{"id":"https://openalex.org/W3017334155","doi":"https://doi.org/10.1172/jci136782","title":"Neuroimaging of hypothalamic mechanisms related to glucose metabolism in anorexia nervosa and obesity","display_name":"Neuroimaging of hypothalamic mechanisms related to glucose metabolism in anorexia nervosa and obesity","publication_year":2020,"publication_date":"2020-04-21","ids":{"openalex":"https://openalex.org/W3017334155","doi":"https://doi.org/10.1172/jci136782","mag":"3017334155","pmid":"https://pubmed.ncbi.nlm.nih.gov/32315289","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7410066"},"language":"en","primary_location":{"id":"doi:10.1172/jci136782","doi":"https://doi.org/10.1172/jci136782","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci136782","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7410066/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020557228","display_name":"Joe J. Simon","orcid":"https://orcid.org/0000-0001-7407-1344","observed_orcids":["https://orcid.org/0000-0001-7407-1344"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joe J. Simon","raw_affiliation_strings":["Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany","Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7407-1344","affiliations":[{"raw_affiliation_string":"Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035533225","display_name":"Marion A. Stopyra","orcid":"https://orcid.org/0000-0003-2046-6476","observed_orcids":["https://orcid.org/0000-0003-2046-6476"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marion A. Stopyra","raw_affiliation_strings":["Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035013037","display_name":"Esther M\u00f6nning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Esther M\u00f6nning","raw_affiliation_strings":["Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060504754","display_name":"Sebastian Sailer","orcid":"https://orcid.org/0000-0003-3484-2989","observed_orcids":["https://orcid.org/0000-0003-3484-2989","https://orcid.org/0000-0003-0520-8874"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Sailer","raw_affiliation_strings":["Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037277154","display_name":"Nora Lavandier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nora Lavandier","raw_affiliation_strings":["Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113776292","display_name":"Lars Kihm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lars P. Kihm","raw_affiliation_strings":["Endocrinology and Nephrology, Department of Internal Medicine I, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology and Nephrology, Department of Internal Medicine I, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019876508","display_name":"Martin Bendszus","orcid":"https://orcid.org/0000-0002-9094-6769","observed_orcids":["https://orcid.org/0000-0002-9094-6769"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Bendszus","raw_affiliation_strings":["Department of Neuroradiology, University Hospital of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology, University Hospital of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066447951","display_name":"Hubert T. Preissl","orcid":"https://orcid.org/0000-0002-8859-4661","observed_orcids":["https://orcid.org/0000-0002-8859-4661"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I4210160326","display_name":"German Center for Diabetes Research","ror":"https://ror.org/04qq88z54","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210160326","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hubert Preissl","raw_affiliation_strings":["Department of Pharmacy and Biochemistry, Interfaculty Centre for Pharmacogenomics and Pharma Research, University of T\u00fcbingen, T\u00fcbingen, Germany","Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, University Hospital T\u00fcbingen, T\u00fcbingen, Germany","German Center for Diabetes Research (DZD e.V.), T\u00fcbingen, Germany","Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich (IDM) at the University of T\u00fcbingen, T\u00fcbingen, Germany","Institute for Diabetes and Obesity, Helmholtz Diabetes Centre, Helmholtz Centre Munich, German Research Centre for Environmental Health (GmbH), Neuherberg, Germany","fMEG Center, Helmholtz Center Munich, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8859-4661","affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Biochemistry, Interfaculty Centre for Pharmacogenomics and Pharma Research, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, University Hospital T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118"]},{"raw_affiliation_string":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210160326"]},{"raw_affiliation_string":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich (IDM) at the University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Institute for Diabetes and Obesity, Helmholtz Diabetes Centre, Helmholtz Centre Munich, German Research Centre for Environmental Health (GmbH), Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"fMEG Center, Helmholtz Center Munich, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041811133","display_name":"Wolfgang Herzog","orcid":"https://orcid.org/0000-0003-2778-4135","observed_orcids":["https://orcid.org/0000-0003-2778-4135"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Herzog","raw_affiliation_strings":["Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082086271","display_name":"Hans\u2010Christoph Friederich","orcid":"https://orcid.org/0000-0003-4344-8959","observed_orcids":["https://orcid.org/0000-0003-4344-8959"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hans-Christoph Friederich","raw_affiliation_strings":["Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany","Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5082086271"],"corresponding_institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I44260953"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":3.0666,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.94618448,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"130","issue":"8","first_page":"4094","last_page":"4103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.06430000066757202,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anorexia-nervosa","display_name":"anorexia nervosa","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.890999972820282},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9879999756813049},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.4650000035762787},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.8479999899864197},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":1.0},{"id":"https://openalex.org/keywords/reward-processing","display_name":"reward processing","score":0.6690000295639038},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"functional connectivity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/appetite-hormones","display_name":"appetite-regulating hormones","score":0.7699999809265137},{"id":"https://openalex.org/keywords/negative-energy-balance","display_name":"negative energy balance","score":0.7730000019073486},{"id":"https://openalex.org/keywords/self-starvation","display_name":"self-starvation","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2777031586","wikidata":"https://www.wikidata.org/wiki/Q131749","display_name":"Anorexia nervosa","level":3,"score":0.7961321473121643},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7240173816680908},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6900599598884583},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.6723887920379639},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6118080615997314},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.595754861831665},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.5715340375900269},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5449721217155457},{"id":"https://openalex.org/C2780606744","wikidata":"https://www.wikidata.org/wiki/Q853930","display_name":"Starvation","level":2,"score":0.48300039768218994},{"id":"https://openalex.org/C2778654693","wikidata":"https://www.wikidata.org/wiki/Q254327","display_name":"Anorexia","level":2,"score":0.4734066426753998},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4714088439941406},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4463304579257965},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.421662300825119},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40033993124961853},{"id":"https://openalex.org/C2776394216","wikidata":"https://www.wikidata.org/wiki/Q373822","display_name":"Eating disorders","level":2,"score":0.3516925871372223},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3463851809501648},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.25482177734375},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2375258207321167}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000856","descriptor_name":"Anorexia Nervosa","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000856","descriptor_name":"Anorexia Nervosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1172/jci136782","doi":"https://doi.org/10.1172/jci136782","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci136782","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:32315289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32315289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7410066","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7410066/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:59510","doi":null,"is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59510","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J. Clin. Invest. 130, 4094-4103 (2020)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:push-zb.helmholtz-munich.de:59510","doi":null,"is_oa":false,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=59510","pdf_url":null,"source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J. Clin. Invest. 