{"id":"https://openalex.org/W3016862897","doi":"https://doi.org/10.37897/rmj.2019.3.2","title":"Periodontal disease and systemic health","display_name":"Periodontal disease and systemic health","publication_year":2019,"publication_date":"2019-09-30","ids":{"openalex":"https://openalex.org/W3016862897","doi":"https://doi.org/10.37897/rmj.2019.3.2","mag":"3016862897"},"language":"en","primary_location":{"id":"doi:10.37897/rmj.2019.3.2","doi":"https://doi.org/10.37897/rmj.2019.3.2","is_oa":true,"landing_page_url":"https://doi.org/10.37897/rmj.2019.3.2","pdf_url":"https://doi.org/10.37897/rmj.2019.3.2","source":{"id":"https://openalex.org/S4210188710","display_name":"Romanian Medical Journal","issn_l":"1220-5478","issn":["1220-5478","2069-606X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.37897/rmj.2019.3.2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047322315","display_name":"Daniela Miricescu","orcid":"https://orcid.org/0000-0002-0769-8961","observed_orcids":["https://orcid.org/0000-0002-0769-8961"]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Daniela Miricescu","raw_affiliation_strings":["Department of Biochemistry, Faculty of Dental Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Dental Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania","institution_ids":["https://openalex.org/I162051807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027885904","display_name":"Alexandra Totan","orcid":"https://orcid.org/0000-0002-4345-282X","observed_orcids":["https://orcid.org/0000-0002-4345-282X"]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]}],"countries":["RO"],"is_corresponding":true,"raw_author_name":"Alexandra Totan","raw_affiliation_strings":["Department of Biochemistry, Faculty of Dental Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Dental Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania","institution_ids":["https://openalex.org/I162051807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001174124","display_name":"Iulia-Ioana St\u0103nescu-Sp\u00eenu","orcid":"https://orcid.org/0000-0001-9224-6056","observed_orcids":["https://orcid.org/0000-0001-9224-6056"]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Iulia-Ioana Stanescu","raw_affiliation_strings":["Department of Biochemistry, Faculty of Dental Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Dental Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania","institution_ids":["https://openalex.org/I162051807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049666107","display_name":"Radu R\u0103dulescu","orcid":"https://orcid.org/0000-0002-7469-0839","observed_orcids":["https://orcid.org/0000-0002-7469-0839"]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Radu Radulescu","raw_affiliation_strings":["Department of Biochemistry, Faculty of Dental Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Dental Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania","institution_ids":["https://openalex.org/I162051807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007551348","display_name":"Constantin \u0218tefani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]},{"id":"https://openalex.org/I4210135041","display_name":"Spitalul Universitar de Urgen\u0163\u0103 Militar Central Dr. Carol Davila","ror":"https://ror.org/03h2qaw95","country_code":"RO","type":"healthcare","lineage":["https://openalex.org/I4210135041"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Constantin Stefani","raw_affiliation_strings":["\"Carol Davila\" University Central Emergency Military Hospital, Bucharest, Romania","Department of Family Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\"Carol Davila\" University Central Emergency Military Hospital, Bucharest, Romania","institution_ids":["https://openalex.org/I4210135041"]},{"raw_affiliation_string":"Department of Family Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania","institution_ids":["https://openalex.org/I162051807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085278189","display_name":"Ana Maria Alexandra St\u0103nescu","orcid":"https://orcid.org/0000-0002-4807-9470","observed_orcids":["https://orcid.org/0000-0002-4807-9470"]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Ana Maria Alexandra Stanescu","raw_affiliation_strings":["Department of Family Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania","institution_ids":["https://openalex.org/I162051807"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005762380","display_name":"Maria Greabu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Maria Greabu","raw_affiliation_strings":["Department of Biochemistry, Faculty of Dental Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Dental Medicine, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania","institution_ids":["https://openalex.org/I162051807"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027885904"],"corresponding_institution_ids":["https://openalex.org/I162051807"],"apc_list":{"value":880,"currency":"RON","value_usd":192},"apc_paid":{"value":880,"currency":"RON","value_usd":192},"fwci":1.3838,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.80119193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"66","issue":"3","first_page":"197","last_page":"201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12439","display_name":"Dental Research and COVID-19","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/systemic-health","display_name":"systemic health","score":0.671999990940094},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7839999794960022},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":1.0},{"id":"https://openalex.org/keywords/oral-pathogens","display_name":"oral pathogens","score":0.6650000214576721},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.6000000238418579},{"id":"https://openalex.org/keywords/oral-systemic-link","display_name":"oral-systemic