{"id":"https://openalex.org/W3016124703","doi":"https://doi.org/10.1021/acsnano.0c00602","title":"RNA Origami Nanostructures for Potent and Safe Anticancer Immunotherapy","display_name":"RNA Origami Nanostructures for Potent and Safe Anticancer Immunotherapy","publication_year":2020,"publication_date":"2020-04-10","ids":{"openalex":"https://openalex.org/W3016124703","doi":"https://doi.org/10.1021/acsnano.0c00602","mag":"3016124703","pmid":"https://pubmed.ncbi.nlm.nih.gov/32275389"},"language":"en","primary_location":{"id":"doi:10.1021/acsnano.0c00602","doi":"https://doi.org/10.1021/acsnano.0c00602","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.0c00602","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033329321","display_name":"Xiaodong Qi","orcid":"https://orcid.org/0000-0001-8200-6630","observed_orcids":["https://orcid.org/0000-0001-8200-6630"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaodong Qi","raw_affiliation_strings":["Arizona State University**"],"raw_orcid":"https://orcid.org/0000-0001-8200-6630","affiliations":[{"raw_affiliation_string":"Arizona State University**","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaowei Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaowei Liu","raw_affiliation_strings":["Arizona State University**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University**","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034035106","display_name":"Lawrence Matiski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence Matiski","raw_affiliation_strings":["Arizona State University**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University**","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072960848","display_name":"Ryan Rodriguez del Villar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Rodriguez Del Villar","raw_affiliation_strings":["Arizona State University**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University**","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075741549","display_name":"Theresa Yip","orcid":"https://orcid.org/0009-0006-8388-0622","observed_orcids":["https://orcid.org/0009-0006-8388-0622"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa Yip","raw_affiliation_strings":["Arizona State University**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University**","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fei Zhang","raw_affiliation_strings":["Arizona State University , , , ,","School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University , , , ,","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sriram Sokalingam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sriram Sokalingam","raw_affiliation_strings":["Arizona State University**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University**","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085137680","display_name":"Shuoxing Jiang","orcid":"https://orcid.org/0000-0002-9235-6447","observed_orcids":["https://orcid.org/0000-0002-9235-6447"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuoxing Jiang","raw_affiliation_strings":["Arizona State University**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University**","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Liu","raw_affiliation_strings":["Arizona State University**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University**","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064979753","display_name":"Hao Yan","orcid":"https://orcid.org/0000-0001-7397-9852","observed_orcids":["https://orcid.org/0000-0001-7397-9852"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hao Yan","raw_affiliation_strings":["Arizona State University**"],"raw_orcid":"https://orcid.org/0000-0001-7397-9852","affiliations":[{"raw_affiliation_string":"Arizona State University**","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078495808","display_name":"Yung Chang","orcid":"https://orcid.org/0000-0002-3480-4563","observed_orcids":["https://orcid.org/0000-0002-3480-4563"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yung Chang","raw_affiliation_strings":["Arizona State University**"],"raw_orcid":"https://orcid.org/0000-0002-3480-4563","affiliations":[{"raw_affiliation_string":"Arizona State University**","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064979753","https://openalex.org/A5078495808"],"corresponding_institution_ids":["https://openalex.org/I55732556"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":3.7814,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.95152033,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"14","issue":"4","first_page":"4727","last_page":"4740"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.4146000146865845,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.4146000146865845,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.2003999948501587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.125,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-origami","display_name":"RNA origami","score":0.9850000143051147},{"id":"https://openalex.org/keywords/rna-self-assembly","display_name":"RNA self-assembly","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tlr3-agonist","display_name":"TLR3 agonist","score":0.824999988079071},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.5989999771118164},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.574999988079071},{"id":"https://openalex.org/keywords/cd8-t-cell-responses","display_name":"CD8+ T cell responses","score":0.7350000143051147},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.7609999775886536},{"id":"https://openalex.org/keywords/serum-stability","display_name":"serum stability","score":0.5360000133514404},{"id":"https://openalex.org/keywords/nucleic-acid-nanotechnology","display_name":"nucleic acid nanotechnology","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C118630614","wikidata":"https://www.wikidata.org/wiki/Q1154606","display_name":"DNA origami","level":3,"score":0.6966269016265869},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5833579301834106},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.55876624584198},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.476589173078537},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4466198682785034},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3508508801460266},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3364560604095459},{"id":"https://openalex.org/C186187911","wikidata":"https://www.wikidata.org/wiki/Q1093894","display_name":"Nanostructure","level":2,"score":0.33083105087280273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32690760493278503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27425417304039},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24882465600967407},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21254071593284607},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17966106534004211},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12130004167556763},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09222099184989929}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011070","descriptor_name":"Poly