{"id":"https://openalex.org/W3016083016","doi":"https://doi.org/10.1212/wnl.0000000000009362","title":"The presubiculum links incipient amyloid and tau pathology to memory function in older persons","display_name":"The presubiculum links incipient amyloid and tau pathology to memory function in older persons","publication_year":2020,"publication_date":"2020-04-10","ids":{"openalex":"https://openalex.org/W3016083016","doi":"https://doi.org/10.1212/wnl.0000000000009362","mag":"3016083016","pmid":"https://pubmed.ncbi.nlm.nih.gov/32273431","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7274925"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000009362","doi":"https://doi.org/10.1212/wnl.0000000000009362","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000009362","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7274925","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000291248","display_name":"Heidi I.L. Jacobs","orcid":"https://orcid.org/0000-0001-7620-3822","observed_orcids":["https://orcid.org/0000-0001-7620-3822"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Heidi I.L. Jacobs","raw_affiliation_strings":["From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-7620-3822","affiliations":[{"raw_affiliation_string":"From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081155754","display_name":"Jean C. Augustinack","orcid":"https://orcid.org/0000-0002-3129-6671","observed_orcids":["https://orcid.org/0000-0002-3129-6671"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Jean C. Augustinack","raw_affiliation_strings":["From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005435770","display_name":"Aaron P. Schultz","orcid":"https://orcid.org/0000-0002-0418-0999","observed_orcids":["https://orcid.org/0000-0002-0418-0999"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Aaron P. Schultz","raw_affiliation_strings":["From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046266581","display_name":"Bernard Jimmy Hanseeuw","orcid":"https://orcid.org/0000-0002-3102-6778","observed_orcids":["https://orcid.org/0000-0002-3102-6778"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Bernard J. Hanseeuw","raw_affiliation_strings":["From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107847656","display_name":"Joseph J. Locascio","orcid":"https://orcid.org/0000-0003-3439-1209","observed_orcids":["https://orcid.org/0000-0003-3439-1209"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Joseph Locascio","raw_affiliation_strings":["From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084568106","display_name":"Rebecca England Amariglio","orcid":"https://orcid.org/0009-0009-5878-8930","observed_orcids":["https://orcid.org/0009-0009-5878-8930"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Rebecca E. Amariglio","raw_affiliation_strings":["From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070766714","display_name":"Kathryn V. Papp","orcid":"https://orcid.org/0000-0003-1687-4370","observed_orcids":["https://orcid.org/0000-0003-1687-4370"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Kathryn V. Papp","raw_affiliation_strings":["From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076768887","display_name":"Dorene M. Rentz","orcid":"https://orcid.org/0000-0002-6318-9213","observed_orcids":["https://orcid.org/0000-0002-6318-9213"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Dorene M. Rentz","raw_affiliation_strings":["From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001795846","display_name":"Reisa Anne Sperling","orcid":"https://orcid.org/0000-0003-1535-6133","observed_orcids":["https://orcid.org/0000-0003-1535-6133"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Reisa A. Sperling","raw_affiliation_strings":["From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090842068","display_name":"Keith A. Johnson","orcid":"https://orcid.org/0000-0002-5916-6043","observed_orcids":["https://orcid.org/0000-0002-5916-6043","https://orcid.org/0000-0002-3577-8299"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Keith A. Johnson","raw_affiliation_strings":["From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3675,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.8768196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"94","issue":"18","first_page":"e1916","last_page":"e1928"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/presubiculum","display_name":"presubiculum","score":0.9919999837875366},{"id":"https://openalex.org/keywords/preclinical-alzheimer-s-disease","display_name":"preclinical Alzheimer's disease","score":0.8579999804496765},{"id":"https://openalex.org/keywords/amyloid-pathology","display_name":"amyloid pathology","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tau-pathology","display_name":"tau pathology","score":0.9929999709129333},{"id":"https://openalex.org/keywords/memory-performance","display_name":"memory performance","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hippocampal-subfields","display_name":"hippocampal subfields","score":0.9639999866485596},{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"entorhinal