{"id":"https://openalex.org/W3017367297","doi":"https://doi.org/10.2174/1381612826666200421123242","title":"Pharmacokinetics of Inter-Alpha Inhibitor Proteins and Effects on Hemostasis After Hypoxic-Ischemic Brain Injury in Neonatal Rats","display_name":"Pharmacokinetics of Inter-Alpha Inhibitor Proteins and Effects on Hemostasis After Hypoxic-Ischemic Brain Injury in Neonatal Rats","publication_year":2020,"publication_date":"2020-04-22","ids":{"openalex":"https://openalex.org/W3017367297","doi":"https://doi.org/10.2174/1381612826666200421123242","mag":"3017367297","pmid":"https://pubmed.ncbi.nlm.nih.gov/32316887","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7545274"},"language":"en","primary_location":{"id":"doi:10.2174/1381612826666200421123242","doi":"https://doi.org/10.2174/1381612826666200421123242","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612826666200421123242","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7545274","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058192036","display_name":"Xiaodi F. Chen","orcid":"https://orcid.org/0000-0002-1860-2814","observed_orcids":["https://orcid.org/0000-0002-1860-2814"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaodi Chen","raw_affiliation_strings":["Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI, United States"],"raw_orcid":"https://orcid.org/0000-0002-1860-2814","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI, United States","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210133025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101434580","display_name":"Dawei Song","orcid":"https://orcid.org/0000-0003-2115-2460","observed_orcids":["https://orcid.org/0000-0003-2115-2460"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawei Song","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, United States"],"raw_orcid":"https://orcid.org/0000-0003-2115-2460","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sakura Nakada","orcid":"https://orcid.org/0000-0003-3327-4414","observed_orcids":["https://orcid.org/0000-0003-3327-4414"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sakura Nakada","raw_affiliation_strings":["Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI, United States"],"raw_orcid":"https://orcid.org/0000-0003-3327-4414","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI, United States","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210133025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076685321","display_name":"Joseph Qiu","orcid":"https://orcid.org/0000-0002-0976-8265","observed_orcids":["https://orcid.org/0000-0002-0976-8265"]},"institutions":[{"id":"https://openalex.org/I4210142502","display_name":"ProThera Biologics (United States)","ror":"https://ror.org/03yzb9c23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142502"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Qiu","raw_affiliation_strings":["ProThera Biologics, Inc., Providence, RI, United States"],"raw_orcid":"https://orcid.org/0000-0002-0976-8265","affiliations":[{"raw_affiliation_string":"ProThera Biologics, Inc., Providence, RI, United States","institution_ids":["https://openalex.org/I4210142502"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053417302","display_name":"Karin Iwamoto","orcid":"https://orcid.org/0000-0002-2161-3127","observed_orcids":["https://orcid.org/0000-0002-2161-3127"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karin Iwamoto","raw_affiliation_strings":["Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI, United States"],"raw_orcid":"https://orcid.org/0000-0002-2161-3127","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI, United States","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210133025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062716392","display_name":"Ray H. Chen","orcid":"https://orcid.org/0000-0003-2705-9320","observed_orcids":["https://orcid.org/0000-0003-2705-9320"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ray H. Chen","raw_affiliation_strings":["Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI, United States"],"raw_orcid":"https://orcid.org/0000-0003-2705-9320","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI, United States","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210133025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064312491","display_name":"Yow\u2010Pin Lim","orcid":"https://orcid.org/0000-0003-2697-7963","observed_orcids":["https://orcid.org/0000-0003-2697-7963"]},"institutions":[{"id":"https://openalex.org/I4210142502","display_name":"ProThera Biologics (United States)","ror":"https://ror.org/03yzb9c23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142502"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yow-Pin Lim","raw_affiliation_strings":["ProThera Biologics, Inc., Providence, RI, United States"],"raw_orcid":"https://orcid.org/0000-0003-2697-7963","affiliations":[{"raw_affiliation_string":"ProThera Biologics, Inc., Providence, RI, United States","institution_ids":["https://openalex.org/I4210142502"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021901997","display_name":"William