{"id":"https://openalex.org/W3017312411","doi":"https://doi.org/10.1093/intimm/dxaa028","title":"Hide and seek: interplay between influenza viruses and B cells","display_name":"Hide and seek: interplay between influenza viruses and B cells","publication_year":2020,"publication_date":"2020-04-15","ids":{"openalex":"https://openalex.org/W3017312411","doi":"https://doi.org/10.1093/intimm/dxaa028","mag":"3017312411","pmid":"https://pubmed.ncbi.nlm.nih.gov/32304215","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7478158"},"language":"en","primary_location":{"id":"doi:10.1093/intimm/dxaa028","doi":"https://doi.org/10.1093/intimm/dxaa028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/intimm/dxaa028","pdf_url":"https://academic.oup.com/intimm/article-pdf/32/9/605/33725488/dxaa028.pdf","source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/intimm/article-pdf/32/9/605/33725488/dxaa028.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005679572","display_name":"Masayuki Kuraoka","orcid":"https://orcid.org/0000-0001-8745-6614","observed_orcids":["https://orcid.org/0000-0001-8745-6614"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Masayuki Kuraoka","raw_affiliation_strings":["Department of Immunology, Duke University , Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Duke University , Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042644677","display_name":"Yu Adachi","orcid":"https://orcid.org/0000-0002-8573-987X","observed_orcids":["https://orcid.org/0000-0002-8573-987X"]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu Adachi","raw_affiliation_strings":["Department of Immunology, National Institute of Infectious Diseases , Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, National Institute of Infectious Diseases , Tokyo, Japan","institution_ids":["https://openalex.org/I4210086300"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011893599","display_name":"Yoshimasa Takahashi","orcid":"https://orcid.org/0000-0001-6342-4087","observed_orcids":["https://orcid.org/0000-0001-6342-4087"]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshimasa Takahashi","raw_affiliation_strings":["Department of Immunology, National Institute of Infectious Diseases , Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, National Institute of Infectious Diseases , Tokyo, Japan","institution_ids":["https://openalex.org/I4210086300"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005679572","https://openalex.org/A5011893599"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210086300"],"apc_list":{"value":3530,"currency":"USD","value_usd":3530},"apc_paid":null,"fwci":0.1458,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.19342291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"32","issue":"9","first_page":"605","last_page":"611"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-virus","display_name":"influenza virus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hemagglutinin","display_name":"hemagglutinin","score":0.9509999752044678},{"id":"https://openalex.org/keywords/conserved-epitopes","display_name":"conserved epitopes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/b-cell-response","display_name":"B cell response","score":0.6489999890327454},{"id":"https://openalex.org/keywords/b-cell-repertoire","display_name":"B cell receptor repertoire","score":0.6769999861717224},{"id":"https://openalex.org/keywords/steric-hindrance","display_name":"steric hindrance","score":0.824999988079071},{"id":"https://openalex.org/keywords/antigenic-variation","display_name":"antigenic variation","score":0.753000020980835},{"id":"https://openalex.org/keywords/universal-influenza-vaccine","display_name":"universal influenza vaccine","score":0.7540000081062317},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.4490000009536743},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5765498876571655},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32099735736846924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2772965431213379}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/intimm/dxaa028","doi":"https://doi.org/10.1093/intimm/dxaa028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/intimm/dxaa028","pdf_url":"https://academic.oup.com/intimm/article-pdf/32/9/605/33725488/dxaa028.pdf","source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7478158","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7478158","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int Immunol","raw_type":"Text"},{"id":"pmid:32304215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32304215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/intimm/dxaa028","doi":"https://doi.org/10.1093/intimm/dxaa028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/intimm/dxaa028","pdf_url":"https://academic.oup.com/intimm/article-pdf/32/9/605/33725488/dxaa028.pdf","source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1199578201","display_name":"Immunity to novel T/F SHIVs: variability in the co-evolution of virus and host immunity","funder_award_id":"R01AI128832","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2205724335","display_name":"Understanding the development and protective mechanism of broadly reactive influenza antibody","funder_award_id":"20K07545","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4585411555","display_name":"Cross-protective antibody response in the lungs upon influenza virus infection","funder_award_id":"19K17656","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5859158","display_name":"Modeling affinity maturation at molecular resolution","funder_award_id":"U19AI117892","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000028040","display_name":null,"funder_award_id":"AI089618","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000337902","display_name":null,"funder_award_id":"AI117892","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000871150","display_name":"Structure-function analysis of infection- and vaccine-induced B-cell repertoires","funder_award_id":"P01AI089618","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3017312411.pdf","grobid_xml":"https://content.openalex.org/works/W3017312411.