{"id":"https://openalex.org/W3017003095","doi":"https://doi.org/10.3233/jad-200061","title":"Blood Amyloid-\u03b2 Oligomerization as a Biomarker of Alzheimer\u2019s Disease: A Blinded Validation Study","display_name":"Blood Amyloid-\u03b2 Oligomerization as a Biomarker of Alzheimer\u2019s Disease: A Blinded Validation Study","publication_year":2020,"publication_date":"2020-04-14","ids":{"openalex":"https://openalex.org/W3017003095","doi":"https://doi.org/10.3233/jad-200061","mag":"3017003095","pmid":"https://pubmed.ncbi.nlm.nih.gov/32310175"},"language":"en","primary_location":{"id":"doi:10.3233/jad-200061","doi":"https://doi.org/10.3233/jad-200061","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-200061","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10572/latest.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012106415","display_name":"Young Chul Youn","orcid":"https://orcid.org/0000-0002-2742-1759","observed_orcids":["https://orcid.org/0000-0002-2742-1759"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Chul Youn","raw_affiliation_strings":["Chung-Ang University Hospital","Department of Neurology, Chung-Ang University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-2742-1759","affiliations":[{"raw_affiliation_string":"Chung-Ang University Hospital","institution_ids":["https://openalex.org/I4210153376"]},{"raw_affiliation_string":"Department of Neurology, Chung-Ang University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064736334","display_name":"Byoung Sub Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128252","display_name":"PeopleBio (South Korea)","ror":"https://ror.org/03gzkvf55","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210128252"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byoung Sub Lee","raw_affiliation_strings":["PeopleBio Inc","Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PeopleBio Inc","institution_ids":["https://openalex.org/I4210128252"]},{"raw_affiliation_string":"Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210128252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000689102","display_name":"Gwang Je Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128252","display_name":"PeopleBio (South Korea)","ror":"https://ror.org/03gzkvf55","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210128252"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gwang Je Kim","raw_affiliation_strings":["PeopleBio Inc","Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PeopleBio Inc","institution_ids":["https://openalex.org/I4210128252"]},{"raw_affiliation_string":"Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210128252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086228631","display_name":"Ji Sun Ryu","orcid":"https://orcid.org/0009-0004-8906-2837","observed_orcids":["https://orcid.org/0009-0004-8906-2837"]},"institutions":[{"id":"https://openalex.org/I4210128252","display_name":"PeopleBio (South Korea)","ror":"https://ror.org/03gzkvf55","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210128252"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Sun Ryu","raw_affiliation_strings":["PeopleBio Inc","Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PeopleBio Inc","institution_ids":["https://openalex.org/I4210128252"]},{"raw_affiliation_string":"Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210128252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057341999","display_name":"Kuntaek Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128252","display_name":"PeopleBio (South Korea)","ror":"https://ror.org/03gzkvf55","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210128252"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kuntaek Lim","raw_affiliation_strings":["PeopleBio Inc","Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PeopleBio Inc","institution_ids":["https://openalex.org/I4210128252"]},{"raw_affiliation_string":"Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210128252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100633591","display_name":"Ryan Lee","orcid":"https://orcid.org/0000-0003-3725-3856","observed_orcids":["https://orcid.org/0000-0003-3725-3856"]},"institutions":[{"id":"https://openalex.org/I4210128252","display_name":"PeopleBio (South Korea)","ror":"https://ror.org/03gzkvf55","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210128252"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ryan Lee","raw_affiliation_strings":["PeopleBio Inc","Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PeopleBio Inc","institution_ids":["https://openalex.org/I4210128252"]},{"raw_affiliation_string":"Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210128252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102773925","display_name":"Jeewon Suh","orcid":"https://orcid.org/0000-0003-3509-6447","observed_orcids":["https://orcid.org/0000-0003-3509-6447"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeewon Suh","raw_affiliation_strings":["Seoul National University Bundang Hospital","Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Bundang Hospital","institution_ids":["https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101595820","display_name":"Young