J. Jusko","orcid":"https://orcid.org/0000-0003-4027-0550","observed_orcids":["https://orcid.org/0000-0003-4027-0550"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Jusko","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, United States"],"raw_orcid":"https://orcid.org/0000-0003-4027-0550","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011689741","display_name":"Barbara S. Stonestreet","orcid":"https://orcid.org/0000-0002-6532-7683","observed_orcids":["https://orcid.org/0000-0002-6532-7683"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Barbara S. Stonestreet","raw_affiliation_strings":["Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI, United States"],"raw_orcid":"https://orcid.org/0000-0002-6532-7683","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI, United States","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210133025"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5011689741"],"corresponding_institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210133025"],"apc_list":null,"apc_paid":null,"fwci":1.6698,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.81947362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"26","issue":"32","first_page":"3997","last_page":"4006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inter-alpha-inhibitor-proteins","display_name":"inter-alpha inhibitor proteins","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hypoxic-ischemic-brain-injury","display_name":"hypoxic-ischemic brain injury","score":0.9380000233650208},{"id":"https://openalex.org/keywords/neonatal-neuroprotection","display_name":"neonatal neuroprotection","score":0.6819999814033508},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.972000002861023},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/bleeding-time","display_name":"bleeding time","score":0.8119999766349792},{"id":"https://openalex.org/keywords/ulinastatin","display_name":"ulinastatin","score":0.7570000290870667},{"id":"https://openalex.org/keywords/protease-inhibition","display_name":"protease inhibition","score":0.7279999852180481},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6959999799728394},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.5260000228881836},{"id":"https://openalex.org/keywords/neonatal-rats","display_name":"neonatal rats","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7317659854888916},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7050975561141968},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6470813751220703},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.5971553325653076},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.49884462356567383},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4665754735469818},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28672051429748535}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006487","descriptor_name":"Hemostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2174/1381612826666200421123242","doi":"https://doi.org/10.2174/1381612826666200421123242","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612826666200421123242","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:32316887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32316887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7545274","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7545274","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Pharm Des","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7545274","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7545274","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Pharm Des","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1544635166","display_name":"COBRE for Perinatal Biology","funder_award_id":"P30GM114750","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1900726553","display_name":"Mechanistic Pharmacokinetics and Pharmacodynamics","funder_award_id":"R35GM131800","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2534476631","display_name":"Corticosteroid Pharmacokinetics and Pharmacodynamics","funder_award_id":"R01GM024211","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3739463737","display_name":"Inter-alpha Inhibitors in Hypoxic-Ischemic Brain Injury","funder_award_id":"R44NS084575","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3957825579","display_name":"Beneficial Effects of Inter-alpha Inhibitors in Fetal Brain Injury","funder_award_id":"R21NS096525","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4066577672","display_name":null,"funder_award_id":"R44-NS084575-02","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7429833947","display_name":null,"funder_award_id":"R35-131800","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G838594032","display_name":"Inter-alpha inhibitors:  Novel neuroinflammatory modulator of neonatal brain