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1539973467","https://openalex.org/W1603729648","https://openalex.org/W1816587284","https://openalex.org/W1907177142","https://openalex.org/W1982289564","https://openalex.org/W1983188536","https://openalex.org/W1993833167","https://openalex.org/W1995510727","https://openalex.org/W1996967283","https://openalex.org/W2001089308","https://openalex.org/W2002632348","https://openalex.org/W2003687800","https://openalex.org/W2011136801","https://openalex.org/W2023388704","https://openalex.org/W2030816309","https://openalex.org/W2031263707","https://openalex.org/W2039239800","https://openalex.org/W2054583440","https://openalex.org/W2062166667","https://openalex.org/W2072040171","https://openalex.org/W2074712481","https://openalex.org/W2076198413","https://openalex.org/W2076747220","https://openalex.org/W2077219861","https://openalex.org/W2079633218","https://openalex.org/W2080330697","https://openalex.org/W2084313663","https://openalex.org/W2094225605","https://openalex.org/W2099576461","https://openalex.org/W2100761378","https://openalex.org/W2105225614","https://openalex.org/W2106088492","https://openalex.org/W2123708888","https://openalex.org/W2127132484","https://openalex.org/W2129138941","https://openalex.org/W2129973151","https://openalex.org/W2130737480","https://openalex.org/W2138216198","https://openalex.org/W2141848036","https://openalex.org/W2142174337","https://openalex.org/W2152617913","https://openalex.org/W2157411488","https://openalex.org/W2159149406","https://openalex.org/W2161738112","https://openalex.org/W2162922414","https://openalex.org/W2163135112","https://openalex.org/W2166834008","https://openalex.org/W2280670021","https://openalex.org/W2289890884","https://openalex.org/W2419025528","https://openalex.org/W2491163602","https://openalex.org/W2491683774","https://openalex.org/W2530723325","https://openalex.org/W2551492487","https://openalex.org/W2588357611","https://openalex.org/W2728375678","https://openalex.org/W2775569101","https://openalex.org/W2777807953","https://openalex.org/W2782903037","https://openalex.org/W2789822082","https://openalex.org/W2792009592","https://openalex.org/W2902442004","https://openalex.org/W2902472115","https://openalex.org/W2911608593","https://openalex.org/W2945681432","https://openalex.org/W2945949699","https://openalex.org/W2945953636","https://openalex.org/W2946776468","https://openalex.org/W2971256066","https://openalex.org/W2983035180","https://openalex.org/W2984500766","https://openalex.org/W3006321527","https://openalex.org/W3144283197","https://openalex.org/W4230654908","https://openalex.org/W4251633039"],"related_works":["https://openalex.org/W2409741120","https://openalex.org/W4391657190","https://openalex.org/W4321238617","https://openalex.org/W4200403158","https://openalex.org/W2060686951","https://openalex.org/W2676284908","https://openalex.org/W7208726368","https://openalex.org/W2777807953","https://openalex.org/W2945953636","https://openalex.org/W3034962194"],"abstract_inverted_index":{"Influenza":[0],"virus":[1,83],"constantly":[2],"acquires":[3],"genetic":[4],"mutations/reassortment":[5],"in":[6,14,56,117,138],"the":[7,15,43,82,90,96,105,109,118,121,130,139,152,175],"major":[8],"surface":[9],"protein,":[10],"hemagglutinin":[11],"(HA),":[12],"resulting":[13],"generation":[16],"of":[17,120,156,177],"strains":[18],"with":[19,78,171],"antigenic":[20],"variations.":[21],"There":[22],"are,":[23],"however,":[24,70],"HA":[25,76,133],"epitopes":[26,55,107,134],"that":[27,135,162],"are":[28,34,71,136,143],"conserved":[29,54,97,106],"across":[30],"influenza":[31,45,64,179],"viruses":[32],"and":[33,154,160],"targeted":[35,144],"by":[36,75,112,145],"broadly":[37,146,157],"protective":[38,67,147,158],"antibodies.":[39,148],"A":[40],"goal":[41],"for":[42,174],"next-generation":[44],"vaccines":[46],"is":[47,102],"to":[48,58,87,95,103,132,166],"stimulate":[49],"B-cell":[50,110,123],"responses":[51,93],"against":[52,62],"such":[53,100],"order":[57],"provide":[59],"broad":[60],"protection":[61],"divergent":[63],"viruses.":[65],"Broadly":[66],"B":[68,164],"cells,":[69],"not":[72],"easily":[73],"activated":[74],"antigens":[77],"native":[79,140],"structure,":[80],"because":[81],"has":[84,128],"multiple":[85],"strategies":[86,161],"escape":[88],"from":[89,108],"humoral":[91],"immune":[92],"directed":[94],"epitopes.":[98],"One":[99],"strategy":[101],"hide":[104],"surveillance":[111],"steric":[113],"hindrance.":[114],"Technical":[115],"advancement":[116],"analysis":[119],"human":[122],"antigen":[124],"receptor":[125],"(BCR)":[126],"repertoire":[127],"dissected":[129],"BCRs":[131],"hidden":[137,169],"structure":[141],"but":[142],"We":[149],"describe":[150],"here":[151],"characterization":[153],"function":[155],"antibodies":[159],"enable":[163],"cells":[165],"seek":[167],"these":[168],"epitopes,":[170],"potential":[172],"implications":[173],"development":[176],"universal":[178],"vaccines.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-04-24T00:00:00"}
