{"id":"https://openalex.org/W3017119097","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.02441","title":"Structure\u2010Activity Relationships of a Negative Allosteric Modulator of the D3 Dopamine Receptor and Investigation of its Binding Site","display_name":"Structure\u2010Activity Relationships of a Negative Allosteric Modulator of the D3 Dopamine Receptor and Investigation of its Binding Site","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3017119097","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.02441","mag":"3017119097"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2020.34.s1.02441","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.02441","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.02441","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028024335","display_name":"Amy E. Moritz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy E. Moritz","raw_affiliation_strings":["NINDS, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NINDS, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060032204","display_name":"Laura R. Inbody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura R. Inbody","raw_affiliation_strings":["NINDS, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NINDS, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040606659","display_name":"Disha M. Gandhi","orcid":"https://orcid.org/0000-0001-5446-8942","observed_orcids":["https://orcid.org/0000-0001-5446-8942"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Disha M. Gandhi","raw_affiliation_strings":["UNC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109993761","display_name":"Emmanuel Oladele Akano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel Akano","raw_affiliation_strings":["NINDS, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NINDS, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068763370","display_name":"Chelesa Fearce","orcid":"https://orcid.org/0000-0001-6372-8531","observed_orcids":["https://orcid.org/0000-0001-6372-8531"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chelesa Fearce","raw_affiliation_strings":["NINDS, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NINDS, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034202004","display_name":"R. Benjamin Free","orcid":"https://orcid.org/0000-0002-2428-0487","observed_orcids":["https://orcid.org/0000-0002-2428-0487"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Benjamin Free","raw_affiliation_strings":["NINDS, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NINDS, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070625220","display_name":"Elena S. Barnaeva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena S. Barnaeva","raw_affiliation_strings":["NCATS, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCATS, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012929232","display_name":"Xin Hu","orcid":"https://orcid.org/0009-0002-6933-4917","observed_orcids":["https://orcid.org/0009-0002-6933-4917","https://orcid.org/0000-0002-3919-870X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Hu","raw_affiliation_strings":["NCATS, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCATS, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036261394","display_name":"Noel T Southall","orcid":"https://orcid.org/0000-0003-4500-880X","observed_orcids":["https://orcid.org/0000-0003-4500-880X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noel T. Southall","raw_affiliation_strings":["NCATS, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCATS, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002699549","display_name":"Marc Ferrer","orcid":"https://orcid.org/0000-0003-4569-9137","observed_orcids":["https://orcid.org/0000-0003-4569-9137"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Ferrer","raw_affiliation_strings":["NCATS, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCATS, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067184628","display_name":"Thomas M. Keck","orcid":"https://orcid.org/0000-0003-1845-9373","observed_orcids":["https://orcid.org/0000-0003-1845-9373"]},"institutions":[{"id":"https://openalex.org/I44265643","display_name":"Rowan University","ror":"https://ror.org/049v69k10","country_code":"US","type":"education","lineage":["https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Keck","raw_affiliation_strings":["Rowan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rowan