relationship","score":0.550000011920929},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.8848636746406555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7421150207519531},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7421071529388428},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7121834754943848},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.6810466051101685},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.5562341213226318},{"id":"https://openalex.org/C2992452445","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontal disease","level":2,"score":0.5218238234519958},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5079582333564758},{"id":"https://openalex.org/C2986629439","wikidata":"https://www.wikidata.org/wiki/Q9635","display_name":"Oral cavity","level":2,"score":0.504827082157135},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4850127398967743},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3824389576911926},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3346136510372162},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.28411608934402466},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2033955454826355},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.1486366093158722},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.37897/rmj.2019.3.2","doi":"https://doi.org/10.37897/rmj.2019.3.2","is_oa":true,"landing_page_url":"https://doi.org/10.37897/rmj.2019.3.2","pdf_url":"https://doi.org/10.37897/rmj.2019.3.2","source":{"id":"https://openalex.org/S4210188710","display_name":"Romanian Medical Journal","issn_l":"1220-5478","issn":["1220-5478","2069-606X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:174dfaaa09984e8da0b9f09afa6a060a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/174dfaaa09984e8da0b9f09afa6a060a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Romanian Medical Journal, Vol 66, Iss 3, Pp 197-201 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.37897/rmj.2019.3.2","doi":"https://doi.org/10.37897/rmj.2019.3.2","is_oa":true,"landing_page_url":"https://doi.org/10.37897/rmj.2019.3.2","pdf_url":"https://doi.org/10.37897/rmj.2019.3.2","source":{"id":"https://openalex.org/S4210188710","display_name":"Romanian Medical Journal","issn_l":"1220-5478","issn":["1220-5478","2069-606X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3016862897.pdf","grobid_xml":"https://content.openalex.org/works/W3016862897.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W83569273","https://openalex.org/W1964134719","https://openalex.org/W1971402418","https://openalex.org/W1978815125","https://openalex.org/W2001015247","https://openalex.org/W2029716901","https://openalex.org/W2031543116","https://openalex.org/W2034035669","https://openalex.org/W2041075406","https://openalex.org/W2062453400","https://openalex.org/W2062898754","https://openalex.org/W2063976524","https://openalex.org/W2077591662","https://openalex.org/W2078734083","https://openalex.org/W2097109467","https://openalex.org/W2097123656","https://openalex.org/W2117582159","https://openalex.org/W2120860878","https://openalex.org/W2126355581","https://openalex.org/W2126941445","https://openalex.org/W2127825892","https://openalex.org/W2135352079","https://openalex.org/W2154600779","https://openalex.org/W2165201727","https://openalex.org/W2165718338","https://openalex.org/W2186928785","https://openalex.org/W2192324536","https://openalex.org/W2274140953","https://openalex.org/W2320898683","https://openalex.org/W2366933243","https://openalex.org/W2425509434","https://openalex.org/W2561585478","https://openalex.org/W2567809950","https://openalex.org/W2735781412","https://openalex.org/W2775618670","https://openalex.org/W2886983344","https://openalex.org/W2901378839","https://openalex.org/W2906328956","https://openalex.org/W2907381139","https://openalex.org/W2921038250","https://openalex.org/W2922756901","https://openalex.org/W2949197080","https://openalex.org/W2953728550","https://openalex.org/W2956655325","https://openalex.org/W2958696065","https://openalex.org/W2965611301","https://openalex.org/W2969078648","https://openalex.org/W2999621870","https://openalex.org/W3001669172","https://openalex.org/W3004736138","https://openalex.org/W6731000537"],"related_works":["https://openalex.org/W2925248657","https://openalex.org/W7216008752","https://openalex.org/W7161148854","https://openalex.org/W17294526","https://openalex.org/W2743302428","https://openalex.org/W2032340782","https://openalex.org/W2402782344","https://openalex.org/W2336053526","https://openalex.org/W4221062961","https://openalex.org/W4377564721"],"abstract_inverted_index":{"Periodontitis":[0],"is":[1,27,70,73,85],"a":[2,28,74],"chronic":[3],"inflammatory":[4],"disease":[5,42],"of":[6,60,63,67,82],"the":[7,13,16,58,64,88,93,96],"oral":[8,99],"cavity":[9],"that":[10,25,38,48],"usually":[11],"affects":[12],"adult":[14],"population.In":[15],"last":[17],"two":[18,79],"decades,":[19],"many":[20,65],"specialized":[21],"studies":[22],"have":[23],"reported":[24],"there":[26,72],"link":[29],"between":[30,77,98],"periodontitis,":[31,71],"cardiovascular":[32,61],"diseases":[33],"and":[34,52,102],"diabetes":[35,68],"mellitus.Main":[36],"factors":[37],"lead":[39],"to":[40,57,86],"periodontal":[41,100],"installation":[43],"are":[44],"several":[45],"bacterial":[46],"species":[47],"induce":[49],"both":[50],"local":[51],"systemic":[53,103],"inflammation,":[54],"negatively":[55],"contributing":[56],"progression":[59],"diseases.One":[62],"complications":[66],"mellitus":[69],"two-way":[75],"relationship":[76,97],"these":[78],"diseases.The":[80],"purpose":[81],"this":[83],"review":[84],"analyze":[87],"recent":[89],"data":[90],"provided":[91],"by":[92],"literature":[94],"regarding":[95],"pathogens":[101],"health.":[104]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-24T00:00:00"}