{"id":"https://openalex.org/W3016725035","doi":"https://doi.org/10.3390/ijms21082844","title":"Pro-Arrhythmic Signaling of Thyroid Hormones and Its Relevance in Subclinical Hyperthyroidism","display_name":"Pro-Arrhythmic Signaling of Thyroid Hormones and Its Relevance in Subclinical Hyperthyroidism","publication_year":2020,"publication_date":"2020-04-19","ids":{"openalex":"https://openalex.org/W3016725035","doi":"https://doi.org/10.3390/ijms21082844","mag":"3016725035","pmid":"https://pubmed.ncbi.nlm.nih.gov/32325836"},"language":"en","primary_location":{"id":"doi:10.3390/ijms21082844","doi":"https://doi.org/10.3390/ijms21082844","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21082844","pdf_url":"https://www.mdpi.com/1422-0067/21/8/2844/pdf","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/21/8/2844/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022101028","display_name":"Narcis Tribulov\u00e1","orcid":"https://orcid.org/0000-0002-5904-4249","observed_orcids":["https://orcid.org/0000-0002-5904-4249"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210143440","display_name":"Centre of Experimental Medicine of the Slovak Academy of Sciences","ror":"https://ror.org/0380mmw63","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210143440"]}],"countries":["SK"],"is_corresponding":true,"raw_author_name":"Narcis Tribulova","raw_affiliation_strings":["Centre of Experimental Medicine, Slovak Academy of Sciences, Institute for Heart Research, 84104 Bratislava, Slovakia"],"raw_orcid":"https://orcid.org/0000-0002-5904-4249","affiliations":[{"raw_affiliation_string":"Centre of Experimental Medicine, Slovak Academy of Sciences, Institute for Heart Research, 84104 Bratislava, Slovakia","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210143440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051400475","display_name":"Lin Hai Kurahara","orcid":"https://orcid.org/0000-0001-7425-5768","observed_orcids":["https://orcid.org/0000-0001-7425-5768"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Lin Hai Kurahara","raw_affiliation_strings":["Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 76 0793, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 76 0793, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052549292","display_name":"Peter Hliv\u00e1k","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093337","display_name":"National Institute of Cardiovascular Diseases","ror":"https://ror.org/00gktjq65","country_code":"SK","type":"healthcare","lineage":["https://openalex.org/I4210093337"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Peter Hlivak","raw_affiliation_strings":["Department of Arrhythmias and Pacing, National Institute of Cardiovascular Diseases, Pod Kr\u00e1snou H\u00f4rkou 1, 83348 Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Arrhythmias and Pacing, National Institute of Cardiovascular Diseases, Pod Kr\u00e1snou H\u00f4rkou 1, 83348 Bratislava, Slovakia","institution_ids":["https://openalex.org/I4210093337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035163478","display_name":"Katsuya Hirano","orcid":"https://orcid.org/0000-0003-0164-1283","observed_orcids":["https://orcid.org/0000-0003-0164-1283"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuya Hirano","raw_affiliation_strings":["Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 76 0793, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0164-1283","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 76 0793, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047595986","display_name":"Barbara Szeiffov\u00e1 Ba\u010dov\u00e1","orcid":"https://orcid.org/0000-0001-8394-7459","observed_orcids":["https://orcid.org/0000-0001-8394-7459"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210143440","display_name":"Centre of Experimental Medicine of the Slovak Academy of Sciences","ror":"https://ror.org/0380mmw63","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210143440"]}],"countries":["SK"],"is_corresponding":true,"raw_author_name":"Barbara Szeiffova Bacova","raw_affiliation_strings":["Centre of Experimental Medicine, Slovak Academy of Sciences, Institute for Heart Research, 84104 Bratislava, Slovakia"],"raw_orcid":"https://orcid.org/0000-0001-8394-7459","affiliations":[{"raw_affiliation_string":"Centre of Experimental Medicine, Slovak Academy of Sciences, Institute for Heart Research, 84104 Bratislava, Slovakia","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210143440"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5022101028","https://openalex.org/A5047595986"],"corresponding_institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210143440"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2112},"fwci":3.3379,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.93206494,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"21","issue":"8","first_page":"2844","last_page":"2844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.490200012922287,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.490200012922287,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.4702000021934509,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.9789999723434448},{"id":"https://openalex.org/keywords/subclinical-hyperthyroidism","display_name":"subclinical