I-C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsnano.0c00602","doi":"https://doi.org/10.1021/acsnano.0c00602","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.0c00602","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},{"id":"pmid:32275389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32275389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS nano","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7580658202","display_name":null,"funder_award_id":"N000141512689","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G8112383791","display_name":null,"funder_award_id":"1334109","funder_id":"https://openalex.org/F4320337391","funder_display_name":"Division of Civil, Mechanical and Manufacturing Innovation"},{"id":"https://openalex.org/G8246932688","display_name":null,"funder_award_id":"1563799","funder_id":"https://openalex.org/F4320337387","funder_display_name":"Division of Computing and Communication Foundations"},{"id":"https://openalex.org/G8452780829","display_name":null,"funder_award_id":"1360635","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"}],"funders":[{"id":"https://openalex.org/F4320309835","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40"},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"},{"id":"https://openalex.org/F4320337387","display_name":"Division of Computing and Communication Foundations","ror":"https://ror.org/01mng8331"},{"id":"https://openalex.org/F4320337391","display_name":"Division of Civil, Mechanical and Manufacturing Innovation","ror":"https://ror.org/028yd4c30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1514540900","https://openalex.org/W1527927437","https://openalex.org/W1803663846","https://openalex.org/W1895265927","https://openalex.org/W1964599873","https://openalex.org/W1969072247","https://openalex.org/W1975679096","https://openalex.org/W1988812533","https://openalex.org/W1994391392","https://openalex.org/W1999574084","https://openalex.org/W1999587028","https://openalex.org/W2001375582","https://openalex.org/W2004899704","https://openalex.org/W2006463083","https://openalex.org/W2007222211","https://openalex.org/W2013284377","https://openalex.org/W2024076972","https://openalex.org/W2028575270","https://openalex.org/W2065554630","https://openalex.org/W2071670416","https://openalex.org/W2072895616","https://openalex.org/W2073115216","https://openalex.org/W2076361525","https://openalex.org/W2077850544","https://openalex.org/W2079812151","https://openalex.org/W2084408879","https://openalex.org/W2090994296","https://openalex.org/W2091691458","https://openalex.org/W2099737063","https://openalex.org/W2100262165","https://openalex.org/W2102953855","https://openalex.org/W2114104545","https://openalex.org/W2123718457","https://openalex.org/W2125529832","https://openalex.org/W2125566625","https://openalex.org/W2126961173","https://openalex.org/W2130421043","https://openalex.org/W2133019048","https://openalex.org/W2138207763","https://openalex.org/W2148910127","https://openalex.org/W2156764325","https://openalex.org/W2161180155","https://openalex.org/W2170551349","https://openalex.org/W2180781760","https://openalex.org/W2202554670","https://openalex.org/W2256675122","https://openalex.org/W2271834483","https://openalex.org/W2313658741","https://openalex.org/W2314164773","https://openalex.org/W2494587789","https://openalex.org/W2503957764","https://openalex.org/W2757519722","https://openalex.org/W2765958338","https://openalex.org/W2769284793","https://openalex.org/W2775235705","https://openalex.org/W2790708193","https://openalex.org/W2808114257","https://openalex.org/W2890827671","https://openalex.org/W2960936603","https://openalex.org/W4292528108","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W7064216283","https://openalex.org/W4391213980","https://openalex.org/W4313405638","https://openalex.org/W4405232075","https://openalex.org/W4385298498","https://openalex.org/W2026485598","https://openalex.org/W3019367578","https://openalex.org/W2108607299","https://openalex.org/W4410721363","https://openalex.org/W4309563562"],"abstract_inverted_index":{"Rapid":[0],"developments":[1],"in":[2,58,136,146],"nucleic":[3],"acid":[4,117],"nanotechnology":[5],"have":[6],"enabled":[7],"the":[8,70,111,124,137,147,152],"rational":[9],"design":[10],"and":[11,16,60,105,109,166],"construction":[12],"of":[13,46,133,154,160],"self-assembling":[14],"DNA":[15],"RNA":[17,29,37,122],"nanostructures":[18,45],"that":[19,33,52,69,163],"are":[20,164],"highly":[21,56],"programmable.":[22],"We":[23,67],"recently":[24],"developed":[25],"a":[26,35,73,79,86,119,130,157],"replicable":[27],"single-stranded":[28],"origami":[30],"(RNA-OG)":[31],"technology":[32],"allows":[34],"long":[36],"molecule":[38],"to":[39,42],"be":[40],"programmed":[41],"self-assemble":[43],"into":[44],"various":[47],"shapes.":[48],"Here,":[49],"we":[50,61],"show":[51],"such":[53],"RNA-OG":[54,71,95,125,155],"is":[55],"stable":[57],"serum/plasma,":[59],"thus":[62],"exploited":[63],"its":[64,143],"immunostimulatory":[65],"potential.":[66],"demonstrated":[68],"stimulates":[72],"potent":[74,158],"innate":[75],"response":[76],"primarily":[77],"through":[78],"Toll-like":[80],"receptor":[81],"3":[82],"(TLR3)":[83],"pathway.":[84],"In":[85],"murine":[87],"peritoneal":[88,112],"metastatic":[89],"colon":[90],"cancer":[91,169],"model,":[92],"intraperitoneally":[93],"injected":[94],"induced":[96],"significant":[97],"tumor":[98],"retardation":[99],"or":[100],"regression":[101],"by":[102],"activating":[103],"NK-":[104],"CD8-dependent":[106],"antitumor":[107],"immunity":[108],"antagonizing":[110],"immunosuppressive":[113],"environment.":[114],"Unlike":[115],"polyinosinic/polycytidylic":[116],"(PolyIC),":[118],"well-known":[120],"double-stranded":[121],"analogue,":[123],"treatment":[126],"did":[127],"not":[128],"cause":[129],"high":[131],"level":[132],"type-I":[134],"interferons":[135],"blood":[138],"nor":[139],"apparent":[140],"toxicity":[141],"upon":[142],"systemic":[144],"administration":[145],"animals.":[148],"This":[149],"work":[150],"establishes":[151],"function":[153],"as":[156],"line":[159],"TLR3":[161],"agonists":[162],"safe":[165],"effective":[167],"for":[168],"immunotherapy.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}