{"id":"https://openalex.org/W3016832973","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06182","title":"Therapeutic Effect of Oridonin Against Inflammatory Bowel Disease Involves Inhibition of Intestinal Fibrosis via NF\u2010\u03baB Pathway","display_name":"Therapeutic Effect of Oridonin Against Inflammatory Bowel Disease Involves Inhibition of Intestinal Fibrosis via NF\u2010\u03baB Pathway","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3016832973","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06182","mag":"3016832973"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2020.34.s1.06182","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06182","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.06182","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051802693","display_name":"Xiaofu Wang","orcid":"https://orcid.org/0000-0001-9323-4022","observed_orcids":["https://orcid.org/0000-0001-9323-4022"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofu Wang","raw_affiliation_strings":["University of Texas Medical Branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015645616","display_name":"Claire B. Cummins","orcid":"https://orcid.org/0000-0003-3934-2633","observed_orcids":["https://orcid.org/0000-0003-3934-2633"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Cummins","raw_affiliation_strings":["University of Texas Medical Branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100948122","display_name":"Yanping Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanping Gu","raw_affiliation_strings":["University of Texas Medical Branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081244175","display_name":"Juquan Song","orcid":"https://orcid.org/0000-0002-9371-9078","observed_orcids":["https://orcid.org/0000-0002-9371-9078"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juquan Song","raw_affiliation_strings":["University of Texas Medical Branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023901418","display_name":"Jia Zhou","orcid":"https://orcid.org/0000-0002-2811-1090","observed_orcids":["https://orcid.org/0000-0002-2811-1090"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia Zhou","raw_affiliation_strings":["University of Texas Medical Branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012902265","display_name":"Ravi S. Radhakrishnan","orcid":"https://orcid.org/0000-0002-8593-5301","observed_orcids":["https://orcid.org/0000-0002-8593-5301"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Radhakrishnan","raw_affiliation_strings":["University of Texas Medical Branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"S1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oridonin","display_name":"oridonin","score":1.0},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/intestinal-fibrosis","display_name":"intestinal fibrosis","score":1.0},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9470000267028809},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.7649999856948853},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8610000014305115},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.753000020980835},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8370000123977661},{"id":"https://openalex.org/keywords/rabdosia-rubescens","display_name":"Rabdosia rubescens","score":0.8809999823570251},{"id":"https://openalex.org/keywords/diterpenes","display_name":"diterpenoids","score":0.7770000100135803},{"id":"https://openalex.org/keywords/ikappabalpha-degradation","display_name":"I\u03baB\u03b1 degradation","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.5718913078308105},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5550037622451782},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.550395667552948},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5404937863349915},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.538365364074707},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5245471596717834},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.5165030360221863},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4594361186027527},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4557766914367676},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.43995293974876404},{"id":"https://openalex.org/C2779730028","wikidata":"https://www.wikidata.org/wiki/Q15325101","display_name":"I\u03baB\u03b1","level":4,"score":0.4390954375267029},