hyperthyroidism","score":0.9860000014305115},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ventricular-fibrillation","display_name":"ventricular fibrillation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.9340000152587891},{"id":"https://openalex.org/keywords/thyroid-disease","display_name":"thyroid dysfunction","score":0.593999981880188},{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.7129999995231628},{"id":"https://openalex.org/keywords/arrhythmia-screening","display_name":"arrhythmia screening","score":0.7319999933242798},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.800000011920929},{"id":"https://openalex.org/keywords/thyroid-monitoring","display_name":"thyroid function monitoring","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.848791241645813},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.7003070712089539},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.6992080807685852},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.6613181829452515},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5986435413360596},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5382959246635437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5178744792938232},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.4682767391204834},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.45102164149284363},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.43789345026016235},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.42282533645629883},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.41521769762039185},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40485942363739014},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms21082844","doi":"https://doi.org/10.3390/ijms21082844","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21082844","pdf_url":"https://www.mdpi.com/1422-0067/21/8/2844/pdf","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:32325836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32325836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7215427","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7215427","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e042dd3d418440a28f17483993b8d47e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e042dd3d418440a28f17483993b8d47e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 21, Iss 2844, p 2844 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms21082844","doi":"https://doi.org/10.3390/ijms21082844","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21082844","pdf_url":"https://www.mdpi.com/1422-0067/21/8/2844/pdf","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1211940974","display_name":null,"funder_award_id":"ITMS 26230120009","funder_id":"https://openalex.org/F4320323251","funder_display_name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja"},{"id":"https://openalex.org/G1560573699","display_name":null,"funder_award_id":"2/0002/20, 2/0158/19","funder_id":"https://openalex.org/F4320323641","funder_display_name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV"},{"id":"https://openalex.org/G1581275680","display_name":"Modul\u00e1cia dysregul\u00e1cie extracelul\u00e1rnej matrix a medzibunkovej komunik\u00e1cie ako protekcia srdcov\u00e9ho svalu pred jeho funk\u010dn\u00fdm zlyhan\u00edm","funder_award_id":"2/0158/19","funder_id":"https://openalex.org/F4320323641","funder_display_name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV"},{"id":"https://openalex.org/G2152067459","display_name":"\u00daloha matrixov\u00fdch metaloprotein\u00e1z v patofyziol\u00f3gii ochoren\u00ed kardiovaskul\u00e1rneho syst\u00e9mu a ich vz\u0165ah k bunkovej redoxnej signaliz\u00e1cii.","funder_award_id":"APVV-18-0548","funder_id":"https://openalex.org/F4320323251","funder_display_name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja"},{"id":"https://openalex.org/G2902531523","display_name":null,"funder_award_id":"18-0548","funder_id":"https://openalex.org/F4320323251","funder_display_name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja"},{"id":"https://openalex.org/G3129661604","display_name":null,"funder_award_id":"2/0002/20","funder_id":"https://openalex.org/F4320323251","funder_display_name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja"},{"id":"https://openalex.org/G3951401579","display_name":null,"funder_award_id":"18-0548","funder_id":"https://openalex.org/F4320323641","funder_display_name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV"},{"id":"https://openalex.org/G8160782162","display_name":null,"funder_award_id":"2/0158/19","funder_id":"https://openalex.org/F4320323251","funder_display_name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja"},{"id":"https://openalex.org/G8444121069","display_name":"Podie\u013eaj\u00fa sa konexinov\u00e9 kan\u00e1ly v pre\u0165a\u017eenom srdcovom svale na extracelul\u00e1rnej