injury","funder_award_id":"R21NS095130","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W289290083","https://openalex.org/W1545311001","https://openalex.org/W1593285591","https://openalex.org/W1846247192","https://openalex.org/W1892429132","https://openalex.org/W1964890610","https://openalex.org/W1970119832","https://openalex.org/W1970760308","https://openalex.org/W1975165843","https://openalex.org/W1976909920","https://openalex.org/W1979612822","https://openalex.org/W1983264618","https://openalex.org/W1984683671","https://openalex.org/W1986531135","https://openalex.org/W1986711186","https://openalex.org/W1997380877","https://openalex.org/W2001116239","https://openalex.org/W2001756618","https://openalex.org/W2006654108","https://openalex.org/W2012942227","https://openalex.org/W2013994985","https://openalex.org/W2016693709","https://openalex.org/W2017331060","https://openalex.org/W2023997512","https://openalex.org/W2025339373","https://openalex.org/W2026830088","https://openalex.org/W2028328541","https://openalex.org/W2036560451","https://openalex.org/W2040981235","https://openalex.org/W2041701146","https://openalex.org/W2042628774","https://openalex.org/W2047810831","https://openalex.org/W2058839184","https://openalex.org/W2064608905","https://openalex.org/W2066215889","https://openalex.org/W2071497357","https://openalex.org/W2071846360","https://openalex.org/W2080706671","https://openalex.org/W2081352444","https://openalex.org/W2089648703","https://openalex.org/W2089882451","https://openalex.org/W2090030205","https://openalex.org/W2112321151","https://openalex.org/W2114709779","https://openalex.org/W2118991879","https://openalex.org/W2120416054","https://openalex.org/W2124604818","https://openalex.org/W2127155176","https://openalex.org/W2132866920","https://openalex.org/W2136967026","https://openalex.org/W2137798697","https://openalex.org/W2144303480","https://openalex.org/W2162597181","https://openalex.org/W2162762952","https://openalex.org/W2208826083","https://openalex.org/W2233730523","https://openalex.org/W2253355615","https://openalex.org/W2473138776","https://openalex.org/W2523566149","https://openalex.org/W2594457749","https://openalex.org/W2607265510","https://openalex.org/W2765187586","https://openalex.org/W2792819261","https://openalex.org/W2795831303","https://openalex.org/W2932622885","https://openalex.org/W2943595097","https://openalex.org/W2954863426"],"related_works":["https://openalex.org/W3083613769","https://openalex.org/W4308194729","https://openalex.org/W2932622885","https://openalex.org/W2765187586","https://openalex.org/W3175303936","https://openalex.org/W2954863426","https://openalex.org/W3107429179","https://openalex.org/W4404093698","https://openalex.org/W2028328541","https://openalex.org/W4221048923"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hypoxic-ischemic":[1],"(HI)":[2],"brain":[3,25,57],"injury":[4,26],"is":[5],"a":[6,157,225],"leading":[7],"cause":[8],"of":[9,34,42,64,77,83,118,227,231,256],"long-term":[10],"neurodevelopmental":[11],"morbidities":[12],"in":[13,27,39,55,85,100,133,181,254,258],"neonates.":[14],"Human":[15],"plasma-derived":[16],"Inter-Alpha":[17],"Inhibitor":[18],"Proteins":[19],"(hIAIPs)":[20],"are":[21],"neuroprotective":[22],"after":[23,79,128,148,192,201,241],"HI":[24,47,93,131,193,228],"neonatal":[28,90],"rats.":[29,91,104],"The":[30,62],"light":[31],"chain":[32],"(bikunin)":[33],"hIAIPs":[35,84,121,175,211],"inhibits":[36],"proteases":[37],"involved":[38],"the":[40,56,65,71,75,97,106,134,149,166,182],"coagulation":[41],"blood.":[43],"Newborns":[44],"exposed":[45,114,260],"to":[46,69,115,164,210,248,261],"can":[48],"be":[49],"at":[50,186],"risk":[51],"for":[52],"significant":[53,207],"bleeding":[54,78,183,196,239],"and":[58,74,88,137,173,189,221,229],"other":[59],"organs.":[60],"OBJECTIVE:":[61],"objectives":[63],"present":[66],"study":[67,136],"were":[68,113,125,154,179],"assess":[70],"pharmacokinetics":[72],"(PK)":[73],"duration":[76],"intraperitoneal":[80],"(IP)":[81],"administration":[82,205,235],"HI-exposed":[86],"male":[87],"female":[89],"METHODS:":[92],"was":[94,139,162],"induced":[95],"with":[96,156,194,212],"Rice-Vannucci":[98],"method":[99],"postnatal":[101],"(P)":[102],"day-7":[103],"After":[105],"right":[107],"common":[108],"carotid":[109],"artery":[110],"ligation,":[111],"rats":[112],"90":[116],"min":[117],"8%":[119],"oxygen.":[120],"(30":[122],"mg/kg,":[123,177],"IP)":[124,178],"given":[126,180],"immediately":[127],"Sham":[129],"or":[130,145],"exposure":[132,209],"PK":[135,168,213],"serum":[138],"collected":[140],"1,":[141],"6,":[142],"12,":[143],"24,":[144],"36":[146],"h":[147,191,200],"injections.":[150],"Serum":[151],"hIAIP":[152,234,250],"concentrations":[153],"measured":[155,198],"competitive":[158],"ELISA.":[159],"ADAPT5":[160],"software":[161],"used":[163],"fit":[165],"pooled":[167],"data":[169],"considering":[170],"first-order":[171],"absorption":[172,220],"disposition.":[174],"(60":[176],"time":[184],"studies":[185,255],"0,":[187],"24":[188],"48":[190],"tail":[195],"times":[197,240],"72":[199],"HI.":[202,242,262],"RESULTS:":[203],"IP":[204],"yielded":[206],"systemic":[208],"being":[214],"affected":[215],"markedly":[216],"including":[217],"primarily":[218],"faster":[219],"reduced":[222],"elimination":[223],"as":[224],"result":[226],"modestly":[230],"sex-related":[232],"differences.":[233],"did":[236],"not":[237],"affect":[238],"CONCLUSION:":[243],"These":[244],"results":[245],"will":[246],"help":[247],"inform":[249],"dosing":[251],"regimen":[252],"schedules":[253],"neuroprotection":[257],"neonates":[259]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2020-04-24T00:00:00"}