{"id":"https://openalex.org/W3017096941","doi":"https://doi.org/10.1038/s41598-020-62341-z","title":"Serum albumin cysteine trioxidation is a potential oxidative stress biomarker of type 2 diabetes mellitus","display_name":"Serum albumin cysteine trioxidation is a potential oxidative stress biomarker of type 2 diabetes mellitus","publication_year":2020,"publication_date":"2020-04-15","ids":{"openalex":"https://openalex.org/W3017096941","doi":"https://doi.org/10.1038/s41598-020-62341-z","mag":"3017096941","pmid":"https://pubmed.ncbi.nlm.nih.gov/32296090","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7160123"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-62341-z","doi":"https://doi.org/10.1038/s41598-020-62341-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-62341-z","pdf_url":"https://www.nature.com/articles/s41598-020-62341-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-62341-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042961817","display_name":"Selvam Paramasivan","orcid":"https://orcid.org/0000-0002-3658-4760","observed_orcids":["https://orcid.org/0000-0002-3658-4760"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Selvam Paramasivan","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058972430","display_name":"Sunil S. Adav","orcid":"https://orcid.org/0000-0002-8559-4885","observed_orcids":["https://orcid.org/0000-0002-8559-4885"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Sunil S. Adav","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049871390","display_name":"SoFong Cam Ngan","orcid":"https://orcid.org/0000-0002-1833-2746","observed_orcids":["https://orcid.org/0000-0002-1833-2746"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"SoFong Cam Ngan","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021018741","display_name":"Rinkoo Dalan","orcid":"https://orcid.org/0000-0001-9769-2696","observed_orcids":["https://orcid.org/0000-0001-9769-2696"]},"institutions":[{"id":"https://openalex.org/I2802408685","display_name":"Tan Tock Seng Hospital","ror":"https://ror.org/032d59j24","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802408685"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Rinkoo Dalan","raw_affiliation_strings":["Department of Endocrinology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore","institution_ids":["https://openalex.org/I2802408685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068939958","display_name":"Melvin Khee\u2010Shing Leow","orcid":"https://orcid.org/0000-0002-2837-5889","observed_orcids":["https://orcid.org/0000-0002-2837-5889"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I2802408685","display_name":"Tan Tock Seng Hospital","ror":"https://ror.org/032d59j24","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802408685"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Melvin Khee-Shing Leow","raw_affiliation_strings":["Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore","Department of Endocrinology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Department of Endocrinology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore","institution_ids":["https://openalex.org/I2802408685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088696701","display_name":"Hee Hwa Ho","orcid":"https://orcid.org/0000-0002-5729-237X","observed_orcids":["https://orcid.org/0000-0002-5729-237X"]},"institutions":[{"id":"https://openalex.org/I2802408685","display_name":"Tan Tock Seng Hospital","ror":"https://ror.org/032d59j24","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802408685"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Hee Hwa Ho","raw_affiliation_strings":["Department of Cardiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore","institution_ids":["https://openalex.org/I2802408685"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080599304","display_name":"Siu Kwan Sze","orcid":"https://orcid.org/0000-0002-5652-1687","observed_orcids":["https://orcid.org/0000-0002-5652-1687"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Siu Kwan Sze","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore. sksze@ntu.edu.sg","School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore. sksze@ntu.edu.sg","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore","institution_ids":["https://openalex.org/I172675005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5080599304"],"corresponding_institution_ids":["https://openalex.org/I172675005"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":1.8581,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.86277195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"6475","last_page":"6475"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.03750000149011612,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6949999928474426},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/thiol-oxidation","display_name":"thiol oxidation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/oxidative-stress-biomarkers","display_name":"oxidative stress biomarkers","score":0.6129999756813049},{"id":"https://openalex.org/keywords/plasma-proteomics","display_name":"plasma proteomics","score":0.597000002861023},{"id":"https://openalex.org/keywords/early-diagnosis-of-diabetes","display_name":"early detection of diabetes","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7783983945846558},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6859936118125916},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6022790670394897},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.580633282661438},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5336312651634216},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5053282380104065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42089059948921204},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.41332292556762695},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3729335367679596},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3190074563026428},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27909529209136963},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25982746481895447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23499968647956848}],"mesh":[{"descriptor_ui":"D000075462","descriptor_name":"Serum Albumin, Human","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000075462","descriptor_name":"Serum