signaliz\u00e1cii?","funder_award_id":"2/0002/20","funder_id":"https://openalex.org/F4320323641","funder_display_name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320323251","display_name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","ror":"https://ror.org/037nx0e70"},{"id":"https://openalex.org/F4320323641","display_name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","ror":"https://ror.org/044gwpv05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3016725035.pdf","grobid_xml":"https://content.openalex.org/works/W3016725035.grobid-xml"},"referenced_works_count":187,"referenced_works":["https://openalex.org/W157290269","https://openalex.org/W210190803","https://openalex.org/W1554539653","https://openalex.org/W1603909332","https://openalex.org/W1711651084","https://openalex.org/W1806387089","https://openalex.org/W1865925416","https://openalex.org/W1878630995","https://openalex.org/W1882702377","https://openalex.org/W1934330082","https://openalex.org/W1934478547","https://openalex.org/W1968825092","https://openalex.org/W1969069960","https://openalex.org/W1972952051","https://openalex.org/W1974115524","https://openalex.org/W1977335079","https://openalex.org/W1979503790","https://openalex.org/W1980066114","https://openalex.org/W1980619039","https://openalex.org/W1981119921","https://openalex.org/W1981468683","https://openalex.org/W1984273763","https://openalex.org/W1984968735","https://openalex.org/W1987278537","https://openalex.org/W1987554263","https://openalex.org/W1988542457","https://openalex.org/W1990902391","https://openalex.org/W1994325234","https://openalex.org/W1996773497","https://openalex.org/W2000829099","https://openalex.org/W2001982932","https://openalex.org/W2002347306","https://openalex.org/W2004880381","https://openalex.org/W2007018022","https://openalex.org/W2007874450","https://openalex.org/W2008261416","https://openalex.org/W2015178517","https://openalex.org/W2016894809","https://openalex.org/W2018003299","https://openalex.org/W2018393972","https://openalex.org/W2019411099","https://openalex.org/W2020239040","https://openalex.org/W2021597262","https://openalex.org/W2023582728","https://openalex.org/W2030514800","https://openalex.org/W2031897378","https://openalex.org/W2037441873","https://openalex.org/W2040165919","https://openalex.org/W2044265494","https://openalex.org/W2048328804","https://openalex.org/W2048767541","https://openalex.org/W2051520924","https://openalex.org/W2054144101","https://openalex.org/W2055181085","https://openalex.org/W2057348494","https://openalex.org/W2059131232","https://openalex.org/W2059521780","https://openalex.org/W2061660782","https://openalex.org/W2069934475","https://openalex.org/W2071876833","https://openalex.org/W2072886802","https://openalex.org/W2072930794","https://openalex.org/W2077566951","https://openalex.org/W2084156736","https://openalex.org/W2084936577","https://openalex.org/W2085412278","https://openalex.org/W2088104087","https://openalex.org/W2088321862","https://openalex.org/W2088360401","https://openalex.org/W2091365349","https://openalex.org/W2091694236","https://openalex.org/W2093671578","https://openalex.org/W2094468923","https://openalex.org/W2094925577","https://openalex.org/W2096578639","https://openalex.org/W2099520632","https://openalex.org/W2103848753","https://openalex.org/W2104878795","https://openalex.org/W2109296221","https://openalex.org/W2113900128","https://openalex.org/W2117655540","https://openalex.org/W2125693777","https://openalex.org/W2125915632","https://openalex.org/W2127231749","https://openalex.org/W2129158124","https://openalex.org/W2131426085","https://openalex.org/W2133889902","https://openalex.org/W2134959627","https://openalex.org/W2136011831","https://openalex.org/W2142884678","https://openalex.org/W2145150141","https://openalex.org/W2147053330","https://openalex.org/W2157187478","https://openalex.org/W2163166383","https://openalex.org/W2166325215","https://openalex.org/W2188037463","https://openalex.org/W2188232659","https://openalex.org/W2285936819","https://openalex.org/W2286191259","https://openalex.org/W2290271902","https://openalex.org/W2295659228","https://openalex.org/W2326962210","https://openalex.org/W2327362588","https://openalex.org/W2334830774","https://openalex.org/W2335515807","https://openalex.org/W2405056447","https://openalex.org/W2405867792","https://openalex.org/W2412682333","https://openalex.org/W2438353738","https://openalex.org/W2510859972","https://openalex.org/W2529810529","https://openalex.org/W2543964031","https://openalex.org/W2548036931","https://openalex.org/W2553971935","https://openalex.org/W2554753136","https://openalex.org/W2555014584","https://openalex.org/W2566015711","https://openalex.org/W2580569340","https://openalex.org/W2585599186","https://openalex.org/W2610341885","https://openalex.org/W2612401584","https://openalex.org/W2615531284","https://openalex.org/W2622087432","https://openalex.org/W2626926653","https://openalex.org/W2728057735","https://openalex.org/W2730554710","https://openalex.org/W2736146023","https://openalex.org/W2740498566","https://openalex.org/W2741267358","https://openalex.org/W2753738702","https://openalex.org/W2765818361","https://openalex.org/W2770169816","https://openalex.org/W2770552330