{"id":"https://openalex.org/W3017048360","doi":"https://doi.org/10.1016/j.molmet.2020.100993","title":"A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion","display_name":"A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion","publication_year":2020,"publication_date":"2020-04-13","ids":{"openalex":"https://openalex.org/W3017048360","doi":"https://doi.org/10.1016/j.molmet.2020.100993","mag":"3017048360","pmid":"https://pubmed.ncbi.nlm.nih.gov/32298772","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7225740"},"language":"en","primary_location":{"id":"doi:10.1016/j.molmet.2020.100993","doi":"https://doi.org/10.1016/j.molmet.2020.100993","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmet.2020.100993","pdf_url":null,"source":{"id":"https://openalex.org/S2764545133","display_name":"Molecular Metabolism","issn_l":"2212-8778","issn":["2212-8778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.molmet.2020.100993","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044736400","display_name":"Dassine Berdous","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dassine Berdous","raw_affiliation_strings":["Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: dassine.berdous@unil.ch","Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: dassine.berdous@unil.ch","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065158949","display_name":"Xavier Pascal Berney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Xavier Berney","raw_affiliation_strings":["Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: xavierpascal.berney@unil.ch","Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: xavierpascal.berney@unil.ch","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013796467","display_name":"Ana Rodr\u00edguez S\u00e1nchez-Archidona","orcid":"https://orcid.org/0000-0001-6002-2779","observed_orcids":["https://orcid.org/0000-0001-6002-2779"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ana Rodriguez Sanchez-Archidona","raw_affiliation_strings":["Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland; Vital-IT, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland. Electronic address: ana.rodriguez.1@unil.ch","Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland","Vital-IT, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland; Vital-IT, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland. Electronic address: ana.rodriguez.1@unil.ch","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I97565354"]},{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Vital-IT, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076442826","display_name":"Maxime Jan","orcid":"https://orcid.org/0000-0001-6483-7430","observed_orcids":["https://orcid.org/0000-0001-6483-7430"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Maxime Jan","raw_affiliation_strings":["Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: maxime.jan@unil.ch","Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: maxime.jan@unil.ch","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054735671","display_name":"Clara Roujeau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Clara Roujeau","raw_affiliation_strings":["Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: clara.roujeau@unil.ch","Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: clara.roujeau@unil.ch","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015907930","display_name":"Isabel C. L\u00f3pez\u2010Mej\u00eda","orcid":"https://orcid.org/0000-0001-5918-0227","observed_orcids":["https://orcid.org/0000-0001-5918-0227"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Isabel C. Lopez-Mejia","raw_affiliation_strings":["Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: isabel.lopezmejia@unil.ch","Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-5918-0227","affiliations":[{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: isabel.lopezmejia@unil.ch","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008448236","display_name":"Randall L. Mynatt","orcid":"https://orcid.org/0000-0003-4399-0019","observed_orcids":["https://orcid.org/0000-0003-4399-0019"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall Mynatt","raw_affiliation_strings":["Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. Electronic address: Randall.Mynatt@pbrc.edu","Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. Electronic address: Randall.Mynatt@pbrc.edu","institution_ids":["https://openalex.org/I103990859"]},{"raw_affiliation_string":"Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079729308","display_name":"Bernard Thorens","orcid":"https://orcid.org/0000-0002-3738-0129","observed_orcids":["https://orcid.org/0000-0002-3738-0129"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Bernard Thorens","raw_affiliation_strings":["Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: Bernard.thorens@unil.ch","Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-3738-0129","affiliations":[{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: Bernard.thorens@unil.ch","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079729308"],"corresponding_institution_ids":["https://openalex.org/I97565354"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":{"value":2700,"currency":"USD","value_usd":2700},"fwci":0.6586,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.66861852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"37","issue":null,"first_page":"100993","last_page":"100993"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crat","display_name":"CRAT","score":0.9049999713897705},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.9860000014305115},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8159999847412109},{"id":"https://openalex.org/keywords/bxd-recombinant-inbred-strains","display_name":"BXD