cortex","score":0.8849999904632568},{"id":"https://openalex.org/keywords/selective-reminding-test","display_name":"Selective Reminding Test","score":0.6690000295639038},{"id":"https://openalex.org/keywords/hippocampal-volume","display_name":"hippocampal volume","score":0.6899999976158142},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5519999861717224},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5573601722717285},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.535590410232544},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5288083553314209},{"id":"https://openalex.org/C3017833866","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tau pathology","level":4,"score":0.4501299262046814},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.43959158658981323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43683600425720215},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4303944706916809},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32602056860923767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2788277268409729},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.22007223963737488},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14864912629127502},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0660569965839386}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020534","descriptor_name":"Parahippocampal Gyrus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058227","descriptor_name":"Amyloidogenic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1212/wnl.0000000000009362","doi":"https://doi.org/10.1212/wnl.0000000000009362","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000009362","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7274925","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7274925","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Text"},{"id":"pmid:32273431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32273431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/bde69bbc-66ea-4a8a-9a28-8edf82abfd7d","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/bde69bbc-66ea-4a8a-9a28-8edf82abfd7d","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jacobs, H I L, Augustinack, J C, Schultz, A P, Hanseeuw, B J, Locascio, J, Amariglio, R E, Papp, K, Rentz, D M, Sperling, R A & Johnson, K A 2020, 'The presubiculumlinks incipient amyloid and tau pathology to memory function in older persons', Neurology, vol. 94, no. 18, pp. E1916-E1928. https://doi.org/10.1212/WNL.0000000000009362","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:dial.uclouvain.be:boreal:235552","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/235552","pdf_url":null,"source":{"id":"https://openalex.org/S4306401902","display_name":"Digital Access to Libraries (Universit\u00e9 catholique de Louvain (UCL), l'Universit\u00e9 de Namur (UNamur) and the Universit\u00e9 Saint-Louis (USL-B))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95674353","host_organization_name":"UCLouvain","host_organization_lineage":["https://openalex.org/I95674353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurology, Vol. 94, no. 18, p. e1916-e1928 (2020)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/bde69bbc-66ea-4a8a-9a28-8edf82abfd7d","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/bde69bbc-66ea-4a8a-9a28-8edf82abfd7d","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurology, 94(18), E1916 - E1928. LIPPINCOTT WILLIAMS &amp; WILKINS","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7274925","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7274925","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G104586243","display_name":null,"funder_award_id":"U01-AG-024904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2227408383","display_name":null,"funder_award_id":"S10-RR019307","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2597276152","display_name":"Building a pathology-validated neuroimaging tool for Alzheimer's Disease","funder_award_id":"R01AG057672","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2904103475","display_name":"Vascular Dysfunction in Cerebral Amyloid Angiopathy","funder_award_id":"R01AG026484","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G393103480","display_name":null,"funder_award_id":"S10-RR-023043","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4092008167","display_name":"The Role of Alzheimer's-associated Abeta in POD and POCD","funder_award_id":"R21AG038994","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5707695498","display_name":"Alzheimer's Disease Neuroimaging Initiative","funder_award_id":"5u01ag024904-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6097830111","display_name":"Computeserver Structural &Functional Image Analysis","funder_award_id":"1s10rr019307-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6209455021","display_name":"Evolution of memory related fMRI activation over the course of MCI and AD","funder_award_id":"R01AG027435","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6285887070","display_name":"3T MRI for Clinical and Translational Imaging","funder_award_id":"1s10od010364-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6473096149","display_name":"Characterizing