{"id":"https://openalex.org/W3016546402","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.03089","title":"Proteomic and Phosphoproteomic Analysis of Skeletal Muscle During Hindlimb Immobilization","display_name":"Proteomic and Phosphoproteomic Analysis of Skeletal Muscle During Hindlimb Immobilization","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3016546402","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.03089","mag":"3016546402"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2020.34.s1.03089","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.03089","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.03089","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051396142","display_name":"Kuan\u2010Hung Lin","orcid":"https://orcid.org/0000-0003-2627-7350","observed_orcids":["https://orcid.org/0000-0003-2627-7350"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuan-Hung Lin","raw_affiliation_strings":["UW Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083978756","display_name":"Rocky Blanco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rocky Blanco","raw_affiliation_strings":["UW Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023703606","display_name":"Gary M. Wilson","orcid":"https://orcid.org/0000-0001-6376-273X","observed_orcids":["https://orcid.org/0000-0001-6376-273X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary M. Wilson","raw_affiliation_strings":["UW Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044920989","display_name":"Nate D. Steinert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nate D. Steinert","raw_affiliation_strings":["UW Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086840789","display_name":"Joshua J. Coon","orcid":"https://orcid.org/0000-0002-0004-8253","observed_orcids":["https://orcid.org/0000-0002-0004-8253"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua J. Coon","raw_affiliation_strings":["UW Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051527512","display_name":"Troy Alan Hornberger","orcid":"https://orcid.org/0000-0002-2349-1899","observed_orcids":["https://orcid.org/0000-0002-2349-1899"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Troy A. Hornberger","raw_affiliation_strings":["UW Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW Madison","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"S1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.10329999774694443,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hindlimb-immobilization","display_name":"hindlimb immobilization","score":0.9769999980926514},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.8360000252723694},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.972000002861023},{"id":"https://openalex.org/keywords/phosphoproteomics","display_name":"phosphoproteomics","score":0.8220000267028809},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.9520000219345093},{"id":"https://openalex.org/keywords/muscle-loss","display_name":"muscle mass loss","score":0.6460000276565552},{"id":"https://openalex.org/keywords/translation-initiation-factors","display_name":"translation initiation factors","score":0.5490000247955322},{"id":"https://openalex.org/keywords/translation-elongation-factor","display_name":"translation elongation factor","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.8727089166641235},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.7103304862976074},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6406353712081909},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6281731128692627},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5119858384132385},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5075923204421997},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49422982335090637},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.4915073812007904},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.41368624567985535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39989036321640015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37688758969306946},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.1958087682723999},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1366237998008728},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05687949061393738}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2020.34.s1.03089","doi":"https://doi.org/10.1096/fasebj.2020.34.s1.03089","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2020.34.s1.03089","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3154010333","https://openalex.org/W2950585161","https://openalex.org/W2163855569","https://openalex.org/W4294043440","https://openalex.org/W2020222868","https://openalex.org/W2010773319","https://openalex.org/W2062834164","https://openalex.org/W2174622319","https://openalex.org/W2618770807","https://openalex.org/W2947586813"],"abstract_inverted_index":{"The":[0,204],"maintenance":[1],"of":[2,16,27,38,63,83,87,127,134,157,191,201],"skeletal":[3],"muscle":[4,28,244],"mass":[5,88],"is":[6,19,36,54],"required":[7],"for":[8,252],"health":[9],"and":[10,30,74,95,111,119,152,178,243],"issues":[11],"associated":[12,167],"with":[13,168,214],"the":[14,25,39,60,64,84,93,125,155,176,188,199,207,215],"quality":[15],"life.":[17],"It":[18],"known":[20],"that":[21,42,51,67,98,194,226],"immobilization":[22],"leads":[23],"to":[24,91,102,109,186,256],"loss":[26],"mass,":[29],"a":[31,234],"decrease":[32,239],"in":[33,59,100,114,171,198,228,237,240],"protein":[34,52,70,128,158,172,202,229,241],"synthesis":[35,53,71,129,159,242],"one":[37],"primary":[40],"mechanisms":[41],"drive":[43],"this":[44,78,144,164],"response.":[45],"Moreover,":[46],"previous":[47],"studies":[48],"have":[49,195],"shown":[50],"largely":[55],"regulated":[56],"by":[57],"changes":[58,170],"phosphorylation":[61,117,138,189,230],"state":[62,190],"various":[65,192],"factors":[66],"can":[68],"control":[69],"(e.g.,":[72],"initiation":[73],"elongation":[75],"factors).":[76],"In":[77,104],"study,":[79],"we":[80,106,181],"took":[81],"advantage":[82],"powerful":[85],"capabilities":[86],"spectrometry":[89],"(MS)":[90],"identify":[92,110],"proteomic":[94,177],"phosphoproteomic":[96,179],"alterations":[97,113,227],"occur":[99],"response":[101],"immobilization.":[103],"total,":[105],"were":[107,140,211],"able":[108],"quantify":[112],"15,020":[115],"unique":[116],"sites":[118,139],"4,646":[120],"proteins.":[121],"To":[122,174],"our":[123,222],"surprise,":[124],"rate":[126,156],"decreased":[130],"within":[131],"6":[132],"hours":[133],"immobilization,":[135],"but":[136,162],"no":[137],"significantly":[141],"altered":[142],"at":[143],"time.":[145],"At":[146],"later":[147],"time":[148],"points":[149],"(i.e.,":[150],"24":[151],"72":[153],"hours),":[154],"further":[160],"decreased,":[161],"again":[163],"was":[165],"not":[166,232],"major":[169,235],"phosphorylation.":[173],"verify":[175],"results,":[180],"performed":[182],"western":[183,208],"blot":[184,209],"analysis":[185,210],"assess":[187],"proteins":[193],"been":[196],"implicated":[197],"regulation":[200],"synthesis.":[203],"results":[205,223],"from":[206],"highly":[212],"congruent":[213],"MS":[216],"results.":[217],"Hence,":[218],"when":[219],"taken":[220],"together,":[221],"strongly":[224],"suggest":[225],"do":[231],"play":[233],"role":[236],"immobilization\u2010induced":[238],"mass.":[245],"Support":[246],"or":[247],"Funding":[248],"Information":[249],"National":[250],"Institutes":[251],"Health":[253],"grant":[254],"1R01AR057347":[255],"T.A.H.":[257]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-24T00:00:00"}
