{"id":"https://openalex.org/W3016864367","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.03497","title":"Effects of the Gut Microbiome on Aged\u2010Related Cognitive Decline and Inflammation","display_name":"Effects of the Gut Microbiome on Aged\u2010Related Cognitive Decline and Inflammation","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3016864367","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.03497","mag":"3016864367"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2020.34.s1.03497","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.03497","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.03497","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087653122","display_name":"June\u2010Young Lee","orcid":"https://orcid.org/0000-0002-6793-6108","observed_orcids":["https://orcid.org/0000-0002-6793-6108"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juneyoung Lee","raw_affiliation_strings":["McGovern Medical School at The University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGovern Medical School at The University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047961915","display_name":"Venugopal Reddy Venna","orcid":"https://orcid.org/0000-0002-7977-4281","observed_orcids":["https://orcid.org/0000-0002-7977-4281"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venugopal R. Venna","raw_affiliation_strings":["McGovern Medical School at The University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGovern Medical School at The University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072518517","display_name":"David J. Durgan","orcid":"https://orcid.org/0000-0002-3358-1935","observed_orcids":["https://orcid.org/0000-0002-3358-1935"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Durgan","raw_affiliation_strings":["Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035455397","display_name":"Louise D. McCullough","orcid":"https://orcid.org/0000-0002-8050-1686","observed_orcids":["https://orcid.org/0000-0002-8050-1686"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louise D. McCullough","raw_affiliation_strings":["McGovern Medical School at The University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGovern Medical School at The University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046974353","display_name":"Robert M. Bryan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Bryan","raw_affiliation_strings":["Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"S1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.972000002861023},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.949999988079071},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/germ-free-mice","display_name":"germ-free mice","score":0.8289999961853027},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.8859999775886536},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.7049999833106995},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.7960000038146973},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.6819999814033508},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.7289999723434448},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/microbiota-diversity","display_name":"microbiome diversity","score":0.5230000019073486},{"id":"https://openalex.org/keywords/lactobacillaceae","display_name":"Lactobacillaceae","score":0.8569999933242798},{"id":"https://openalex.org/keywords/butyrate","display_name":"butyrate","score":0.6489999890327454},{"id":"https://openalex.org/keywords/acetate","display_name":"acetate","score":0.5230000019073486},{"id":"https://openalex.org/keywords/propionate","display_name":"propionate","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.8600260019302368},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.770476222038269},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.637951135635376},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5475533604621887},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4857957363128662},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.481586217880249},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.47998687624931335},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4775455892086029},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4475732445716858},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30316096544265747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2961890399456024},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.271431028842926},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.17756032943725586},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07897835969924927},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2020.34.s1.03497","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.03497","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