University","institution_ids":["https://openalex.org/I44265643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087938892","display_name":"Kevin J. Frankowski","orcid":"https://orcid.org/0000-0002-7173-6352","observed_orcids":["https://orcid.org/0000-0002-7173-6352"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin J. Frankowski","raw_affiliation_strings":["UNC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076880355","display_name":"David R. Sibley","orcid":"https://orcid.org/0000-0002-0624-962X","observed_orcids":["https://orcid.org/0000-0002-0624-962X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Sibley","raw_affiliation_strings":["NINDS, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NINDS, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"S1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/negative-allosteric-modulators","display_name":"negative allosteric modulators","score":0.9100000262260437},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9470000267028809},{"id":"https://openalex.org/keywords/allosteric-site","display_name":"allosteric site","score":0.8730000257492065},{"id":"https://openalex.org/keywords/noncompetitive-antagonism","display_name":"non-competitive antagonism","score":0.6940000057220459},{"id":"https://openalex.org/keywords/schild-analysis","display_name":"Schild analysis","score":0.6190000176429749},{"id":"https://openalex.org/keywords/beta-arrestin-recruitment","display_name":"\u03b2-arrestin recruitment","score":0.75},{"id":"https://openalex.org/keywords/g-protein-activation","display_name":"G protein activation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.6990000009536743},{"id":"https://openalex.org/keywords/dopamine-receptor-antagonists","display_name":"dopamine antagonists","score":0.6230000257492065},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.4429999887943268},{"id":"https://openalex.org/keywords/substance-use-disorders","display_name":"substance use disorders","score":0.9639999866485596},{"id":"https://openalex.org/keywords/ligand-optimization","display_name":"ligand optimization","score":0.4429999887943268},{"id":"https://openalex.org/keywords/radioligand-binding","display_name":"radioligand binding","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.7973198890686035},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.6959270238876343},{"id":"https://openalex.org/C199596767","wikidata":"https://www.wikidata.org/wiki/Q21110872","display_name":"Dopamine receptor D3","level":4,"score":0.6774473190307617},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.552085280418396},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5446128845214844},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.516653835773468},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.48901447653770447},{"id":"https://openalex.org/C43587935","wikidata":"https://www.wikidata.org/wiki/Q1258877","display_name":"Functional selectivity","level":4,"score":0.45215392112731934},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43818220496177673},{"id":"https://openalex.org/C67847695","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand","level":3,"score":0.4291744530200958},{"id":"https://openalex.org/C2776743251","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Ventral striatum","level":4,"score":0.4180796146392822},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38494783639907837},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3546847105026245},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3453825116157532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30132412910461426},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1344844400882721}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2020.34.s1.02441","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.02441","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.02441","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3175205722","https://openalex.org/W4377029261","https://openalex.org/W4396850143","https://openalex.org/W1547576768","https://openalex.org/W4389008357","https://openalex.org/W4389023068","https://openalex.org/W1748705758","https://openalex.org/W2897245227","https://openalex.org/W2180561897","https://openalex.org/W2735454576"],"abstract_inverted_index":{"Dopamine":[0],"receptors":[1,6],"(DARs)":[2],"are":[3,21,42,67,308],"G":[4],"protein\u2010coupled":[5],"(GPCRs)":[7],"that":[8,163,221,251,265,307],"regulate":[9],"diverse":[10],"physiological":[11],"functions":[12],"including":[13,32,234],"movement,":[14,89],"cognition,":[15],"mood,":[16],"and":[17,20,38,48,54,60,106,146,237,243,287,296],"reward\u2010related":[18],"behaviors,":[19],"involved":[22],"in":[23,83,230],"the":[24,78,84,90,102,129,144,176,179,192,201,225,228,275,301,315,321,325,342],"treatment":[25],"or":[26,50,116,124,365,372],"etiology":[27],"of":[28,64,104,139,175,191,200,274,281,300,341,359],"many":[29,74],"neuropsychiatric":[30],"disorders":[31],"schizophrenia,":[33],"substance":[34],"use":[35],"disorder":[36],"(SUD),":[37],"Parkinson\u2019s":[39],"disease.":[40],"DARs":[41,66],"classified":[43],"as":[44,70,114,119,361],"either":[45],"D1\u2010like":[46],"(D1R":[47],"D5R)":[49],"D2\u2010like":[51,65],"(D2R,":[52],"D3R,":[53,193,326],"D4R)":[55],"based":[56],"on":[57,324],"structural":[58],"homology":[59,155],"pharmacological":[61,363],"properties.":[62],"Antagonists":[63],"currently":[68],"used":[69],"drug":[71,125],"therapies":[72],"for":[73,143,224,290,336,345,368],"psychiatric":[75],"disorders.":[76],"While":[77],"D2R":[79,147,229],"is":[80,267],"highly":[81,183,187],"expressed":[82],"dorsal":[85],"striatum,":[86],"which":[87,292,331],"regulates":[88],"D3R":[91,145,226],"has":[92,148,253],"a":[93,170,197,211,268,362],"more":[94,312],"limited":[95,255],"distribution":[96],"to":[97,152,181,310],"limbic":[98],"regions":[99,334],"associated":[100],"with":[101,169,257],"control":[103],"mood":[105],"emotion.":[107],"D3R\u2010selective":[108],"antagonists":[109,190],"may":[110,357],"therefore":[111],"be":[112,182,358],"useful":[113],"schizophrenia":[115],"SUD":[117],"therapeutics":[118],"they":[120],"could":[121],"attenuate":[122],"psychotic":[123],"craving":[126],"symptoms":[127],"without":[128],"motor":[130],"side":[131],"effects":[132],"frequently":[133],"produced":[134,305],"by":[135],"D2R\u2010preferring":[136],"antagonists.":[137],"Discovery":[138],"subtype":[140],"selective":[141,188,223],"compounds":[142,162],"been":[149],"challenging":[150],"due":[151],"high":[153],"sequence":[154],"within":[156],"their":[157],"orthosteric":[158],"binding":[159,242,343],"sites.":[160],"However,":[161],"modulate":[164],"receptor":[165,177,333],"activity":[166,291],"through":[167],"interactions":[168],"less":[171],"conserved":[172],"allosteric":[173,189,272,322],"site":[174,323],"have":[178],"potential":[180],"selective.":[184],"To":[185,319],"find":[186],"our":[194],"lab":[195],"utilized":[196,328],"high\u2010throughput":[198],"screen":[199],"NIH":[202],"Molecular":[203],"Libraries":[204],"Program":[205,378],"400,000+":[206],"small":[207],"molecule":[208],"library":[209],"using":[210,246,283],"D3R\u2010mediated":[212],"\u03b2\u2010arrestin":[213,235],"recruitment":[214,236],"assay.":[215],"We":[216,277],"found":[217,264],"one":[218],"compound,":[219],"MLS6357,":[220],"was":[222],"versus":[227],"several":[231],"functional":[232,244,262],"outputs":[233],"G\u2010protein":[238],"activation.":[239],"Further,":[240],"radioligand":[241],"assays":[245,263],"closely":[247],"related":[248],"GPCRs":[249],"revealed":[250,293,332],"MLS6357":[252,266,282,346],"very":[254],"cross\u2010reactivity":[256],"other":[258],"GPCRs.":[259],"Additionally,":[260],"Schild\u2010type":[261],"purely":[269],"non\u2010competitive":[270],"negative":[271],"modulator":[273],"D3R.":[276],"synthesized":[278],"46":[279],"analogs":[280],"iterative":[284],"medicinal":[285,350],"chemistry":[286,351],"tested":[288],"them":[289],"structure":[294],"activity\u2010relationships":[295],"enabled":[297],"further":[298],"refinement":[299,340],"scaffold.":[302],"These":[303],"efforts":[304],"modulators":[306],"5\u2010":[309],"9\u2010fold":[311],"potent":[313],"than":[314],"original":[316],"hit":[317],"compound.":[318],"identify":[320],"we":[327],"D3R/D2R":[329],"chimeras":[330],"necessary":[335],"compound":[337],"efficacy.":[338],"Further":[339],"pocket":[344],"will":[347],"inform":[348],"future":[349],"efforts.":[352],"Ultimately,":[353],"this":[354],"novel":[355],"scaffold":[356],"benefit":[360],"probe":[364],"therapeutic":[366],"lead":[367],"D3R\u2010related":[369],"pathophysiology.":[370],"Support":[371],"Funding":[373],"Information":[374],"NINDS":[375],"Intramural":[376],"Research":[377]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-04-24T00:00:00"}
