{"id":"https://openalex.org/W3016794476","doi":"https://doi.org/10.1038/s41467-020-15685-z","title":"A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision","display_name":"A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision","publication_year":2020,"publication_date":"2020-04-15","ids":{"openalex":"https://openalex.org/W3016794476","doi":"https://doi.org/10.1038/s41467-020-15685-z","mag":"3016794476","pmid":"https://pubmed.ncbi.nlm.nih.gov/32296067","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7160111"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-020-15685-z","doi":"https://doi.org/10.1038/s41467-020-15685-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-020-15685-z","pdf_url":"https://www.nature.com/articles/s41467-020-15685-z.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-020-15685-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084334648","display_name":"Rainis Venta","orcid":"https://orcid.org/0000-0001-6635-992X","observed_orcids":["https://orcid.org/0000-0001-6635-992X"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Rainis Venta","raw_affiliation_strings":["Institute of Technology, University of Tartu, Tartu, 50411, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076532991","display_name":"Ervin Valk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Ervin Valk","raw_affiliation_strings":["Institute of Technology, University of Tartu, Tartu, 50411, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051835645","display_name":"Mihkel \u00d6rd","orcid":"https://orcid.org/0000-0003-0454-7241","observed_orcids":["https://orcid.org/0000-0003-0454-7241"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Mihkel \u00d6rd","raw_affiliation_strings":["Institute of Technology, University of Tartu, Tartu, 50411, Estonia"],"raw_orcid":"https://orcid.org/0000-0003-0454-7241","affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016779223","display_name":"Oleg Ko\u0161ik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Oleg Ko\u0161ik","raw_affiliation_strings":["Institute of Technology, University of Tartu, Tartu, 50411, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049566099","display_name":"Kaur P\u00e4\u00e4bo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Kaur P\u00e4\u00e4bo","raw_affiliation_strings":["Institute of Technology, University of Tartu, Tartu, 50411, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059933422","display_name":"Artemi Maljavin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Artemi Maljavin","raw_affiliation_strings":["Institute of Technology, University of Tartu, Tartu, 50411, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078288183","display_name":"Rait Kivi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Rait Kivi","raw_affiliation_strings":["Institute of Technology, University of Tartu, Tartu, 50411, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080817194","display_name":"Ilona Faustova","orcid":"https://orcid.org/0000-0002-6327-5293","observed_orcids":["https://orcid.org/0000-0002-6327-5293"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Ilona Faustova","raw_affiliation_strings":["Institute of Technology, University of Tartu, Tartu, 50411, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050436876","display_name":"Nastassia Shtaida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Nastassia Shtaida","raw_affiliation_strings":["Institute of Technology, University of Tartu, Tartu, 50411, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062598931","display_name":"Martin Lepiku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Martin Lepiku","raw_affiliation_strings":["Institute of Technology, University of Tartu, Tartu, 50411, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048924264","display_name":"Kaidi M\u00f6ll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Kaidi M\u00f6ll","raw_affiliation_strings":["Institute of Technology, University of Tartu, Tartu, 50411, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030639395","display_name":"Andreas Doncic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andreas Doncic","raw_affiliation_strings":["Department of Biology, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016233010","display_name":"Mardo K\u00f5ivom\u00e4gi","orcid":"https://orcid.org/0000-0003-4691-6930","observed_orcids":["https://orcid.org/0000-0003-4691-6930"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["EE","US"],"is_corresponding":false,"raw_author_name":"Mardo K\u00f5ivom\u00e4gi","raw_affiliation_strings":["Department of Biology, Stanford University, Stanford, CA, 94305, USA","Institute of Technology, University of Tartu, Tartu, 50411, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090178938","display_name":"Mart