Ho Park","orcid":"https://orcid.org/0000-0002-2756-1786","observed_orcids":["https://orcid.org/0000-0002-2756-1786"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Ho Park","raw_affiliation_strings":["Seoul National University Bundang Hospital","Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Bundang Hospital","institution_ids":["https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046271018","display_name":"Jung\u2010Min Pyun","orcid":"https://orcid.org/0000-0002-8391-5729","observed_orcids":["https://orcid.org/0000-0002-8391-5729"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung-Min Pyun","raw_affiliation_strings":["Seoul National University Bundang Hospital","Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Bundang Hospital","institution_ids":["https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nayoung Ryu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nayoung Ryu","raw_affiliation_strings":["Seoul National University Bundang Hospital","Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Bundang Hospital","institution_ids":["https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018017627","display_name":"Min Ju Kang","orcid":"https://orcid.org/0000-0002-7736-6073","observed_orcids":["https://orcid.org/0000-0002-7736-6073"]},"institutions":[{"id":"https://openalex.org/I4210101595","display_name":"Veterans Health Service Medical Center","ror":"https://ror.org/00xhz2q61","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210101595","https://openalex.org/I4210129722"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Ju Kang","raw_affiliation_strings":["Veterans Health Service Medical Center","Department of Neurology, Veterans Health Service Medical Center, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Health Service Medical Center","institution_ids":["https://openalex.org/I4210101595"]},{"raw_affiliation_string":"Department of Neurology, Veterans Health Service Medical Center, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210101595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101722610","display_name":"Hye Ryoun Kim","orcid":"https://orcid.org/0000-0002-9229-9665","observed_orcids":["https://orcid.org/0000-0002-9229-9665"]},"institutions":[{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Ryoun Kim","raw_affiliation_strings":["Chung-Ang University College of Medicine","Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chung-Ang University College of Medicine","institution_ids":["https://openalex.org/I67900169"]},{"raw_affiliation_string":"Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034466734","display_name":"Sungmin Kang","orcid":"https://orcid.org/0000-0002-4440-3544","observed_orcids":["https://orcid.org/0000-0002-4440-3544"]},"institutions":[{"id":"https://openalex.org/I4210128252","display_name":"PeopleBio (South Korea)","ror":"https://ror.org/03gzkvf55","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210128252"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sungmin Kang","raw_affiliation_strings":["PeopleBio Inc","Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PeopleBio Inc","institution_ids":["https://openalex.org/I4210128252"]},{"raw_affiliation_string":"Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210128252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013951360","display_name":"Seong Soo A. An","orcid":"https://orcid.org/0000-0002-8123-6183","observed_orcids":["https://orcid.org/0000-0002-8123-6183","https://orcid.org/0000-0003-0385-2105"]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong Soo A. An","raw_affiliation_strings":["Gachon University","Department of Bionanotechnology, Gachon University, Gyeonggi-do, Republic of Korea","E-mail:"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gachon University","institution_ids":["https://openalex.org/I12832649"]},{"raw_affiliation_string":"Department of Bionanotechnology, Gachon University, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I12832649"]},{"raw_affiliation_string":"E-mail:","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001679413","display_name":"SangYun Kim","orcid":"https://orcid.org/0000-0002-9101-5704","observed_orcids":["https://orcid.org/0000-0002-9101-5704"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"SangYun Kim","raw_affiliation_strings":["Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-9101-5704","affiliations":[{"raw_affiliation_string":"Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5001679413"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"],"apc_list":null,"apc_paid":null,"fwci":3.2274,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.93381267,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"75","issue":"2","first_page":"493","last_page":"499"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.17810000479221344,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9120000004768372},{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.8122292160987854},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6211630702018738},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