","https://openalex.org/W2783160943","https://openalex.org/W2784029422","https://openalex.org/W2789196755","https://openalex.org/W2789587536","https://openalex.org/W2789933752","https://openalex.org/W2793681123","https://openalex.org/W2807412777","https://openalex.org/W2807811640","https://openalex.org/W2807860131","https://openalex.org/W2825870779","https://openalex.org/W2884110630","https://openalex.org/W2888765975","https://openalex.org/W2890226705","https://openalex.org/W2891312160","https://openalex.org/W2891685194","https://openalex.org/W2895921009","https://openalex.org/W2896088203","https://openalex.org/W2898861888","https://openalex.org/W2899397337","https://openalex.org/W2909558076","https://openalex.org/W2910737182","https://openalex.org/W2912012956","https://openalex.org/W2912085287","https://openalex.org/W2914211653","https://openalex.org/W2919115270","https://openalex.org/W2921726967","https://openalex.org/W2932100740","https://openalex.org/W2935962098","https://openalex.org/W2939096132","https://openalex.org/W2940263020","https://openalex.org/W2943629577","https://openalex.org/W2945392393","https://openalex.org/W2946816927","https://openalex.org/W2952761908","https://openalex.org/W2952819244","https://openalex.org/W2969282106","https://openalex.org/W2969499723","https://openalex.org/W2979761477","https://openalex.org/W2981577402","https://openalex.org/W2982743602","https://openalex.org/W2988929105","https://openalex.org/W2988935662","https://openalex.org/W2989882033","https://openalex.org/W2990444645","https://openalex.org/W2991834023","https://openalex.org/W2994242452","https://openalex.org/W2995656233","https://openalex.org/W2998911611","https://openalex.org/W3003956197","https://openalex.org/W3005463714","https://openalex.org/W3006667688","https://openalex.org/W3027405891","https://openalex.org/W3155374261","https://openalex.org/W4210957724"],"related_works":["https://openalex.org/W4206182164","https://openalex.org/W1952985933","https://openalex.org/W2374354250","https://openalex.org/W3148222271","https://openalex.org/W2023982075","https://openalex.org/W2744046436","https://openalex.org/W2087959434","https://openalex.org/W3036503483","https://openalex.org/W2909419072","https://openalex.org/W2356716659"],"abstract_inverted_index":{"A":[0],"perennial":[1],"task":[2],"is":[3,182],"to":[4,55,100,173],"prevent":[5,207],"the":[6,47,51,59,85,102,111,121,129,141,152,212],"occurrence":[7,130],"and/or":[8],"recurrence":[9,132],"of":[10,40,44,62,90,104,123,133,143,199,214,225,246],"most":[11],"frequent":[12],"or":[13,37],"life-threatening":[14],"cardiac":[15,134,238],"arrhythmias":[16,239],"such":[17],"as":[18,155,157],"atrial":[19],"fibrillation":[20,24],"(AF)":[21],"and":[22,76,81,93,131,148,163,210,241],"ventricular":[23],"(VF).":[25],"VF":[26],"may":[27,206,218],"be":[28,197,219,233],"lethal":[29],"in":[30,72,88,107,110,151,158,171,184,227],"cases":[31,89],"without":[32],"an":[33,222],"implantable":[34],"cardioverter":[35],"defibrillator":[36],"with":[38,160,186,202],"failure":[39],"this":[41],"device.":[42],"Incidences":[43],"AF,":[45],"even":[46],"asymptomatic":[48,203],"ones,":[49],"jeopardize":[50],"patient's":[52],"life":[53],"due":[54],"its":[56],"complication,":[57],"notably":[58],"high":[60],"risk":[61],"embolic":[63],"stroke.":[64],"Therefore,":[65],"there":[66],"has":[67],"been":[68],"a":[69,235],"growing":[70],"interest":[71],"subclinical":[73],"AF":[74,149,169,181,226],"screening":[75,150,240],"searching":[77],"for":[78,221,237],"novel":[79],"electrophysiological":[80],"molecular":[82],"markers.":[83],"Considering":[84],"worldwide":[86],"increase":[87],"thyroid":[91,96,105,125,145,161,174,187,192],"dysfunction":[92,162],"diseases,":[94],"including":[95],"carcinoma,":[97],"we":[98],"aimed":[99],"explore":[101],"implication":[103],"hormones":[106,231],"pro-arrhythmic":[108],"signaling":[109],"pathophysiological":[112],"setting.":[113],"The":[114],"present":[115],"review":[116],"provides":[117],"updated":[118,223],"information":[119],"about":[120],"impact":[122],"altered":[124],"status":[126,146],"on":[127,167],"both":[128,144],"arrhythmias,":[135],"predominantly":[136],"AF.":[137,204],"Moreover,":[138],"it":[139],"emphasizes":[140],"importance":[142],"monitoring":[147],"general":[153],"population,":[154],"well":[156],"patients":[159,185],"malignancies.":[164],"Real-world":[165],"data":[166],"early":[168],"identification":[170],"relation":[172],"function":[175],"are":[176,190],"scarce.":[177],"Even":[178],"though":[179],"symptomatic":[180],"rare":[183],"malignancies,":[188],"who":[189],"under":[191],"suppressive":[193],"therapy,":[194],"clinicians":[195],"should":[196,232],"aware":[198],"potential":[200],"interaction":[201],"It":[205],"adverse":[208],"consequences":[209],"improve":[211],"quality":[213],"life.":[215],"This":[216],"issue":[217],"challenging":[220],"registry":[224],"clinical":[228],"practice.":[229],"Thyroid":[230],"considered":[234],"biomarker":[236],"their":[242,247],"tailored":[243],"management":[244],"because":[245],"multifaceted":[248],"cellular":[249],"actions.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}