{"id":"https://openalex.org/W3016991806","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06012","title":"ONC201 and Its Potent Analogues Disrupt Mitochondrial Metabolic Function in Triple Negative Breast Cancer","display_name":"ONC201 and Its Potent Analogues Disrupt Mitochondrial Metabolic Function in Triple Negative Breast Cancer","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3016991806","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06012","mag":"3016991806"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2020.34.s1.06012","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06012","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.06012","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044954592","display_name":"Emily M.J. Fennell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily M.J. Fennell","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076370787","display_name":"Lucas J. Aponte\u2010Collazo","orcid":"https://orcid.org/0000-0001-9085-2415","observed_orcids":["https://orcid.org/0000-0001-9085-2415"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucas J. Aponte-Collazo","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005157610","display_name":"Paul R. Graves","orcid":"https://orcid.org/0000-0002-4958-7450","observed_orcids":["https://orcid.org/0000-0002-4958-7450"]},"institutions":[{"id":"https://openalex.org/I1341523491","display_name":"NewYork\u2013Presbyterian Brooklyn Methodist Hospital","ror":"https://ror.org/04929s478","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700","https://openalex.org/I1341523491"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul R. Graves","raw_affiliation_strings":["New York Presbyterian Brooklyn Methodist Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Presbyterian Brooklyn Methodist Hospital","institution_ids":["https://openalex.org/I1341523491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053713564","display_name":"Laura E. Herring","orcid":"https://orcid.org/0000-0003-4496-7312","observed_orcids":["https://orcid.org/0000-0003-4496-7312"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura E. Herring","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045292739","display_name":"Edwin J. Iwanowicz","orcid":"https://orcid.org/0009-0005-0690-3301","observed_orcids":["https://orcid.org/0009-0005-0690-3301"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ed J. Iwanowicz","raw_affiliation_strings":["Madera Therapeutics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madera Therapeutics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083812801","display_name":"Ekhson Holmuhamedov","orcid":"https://orcid.org/0000-0002-0809-350X","observed_orcids":["https://orcid.org/0000-0002-0809-350X"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekhson Holmuhamedov","raw_affiliation_strings":["Russian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Russian Academy of Sciences","institution_ids":["https://openalex.org/I1313323035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082891287","display_name":"Lee M. Graves","orcid":"https://orcid.org/0000-0002-4736-9855","observed_orcids":["https://orcid.org/0000-0002-4736-9855"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee M. Graves","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"S1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.4377000033855438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.4377000033855438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.3522999882698059,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.058800000697374344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/onc201","display_name":"ONC201","score":0.9990000128746033},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/clpp","display_name":"ClpP","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mitochondrial-protease","display_name":"mitochondrial protease","score":0.8050000071525574},{"id":"https://openalex.org/keywords/glutamine-utilization","display_name":"glutamine utilization","score":0.8930000066757202},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.7409999966621399},{"id":"https://openalex.org/keywords/galactose","display_name":"galactose","score":0.6629999876022339},{"id":"https://openalex.org/keywords/aerobic-respiration","display_name":"aerobic respiration","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mitochondrial-stress","display_name":"mitochondrial stress","score":0.5860000252723694},{"id":"https://openalex.org/keywords/mitochondrial-membrane-depolarization","display_name":"mitochondrial depolarization","score":0.6359999775886536},{"id":"https://openalex.org/keywords/13c-labeled-substrates","display_name":"13C-labeled