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4205307960510254},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.41856229305267334},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.41835853457450867},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.40435078740119934},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28386300802230835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23397493362426758},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2053786814212799},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12725955247879028},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08221679925918579},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2020.34.s1.06182","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.06182","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.06182","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3095592452","https://openalex.org/W2981615747","https://openalex.org/W1915064147","https://openalex.org/W2904897259","https://openalex.org/W4320495290","https://openalex.org/W7133293287","https://openalex.org/W2005224639","https://openalex.org/W4399392640","https://openalex.org/W2794319920","https://openalex.org/W7135084550"],"abstract_inverted_index":{"Introduction":[0],"Intestinal":[1],"fibrosis":[2],"and":[3,72,80,123,131,158,168,174,243],"stricture":[4],"formation":[5],"are":[6],"frequent":[7],"complications":[8],"of":[9,129,145,163,228,238],"inflammatory":[10,17],"bowel":[11],"disease":[12],"(IBD).":[13],"In":[14],"response":[15],"to":[16,53,84],"stimuli,":[18],"intestinal":[19,41,75,231],"epithelial":[20,33,76,232],"cells":[21,34,82,205,210,233],"may":[22,234],"undergo":[23],"epithelial\u2010mesenchymal":[24],"transition":[25,207],"(EMT).":[26],"EMT":[27,71],"is":[28],"a":[29,36,44,194],"process":[30],"by":[31,116,141,151,172,176],"which":[32],"acquire":[35],"mesenchymal\u2010like":[37],"phenotype,":[38],"resulting":[39],"in":[40,74,197,230],"fibrosis.":[42],"Oridonin,":[43],"bioactive":[45],"diterpenoid":[46],"isolated":[47],"from":[48],"Rabdosia":[49],"rubescens,":[50],"was":[51,104,149],"reported":[52],"have":[54],"therapeutic":[55],"effects":[56,227],"for":[57],"IBD.":[58],"However,":[59],"the":[60,181,239],"cellular":[61],"mechanism":[62],"remains":[63],"unclear.":[64],"We":[65],"hypothesize":[66],"that":[67,186,203],"oridonin":[68,215,229],"attenuates":[69],"inflammation\u2010related":[70],"fibrogenesis":[73],"cells.":[77,199],"Methods":[78],"IEC\u20106":[79,198,204],"IEC\u201018":[81],"exposed":[83],"TNF\u03b1":[85,173,187,212],"were":[86,94,139,170],"pre\u2010treated":[87],"with":[88,96,106,178],"or":[89,99],"without":[90],"oridonin.":[91,142,152,179],"Cellular":[92],"proteins":[93,166],"analyzed":[95],"Western":[97],"blot":[98],"immunofluorescence":[100],"assay.":[101],"Cytokine":[102],"secretion":[103,144],"determined":[105],"ELISA.":[107],"Results":[108],"Oridonin":[109,153],"treatment":[110],"suppressed":[111,175],"TNF\u03b1\u2010induced":[112,118,127,240],"NF\u2010\u03baB":[113,119,241],"activation":[114],"evidenced":[115],"blocking":[117],"p65":[120],"nuclear":[121],"translocation":[122],"DNA":[124],"binding":[125],"activity.":[126],"phosphorylation":[128],"IKK\u03b1/\u03b2":[130],"I\u03baB\u03b1":[132,137],"as":[133,135],"well":[134],"total":[136],"degradation":[138],"prevented":[140],"TNF\u03b1\u2010stimulated":[143,217],"pro\u2010inflammatory":[146],"cytokine":[147],"IL\u20106":[148],"inhibited":[150,216],"moderately":[154],"up\u2010regulates":[155],"endogenous":[156],"E\u2010cadherin":[157],"down\u2010regulates":[159],"Snail.":[160],"The":[161,225],"expression":[162],"extracellular":[164],"matrix":[165],"fibronectin":[167],"laminin":[169],"increased":[171],"pre\u2010treatment":[177],"For":[180],"first":[182],"time,":[183],"we":[184],"demonstrated":[185],"dose\u2010dependently":[188],"up\u2010regulated":[189],"\u03b1\u2010smooth":[190],"muscle":[191],"actin":[192],"(\u03b1\u2010SMA),":[193],"myofibroblast":[195],"marker,":[196],"These":[200],"results":[201],"indicate":[202],"underwent":[206],"into":[208],"mesenchymal":[209],"after":[211],"stimulation.":[213],"Notably,":[214],"\u03b1\u2010SMA,":[218],"but":[219],"not":[220],"TGF\u03b21\u2010stimulated":[221],"EMT\u2010related":[222,244],"proteins.":[223],"Conclusion":[224],"protective":[226],"occur":[235],"through":[236],"suppression":[237],"pathway":[242],"fibrogenesis.":[245]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2020-04-24T00:00:00"}