{"id":"https://openalex.org/W3017092002","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.04578","title":"Upregulation of Inflammatory Biomarkers in Pulmonary Embolism as Studied by a Biochip\u2010Array Profiling Approach","display_name":"Upregulation of Inflammatory Biomarkers in Pulmonary Embolism as Studied by a Biochip\u2010Array Profiling Approach","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3017092002","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.04578","mag":"3017092002"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2020.34.s1.04578","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.04578","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.04578","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045440264","display_name":"Emily Bontekoe","orcid":"https://orcid.org/0000-0002-0880-1721","observed_orcids":["https://orcid.org/0000-0002-0880-1721"]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Bontekoe","raw_affiliation_strings":["Loyola University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center","institution_ids":["https://openalex.org/I1304196042"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eugene Brailovsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene Brailovsky","raw_affiliation_strings":["Loyola University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center","institution_ids":["https://openalex.org/I1304196042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064983817","display_name":"Debra Hoppensteadt","orcid":"https://orcid.org/0000-0001-9342-4213","observed_orcids":["https://orcid.org/0000-0001-9342-4213"]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra Hoppensteadt","raw_affiliation_strings":["Loyola University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center","institution_ids":["https://openalex.org/I1304196042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002339847","display_name":"Fakiha Siddiqui","orcid":"https://orcid.org/0000-0002-2219-7049","observed_orcids":["https://orcid.org/0000-0002-2219-7049"]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fakiha Siddiqui","raw_affiliation_strings":["Loyola University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center","institution_ids":["https://openalex.org/I1304196042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061104873","display_name":"Ambar Farooqui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ambar Farooqui","raw_affiliation_strings":["Loyola University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center","institution_ids":["https://openalex.org/I1304196042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034121067","display_name":"Omer Iqbal","orcid":"https://orcid.org/0000-0002-0791-6957","observed_orcids":["https://orcid.org/0000-0002-0791-6957"]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omer Iqbal","raw_affiliation_strings":["Loyola University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center","institution_ids":["https://openalex.org/I1304196042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007859032","display_name":"Jawed Fareed","orcid":"https://orcid.org/0000-0003-3465-2499","observed_orcids":["https://orcid.org/0000-0003-3465-2499"]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jawed Fareed","raw_affiliation_strings":["Loyola University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center","institution_ids":["https://openalex.org/I1304196042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045481977","display_name":"Amir Darki","orcid":"https://orcid.org/0000-0003-0144-1804","observed_orcids":["https://orcid.org/0000-0003-0144-1804"]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amir Darki","raw_affiliation_strings":["Loyola University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center","institution_ids":["https://openalex.org/I1304196042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1304196042"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"S1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-embolism","display_name":"pulmonary embolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6499999761581421},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8870000243186951},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.996999979019165},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7149999737739563},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.859000027179718},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.9169999957084656},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7689999938011169},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8759999871253967},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7252687215805054},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.5777082443237305},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5215044617652893},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5095882415771484},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4684945046901703},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4631694257259369},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4538217782974243},{"id":"https://openalex.org/C2776265017","wikidata":"https://www.wikidata.org/wiki/Q220570","display_name":"Pulmonary