{"id":"https://openalex.org/W3016571298","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.00151","title":"Mitochondrial NAD Transport","display_name":"Mitochondrial NAD Transport","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3016571298","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.00151","mag":"3016571298"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2020.34.s1.00151","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.00151","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.00151","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008922330","display_name":"Joseph A. Baur","orcid":"https://orcid.org/0000-0001-8262-6549","observed_orcids":["https://orcid.org/0000-0001-8262-6549"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Baur","raw_affiliation_strings":["University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084496844","display_name":"Timothy S. Luongo","orcid":"https://orcid.org/0000-0001-7621-7992","observed_orcids":["https://orcid.org/0000-0001-7621-7992"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Luongo","raw_affiliation_strings":["University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057855935","display_name":"Sarmistha Mukherjee","orcid":"https://orcid.org/0000-0002-3258-0287","observed_orcids":["https://orcid.org/0000-0002-3258-0287"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarmistha Mukherjee","raw_affiliation_strings":["University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011678311","display_name":"Jared Eller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared Eller","raw_affiliation_strings":["University of Texas at Austin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Austin","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036669790","display_name":"Karthikeyani Chellappa","orcid":"https://orcid.org/0000-0001-7397-5974","observed_orcids":["https://orcid.org/0000-0001-7397-5974"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karthikeyani Chellappa","raw_affiliation_strings":["University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055921856","display_name":"Mu\u2010Jie Lu","orcid":"https://orcid.org/0000-0002-2174-1153","observed_orcids":["https://orcid.org/0000-0002-2174-1153"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mu-Jie Lu","raw_affiliation_strings":["University of Texas at Austin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Austin","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058964755","display_name":"Lulu Cambronne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lulu Cambronne","raw_affiliation_strings":["University of Texas at Austin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Austin","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"S1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-capacity","display_name":"respiratory capacity","score":0.6449999809265137},{"id":"https://openalex.org/keywords/nad-depletion","display_name":"NAD+ depletion","score":0.7459999918937683},{"id":"https://openalex.org/keywords/isotopic-labeling","display_name":"isotopic labeling","score":0.746999979019165},{"id":"https://openalex.org/keywords/nad-precursors","display_name":"NAD+ precursors","score":0.7850000262260437},{"id":"https://openalex.org/keywords/healthspan","display_name":"healthspan","score":0.6589999794960022},{"id":"https://openalex.org/keywords/mitochondrial-matrix","display_name":"mitochondrial matrix","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.9693834781646729},{"id":"https://openalex.org/C2776901170","wikidata":"https://www.wikidata.org/wiki/Q12499775","display_name":"Nicotinamide adenine dinucleotide","level":4,"score":0.6789246797561646},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6703817844390869},{"id":"https://openalex.org/C45566312","wikidata":"https://www.wikidata.org/wiki/Q307765","display_name":"Glycerol-3-phosphate dehydrogenase","level":4,"score":0.5325798988342285},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5074211955070496},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.4597497284412384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4479512572288513},{"id":"https://openalex.org/C11701378","wikidata":"https://www.wikidata.org/wiki/Q3493378","display_name":"Mitochondrial matrix","level":4,"score":0.43967005610466003},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.4383547604084015},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43569377064704895},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39353275299072266},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.2868002951145172},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14868062734603882}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2020.34.s1.00151","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.00151","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.00151","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3117313246","https://openalex.org/W3171778019","https://openalex.org/W3084174900","https://openalex.org/W4390065260","https://openalex.org/W6965196758","https://openalex.org/W2808587354","https://openalex.org/W4389884737","https://openalex.org/W7019290111","https://openalex.org/W3131251965","https://openalex.org/W4416515893"],"abstract_inverted_index":{"Tissue":[0],"nicotinamide":[1],"adenine":[2],"dinucleotide":[3],"(NAD)":[4],"levels":[5],"correlate":[6],"with":[7,10,16],"healthspan,":[8],"falling":[9],"age":[11],"or":[12,18,173],"disease,":[13],"and":[14,64,123,154],"rising":[15],"exercise":[17],"caloric":[19],"restriction.":[20],"Moreover,":[21],"the":[22,45,61,67,70,72,132,150,166],"demonstration":[23],"that":[24,56,89,110,129,160],"supplemental":[25],"NAD":[26,57,76,94,135,142],"precursors":[27],"drive":[28],"beneficial":[29],"effects":[30],"in":[31,42,44,60,119,149],"a":[32,40,127,146],"variety":[33],"of":[34,48,69,74,92,134,141,152],"rodent":[35],"models":[36],"has":[37,77],"led":[38],"to":[39,66,87,103,115,156,177,180],"resurgence":[41],"interest":[43],"basic":[46],"biology":[47],"this":[49,105,111],"molecule.":[50],"Although":[51],"it":[52],"is":[53,58,95,113],"widely":[54],"recognized":[55],"present":[59],"mitochondrial":[62,75,137],"matrix":[63],"critical":[65],"function":[68],"organelle,":[71],"source":[73],"been":[78,170],"debated.":[79],"We":[80],"recently":[81],"used":[82],"an":[83],"isotopic":[84],"labeling":[85],"approach":[86],"demonstrate":[88],"direct":[90],"uptake":[91],"intact":[93],"one":[96],"mechanism":[97],"by":[98],"which":[99],"mitochondria":[100],"are":[101],"able":[102],"obtain":[104],"nucleotide.":[106],"Here,":[107],"we":[108],"show":[109],"activity":[112],"sufficient":[114],"restore":[116],"respiratory":[117],"capacity":[118],"NAD\u2010deficient":[120],"isolated":[121],"mitochondria,":[122],"identify":[124],"SLC25A51":[125],"as":[126],"carrier":[128],"can":[130],"mediate":[131],"transport":[133],"across":[136],"membranes.":[138],"Compartment\u2010specific":[139],"regulation":[140],"concentration":[143],"may":[144],"be":[145,162],"crucial":[147],"element":[148],"adaptation":[151],"cells":[153],"tissues":[155],"changing":[157],"metabolic":[158],"environment":[159],"could":[161],"targeted":[163],"therapeutically":[164],"once":[165],"underlying":[167],"mechanisms":[168],"have":[169],"revealed.":[171],"Support":[172],"Funding":[174],"Information":[175],"DK098656":[176],"J.A.B.,":[178],"GM126897":[179],"L.A.C.":[181]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2020-04-24T00:00:00"}
