{"id":"https://openalex.org/W3016692580","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.00418","title":"Mechanisms of Linear Growth Acceleration in Childhood Obesity","display_name":"Mechanisms of Linear Growth Acceleration in Childhood Obesity","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3016692580","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.00418","mag":"3016692580"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2020.34.s1.00418","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.00418","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.00418","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020468105","display_name":"Maria A. Serrat","orcid":"https://orcid.org/0000-0001-9211-9508","observed_orcids":["https://orcid.org/0000-0001-9211-9508"]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria A. Serrat","raw_affiliation_strings":["Marshall University Joan C. Edwards School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marshall University Joan C. Edwards School of Medicine","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037271508","display_name":"Allison L. Machnicki","orcid":"https://orcid.org/0000-0002-4784-8004","observed_orcids":["https://orcid.org/0000-0002-4784-8004"]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison L. Machnicki","raw_affiliation_strings":["Marshall University Joan C. Edwards School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marshall University Joan C. Edwards School of Medicine","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109236535","display_name":"Cassaundra A. Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cassaundra A. Song","raw_affiliation_strings":["Marshall University Joan C. Edwards School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marshall University Joan C. Edwards School of Medicine","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030106193","display_name":"Sarah Evans","orcid":"https://orcid.org/0000-0002-6390-6729","observed_orcids":["https://orcid.org/0000-0002-6390-6729"]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Evans","raw_affiliation_strings":["Marshall University Joan C. Edwards School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marshall University Joan C. Edwards School of Medicine","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053845760","display_name":"Darby McCloud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darby McCloud","raw_affiliation_strings":["Marshall University Joan C. Edwards School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marshall University Joan C. Edwards School of Medicine","institution_ids":["https://openalex.org/I88694374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I88694374"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"S1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10010","display_name":"Obesity, Physical Activity, Diet","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"childhood obesity","score":0.996999979019165},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8769999742507935},{"id":"https://openalex.org/keywords/growth-plate","display_name":"growth plate","score":0.6510000228881836},{"id":"https://openalex.org/keywords/bone-elongation","display_name":"bone elongation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9490000009536743},{"id":"https://openalex.org/keywords/igf-i-bioavailability","display_name":"IGF-I bioavailability","score":0.796999990940094},{"id":"https://openalex.org/keywords/growth-plate-cartilage","display_name":"growth plate cartilage","score":0.7289999723434448},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7422582507133484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7121502757072449},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6163063645362854},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.5372905731201172},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4437348246574402},{"id":"https://openalex.org/C2991750140","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Bone growth","level":2,"score":0.43102186918258667},{"id":"https://openalex.org/C2779422640","wikidata":"https://www.wikidata.org/wiki/Q3241451","display_name":"Childhood obesity","level":4,"score":0.43037691712379456},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4205726385116577},{"id":"https://openalex.org/C2777871287","wikidata":"https://www.wikidata.org/wiki/Q7502090","display_name":"Short