{"id":"https://openalex.org/W3016356434","doi":"https://doi.org/10.1093/biostatistics/kxaa016","title":"Matrix decomposition for modeling lesion development processes in multiple sclerosis","display_name":"Matrix decomposition for modeling lesion development processes in multiple sclerosis","publication_year":2020,"publication_date":"2020-03-17","ids":{"openalex":"https://openalex.org/W3016356434","doi":"https://doi.org/10.1093/biostatistics/kxaa016","mag":"3016356434","pmid":"https://pubmed.ncbi.nlm.nih.gov/32318692","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9118558"},"language":"en","primary_location":{"id":"doi:10.1093/biostatistics/kxaa016","doi":"https://doi.org/10.1093/biostatistics/kxaa016","is_oa":false,"landing_page_url":"https://doi.org/10.1093/biostatistics/kxaa016","pdf_url":null,"source":{"id":"https://openalex.org/S190140075","display_name":"Biostatistics","issn_l":"1465-4644","issn":["1465-4644","1468-4357"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9118558","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058455658","display_name":"Menghan Hu","orcid":"https://orcid.org/0000-0002-8557-8930","observed_orcids":["https://orcid.org/0000-0002-8557-8930"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Menghan Hu","raw_affiliation_strings":["Department of Biostatistics, Brown University, Providence, RI 02903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Brown University, Providence, RI 02903, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089030792","display_name":"Ciprian M. Crainiceanu","orcid":"https://orcid.org/0000-0001-6601-3881","observed_orcids":["https://orcid.org/0000-0001-6601-3881"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ciprian Crainiceanu","raw_affiliation_strings":["Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044579001","display_name":"Matthew K. Schindler","orcid":"https://orcid.org/0000-0003-0157-5669","observed_orcids":["https://orcid.org/0000-0003-0157-5669"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew K Schindler","raw_affiliation_strings":["Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044628433","display_name":"Blake E. Dewey","orcid":"https://orcid.org/0000-0003-4554-5058","observed_orcids":["https://orcid.org/0000-0003-4554-5058"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blake Dewey","raw_affiliation_strings":["Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA and Department of Electrical and Computer Engineering, Johns Hopkins Whiting School of Engineering, Baltimore, MD 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA and Department of Electrical and Computer Engineering, Johns Hopkins Whiting School of Engineering, Baltimore, MD 21218, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024904743","display_name":"Daniel S. Reich","orcid":"https://orcid.org/0000-0002-2628-4334","observed_orcids":["https://orcid.org/0000-0002-2628-4334"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S Reich","raw_affiliation_strings":["Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037974362","display_name":"Russell Taki Shinohara","orcid":"https://orcid.org/0000-0001-8627-8203","observed_orcids":["https://orcid.org/0000-0001-8627-8203"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell T Shinohara","raw_affiliation_strings":["Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA and Department of Radiology, Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA and Department of Radiology, Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080505451","display_name":"Ani Eloyan","orcid":"https://orcid.org/0000-0002-8110-7680","observed_orcids":["https://orcid.org/0000-0002-8110-7680"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ani Eloyan","raw_affiliation_strings":["Department of Biostatistics, Brown University, Providence, RI 02903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Brown University, Providence, RI 02903, USA","institution_ids":["https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5080505451"],"corresponding_institution_ids":["https://openalex.org/I27804330"],"apc_list":{"value":3296,"currency":"USD","value_usd":3296},"apc_paid":null,"fwci":0.161,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44328662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"23","issue":"1","first_page":"83","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.03680000081658363,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11871","display_name":"Advanced Statistical Methods and Models","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lesion-evolution","display_name":"lesion evolution","score":0.9459999799728394},{"id":"https://openalex.org/keywords/longitudinal-mri","display_name":"longitudinal MRI","score":0.5180000066757202},{"id":"https://openalex.org/keywords/structural-mri","display_name":"structural MRI","score":0.5889999866485596},{"id":"https://openalex.org/keywords/functional-principal-component-analysis","display_name":"functional principal component analysis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/matrix-factorization","display_name":"matrix factorization","score":0.6499999761581421},{"id":"https://openalex.org/keywords/multilevel-data","display_name":"multilevel data","score":0.703000009059906},{"id":"https://openalex.org/keywords/hypothesis-testing","display_name":"hypothesis