{"id":"https://openalex.org/W3016567408","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.04083","title":"Role of transporters and S100A8/A9 in paclitaxel\u2010induced peripheral neuropathy","display_name":"Role of transporters and S100A8/A9 in paclitaxel\u2010induced peripheral neuropathy","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3016567408","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.04083","mag":"3016567408"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2020.34.s1.04083","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.04083","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.04083","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100769864","display_name":"Yang Li","orcid":"https://orcid.org/0000-0001-8950-1212","observed_orcids":["https://orcid.org/0000-0001-8950-1212"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Li","raw_affiliation_strings":["College of Pharmacy, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036117354","display_name":"Megan E. Zavorka Thomas","orcid":"https://orcid.org/0009-0006-4825-8168","observed_orcids":["https://orcid.org/0009-0006-4825-8168"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan E. Zavorka Thomas","raw_affiliation_strings":["College of Pharmacy, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108816051","display_name":"Alix F. Leblanc","orcid":"https://orcid.org/0000-0001-8667-103X","observed_orcids":["https://orcid.org/0000-0001-8667-103X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alix F. Leblanc","raw_affiliation_strings":["College of Pharmacy, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009516908","display_name":"Kevin M. Huang","orcid":"https://orcid.org/0000-0001-6561-3295","observed_orcids":["https://orcid.org/0000-0001-6561-3295"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin M. Huang","raw_affiliation_strings":["College of Pharmacy, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101957764","display_name":"Mingqing Chen","orcid":"https://orcid.org/0000-0002-9421-8355","observed_orcids":["https://orcid.org/0000-0002-9421-8355"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingqing Chen","raw_affiliation_strings":["College of Pharmacy, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026188123","display_name":"Jason A. Sprowl","orcid":"https://orcid.org/0000-0003-2573-2518","observed_orcids":["https://orcid.org/0000-0003-2573-2518"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason A. Sprowl","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences, University of Buffalo, State University of New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, University of Buffalo, State University of New York","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068080699","display_name":"Alice A. Gibson","orcid":"https://orcid.org/0000-0001-5910-5067","observed_orcids":["https://orcid.org/0000-0001-5910-5067"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice A. Gibson","raw_affiliation_strings":["College of Pharmacy, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035393849","display_name":"Maryam B. Lustburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam M. Lustburg","raw_affiliation_strings":["Comprehensive Cancer Center, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, The Ohio State University","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065279964","display_name":"Alex Sparreboom","orcid":"https://orcid.org/0000-0003-2660-6644","observed_orcids":["https://orcid.org/0000-0003-2660-6644"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Sparreboom","raw_affiliation_strings":["College of Pharmacy, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077955893","display_name":"Shuiying Hu","orcid":"https://orcid.org/0000-0002-9806-7734","observed_orcids":["https://orcid.org/0000-0002-9806-7734"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuiying Hu","raw_affiliation_strings":["College of Pharmacy, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"S1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.984000027179718},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/oatp1b2","display_name":"Oatp1b2","score":0.8849999904632568},{"id":"https://openalex.org/keywords/s100a8-a9","display_name":"S100A8/A9","score":0.9210000038146973},{"id":"https://openalex.org/keywords/s100a9","display_name":"S100A9","score":0.9409999847412109},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.6520000100135803},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.949999988079071},{"id":"https://openalex.org/keywords/nilotinib","display_name":"nilotinib","score":0.9539999961853027},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.8899999856948853},{"id":"https://openalex.org/keywords/allodynia","display_name":"allodynia","score":0.7039999961853027},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.7580000162124634},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.6625947952270508},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6525402665138245},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.6436160802841187},{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.5399539470672607},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5316945314407349},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44959110021591187},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.44436532258987427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4219818711280823},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.4208836257457733},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