recombinant inbred mice","score":0.8949999809265137},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.8820000290870667},{"id":"https://openalex.org/keywords/islet-transcriptome","display_name":"islet transcriptome","score":0.7229999899864197},{"id":"https://openalex.org/keywords/insulin-content","display_name":"insulin content","score":0.7200000286102295},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.656000018119812},{"id":"https://openalex.org/keywords/exendin-4","display_name":"exendin-4","score":0.7620000243186951},{"id":"https://openalex.org/keywords/genetic-background","display_name":"genetic background","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.7147828340530396},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.6591922044754028},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6167710423469543},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5405747890472412},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5171467661857605},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5143402814865112},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42955976724624634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2898993492126465},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15100336074829102},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1390683650970459},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.11297294497489929}],"mesh":[{"descriptor_ui":"D000077270","descriptor_name":"Exenatide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002332","descriptor_name":"Carnitine O-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002332","descriptor_name":"Carnitine O-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.molmet.2020.100993","doi":"https://doi.org/10.1016/j.molmet.2020.100993","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmet.2020.100993","pdf_url":null,"source":{"id":"https://openalex.org/S2764545133","display_name":"Molecular Metabolism","issn_l":"2212-8778","issn":["2212-8778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7225740","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7225740/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7225740/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Metab","raw_type":"Text"},{"id":"pmid:32298772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32298772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:serval.unil.ch:BIB_E7C44B7C6874","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_E7C44B7C6874","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular metabolism, vol. 37, pp. 100993","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:9103d987d7864a2aba8fec731d2d5688","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9103d987d7864a2aba8fec731d2d5688","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Metabolism, Vol 37, Iss , Pp 100993- (2020)","raw_type":"article"},{"id":"pmh:oai:iris.unil.ch:iris/256870","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/256870","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1016/j.molmet.2020.100993","doi":"https://doi.org/10.1016/j.molmet.2020.100993","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmet.2020.100993","pdf_url":null,"source":{"id":"https://openalex.org/S2764545133","display_name":"Molecular Metabolism","issn_l":"2212-8778","issn":["2212-8778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4724302468","display_name":null,"funder_award_id":"16.0097","funder_id":"https://openalex.org/F4320320760","funder_display_name":"Singapore Eye Research Institute"},{"id":"https://openalex.org/G560916241","display_name":null,"funder_award_id":"115797]","funder_id":"https://openalex.org/F4320326631","funder_display_name":"Innovative Medicines Initiative"},{"id":"https://openalex.org/G6499055791","display_name":"Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes \u2013 Sofia ref.: 115797","funder_award_id":"115797","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6919409805","display_name":"Central glycemia detection, glucose homeostasis and feeding behavior","funder_award_id":"182496","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G7696965656","display_name":null,"funder_award_id":"115797","funder_id":"https://openalex.org/F4320314178","funder_display_name":"European Federation of Pharmaceutical Industries and Associations"},{"id":"https://openalex.org/G8041914798","display_name":null,"funder_award_id":"16.0097","funder_id":"https://openalex.org/F4320314178","funder_display_name":"European Federation of Pharmaceutical Industries and Associations"},{"id":"https://openalex.org/G8312218698","display_name":null,"funder_award_id":"115797","funder_id":"https://openalex.org/F4320309446","funder_display_name":"Leona M. and Harry B. Helmsley Charitable Trust"},{"id":"https://openalex.org/G8690818240","display_name":null,"funder_award_id":"310030","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G9000898112","display_name":"Louisiana Clinical and Translational Science Center","funder_award_id":"U54GM104940","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309446","display_name":"Leona M. and Harry B. Helmsley Charitable Trust","ror":"https://ror.org/011x6n313"},{"id":"https://openalex.org/F4320314178","display_name":"European Federation of Pharmaceutical Industries and Associations","ror":"https://ror.org/00g1x4v36"},{"id":"https://openalex.org/F4320314731","display_name":"UK Research and Innovation","ror":"https://ror.org/001aqnf71"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320760","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320323831","display_name":"Universit\u00e9 de Lausanne","ror":"https://ror.org/019whta54"},{"id":"https://openalex.org/F4320326631","display_name":"Innovative Medicines Initiative","ror":"https://ror.org/019af4n30"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3017048360.pdf","grobid_xml":"https://content.openalex.org/works/W3017048360.