6062036752700806},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.5416460633277893},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48243436217308044},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4601943790912628},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36728203296661377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36258891224861145},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28867703676223755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19616800546646118},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17833024263381958}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3233/jad-200061","doi":"https://doi.org/10.3233/jad-200061","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-200061","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"doi:10.21203/rs.2.19960/v1","doi":"https://doi.org/10.21203/rs.2.19960/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.19960/v1","pdf_url":"https://www.researchsquare.com/article/rs-10572/latest.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:32310175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32310175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21203/rs.2.19960/v1","doi":"https://doi.org/10.21203/rs.2.19960/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.19960/v1","pdf_url":"https://www.researchsquare.com/article/rs-10572/latest.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3017003095.pdf","grobid_xml":"https://content.openalex.org/works/W3017003095.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1437299811","https://openalex.org/W1968111065","https://openalex.org/W1970016175","https://openalex.org/W1974300727","https://openalex.org/W1976118830","https://openalex.org/W1979633280","https://openalex.org/W1980099228","https://openalex.org/W1984133805","https://openalex.org/W1985879372","https://openalex.org/W1993571512","https://openalex.org/W1994580857","https://openalex.org/W2004445346","https://openalex.org/W2008752021","https://openalex.org/W2011402798","https://openalex.org/W2016293149","https://openalex.org/W2046703193","https://openalex.org/W2051075927","https://openalex.org/W2053819991","https://openalex.org/W2056745213","https://openalex.org/W2082375619","https://openalex.org/W2096890121","https://openalex.org/W2106931873","https://openalex.org/W2120564388","https://openalex.org/W2130631201","https://openalex.org/W2135922212","https://openalex.org/W2140963804","https://openalex.org/W2150231759","https://openalex.org/W2164443763","https://openalex.org/W2171250577","https://openalex.org/W2269589716","https://openalex.org/W2511246053","https://openalex.org/W2765541445","https://openalex.org/W2775139260","https://openalex.org/W2787631544","https://openalex.org/W2809078375","https://openalex.org/W2899213164","https://openalex.org/W3025895001"],"related_works":["https://openalex.org/W2775139260","https://openalex.org/W2076895829","https://openalex.org/W2765541445","https://openalex.org/W4225266925","https://openalex.org/W2094195964","https://openalex.org/W1995146110","https://openalex.org/W2051075927","https://openalex.org/W3111563778","https://openalex.org/W4316669724","https://openalex.org/W2895955482"],"abstract_inverted_index":{"BACKGROUND:":[0],"Oligomeric":[1],"amyloid-\u03b2":[2],"(A\u03b2)":[3],"is":[4,146],"one":[5],"of":[6,13,45,51,95,105,128,154],"the":[7,11,40,46,86,98,103,131],"major":[8],"contributors":[9],"to":[10,141],"pathomechanism":[12],"Alzheimer's":[14],"disease":[15],"(AD);":[16],"A\u03b2":[17,29,144],"oligomerization":[18,145],"in":[19,62,70,102,114,121],"plasma":[20,64,143],"can":[21],"be":[22],"measured":[23,57],"using":[24,58],"a":[25,125,147],"Multimer":[26],"Detection":[27],"System-Oligomeric":[28],"(MDS-OA\u03b2)":[30],"after":[31],"incubation":[32],"with":[33,72,76,156],"spiked":[34],"synthetic":[35],"A\u03b2.":[36],"OBJECTIVE:":[37],"We":[38],"evaluated":[39],"clinical":[41,100,152],"sensitivity":[42,135,158],"and":[43,88,116,136,159],"specificity":[44],"MDS-OA\u03b2":[47,55,109,140],"values":[48,56,110],"for":[49,151],"prediction":[50],"AD.":[52,106],"METHODS:":[53],"The":[54,80,108],"inBlood\u2122":[59],"OA\u03b2":[60],"test":[61],"heparin-treated":[63],"samples":[65],"from":[66,97],"52":[67,73],"AD":[68,115],"patients":[69],"comparison":[71],"community-based":[74],"subjects":[75],"normal":[77],"cognition":[78],"(NC).":[79],"inclusion":[81],"criterion":[82],"was":[83],"proposed":[84],"by":[85],"NINCDS-ADRDA":[87],"additionally":[89],"required":[90],"at":[91],"least":[92],"6":[93],"months":[94],"follow-up":[96],"initial":[99],"diagnosis":[101,153],"course":[104],"RESULTS:":[107],"were":[111],"1.43\u00b10.30":[112],"ng/ml":[113],"0.45\u00b10.19":[117],"(p":[118],"<":[119],"0.001)":[120],"NC,":[122],"respectively.":[123],"Using":[124],"cut-off":[126],"value":[127],"0.78":[129],"ng/ml,":[130],"results":[132],"revealed":[133],"100%":[134],"92.31%":[137],"specificity.":[138,160],"CONCLUSION:":[139],"measure":[142],"valuable":[148],"blood-based":[149],"biomarker":[150],"AD,":[155],"high":[157]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-04-24T00:00:00"}