W7113784976","https://openalex.org/W1965345197","https://openalex.org/W3169756403","https://openalex.org/W4307350400"],"abstract_inverted_index":{"Patients":[0],"with":[1,43,129,203,372],"type":[2],"2":[3,13,58,95,246,254,271,359,428],"diabetes":[4],"(T2D)":[5],"have":[6,38],"exaggerated":[7],"\u03b1":[8,12,53,57,88,94,266,270,332,358,427],"1":[9,54,89,267,333],"\u2010":[10,55,268],"and":[11,150,170,177,190,226,280,297,318,323,348,410],"\u2010vasoconstrictor":[14,59,272],"responsiveness":[15,60,81,194,273,336,362,431],"during":[16,31,61,97,125,135,337,363],"exercise":[17,32,62,99,109,227,306,338,364,415],"indicating":[18],"reduced":[19,79,357],"functional":[20,438],"sympatholysis.":[21],"Nitric":[22],"oxide":[23],"(NO)":[24],"is":[25,34],"purported":[26],"to":[27,82,103,238,293,300,305,311,316,320,366,370,381,385,388,414,425],"offset":[28],"\u03b1\u2010mediated":[29],"vasoconstriction":[30],"(i.e.,":[33,436],"sympatholytic).":[35],"Given":[36],"T2D":[37,101,234],"attenuated":[39],"NO":[40,76,240,284,353],"bioavailability,":[41],"supplementation":[42,73,256,405],"inorganic":[44,71,403],"nitrate":[45,72,404],"(an":[46],"exogenous":[47],"source":[48],"of":[49,70,85,164,188,215,343,378,402],"NO)":[50],"may":[51],"reduce":[52],"and/or":[56,91],"in":[63,100,222,264,290,375,416,432],"T2D.":[64,417],"Thus,":[65],"we":[66,399],"examined":[67],"if":[68],"8wks":[69,401],"(250mg":[74],"daily,":[75],"3":[77,241,285,354],"group)":[78],"vasoconstrictor":[80,335,361,430],"intra\u2010arterial":[83],"infusions":[84],"phenylephrine":[86],"(PE,":[87],"\u2010agonist)":[90,96],"dexmedetomidine":[92],"(DEX,":[93],"handgrip":[98],"relative":[102,310],"a":[104,162],"placebo":[105],"(PL":[106],"group).":[107],"Handgrip":[108],"trials":[110,197],"lasted":[111],"for":[112,195,228,331,396],"6min":[113],"at":[114,224],"20%":[115],"maximum":[116],"grip":[117],"strength.":[118],"Steady\u2010state":[119],"(SS)":[120],"blood":[121,140,151],"flow":[122,141],"was":[123,144,166,198,217],"achieved":[124],"the":[126,136,185,220,239,312,340,352,376,389,407],"first":[127],"3min":[128],"either":[130],"PE":[131],"or":[132,248,269,339,441],"DEX":[133],"infused":[134],"latter":[137],"3min.":[138],"Forearm":[139,157],"(FBF,":[142],"ml/min)":[143],"calculated":[145,167,180,218],"using":[146,168],"brachial":[147],"artery":[148],"diameter":[149],"velocity":[152],"measured":[153],"via":[154],"Doppler":[155],"ultrasound.":[156],"vascular":[158],"conductance":[159],"(FVC,":[160],"ml/min/100mmHg),":[161],"surrogate":[163],"vasodilation,":[165],"FBF":[169,176,291],"mean":[171],"arterial":[172],"pressure":[173],"(MAP).":[174],"Both":[175],"FVC":[178,202,207,210,298],"were":[179,235,261,329],"from":[181,308],"data":[182],"averaged":[183],"over":[184],"final":[186],"30sec":[187],"rest":[189,225],"SS":[191,206],"exercise.":[192],"Vasoconstrictor":[193],"all":[196],"quantified":[199],"as:":[200],"((SS":[201],"drug":[204],"\u2212":[205],"pre\u2010drug":[208,211],")/SS":[209],")x100%.":[212],"The":[213,283],"magnitude":[214,342,377],"sympatholysis":[216,344,379],"as":[219],"difference":[221],"%vasoconstriction":[223],"both":[229],"\u03b1\u2010agonists.":[230],"After":[231],"baseline":[232],"assessments,":[233],"randomly":[236],"assigned":[237],"(n=17,":[242,250],"13M/4F,":[243],"58\u00b19yrs,":[244,252],"31.8\u00b15.2kg/m":[245],")":[247,255],"PL":[249,313,390],"12M/5F,":[251],"32.3\u00b15.3kg/m":[253],"groups.":[257],"Following":[258],"supplementation,":[259],"there":[260],"no":[262],"differences":[263,328],"resting":[265],"observed":[274,330],"between":[275],"groups":[276],"(group\u2010by\u2010time":[277,345],"p":[278,295,302,346,394],"=0.86":[279],"0.15,":[281],"respectively).":[282,325,350],"group":[286,314,355],"had":[287,356],"greater":[288],"increases":[289],"(164\u00b168":[292],"185\u00b170ml/min,":[294],"<0.05)":[296,303],"(136\u00b153":[299],"164\u00b161ml/min/100mmHg,":[301],"responses":[304,413],"(\u0394":[307],"rest)":[309],"(149\u00b166":[315],"149\u00b165ml/min":[317],"129\u00b164":[319],"133\u00b160ml/min/100mmHg,":[321],"p=0.93":[322],"0.59,":[324],"No":[326],"between\u2010group":[327],"\u2010mediated":[334,360,429],"corresponding":[341],"=0.41":[347],"0.90,":[349],"However,":[351],"(\u221223.4\u00b16.9":[365],"\u221220.2\u00b15.6%":[367],"vs.":[368,383],"\u221224.0\u00b17.9":[369],"\u221226.5\u00b110.5%)":[371],"concomitant":[373],"improvement":[374],"(\u221226.1\u00b112.9":[380],"\u221238.1\u00b119.4":[382],"\u221225.1\u00b115.9":[384],"\u221224.7\u00b115.6)":[386],"compared":[387],"cohort,":[391],"respectively":[392],"(":[393],"<0.05":[395],"both).":[397],"Principally,":[398],"found":[400],"augments":[406],"hyperemic":[408],"(FBF)":[409],"vasodilatory":[411],"(FVC)":[412],"Additionally,":[418],"these":[419],"beneficial":[420],"effects":[421],"could":[422],"be":[423],"attributable":[424],"decreased":[426],"contracting":[433],"skeletal":[434],"muscle":[435],"improved":[437],"sympatholysis).":[439],"Support":[440],"Funding":[442],"Information":[443],"American":[444],"Diabetes":[445],"Association":[446],"1\u201016\u20101CTA\u2010015.":[447]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2020-04-24T00:00:00"}