stature","level":2,"score":0.4169689118862152},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.41189080476760864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36139732599258423},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.15125834941864014}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2020.34.s1.00418","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.00418","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.00418","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3177027272","https://openalex.org/W4206105257","https://openalex.org/W3017292888","https://openalex.org/W4225392896","https://openalex.org/W3171480439","https://openalex.org/W3016892195","https://openalex.org/W2916151214","https://openalex.org/W2321723885","https://openalex.org/W2172030972","https://openalex.org/W2588651438"],"abstract_inverted_index":{"The":[0,76],"obesity":[1,110],"epidemic":[2],"is":[3,60,246,255,288],"alarming.":[4],"Nearly":[5],"one\u2010third":[6],"of":[7,35,70,78,92,108,174,193,217,239,264,282,294,319,324,336,344,351,355],"children":[8,64,259],"in":[9,96,111,141,155,167,197,219,231,244,257,271,285,308],"the":[10,18,72,106,168,171,191,198,280,320,333,352],"Unites":[11],"States":[12],"are":[13,31,273],"overweight":[14],"or":[15,133,328],"obese":[16,63,258],"by":[17,332],"time":[19],"they":[20],"reach":[21],"their":[22],"pre\u2010teen":[23],"years.":[24],"Tall":[25],"stature":[26],"and":[27,52,228,277,291,341,346,348],"accelerated":[28,256],"bone":[29,100,126,286],"elongation":[30,101,127],"distinctive":[32],"clinical":[33],"features":[34],"childhood":[36,325],"obesity,":[37],"which":[38],"tend":[39],"to":[40,98,121,145,152,181],"co\u2010occur":[41],"with":[42,105],"painful":[43],"conditions":[44],"such":[45],"as":[46,164],"limb":[47],"bowing,":[48],"slipped":[49],"epiphyses,":[50],"fractures,":[51],"early":[53],"onset":[54],"osteoarthritis.":[55],"Although":[56],"linear":[57,253],"growth":[58,80,153,172,199,220,241,254,309],"rate":[59,128],"markedly":[61],"increased,":[62],"paradoxically":[65],"have":[66,261],"normal":[67,262],"circulating":[68,134],"levels":[69,263],"IGF\u2010I,":[71],"major":[73],"growth\u2010stimulating":[74],"hormone.":[75],"causes":[77],"obesity\u2010induced":[79],"acceleration":[81],"remain":[82],"elusive.":[83],"Our":[84],"lab":[85],"has":[86],"used":[87,140],"a":[88,122,177,187,211,289,313],"well\u2010established":[89],"mouse":[90],"model":[91],"excess":[93],"dietary":[94,283],"fat":[95,272,284],"order":[97],"examine":[99],"changes":[102,230],"that":[103,118,186,210],"occur":[104],"development":[107],"juvenile":[109],"young":[112],"growing":[113],"mice.":[114],"We":[115],"found,":[116],"surprisingly,":[117],"brief":[119],"exposure":[120],"high\u2010fat":[123,178,188,212],"diet":[124,179,189,213],"accelerates":[125],"without":[129,223],"increasing":[130],"body":[131,232],"mass":[132,233],"IGF\u2010I":[135,150,166,195,218,226,306],"levels.":[136],"Interestingly,":[137],"when":[138],"we":[139,158],"vivo":[142],"multiphoton":[143],"microscopy":[144],"measure":[146],"how":[147],"much":[148],"systemic":[149,225,265],"localized":[151],"plates":[154,173,310],"real":[156],"time,":[157],"found":[159],"significantly":[160],"more":[161],"(nearly":[162],"twice":[163],"much)":[165],"vasculature":[169],"surrounding":[170],"mice":[175],"on":[176],"relative":[180],"controls.":[182],"Post\u2010mortem":[183],"immunostaining":[184],"confirmed":[185],"increased":[190],"number":[192],"activated":[194],"receptors":[196],"plate,":[200],"but":[201],"not":[202],"total":[203],"receptor":[204],"number.":[205],"Together,":[206],"these":[207],"results":[208],"suggest":[209],"increases":[214],"local":[215],"bioavailability":[216],"plate":[221],"cartilage":[222,245],"altering":[224],"levels,":[227],"before":[229],"become":[234],"evident.":[235],"This":[236],"unique":[237],"method":[238],"imaging":[240],"factor":[242],"transport":[243],"an":[247],"important":[248],"advancement":[249],"for":[250,275,302,316],"addressing":[251],"why":[252],"who":[260],"growth\u2010promoting":[266],"hormones.":[267],"While":[268],"diets":[269],"high":[270],"well\u2010recognized":[274],"cardiovascular":[276],"metabolic":[278],"complications,":[279],"role":[281],"lengthening":[287],"novel":[290],"timely":[292],"area":[293],"research.":[295],"These":[296],"studies":[297],"may":[298],"provide":[299],"essential":[300],"data":[301],"testing":[303],"whether":[304],"impeding":[305],"actions":[307],"could":[311],"be":[312],"beneficial":[314],"approach":[315],"mitigating":[317],"some":[318],"deleterious":[321],"skeletal":[322],"consequences":[323],"obesity.":[326],"Support":[327],"Funding":[329],"Information":[330],"Supported":[331],"National":[334,342,353],"Institute":[335,343],"General":[337],"Medical":[338],"Sciences":[339],"(1P20GM121299\u201001)":[340],"Arthritis":[345],"Musculoskeletal":[347],"Skin":[349],"Diseases":[350],"Institutes":[354],"Health":[356],"(1R15AR067451\u201001).":[357]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2020-04-24T00:00:00"}