Loog","orcid":"https://orcid.org/0000-0003-1330-8453","observed_orcids":["https://orcid.org/0000-0003-1330-8453","https://orcid.org/0000-0002-1298-8461"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":true,"raw_author_name":"Mart Loog","raw_affiliation_strings":["Institute of Technology, University of Tartu, Tartu, 50411, Estonia. mart.loog@ut.ee","Institute of Technology, University of Tartu, Tartu, 50411, Estonia"],"raw_orcid":"https://orcid.org/0000-0003-1330-8453","affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia. mart.loog@ut.ee","institution_ids":["https://openalex.org/I56085075"]},{"raw_affiliation_string":"Institute of Technology, University of Tartu, Tartu, 50411, Estonia","institution_ids":["https://openalex.org/I56085075"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090178938"],"corresponding_institution_ids":["https://openalex.org/I56085075"],"apc_list":{"value":5380,"currency":"USD","value_usd":5380},"apc_paid":{"value":5380,"currency":"USD","value_usd":5380},"fwci":0.8727,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.68066873,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"1836","last_page":"1836"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.36959999799728394,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.36959999799728394,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.23929999768733978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.1371999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sic1","display_name":"Sic1","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.8790000081062317},{"id":"https://openalex.org/keywords/g1-s-transition","display_name":"G1/S transition","score":0.8009999990463257},{"id":"https://openalex.org/keywords/multisite-phosphorylation","display_name":"multisite phosphorylation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.6769999861717224},{"id":"https://openalex.org/keywords/signal-integration","display_name":"signal integration","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.44200000166893005},{"id":"https://openalex.org/keywords/disordered-proteins","display_name":"disordered proteins","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.889000415802002},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.8444284200668335},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6118429899215698},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5971530079841614},{"id":"https://openalex.org/C104551158","wikidata":"https://www.wikidata.org/wiki/Q7187581","display_name":"Phosphorylation cascade","level":5,"score":0.5676906108856201},{"id":"https://openalex.org/C2778298596","wikidata":"https://www.wikidata.org/wiki/Q17143494","display_name":"CDK inhibitor","level":5,"score":0.47494080662727356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4468110203742981},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42706745862960815},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.4085714817047119},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.3523937463760376},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.30306345224380493},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27774113416671753},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.17605388164520264},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.172859787940979}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41467-020-15685-z","doi":"https://doi.org/10.1038/s41467-020-15685-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-020-15685-z","pdf_url":"https://www.nature.com/articles/s41467-020-15685-z.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7160111","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7160111","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:32296067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32296067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15685-z","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-020-15685-z","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:4193f9a7643148afba8fdec5cd394703","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4193f9a7643148afba8fdec5cd394703","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-020-15685-z","doi":"https://doi.org/10.1038/s41467-020-15685-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-020-15685-z","pdf_url":"https://www.nature.com/articles/s41467-020-15685-z.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6394319100","display_name":"Mechanisms of restriction point response to dynamic growth factor signals","funder_award_id":"R01GM092925","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8029740613","display_name":"Biological signal processing via multisite phosphorylation networks","funder_award_id":"649124","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3016794476.pdf","grobid_xml":"https://content.openalex.org/works/W3016794476.