{"id":"https://openalex.org/W3016536368","doi":"https://doi.org/10.1101/sqb.2019.84.039818","title":"Recognition of Poly(A) RNA through Its Intrinsic Helical Structure","display_name":"Recognition of Poly(A) RNA through Its Intrinsic Helical Structure","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3016536368","doi":"https://doi.org/10.1101/sqb.2019.84.039818","mag":"3016536368","pmid":"https://pubmed.ncbi.nlm.nih.gov/32295929","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7116106"},"language":"en","primary_location":{"id":"doi:10.1101/sqb.2019.84.039818","doi":"https://doi.org/10.1101/sqb.2019.84.039818","is_oa":true,"landing_page_url":"https://doi.org/10.1101/sqb.2019.84.039818","pdf_url":"http://symposium.cshlp.org/content/early/2020/04/15/sqb.2019.84.039818.full.pdf","source":{"id":"https://openalex.org/S78756772","display_name":"Cold Spring Harbor Symposia on Quantitative Biology","issn_l":"0091-7451","issn":["0091-7451","1943-4456"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Symposia on Quantitative Biology","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://symposium.cshlp.org/content/early/2020/04/15/sqb.2019.84.039818.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067282549","display_name":"Terence T. L. Tang","orcid":"https://orcid.org/0000-0002-7802-0461","observed_orcids":["https://orcid.org/0000-0002-7802-0461"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Terence T.L. Tang","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026689567","display_name":"Lori A. Passmore","orcid":"https://orcid.org/0000-0003-1815-3710","observed_orcids":["https://orcid.org/0000-0003-1815-3710"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lori A. Passmore","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom","institution_ids":["https://openalex.org/I170203145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170203145"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":null,"first_page":"21","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poly-a-tail","display_name":"poly(A) tail","score":0.9340000152587891},{"id":"https://openalex.org/keywords/rna-secondary-structure","display_name":"RNA secondary structure","score":0.4959999918937683},{"id":"https://openalex.org/keywords/deadenylation","display_name":"deadenylation","score":0.875},{"id":"https://openalex.org/keywords/ccr4-not-complex","display_name":"CCR4-NOT complex","score":0.8230000138282776},{"id":"https://openalex.org/keywords/mrna-turnover","display_name":"mRNA turnover","score":0.8069999814033508},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.44125938415527344},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35914289951324463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34152287244796753},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3219490647315979},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2521975040435791},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08118727803230286}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/sqb.2019.84.039818","doi":"https://doi.org/10.1101/sqb.2019.84.039818","is_oa":true,"landing_page_url":"https://doi.org/10.1101/sqb.2019.84.039818","pdf_url":"http://symposium.cshlp.org/content/early/2020/04/15/sqb.2019.84.039818.full.pdf","source":{"id":"https://openalex.org/S78756772","display_name":"Cold Spring Harbor Symposia on Quantitative Biology","issn_l":"0091-7451","issn":["0091-7451","1943-4456"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Symposia on Quantitative Biology","raw_type":"journal-article"},{"id":"pmid:32295929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32295929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor symposia on quantitative biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7116106","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7116106","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cold Spring Harb Symp Quant Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/sqb.2019.84.039818","doi":"https://doi.org/10.1101/sqb.2019.84.039818","is_oa":true,"landing_page_url":"https://doi.org/10.1101/sqb.2019.84.039818","pdf_url":"http://symposium.cshlp.org/content/early/2020/04/15/sqb.2019.84.039818.full.pdf","source":{"id":"https://openalex.org/S78756772","display_name":"Cold Spring Harbor Symposia on Quantitative Biology","issn_l":"0091-7451","issn":["0091-7451","1943-4456"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Symposia on Quantitative Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2467026419","display_name":null,"funder_award_id":"725685","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5160903979","display_name":"The polyA machinery: Elucidating the molecular mechanisms of mRNA polyadenylation, deadenylation and RNA recognition","funder_award_id":"725685","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G7289619781","display_name":null,"funder_award_id":"MC_U105192715","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320320273","display_name":"University of Cambridge","ror":"https://ror.org/013meh722"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3016536368.pdf","grobid_xml":"https://content.openalex.org/works/W3016536368.