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W988102425","https://openalex.org/W1598254642","https://openalex.org/W1870996486","https://openalex.org/W1908991493","https://openalex.org/W1977274289","https://openalex.org/W1977303460","https://openalex.org/W1997229859","https://openalex.org/W1999697076","https://openalex.org/W2002094413","https://openalex.org/W2007056893","https://openalex.org/W2011267160","https://openalex.org/W2018384382","https://openalex.org/W2024692114","https://openalex.org/W2032487852","https://openalex.org/W2052345184","https://openalex.org/W2065070435","https://openalex.org/W2070332131","https://openalex.org/W2071510932","https://openalex.org/W2075001023","https://openalex.org/W2075186231","https://openalex.org/W2083370145","https://openalex.org/W2091676281","https://openalex.org/W2098412291","https://openalex.org/W2103951982","https://openalex.org/W2104382389","https://openalex.org/W2111341687","https://openalex.org/W2116053845","https://openalex.org/W2139651996","https://openalex.org/W2140049768","https://openalex.org/W2153392081","https://openalex.org/W2153791770","https://openalex.org/W2154652388","https://openalex.org/W2163179623","https://openalex.org/W2269815321","https://openalex.org/W2319307509","https://openalex.org/W2556766149","https://openalex.org/W2588250469","https://openalex.org/W2611238787","https://openalex.org/W2753133554","https://openalex.org/W2785725047","https://openalex.org/W2786903684","https://openalex.org/W2886338089","https://openalex.org/W2911703946","https://openalex.org/W2924729402","https://openalex.org/W2963589105","https://openalex.org/W3025274120"],"related_works":["https://openalex.org/W3110820719","https://openalex.org/W2149537558","https://openalex.org/W4205784257","https://openalex.org/W2580636203","https://openalex.org/W2767936662","https://openalex.org/W1987722712","https://openalex.org/W2153392081","https://openalex.org/W2040692229","https://openalex.org/W1989774085","https://openalex.org/W3173273151"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Glucose-stimulated":[1],"insulin":[2,53,68,182,192,195,203,228,267,279,308,316],"secretion":[3,69,107,148,183,196,206,268,309],"is":[4,17,271,311],"a":[5,29,161,176,224,255,264],"critical":[6],"function":[7],"in":[8,133,188,242,254,299],"the":[9,20,36,86,120,150,181,250,286,290,300,303,307,315],"regulation":[10],"of":[11,22,39,45,52,180,227,266,289,302],"glucose":[12,79,153,256],"homeostasis,":[13],"and":[14,55,67,95,109,136,140,194,205,246],"its":[15],"deregulation":[16],"associated":[18],"with":[19,80,111,142,213],"development":[21],"type":[23],"2":[24,163],"diabetes.":[25],"Here,":[26],"we":[27],"performed":[28,104,127],"genetic":[30,287],"screen":[31],"using":[32],"islets":[33,59,141,210,248],"isolated":[34,61],"from":[35,62,85,211],"BXD":[37,65],"panel":[38],"advanced":[40],"recombinant":[41],"inbred":[42],"(RI)":[43],"lines":[44,66,89],"mice":[46,139,212],"to":[47,74,114,160,219,232,314],"search":[48],"for":[49,92,105],"novel":[50],"regulators":[51],"production":[54],"secretion.":[56],"METHODS:":[57],"Pancreatic":[58],"were":[60,90,126,217],"36":[63],"RI":[64,88,291],"was":[70,103,157],"measured":[71],"following":[72],"exposure":[73],"2.8":[75],"or":[76,81,131],"16.7":[77,151],"mM":[78,152],"without":[82],"exendin-4.":[83],"Islets":[84],"same":[87],"used":[91,306],"RNA":[93],"extraction":[94],"transcript":[96],"profiling.":[97],"Quantitative":[98],"trait":[99],"loci":[100],"(QTL)":[101],"mapping":[102],"each":[106],"condition":[108,156],"combined":[110],"transcriptome":[112],"data":[113,169,295],"prioritize":[115],"candidate":[116,178],"regulatory":[117],"genes":[118],"within":[119],"identified":[121,261],"QTL":[122],"regions.":[123],"Functional":[124],"studies":[125],"by":[128,137,197,207,273],"mRNA":[129],"silencing":[130],"overexpression":[132,201],"MIN6B1":[134,189,244],"cells":[135,190,245],"studying":[138],"beta-cell-specific":[143,214],"gene":[144],"inactivation.":[145],"RESULTS:":[146],"Insulin":[147],"under":[149],"plus":[154],"exendin-4":[155],"mapped":[158],"significantly":[159],"chromosome":[162],"QTL.":[164],"Within":[165],"this":[166,281],"QTL,":[167],"RNA-Seq":[168],"prioritized":[170],"Crat":[171,186,200,215,240,262],"(carnitine":[172],"O-acetyl":[173],"transferase)":[174],"as":[175,230,263],"strong":[177],"regulator":[179,265],"trait.":[184],"Silencing":[185],"expression":[187,241],"reduced":[191,249],"content":[193,204,229],"\u223c30%.":[198,208],"Conversely,":[199],"enhanced":[202],"When":[209],"inactivation":[216],"exposed":[218],"high":[220],"glucose,":[221],"they":[222],"displayed":[223],"30%":[225],"reduction":[226],"compared":[231],"control":[233],"islets.":[234],"We":[235,260],"further":[236],"showed":[237],"that":[238,298],"decreased":[239],"both":[243],"pancreatic":[247],"oxygen":[251],"consumption":[252],"rate":[253,310],"concentration-dependent":[257],"manner.":[258],"CONCLUSIONS:":[259],"whose":[269],"action":[270],"mediated":[272],"an":[274],"effect":[275,282],"on":[276,285],"total":[277],"cellular":[278],"content;":[280],"also":[283,296],"depends":[284],"background":[288],"mouse":[292],"lines.":[293],"These":[294],"show":[297],"presence":[301],"stimulatory":[304],"conditions":[305],"directly":[312],"related":[313],"content.":[317]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-04-24T00:00:00"}