.03497","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3084005946","https://openalex.org/W3021505828","https://openalex.org/W4212782410","https://openalex.org/W7135332413","https://openalex.org/W2585159410","https://openalex.org/W7135012063","https://openalex.org/W3119586409","https://openalex.org/W3135366964","https://openalex.org/W4389027015","https://openalex.org/W4200441876"],"abstract_inverted_index":{"Introduction":[0],"Aging":[1],"is":[2,32],"associated":[3,369,390],"with":[4,170,228,244,249,295,316,339,370,391],"low":[5],"level":[6],"inflammation":[7,213],"and":[8,27,79,100,109,125,128,143,180,202,239,251,262,267,271,288,299,307,326,359,364,400,405],"cognitive":[9,357,362],"decline.":[10],"We":[11,345],"tested":[12],"the":[13,16,35,81,84,92,116,126,134,153,190,194,197,203,233,281,284,348,376,381,387],"hypothesis":[14],"that":[15,28,347],"gut":[17,36,72,324,349,377,382],"microbiome":[18,37,173,211,342,350,383],"has":[19,351],"a":[20,46,331,352],"major":[21,353],"role":[22,354],"in":[23,38,74,91,148,164,257,293,314,337,355],"these":[24],"age\u2010related":[25,30],"changes":[26],"this":[29,42],"decline":[31,363],"transferrable":[33],"through":[34],"mice.":[39],"Methods":[40],"For":[41],"study":[43,117],"we":[44],"gavaged":[45],"suspension":[47],"of":[48,71,83,98,111],"fresh":[49],"fecal":[50,112,149],"contents":[51],"from":[52,386],"aged":[53,85,172,210,230,246,250,296,318,341],"(~20":[54],"months)":[55,59],"or":[56,86,394],"young":[57,87,252],"(~3":[58],"BL/6":[60,64],"mice":[61,65,76,94,122,294,315,338],"into":[62],"germ\u2010free":[63,75,93],"(N=10":[66],"per":[67],"group).":[68],"The":[69,209],"absence":[70],"bacteria":[73,285],"reduced":[77],"competition":[78],"enhanced":[80,366],"colonization":[82],"microbiomes.":[88],"Gavages":[89],"began":[90],"at":[95,185],"12":[96],"weeks":[97],"age":[99],"were":[101,123,130,146,162,225,236,241,290,312],"repeated":[102],"monthly":[103],"for":[104,132,184,265,275,310],"3":[105,120,187,278,321],"months.":[106],"Behavioral":[107],"testing":[108],"collection":[110],"samples":[113,150],"occurred":[114],"over":[115],"period.":[118],"After":[119],"months,":[121],"euthanized,":[124],"brain":[127,221],"colon":[129],"harvested":[131],"assessing":[133],"inflammatory":[135,367],"state":[136,368],"using":[137,166,193],"flow":[138,217],"cytometry.":[139],"Bacterial":[140],"community":[141],"structures":[142],"relative":[144],"abundances":[145],"measured":[147,163],"by":[151,216],"sequencing":[152],"bacterial":[154,258],"16S":[155],"rRNA":[156],"gene.":[157],"Short\u2010chain":[158],"fatty":[159],"acids":[160],"(SCFA)":[161],"feces":[165],"LC\u2010MS.":[167],"Results":[168],"Mice":[169,248],"an":[171,229,245,317,340,365],"demonstrated":[174],"depressive\u2010like":[175],"behavior,":[176],"impaired":[177,181],"short\u2010term":[178],"memory,":[179],"spatial":[182],"memory":[183],"least":[186],"months":[188,279],"after":[189,280],"initial":[191,282],"gavage":[192],"tail\u2010suspension":[195],"(P=0.008),":[196],"Novel":[198],"Object":[199],"Recognition":[200],"(P<0.001),":[201],"Barnes":[204],"Maze":[205],"(P=0.019)":[206],"tests":[207],"respectively.":[208],"increased":[212,226,237],"as":[214],"revealed":[215],"cytometry":[218],"studies.":[219],"In":[220,232],"\u03b3\u0394":[222],"T":[223],"cells":[224],"(P=0.017)":[227],"microbiome.":[231,247,319,378],"gut,":[234],"leukocytes":[235],"(P<0.001)":[238],"Tregs":[240],"decreased":[242,292,313,335],"(P=0.029)":[243],"microbiomes":[253,297],"showed":[254],"clear":[255],"differences":[256],"\u03b1":[259],"diversity":[260,269],"(Simpsons":[261],"Fisher,":[263],"P<0.001":[264],"both)":[266],"\u03b2":[268],"(weighted":[270],"unweighted":[272],"PCoA,":[273],"P=0.001":[274],"both).":[276],"At":[277],"gavage,":[283],"families,":[286],"Defluviitaleaceae":[287],"Lactobacillaceae,":[289],"significantly":[291],"(P<0.001":[298],"P=0.01":[300],"respectively).":[301],"Fecal":[302],"SCFAs,":[303],"including":[304],"acetate,":[305],"propionate,":[306],"butyrate":[308],"(P<0.01":[309],"each),":[311],"These":[320],"SCFAs":[322],"are":[323],"protective":[325],"anti\u2010inflammatory.":[327],"Of":[328],"note,":[329],"Lactobacillus,":[330],"SCFA\u2010producing":[332],"genus,":[333],"was":[334],"3\u2010fold":[336],"(P=0.009).":[343],"Conclusion":[344],"conclude":[346],"aged\u2010related":[356],"impairment":[358],"inflammation.":[360],"Furthermore,":[361],"aging":[371],"can":[372,384],"be":[373],"transferred":[374],"via":[375],"Thus,":[379],"manipulating":[380],"protect":[385],"detrimental":[388],"effects":[389],"aging.":[392],"Support":[393],"Funding":[395],"Information":[396],"RO1":[397,402],"AG058463":[398],"(RMB":[399],"LDM)":[401],"NS103592":[403],"(LDM":[404],"RMB)":[406]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2020-04-24T00:00:00"}