3382588028907776},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32140052318573},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.23894032835960388},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20999619364738464},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.17551791667938232},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17334574460983276},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1557214856147766},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13160225749015808},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.0},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2020.34.s1.04083","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.04083","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.04083","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2783215140","https://openalex.org/W7160829351","https://openalex.org/W2105336120","https://openalex.org/W4367053357","https://openalex.org/W2395081757","https://openalex.org/W2900968864","https://openalex.org/W4323668161","https://openalex.org/W7096057662","https://openalex.org/W4398765384","https://openalex.org/W2989582075"],"abstract_inverted_index":{"BACKGROUND":[0],"Paclitaxel":[1],"(PTX)":[2],"is":[3,92,197,290,296],"a":[4,11,45,187,283,349],"widely":[5],"used":[6],"anticancer":[7],"drug":[8,105],"that":[9,78,227,328,341],"causes":[10],"debilitating,":[12],"dose\u2010limiting":[13],"acute":[14,48,324,361],"and":[15,49,58,88,115,141,165,171,201,254,326,351,380],"chronic":[16,50],"peripheral":[17,53],"neuropathy":[18,54],"(PIPN)":[19],"in":[20,86,127,136,184,215,236,271,323,348],"up":[21],"to":[22,47,157,238,242,298,369,381],"80%":[23],"of":[24,30,52,90,104,124,148,189,199,207,219,249,266,277,282,286,313,321,357,363,386,391],"patients.":[25],"Although":[26],"the":[27,65,81,205,272,310,318,383],"mechanistic":[28],"basis":[29],"this":[31,59,97],"side":[32],"effect":[33,60,103],"remains":[34],"largely":[35],"unknown,":[36],"we":[37,99,315],"previously":[38],"identified":[39],"transport":[40],"by":[41,64,203,300,377],"OATP1B\u2010type":[42],"carriers":[43],"as":[44,121,305,389],"contributor":[46],"forms":[51,362],"associated":[55,93],"with":[56,94,151,177,186],"PTX,":[57,314],"can":[61,374],"be":[62,375],"ameliorated":[63],"OATP1B2":[66,170,191,253,342],"inhibitor,":[67],"nilotinib,":[68],"without":[69,179,307],"compromising":[70],"anti\u2010tumor":[71,311],"efficacy.":[72],"Prior":[73],"investigations":[74],"have":[75],"also":[76],"shown":[77],"PTX":[79,180,196],"induces":[80],"toll\u2010like":[82],"receptor":[83],"4":[84],"(TLR4)":[85],"neurons":[87],"activation":[89],"TLR4":[91],"PIPN.":[95,128,364,392],"In":[96,130],"study,":[98],"will":[100],"explore":[101],"potential":[102],"metabolism":[106],"or":[107,174,178,192,209,222,257],"transporter":[108],"mediated":[109,376],"drug\u2010drug":[110],"interactions":[111],"(DDIs)":[112],"on":[113,211,293],"PIPN,":[114,325],"novel":[116],"mechanism":[117],"involving":[118],"S100A8/A9":[119,387],"proteins,":[120],"important":[122],"mediators":[123],"inflammatory":[125],"response":[126],"METHODS":[129],"vivo":[131],"toxicity":[132],"studies":[133,366],"were":[134,155],"performed":[135],"wild\u2010type,":[137],"OATP1B2\u2010deficient,":[138],"P\u2010gp\u2010deficient,":[139],"CYP3A4\u2010deficient":[140],"S100A9\u2010deficient":[142],"mice":[143,185,233,244,279],"receiving":[144],"PTX.":[145,250,287],"Standard":[146],"assessments":[147],"mechanical\u2010induced":[149],"allodynia":[150],"Von":[152],"Frey":[153],"Hairs":[154],"conducted":[156],"evaluate":[158,382],"PIPN":[159,212,289,347],"at":[160,263],"timed":[161],"intervals":[162],"before,":[163],"during,":[164],"after":[166,245,280],"treatment.":[167],"Relationships":[168],"between":[169],"S100A9":[172,255,267,322,329,358],"gene":[173,256],"protein":[175,258],"expression":[176,259,265],"treatment":[181],"was":[182,213,268],"tested":[183,214],"deficiency":[188,330],"either":[190,220],"S100A9.":[193],"RESULTS":[194],"Since":[195,288],"substrate":[198],"P\u2010gp":[200,231,350],"metabolized":[202],"CYP3A4,":[204],"influence":[206],"P\u2010pg":[208],"CYP3A4":[210,221,229,352],"mouse":[216],"models":[217],"deficient":[218,232],"P\u2010gp.":[223],"Our":[224,337],"results":[225,339],"suggest":[226,340],"neither":[228],"nor":[230],"showed":[234],"differences":[235],"sensitivity":[237],"mechanical":[239,334],"stimuli":[240],"compared":[241],"wild\u2010type":[243,278],"an":[246],"i.v.":[247],"dose":[248,285],"Interestingly,":[251],"while":[252],"are":[260,367],"independently":[261],"regulated":[262],"baseline,":[264],"dramatically":[269],"upregulated":[270],"dorsal":[273],"root":[274],"ganglia":[275],"(DRG)":[276],"administration":[281],"single":[284],"functionally":[291],"dependent":[292],"OATP1B2,":[294],"which":[295],"sensitive":[297],"inhibition":[299],"small":[301],"molecule":[302],"inhibitors":[303,388],"such":[304],"nilotinib":[306,344],"negatively":[308],"affecting":[309],"efficacy":[312],"next":[316],"evaluated":[317],"direct":[319],"role":[320],"found":[327],"protects":[331,359],"against":[332,360],"paclitaxel\u2010induced":[333],"allodynia.":[335],"CONCLUSION":[336],"preliminary":[338],"inhibitor":[343],"could":[345],"protect":[346],"independent":[353],"way.":[354],"Genetic":[355],"knockout":[356],"Further":[365],"warranted":[368],"determine":[370],"similar":[371],"protective":[372],"effects":[373],"S100A8":[378],"deficiency,":[379],"translational":[384],"utility":[385],"modulators":[390]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-24T00:00:00"}