Albumin, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000075462","descriptor_name":"Serum Albumin, Human","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-020-62341-z","doi":"https://doi.org/10.1038/s41598-020-62341-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-62341-z","pdf_url":"https://www.nature.com/articles/s41598-020-62341-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7160123","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7160123","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:32296090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32296090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/177321","doi":null,"is_oa":false,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/177321","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/146114","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10356/146114","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-62341-z","doi":"https://doi.org/10.1038/s41598-020-62341-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-62341-z","pdf_url":"https://www.nature.com/articles/s41598-020-62341-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1902124312","display_name":null,"funder_award_id":"OF-IRG-0003-2016","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"},{"id":"https://openalex.org/G2099710928","display_name":null,"funder_award_id":"NMRC\u2010OF\u2010IRG\u20100003\u20102016","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"},{"id":"https://openalex.org/G3410964475","display_name":null,"funder_award_id":"MOE2016-T2-2-018","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G5483765398","display_name":null,"funder_award_id":"IRG-0003-2016","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320320751","display_name":"Ministry of Education - Singapore","ror":"https://ror.org/01kcva023"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3017096941.pdf","grobid_xml":"https://content.openalex.org/works/W3017096941.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1504792186","https://openalex.org/W1965336681","https://openalex.org/W1968138979","https://openalex.org/W1970463993","https://openalex.org/W1972418851","https://openalex.org/W1974332498","https://openalex.org/W1998643708","https://openalex.org/W2007790334","https://openalex.org/W2022273685","https://openalex.org/W2023161542","https://openalex.org/W2026841676","https://openalex.org/W2031985670","https://openalex.org/W2038607344","https://openalex.org/W2055694299","https://openalex.org/W2059467226","https://openalex.org/W2065326103","https://openalex.org/W2093736091","https://openalex.org/W2110664743","https://openalex.org/W2111326316","https://openalex.org/W2113229974","https://openalex.org/W2115511703","https://openalex.org/W2120631754","https://openalex.org/W2123560318","https://openalex.org/W2130811027","https://openalex.org/W2134551390","https://openalex.org/W2135326009","https://openalex.org/W2141091417","https://openalex.org/W2155704907","https://openalex.org/W2166361259","https://openalex.org/W2232919038","https://openalex.org/W2262268009","https://openalex.org/W2281026626","https://openalex.org/W2298958423","https://openalex.org/W2330731414","https://openalex.org/W2528857580","https://openalex.org/W2549002657","https://openalex.org/W2616009730","https://openalex.org/W2629129934","https://openalex.org/W2752317246"],"related_works":["https://openalex.org/W4396573948","https://openalex.org/W2185281655","https://openalex.org/W7139981945","https://openalex.org/W2326408680","https://openalex.org/W41825302","https://openalex.org/W131590133","https://openalex.org/W7165905794","https://openalex.org/W4289109869","https://openalex.org/W3156018043","https://openalex.org/W2114931400"],"abstract_inverted_index":{"Abstract":[0],"Metabolic":[1],"disorders":[2],"in":[3,49,142,193,213,215,232],"T2DM":[4,68],"generate":[5],"multiple":[6,163],"sources":[7],"of":[8,53,98,103,146,170,203,218,229],"free":[9],"radicals":[10],"and":[11,28,31,69,115,125,138,152,178,189,226],"oxidative":[12,47,91,230],"stress":[13,92,231],"that":[14,75,119,200],"accelerate":[15],"nonenzymatic":[16],"degenerative":[17],"protein":[18,23],"modifications":[19],"(DPMs)":[20],"such":[21],"as":[22],"oxidation,":[24],"disrupt":[25],"redox":[26],"signaling":[27],"physiological":[29],"function,":[30],"remain":[32],"a":[33,89,113,201],"major":[34],"risk":[35],"factor":[36],"for":[37,94],"clinical":[38],"diabetic":[39],"vascular":[40],"complications.":[41],"In":[42],"order":[43],"to":[44,61,123],"identify":[45],"potential":[46,90,227],"biomarkers":[48,228],"the":[50,95,171,216],"blood":[51],"plasma":[52,63,217],"patients":[54,66,219],"with":[55,67,154,173,181,195,220],"T2DM,":[56,221],"we":[57,111],"used":[58,122],"LC-MS/MS-based":[59],"proteomics":[60],"profile":[62],"samples":[64,145],"from":[65],"healthy":[70,147],"controls.":[71],"The":[72,100,197],"results":[73,198],"showed":[74],"human":[76],"serum":[77],"albumin":[78],"(HSA)":[79],"is":[80,107],"damaged":[81,212],"by":[82],"irreversible":[83],"cysteine":[84],"trioxidation,":[85],"which":[86,208],"can":[87,222],"be":[88,223],"biomarker":[93],"early":[96],"diagnosis":[97],"T2DM.":[99,233],"quantitative":[101,160],"detection":[102],"site-specific":[104],"thiol":[105],"trioxidation":[106],"technically":[108],"challenging;":[109],"thus,":[110],"developed":[112],"sensitive":[114],"selective":[116],"LC-MS/MS":[117],"workflow":[118],"has":[120],"been":[121],"discover":[124],"quantify":[126],"three":[127,204],"unique":[128],"thiol-trioxidized":[129,206],"HSA":[130,205,214],"peptides,":[131,207],"ALVLIAFAQYLQQC(SO3H)PFEDHVK":[132],"(m/z":[133,136,140],"1241.13),":[134],"YIC(SO3H)ENQDSISSK":[135],"717.80)":[137],"RPC(SO3H)FSALEVDETYVPK":[139],"951.45),":[141],"16":[143],"individual":[144],"controls":[148],"(n":[149,156],"=":[150,157],"8)":[151],"individuals":[153,194],"diabetes":[155],"8).":[158],"Targeted":[159],"analysis":[161],"using":[162],"reaction":[164],"monitoring":[165],"mass":[166],"spectrometry":[167],"revealed":[168],"impairment":[169],"peptides":[172],"m/z":[174,176,179],"1241.13,":[175],"717.80":[177],"951.45,":[180],"significance":[182],"(P":[183],"<":[184,187,191],"0.02,":[185],"P":[186,190],"0.002":[188],"0.03),":[192],"diabetes.":[196],"demonstrated":[199],"set":[202],"are":[209],"irreversibly":[210],"oxidatively":[211],"important":[224],"indicators":[225]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-04-24T00:00:00"}