substrates","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.689885139465332},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.5240271687507629},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5180380940437317},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5170943737030029},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.505959689617157},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4436679780483246},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4361400306224823},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.4254592955112457},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42278599739074707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4194096624851227},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3959167003631592},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3668076992034912},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2719748914241791},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2368544340133667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16391906142234802},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.13372811675071716}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2020.34.s1.06012","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06012","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.06012","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3181547813","https://openalex.org/W6887820505","https://openalex.org/W6962658589","https://openalex.org/W4362519152","https://openalex.org/W7129244098","https://openalex.org/W2159937179","https://openalex.org/W3016725612","https://openalex.org/W4396590914","https://openalex.org/W2329653345","https://openalex.org/W3083396573"],"abstract_inverted_index":{"Background":[0],"ONC201":[1,19,41,77,107,148,181,188,208,227,259,274,304,356,374],"is":[2,20,48,73,139,310,332],"an":[3],"imipridone":[4],"compound":[5,80,211,307,359,377],"in":[6,63,83,97,119,169,176,204,231,263,320,350,373],"clinical":[7],"trials":[8],"for":[9,117],"multiple":[10],"cancer":[11,17,321],"types,":[12],"including":[13],"triple":[14],"negative":[15],"breast":[16],"(TNBC).":[18],"a":[21,84,201,239,294,371],"promising":[22],"anticancer":[23,378],"therapy":[24],"whose":[25],"pharmacological":[26],"target":[27,39],"and":[28,42,61,78,100,108,149,228,246,260,267,275,283,300,317,326,352,357,366,375],"function":[29],"are":[30],"not":[31],"clearly":[32],"defined.":[33],"We":[34,123,213],"have":[35],"demonstrated":[36,215],"that":[37,216,273],"the":[38,49,170,223,327],"of":[40,57,70,86,91,147,172,187,218,226,242,250,258,269,280,296,362],"its":[43],"potent":[44],"analogues":[45],"(TR":[46],"compounds)":[47],"mitochondrial":[50,59,87,101,205,270,281,363],"protease":[51],"ClpP,":[52,92],"consistent":[53],"with":[54,154,180,220,288],"previous":[55],"reports":[56],"ONC201\u2010induced":[58],"stress":[60],"depolarization":[62],"TNBC":[64,177,232,264],"cells.":[65,233,265],"Study":[66],"Objective":[67],"The":[68,144],"objective":[69],"this":[71],"study":[72],"to":[74,94,129,134,166,252,312,335,347],"determine":[75,105],"if":[76,106],"TR":[79,109,150,183,190,210,229,261,276,306,358,376],"treatment":[81],"result":[82],"loss":[85,268,279,295],"protein":[88,282,324,338],"through":[89,141,323],"activation":[90],"leading":[93],"metabolic":[95,285,364],"disruption":[96],"glutamine":[98,367],"utilization":[99,171,241,302,368],"function.":[102],"Methods":[103],"To":[104],"compounds":[110,151,230,262,277],"disrupt":[111],"aerobic":[112,135,142],"respiration,":[113,136],"galactose":[114,138,221,251],"was":[115,152,193],"substituted":[116],"glucose":[118,219],"cell":[120,126,253,315],"culture":[121,127,254],"media.":[122],"used":[124,334,346],"galactose\u2010containing":[125,157],"media":[128,158,255],"shift":[130],"cells":[131,178,192,322],"from":[132],"anaerobic":[133],"as":[137],"utilized":[140],"respiration.":[143],"IC":[145,224],"50":[146,225],"measured":[153],"glucose\u2010":[155],"or":[156,182,189,209,305,381],"by":[159],"MTS.":[160],"MitoPlate":[161,236,291],"assays":[162,237],"(Biolog)":[163],"were":[164],"performed":[165],"identify":[167,336,348],"perturbations":[168,349],"30":[173],"different":[174],"substrates":[175,245,343],"treated":[179],"compounds.":[184],"Proteomic":[185,198,330],"analysis":[186,199,331],"compound\u2010treated":[191],"conducted":[194],"using":[195],"LC\u2010MS.":[196],"Results":[197],"revealed":[200],"large":[202],"decline":[203],"peptides":[206,271],"following":[207,303,355],"treatment.":[212,308,360],"also":[214],"substitution":[217],"reduced":[222,240],"In":[234],"addition,":[235],"suggest":[238,272],"TCA":[243,297,328],"cycle":[244,298],"L\u2010glutamine.":[247],"Conclusions":[248],"Addition":[249],"improved":[256],"efficacy":[257],"Sensitization":[266],"cause":[278],"reduction":[284],"activity.":[286,379],"Consistent":[287],"sensitization":[289],"results,":[290],"data":[292],"demonstrates":[293],"substrate":[299],"L\u2010glutamine":[301],"Glutamine":[309],"known":[311],"facilitate":[313],"both":[314],"proliferation":[316],"energy":[318],"production":[319],"biosynthesis":[325],"cycle.":[329],"being":[333],"ClpP\u2010dependent":[337],"loss.":[339],"Uniformly":[340],"13":[341],"C\u2010labeled":[342],"will":[344],"be":[345],"energetic":[351],"biosynthetic":[353],"pathways":[354],"Loss":[361],"activity":[365],"may":[369],"play":[370],"role":[372],"Support":[380],"Funding":[382],"Information":[383],"NIH":[384],"Pharmacological":[385],"Sciences":[386],"T32":[387],"(GM007040),":[388],"University":[389],"Cancer":[390],"Research":[391],"Fund":[392]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2020-04-24T00:00:00"}