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W41378854","https://openalex.org/W169216998","https://openalex.org/W1966034049","https://openalex.org/W1966072209","https://openalex.org/W1966385942","https://openalex.org/W1967071341","https://openalex.org/W1968611560","https://openalex.org/W1968854534","https://openalex.org/W1969613597","https://openalex.org/W1971353345","https://openalex.org/W1972312016","https://openalex.org/W1973582015","https://openalex.org/W1973939200","https://openalex.org/W1977770535","https://openalex.org/W1979845031","https://openalex.org/W1982197097","https://openalex.org/W1988243100","https://openalex.org/W2002315746","https://openalex.org/W2005984054","https://openalex.org/W2008789097","https://openalex.org/W2014238063","https://openalex.org/W2014946189","https://openalex.org/W2015853575","https://openalex.org/W2019557118","https://openalex.org/W2020968606","https://openalex.org/W2029888437","https://openalex.org/W2031893066","https://openalex.org/W2034062282","https://openalex.org/W2040412126","https://openalex.org/W2043591644","https://openalex.org/W2046193145","https://openalex.org/W2051144392","https://openalex.org/W2056658675","https://openalex.org/W2060515398","https://openalex.org/W2069405322","https://openalex.org/W2073341454","https://openalex.org/W2074126694","https://openalex.org/W2075053787","https://openalex.org/W2075408326","https://openalex.org/W2083474696","https://openalex.org/W2083731894","https://openalex.org/W2084350197","https://openalex.org/W2085289028","https://openalex.org/W2091538074","https://openalex.org/W2092062544","https://openalex.org/W2093070862","https://openalex.org/W2093330988","https://openalex.org/W2099357760","https://openalex.org/W2099626489","https://openalex.org/W2105131913","https://openalex.org/W2107325325","https://openalex.org/W2121121043","https://openalex.org/W2142437744","https://openalex.org/W2149676146","https://openalex.org/W2154046032","https://openalex.org/W2156413613","https://openalex.org/W2168964561","https://openalex.org/W2170314995","https://openalex.org/W2342067135","https://openalex.org/W2345490732","https://openalex.org/W2560559217","https://openalex.org/W2567255685","https://openalex.org/W2584719621","https://openalex.org/W2611554531","https://openalex.org/W2793849443","https://openalex.org/W2804803879","https://openalex.org/W2856084368","https://openalex.org/W2903877841","https://openalex.org/W2910736320","https://openalex.org/W2945104395","https://openalex.org/W2955338246","https://openalex.org/W6671172785"],"related_works":["https://openalex.org/W2083474696","https://openalex.org/W2056658675","https://openalex.org/W2910296327","https://openalex.org/W2131267458","https://openalex.org/W2075408326","https://openalex.org/W2274793994","https://openalex.org/W2955338246","https://openalex.org/W2793849443","https://openalex.org/W2075053787","https://openalex.org/W1966385942"],"abstract_inverted_index":{"Studies":[0],"on":[1],"multisite":[2],"phosphorylation":[3,36,48,63,71,102,126,131],"networks":[4],"of":[5,15,112,124],"cyclin-dependent":[6],"kinase":[7,141],"(CDK)":[8],"targets":[9],"have":[10],"opened":[11],"a":[12,53,73,82,135],"new":[13],"level":[14],"signaling":[16],"complexity":[17],"by":[18],"revealing":[19],"signal":[20,54],"processing":[21,55,139],"routes":[22,64,103],"encoded":[23],"into":[24],"disordered":[25],"proteins.":[26],"A":[27],"model":[28],"target,":[29],"the":[30,66,88,115,122],"CDK":[31],"inhibitor":[32],"Sic1,":[33],"contains":[34],"linear":[35],"motifs,":[37],"docking":[38],"sites,":[39],"and":[40,80,90,108],"phosphodegrons":[41],"to":[42,84,120,143],"empower":[43],"an":[44],"N-to-C":[45],"terminally":[46],"directed":[47],"process.":[49],"Here,":[50],"we":[51],"uncover":[52],"mechanism":[56,83],"involving":[57],"multi-step":[58],"competition":[59,123],"between":[60],"mutually":[61,129],"diversional":[62,130],"within":[65],"S-CDK-Sic1":[67],"inhibitory":[68],"complex.":[69],"Intracomplex":[70],"plays":[72],"direct":[74],"role":[75],"in":[76,147],"controlling":[77],"Sic1":[78,106],"degradation,":[79],"provides":[81],"sequentially":[85],"integrate":[86],"both":[87],"G1-":[89],"S-CDK":[91,95],"activities":[92],"while":[93],"keeping":[94],"inhibited":[96],"towards":[97],"other":[98],"targets.":[99],"The":[100,128],"competing":[101],"prevent":[104],"premature":[105],"degradation":[107],"demonstrate":[109],"how":[110],"integration":[111],"MAPK":[113],"from":[114],"pheromone":[116],"pathway":[117],"allows":[118],"one":[119],"tune":[121],"alternative":[125],"paths.":[127],"circuits":[132],"may":[133],"be":[134],"general":[136],"way":[137],"for":[138],"multiple":[140],"signals":[142],"coordinate":[144],"cellular":[145],"decisions":[146],"eukaryotes.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-24T00:00:00"}