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W233265278","https://openalex.org/W280694366","https://openalex.org/W1584476217","https://openalex.org/W1912536894","https://openalex.org/W1976365049","https://openalex.org/W1978974023","https://openalex.org/W1981260293","https://openalex.org/W1982263548","https://openalex.org/W1985459186","https://openalex.org/W1991786909","https://openalex.org/W1993987952","https://openalex.org/W1994418194","https://openalex.org/W1998068779","https://openalex.org/W2001226185","https://openalex.org/W2009129041","https://openalex.org/W2013981755","https://openalex.org/W2021302019","https://openalex.org/W2027740340","https://openalex.org/W2031707270","https://openalex.org/W2035268935","https://openalex.org/W2041882533","https://openalex.org/W2042335793","https://openalex.org/W2045596763","https://openalex.org/W2051468886","https://openalex.org/W2055708350","https://openalex.org/W2059633680","https://openalex.org/W2060555689","https://openalex.org/W2062717825","https://openalex.org/W2067320744","https://openalex.org/W2072770570","https://openalex.org/W2076627305","https://openalex.org/W2076882737","https://openalex.org/W2080293749","https://openalex.org/W2080940607","https://openalex.org/W2085840788","https://openalex.org/W2088399865","https://openalex.org/W2091998897","https://openalex.org/W2092910058","https://openalex.org/W2094554391","https://openalex.org/W2103829007","https://openalex.org/W2104752637","https://openalex.org/W2105879579","https://openalex.org/W2108361054","https://openalex.org/W2111403104","https://openalex.org/W2123281294","https://openalex.org/W2123742352","https://openalex.org/W2124983646","https://openalex.org/W2133935239","https://openalex.org/W2150404156","https://openalex.org/W2152571861","https://openalex.org/W2153101998","https://openalex.org/W2163731437","https://openalex.org/W2171682992","https://openalex.org/W2265308074","https://openalex.org/W2269054226","https://openalex.org/W2507685096","https://openalex.org/W2552910574","https://openalex.org/W2568866823","https://openalex.org/W2580905939","https://openalex.org/W2767360874","https://openalex.org/W2884627335","https://openalex.org/W2900749844","https://openalex.org/W2902152744","https://openalex.org/W2946204923","https://openalex.org/W2946217053","https://openalex.org/W2946310282","https://openalex.org/W2959219826","https://openalex.org/W2966617337","https://openalex.org/W2971454256","https://openalex.org/W2971484369","https://openalex.org/W2991309186","https://openalex.org/W2995107466","https://openalex.org/W2996988556"],"related_works":["https://openalex.org/W2946310282","https://openalex.org/W6906714570","https://openalex.org/W2946204923","https://openalex.org/W7095479311","https://openalex.org/W1977889559","https://openalex.org/W2137183892","https://openalex.org/W2171682992","https://openalex.org/W2083101210","https://openalex.org/W4416542887","https://openalex.org/W2111839425"],"abstract_inverted_index":{"The":[0],"polyadenosine":[1],"(poly(A))":[2],"tail,":[3,33,113],"which":[4],"is":[5,39,52,143],"found":[6],"on":[7],"the":[8,23,31,43,55,79,83,87,105,111,121,176,179],"3'":[9],"end":[10],"of":[11,26,30,48,81,123,150,178,182],"almost":[12],"all":[13],"eukaryotic":[14],"messenger":[15],"RNAs":[16],"(mRNAs),":[17],"plays":[18],"an":[19,136],"important":[20,166],"role":[21],"in":[22,167,170],"posttranscriptional":[24],"regulation":[25],"gene":[27],"expression.":[28],"Shortening":[29],"poly(A)":[32,88,112,124,134,168],"a":[34],"process":[35],"known":[36],"as":[37],"deadenylation,":[38],"thought":[40],"to":[41,164],"be":[42,165],"first":[44],"and":[45,57,67,69,129,147,156],"rate-limiting":[46],"step":[47],"mRNA":[49],"turnover.":[50],"Deadenylation":[51],"performed":[53],"by":[54,145],"Pan2-Pan3":[56],"Ccr4-Not":[58],"complexes":[59,73],"that":[60,104,133,142,148],"contain":[61],"highly":[62,106],"conserved":[63,107],"exonuclease":[64,109],"enzymes":[65,85],"Pan2,":[66,146],"Ccr4":[68],"Caf1,":[70],"respectively.":[71],"These":[72],"have":[74],"been":[75,162],"extensively":[76],"studied,":[77],"but":[78,119],"mechanisms":[80],"how":[82],"deadenylase":[84],"recognize":[86],"tail":[89],"were":[90],"poorly":[91],"understood":[92],"until":[93],"recently.":[94],"Here,":[95],"we":[96],"summarize":[97],"recent":[98],"work":[99],"from":[100],"our":[101],"laboratory":[102],"demonstrating":[103],"Pan2":[108,155],"recognizes":[110],"not":[114],"through":[115,120],"adenine-specific":[116],"functional":[117],"groups,":[118],"conformation":[122,141,181],"RNA.":[125],"Our":[126],"biochemical,":[127],"biophysical,":[128],"structural":[130],"investigations":[131],"suggest":[132],"forms":[135],"intrinsic":[137,159],"base-stacked,":[138],"single-stranded":[139],"helical":[140],"recognized":[144],"disruption":[149],"this":[151],"structure":[152,160],"inhibits":[153],"both":[154],"Caf1.":[157],"This":[158],"has":[161],"shown":[163],"recognition":[169],"other":[171],"biological":[172],"processes,":[173],"further":[174],"underlining":[175],"importance":[177],"unique":[180],"poly(A).":[183]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-24T00:00:00"}