embolism","level":2,"score":0.4340091347694397},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4227096438407898},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4155055582523346},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.414126992225647},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37486982345581055},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34007179737091064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.131393700838089},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.08100739121437073},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2020.34.s1.04578","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.04578","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.04578","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3160387413","https://openalex.org/W4417021025","https://openalex.org/W3145173078","https://openalex.org/W4380677223","https://openalex.org/W4205510049","https://openalex.org/W4310120301","https://openalex.org/W4417013946","https://openalex.org/W3093466857","https://openalex.org/W4415600375","https://openalex.org/W4286863991"],"abstract_inverted_index":{"Introduction":[0],"The":[1,30,99,205,219,238],"incidence":[2],"of":[3,18,32,60,101,108,233,235,321,359,366,373,404,426,438],"Pulmonary":[4],"embolism":[5],"(PE)":[6],"is":[7,21,34,104,361],"estimated":[8],"to":[9,12,55,76,105,257,312],"be":[10],"60":[11],"70":[13],"per":[14,23],"100,000,":[15],"and":[16,40,47,58,71,123,145,200,249,297,329,378],"that":[17,356,422],"venous":[19],"thrombosis":[20],"125":[22],"100,000":[24],"cases,":[25],"in":[26,91,111,137,263,303,307,310,317,337,347,370,415,434],"the":[27,38,56,66,77,112,231,258,304,313,318,338,343,357,364,371,381,390,411,424,435],"general":[28],"population.":[29],"pathophysiology":[31,358],"PE":[33,239,308,360],"complex":[35],"including":[36],"both":[37],"systemic":[39],"localized":[41],"involvement.":[42],"Hemostatic":[43],"activation,":[44],"inflammatory":[45,109,367,386,412],"processes,":[46,387,428],"cellular":[48,73],"dysfunction,":[49],"along":[50,388],"with":[51,120,130,363,389],"hemodynamic":[52],"aberrations":[53],"contribute":[54,75],"progression":[57],"outcome":[59],"PE.":[61,121,439],"Inflammatory":[62],"mediators":[63,345],"such":[64,173,322],"as":[65,175,244,324],"interleukins,":[67],"oxidative":[68],"stress":[69],"molecules,":[70],"other":[72,391],"products":[74],"overall":[78,436],"pathophysiology.":[79],"Biochip\u2010array":[80],"technology":[81],"using":[82],"protein":[83,198],"chips":[84],"provides":[85,396],"an":[86,146,150,397,431],"integrated":[87,398],"high":[88],"throughput":[89],"approach":[90,399],"analyzing":[92],"blood":[93,114],"plasma":[94,126],"samples":[95,115,127,155,168,221],"for":[96,158,172,215,230,406,410],"multiple":[97],"parameters.":[98],"purpose":[100],"this":[102,348,416],"study":[103,349],"profile":[106,409],"biomarkers":[107,174,323],"processes":[110,368],"baseline":[113],"collected":[116,136],"from":[117,128,226],"patients":[118,129,309],"diagnosed":[119],"Materials":[122],"Methods":[124],"Blood":[125],"clinically":[131],"confirmed":[132],"diagnosis":[133],"(n=119)":[134],"were":[135,156,169,242,331],"citrated":[138],"tubes":[139],"at":[140,164],"Loyola":[141],"University":[142],"Medical":[143],"Center":[144],"affiliated":[147],"hospital":[148],"under":[149],"IRB":[151],"approved":[152],"protocol.":[153],"These":[154,167,353,418],"processed":[157],"platelet\u2010poor":[159],"plasma,":[160],"which":[161],"was":[162,213,252,350],"banked":[163],"\u221280":[165],"C.":[166],"retrospectively":[170],"analyzed":[171],"IL2,":[176],"IL4,":[177],"IL6,":[178,325,376],"IL8,":[179,326,377],"IL10,":[180],"vascular":[181],"endothelial":[182],"growth":[183,202],"factor":[184,191,203],"(VEGF),":[185],"gamma":[186],"interferon":[187],"(IFNG),":[188],"tumor":[189],"necrosis":[190],"a":[192,223,301,334,401,407],"(TNFa),":[193],"IL1a,":[194],"IL1b,":[195],"monocyte":[196],"chemotactic":[197],"(MCP1),":[199],"epidermal":[201],"(EGF).":[204],"Randox":[206,393],"Signature":[207],"System":[208],"(Crumlin,":[209],"North":[210],"Ireland,":[211],"UK)":[212],"used":[214],"profiling":[216],"these":[217,236],"markers.":[218],"control":[220],"represented":[222],"pool":[224],"prepared":[225],"healthy":[227],"normal":[228,259],"individuals":[229],"comparison":[232,256,311],"each":[234],"biomarkers.":[237,375,392],"patient":[240],"results":[241,354,419],"compiled":[243],"group":[245],"mean":[246],"\u00b1/\u2010":[247],"SD":[248],"fold":[250],"change":[251],"calculated.":[253],"Results":[254],"In":[255,291],"controls,":[260],"marked":[261],"increase":[262],"IL6":[264],"(53":[265],"fold),":[266,269,272,275,278,281,284,287],"IL8":[267],"(8":[268],"IL10":[270,379],"(6":[271],"VEGF":[273,330],"(0.9":[274,277],"TNFa":[276],"IL1a":[279],"(0.5":[280,286],"IL1b":[282],"(0.7":[283],"MCP1":[285],"EGF":[288],"(4":[289],"fold).":[290],"contrast,":[292],"IL2":[293],"(14%),":[294],"IL4":[295],"(3%),":[296],"IFNG":[298],"(25%)":[299],"showed":[300,380],"decrease":[302],"circulating":[305,319],"levels":[306,320],"controls.":[314],"Marked":[315],"variations":[316],"IL":[327],"10":[328],"evident":[332],"by":[333],"large":[335],"scatter":[336],"data.":[339],"No":[340],"correlation":[341],"between":[342],"individual":[344],"profiled":[346],"noted.":[351],"Discussion":[352],"demonstrate":[355],"associated":[362],"activation":[365,425],"resulting":[369],"upregulation":[372],"various":[374],"most":[382],"significant":[383],"increase,":[384],"reflecting":[385],"biochip\u2010array":[394],"biotechnology":[395],"utilizing":[400],"small":[402],"amount":[403],"sample":[405],"complete":[408],"cytokines":[413],"included":[414],"study.":[417],"clearly":[420],"suggest":[421],"aside":[423],"clotting":[427],"inflammation":[429],"plays":[430],"important":[432],"role":[433],"pathogenesis":[437]},"counts_by_year":[],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2020-04-24T00:00:00"}