130, 4094-4103 (2020)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7410066","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7410066/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3129716326","display_name":null,"funder_award_id":"SI 2087/2-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1508521369","https://openalex.org/W1553417097","https://openalex.org/W1827685313","https://openalex.org/W1967074973","https://openalex.org/W1973621674","https://openalex.org/W1981468083","https://openalex.org/W1983183519","https://openalex.org/W1993623582","https://openalex.org/W2002476886","https://openalex.org/W2042181481","https://openalex.org/W2045798561","https://openalex.org/W2057908401","https://openalex.org/W2067637201","https://openalex.org/W2074382500","https://openalex.org/W2075048575","https://openalex.org/W2079395662","https://openalex.org/W2080877392","https://openalex.org/W2093925183","https://openalex.org/W2098766452","https://openalex.org/W2114918553","https://openalex.org/W2124737580","https://openalex.org/W2125143421","https://openalex.org/W2125749907","https://openalex.org/W2127852211","https://openalex.org/W2130010412","https://openalex.org/W2138724749","https://openalex.org/W2141793702","https://openalex.org/W2142417146","https://openalex.org/W2146237811","https://openalex.org/W2153095332","https://openalex.org/W2154696002","https://openalex.org/W2155962758","https://openalex.org/W2167525293","https://openalex.org/W2168093058","https://openalex.org/W2315350671","https://openalex.org/W2319856003","https://openalex.org/W2546647959","https://openalex.org/W2556106115","https://openalex.org/W2586782237","https://openalex.org/W2612954267","https://openalex.org/W2623177225","https://openalex.org/W2731330099","https://openalex.org/W2751790104","https://openalex.org/W2808755720","https://openalex.org/W2905033532","https://openalex.org/W2937870564","https://openalex.org/W2960372990","https://openalex.org/W2971575234","https://openalex.org/W2979227706","https://openalex.org/W2999900816"],"related_works":["https://openalex.org/W1553417097","https://openalex.org/W2971575234","https://openalex.org/W2068896656","https://openalex.org/W4416334879","https://openalex.org/W7214228846","https://openalex.org/W3181045166","https://openalex.org/W4366090350","https://openalex.org/W4391053419","https://openalex.org/W1983116212","https://openalex.org/W2003244269"],"abstract_inverted_index":{"BACKGROUNDGiven":[0],"the":[1,68,77,80,83,97,124,131,139,149,152,164,192,210,216,225],"heightened":[2],"tolerance":[3],"to":[4,27,66,144,160,191],"self-starvation":[5],"in":[6,32,50,123],"anorexia":[7],"nervosa":[8],"(AN),":[9],"a":[10,51,177,222],"hypothalamic":[11,25,102,114,185],"dysregulation":[12],"of":[13,62,71,76,82,101,172,194,209,215],"energy":[14,179],"and":[15,40,64,79,108,127,134,151],"glucose":[16,28,63,161,186],"homeostasis":[17],"has":[18],"been":[19],"hypothesized.":[20],"Therefore,":[21],"we":[22],"investigated":[23,90],"whether":[24],"reactivity":[26,122,187],"metabolism":[29],"is":[30,205],"impaired":[31],"AN.METHODSTwenty-four":[33],"participants":[34,43,95,109,133,136],"with":[35,44,85,106,110,118,130,137,141,166],"AN,":[36],"28":[37],"normal-weight":[38,132],"participants,":[39],"24":[41],"healthy":[42],"obesity":[45,111],"underwent":[46],"2":[47],"MRI":[48],"sessions":[49],"single-blind,":[52],"randomized,":[53],"case-controlled":[54],"crossover":[55],"study.":[56],"We":[57],"used":[58],"an":[59,206],"intragastric":[60],"infusion":[61,158],"water":[65,157],"bypass":[67],"cephalic":[69],"phase":[70],"food":[72],"intake.":[73],"The":[74],"responsivity":[75],"hypothalamus":[78,84,150],"crosstalk":[81],"reward-related":[86,153],"brain":[87,154],"regions":[88,155],"were":[89],"using":[91],"high-resolution":[92],"MRI.RESULTSNormal-weight":[93],"control":[94,135],"displayed":[96,120,168],"expected":[98],"glucose-induced":[99],"deactivation":[100],"activation,":[103],"whereas":[104],"patients":[105,117,140,165],"AN":[107,119,142,167],"showed":[112],"blunted":[113,121,184],"reactivity.":[115],"Furthermore,":[116],"nucleus":[125],"accumbens":[126],"amygdala.":[128],"Compared":[129],"obesity,":[138],"failed":[143],"show":[145],"functional":[146],"connectivity":[147],"between":[148],"during":[156,176],"relative":[159],"infusion.":[162],"Finally,":[163],"typical":[169],"baseline":[170],"levels":[171],"peripheral":[173],"appetite":[174],"hormones":[175],"negative":[178],"balance.CONCLUSIONThese":[180],"results":[181],"indicate":[182],"that":[183],"might":[188],"be":[189],"related":[190],"pathophysiology":[193],"AN.":[195],"This":[196],"study":[197,218],"provides":[198],"insights":[199],"for":[200],"future":[201],"research,":[202],"as":[203],"it":[204],"extended":[207],"perspective":[208],"traditional":[211],"primary":[212],"nonhomeostatic":[213],"understanding":[214],"disease.FUNDINGThis":[217],"was":[219],"supported":[220],"by":[221],"grant":[223],"from":[224],"DFG":[226],"(SI":[227],"2087/2-1).":[228]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-04-24T00:00:00"}
