{"id":"https://openalex.org/W3016802569","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.02258","title":"The Glucosome: A Metabolic Complex for Glucose Metabolism and Its Functional Contribution to Cellular Metabolism in Living Cells","display_name":"The Glucosome: A Metabolic Complex for Glucose Metabolism and Its Functional Contribution to Cellular Metabolism in Living Cells","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3016802569","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.02258","mag":"3016802569"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2020.34.s1.02258","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.02258","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.02258","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033010881","display_name":"Songon An","orcid":"https://orcid.org/0000-0003-2189-7374","observed_orcids":["https://orcid.org/0000-0003-2189-7374"]},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Songon An","raw_affiliation_strings":["University of Maryland, Baltimore County (UMBC)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore County (UMBC)","institution_ids":["https://openalex.org/I79272384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033010881"],"corresponding_institution_ids":["https://openalex.org/I79272384"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"S1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.37450000643730164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.37450000643730164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.35670000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7329999804496765},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":1.0},{"id":"https://openalex.org/keywords/enzyme-interaction","display_name":"enzyme interaction","score":0.5730000138282776},{"id":"https://openalex.org/keywords/cell-cycle-oscillations","display_name":"cell cycle oscillations","score":0.7379999756813049},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"single-cell analysis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/high-content-imaging","display_name":"high-content imaging","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.7541903257369995},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.6760942339897156},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6157690286636353},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.607633113861084},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.5990018844604492},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5469688177108765},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5381293296813965},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5142654776573181},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4919430911540985},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.47505852580070496},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.45756086707115173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4307297468185425},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43016207218170166},{"id":"https://openalex.org/C78885561","wikidata":"https://www.wikidata.org/wiki/Q189055","display_name":"Cellular compartment","level":3,"score":0.4229665994644165},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4167841374874115},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2020.34.s1.02258","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.02258","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.02258","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6903505279","https://openalex.org/W4280577979","https://openalex.org/W4391642240","https://openalex.org/W3017037206","https://openalex.org/W2791486327","https://openalex.org/W2913052188","https://openalex.org/W4391641779","https://openalex.org/W7099793743","https://openalex.org/W2098229250","https://openalex.org/W2623049174"],"abstract_inverted_index":{"There":[0],"have":[1,31],"been":[2],"growing":[3],"evidence":[4],"that":[5,33,69,100,126,142],"metabolic":[6,51,157],"enzymes":[7,38,71,144],"not":[8],"only":[9],"compartmentalize":[10],"in":[11,23,39,59,62,91,117,135,145,162],"the":[12,24,27,35,54,70,73,82,92,132,143],"membrane\u2010bound":[13],"organelles,":[14],"like":[15],"mitochondria,":[16],"but":[17],"also":[18,85],"form":[19,58,149],"spatially\u2010resolved,":[20],"membraneless":[21],"granules":[22,57,75,83,102,128],"cytoplasm":[25],"of":[26],"cells.":[28,64,164],"Recently,":[29],"we":[30,140],"demonstrated":[32],"all":[34],"cytoplasmic,":[36],"irreversible":[37],"glycolysis":[40],"and":[41,89,113,172],"gluconeogenesis":[42],"(i.e.":[43],"glucose":[44,108,146,160],"metabolism)":[45],"dynamically":[46,86],"organizes":[47],"into":[48],"a":[49,118,136],"macromolecular":[50],"complex,":[52],"namely":[53],"\u201cglucosome,\u201d":[55],"whose":[56],"various":[60],"sizes":[61],"human":[63,163],"Our":[65],"biophysical":[66],"characterization":[67],"reveals":[68,125],"inside":[72],"glucosome":[74,101,127,151],"directly":[76],"interact":[77],"with":[78],"each":[79],"other":[80],"while":[81],"themselves":[84],"undergo":[87],"fusion":[88],"fission":[90],"cytoplasm.":[93],"Importantly,":[94],"quantitative":[95],"high\u2010content":[96],"imaging":[97],"assays":[98],"support":[99],"are":[103,154],"metabolically":[104],"functional":[105],"to":[106],"regulate":[107],"flux":[109],"between":[110],"energy":[111],"metabolism":[112,147,161],"building":[114],"block":[115],"biosynthesis":[116],"size\u2010dependent":[119,137],"manner.":[120,138],"Furthermore,":[121],"our":[122],"single\u2010cell":[123],"analysis":[124],"functionally":[129,155],"oscillate":[130],"during":[131],"cell":[133],"cycle":[134],"Collectively,":[139],"propose":[141],"reversibly":[148],"phase\u2010separated":[150],"granules,":[152],"which":[153],"relevant":[156],"complexes":[158],"for":[159],"Support":[165],"or":[166],"Funding":[167],"Information":[168],"\u2022":[169],"GM125981":[170],"(An)":[171,174],"CA219609":[173]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-04-24T00:00:00"}