testing","score":0.5720000267028809},{"id":"https://openalex.org/keywords/treatment-effect-comparison","display_name":"treatment effect comparison","score":0.6050000190734863},{"id":"https://openalex.org/keywords/therapeutic-interventions","display_name":"therapeutic interventions","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.76316237449646},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6315124034881592},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.5744012594223022},{"id":"https://openalex.org/C71176878","wikidata":"https://www.wikidata.org/wiki/Q17014987","display_name":"Functional principal component analysis","level":3,"score":0.5470621585845947},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.480273962020874},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.4748977720737457},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.46016284823417664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22877126932144165},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15795597434043884}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/biostatistics/kxaa016","doi":"https://doi.org/10.1093/biostatistics/kxaa016","is_oa":false,"landing_page_url":"https://doi.org/10.1093/biostatistics/kxaa016","pdf_url":null,"source":{"id":"https://openalex.org/S190140075","display_name":"Biostatistics","issn_l":"1465-4644","issn":["1465-4644","1468-4357"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9118558","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9118558","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics","raw_type":"Text"},{"id":"pmid:32318692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32318692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9118558","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9118558","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2857857653","display_name":"Center for Central Nervous System Function","funder_award_id":"P20GM103645","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4025701451","display_name":"Spatiotemporal Modeling of MRI Brain Lesion Trajectories of Biomarker Discovery","funder_award_id":"R21NS093349","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W611353362","https://openalex.org/W1583277614","https://openalex.org/W1893329038","https://openalex.org/W1976778743","https://openalex.org/W1982959792","https://openalex.org/W1989774929","https://openalex.org/W2000278813","https://openalex.org/W2011598139","https://openalex.org/W2019302122","https://openalex.org/W2025009638","https://openalex.org/W2026118200","https://openalex.org/W2030758636","https://openalex.org/W2040373108","https://openalex.org/W2047440597","https://openalex.org/W2047544764","https://openalex.org/W2051588049","https://openalex.org/W2056362049","https://openalex.org/W2071415177","https://openalex.org/W2085032988","https://openalex.org/W2096609500","https://openalex.org/W2098344611","https://openalex.org/W2104680149","https://openalex.org/W2106575405","https://openalex.org/W2130351130","https://openalex.org/W2137077530","https://openalex.org/W2138071406","https://openalex.org/W2146531642","https://openalex.org/W2166219471","https://openalex.org/W2410237123","https://openalex.org/W2480860902","https://openalex.org/W2547866317","https://openalex.org/W2949537047","https://openalex.org/W4292156489"],"related_works":["https://openalex.org/W1928338241","https://openalex.org/W2106169817","https://openalex.org/W2410237123","https://openalex.org/W2959103409","https://openalex.org/W2586478693","https://openalex.org/W2921496905","https://openalex.org/W4232888989","https://openalex.org/W6902042608","https://openalex.org/W2007616904","https://openalex.org/W7211997245"],"abstract_inverted_index":{"Our":[0],"main":[1],"goal":[2],"is":[3],"to":[4],"study":[5,74],"and":[6,41,85],"quantify":[7],"the":[8,38,45,55,87,104,108],"evolution":[9,100,122],"of":[10,33,44,91,94,107],"multiple":[11],"sclerosis":[12],"lesions":[13],"observed":[14],"longitudinally":[15],"over":[16],"many":[17],"years":[18],"in":[19,49,69,120],"multi-sequence":[20],"structural":[21],"magnetic":[22],"resonance":[23],"imaging":[24],"(sMRI).":[25],"To":[26,53],"achieve":[27],"that,":[28],"we":[29,76,115],"propose":[30,84],"a":[31],"class":[32],"functional":[34,79],"models":[35],"for":[36,103],"capturing":[37],"temporal":[39],"dynamics":[40],"spatial":[42],"distribution":[43],"voxel-specific":[46],"intensity":[47],"trajectories":[48],"all":[50],"sMRI":[51],"sequences.":[52],"accommodate":[54],"hierarchical":[56],"data":[57],"structure":[58,106],"(observations":[59],"nested":[60,65,72],"within":[61,66,73],"voxels,":[62],"which":[63],"are":[64,71],"lesions,":[67],"which,":[68],"turn,":[70],"participants),":[75],"use":[77],"structured":[78],"principal":[80],"component":[81],"analysis.":[82],"We":[83],"evaluate":[86],"finite":[88],"sample":[89],"properties":[90],"hypothesis":[92],"tests":[93],"therapeutic":[95],"intervention":[96],"effects":[97],"on":[98],"lesion":[99,121],"while":[101],"accounting":[102],"multilevel":[105],"data.":[109],"Using":[110],"this":[111],"novel":[112],"testing":[113],"strategy,":[114],"found":[116],"statistically":[117],"significant":[118],"differences":[119],"between":[123],"treatment":[124],"groups.":[125]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-24T00:00:00"}