the Evolution of Amyloid Deposition in Normal Elderly","funder_award_id":"R01AG037497","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G653110949","display_name":null,"funder_award_id":"S10\u2010RR\u2010021110","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G752701921","display_name":"MR-assisted PET data optimization for neuroimaging studies","funder_award_id":"R01EB014894","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G7561825926","display_name":"A Siemens MAGNETOTOM Trio 3 Tesla MRI System","funder_award_id":"1s10rr021110-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7637191593","display_name":"Massachusetts Alzheimer's Disease Research Center","funder_award_id":"P50AG005134","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7841877555","display_name":"Center for Functional Imaging Technologies","funder_award_id":"P41EB015896","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G7867016969","display_name":"Alzheimer's Disease Cooperative Study","funder_award_id":"U19AG010483","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8037548806","display_name":"Dominantly Inherited Alzheimer Network","funder_award_id":"U01AG032438","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8753502932","display_name":"Optimizing semantic memory measures to detect tau- and amyloid- related cognitive change","funder_award_id":"K23AG053422","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8801679355","display_name":"A Storage Area Network for Structural and Functional Image Analysis","funder_award_id":"S10RR023401","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8838241356","display_name":"Neural Processes Underlying Cognitive Aging","funder_award_id":"R01AG034556","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000885443","display_name":"Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study","funder_award_id":"P01AG036694","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000916845","display_name":"Massachusetts Alzheimer's Disease Research Center (MADRC)","funder_award_id":"P30AG062421","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G95811799","display_name":"Silicon Graphics Prism Extreme 128P/1TB","funder_award_id":"1s10rr023043-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W10604852","https://openalex.org/W1127418533","https://openalex.org/W1778724008","https://openalex.org/W1841441562","https://openalex.org/W1899603055","https://openalex.org/W1915842929","https://openalex.org/W1964604453","https://openalex.org/W1967823816","https://openalex.org/W1969001168","https://openalex.org/W1980842500","https://openalex.org/W1984757600","https://openalex.org/W1993940897","https://openalex.org/W1994370651","https://openalex.org/W2003109983","https://openalex.org/W2021753155","https://openalex.org/W2026060908","https://openalex.org/W2048251539","https://openalex.org/W2052742260","https://openalex.org/W2059875787","https://openalex.org/W2063017390","https://openalex.org/W2071006250","https://openalex.org/W2073880678","https://openalex.org/W2074932610","https://openalex.org/W2075575934","https://openalex.org/W2075580913","https://openalex.org/W2084443965","https://openalex.org/W2093488421","https://openalex.org/W2095963715","https://openalex.org/W2101480437","https://openalex.org/W2119523390","https://openalex.org/W2126128897","https://openalex.org/W2132948185","https://openalex.org/W2137226568","https://openalex.org/W2143461767","https://openalex.org/W2151721316","https://openalex.org/W2154763875","https://openalex.org/W2155715089","https://openalex.org/W2156981442","https://openalex.org/W2165570456","https://openalex.org/W2169831064","https://openalex.org/W2171016535","https://openalex.org/W2215958284","https://openalex.org/W2539685118","https://openalex.org/W2592945305","https://openalex.org/W2763470121","https://openalex.org/W2775311168","https://openalex.org/W2783797800","https://openalex.org/W2794050431","https://openalex.org/W2794754680","https://openalex.org/W2948955289"],"related_works":["https://openalex.org/W2766149726","https://openalex.org/W2015614637","https://openalex.org/W2167733613","https://openalex.org/W4232314274","https://openalex.org/W2794050431","https://openalex.org/W2154763875","https://openalex.org/W2756123852","https://openalex.org/W2765642789","https://openalex.org/W2884669466","https://openalex.org/W4404631391"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"identify":[2],"the":[3,32,90,104,170,177,220],"hippocampal":[4,86,94,98,159,185,202,232],"subregions":[5,95],"linking":[6],"initial":[7],"amyloid":[8,82,144,160,186,233,236],"and":[9,68,80,85,89,96,109,117,125,132,145,152,180,215,226],"tau":[10,87,151],"pathology":[11],"to":[12,218,244],"memory":[13,138,146,174,213,227],"performance":[14,175],"in":[15,176,181,200,247],"clinically":[16],"normal":[17],"older":[18],"individuals,":[19],"reflecting":[20],"preclinical":[21],"Alzheimer":[22],"disease":[23],"(AD).":[24],"METHODS:":[25],"A":[26],"total":[27,97,178,201],"of":[28,52,92,211],"127":[29],"individuals":[30,182],"from":[31],"Harvard":[33],"Aging":[34],"Brain":[35],"Study":[36],"(mean":[37],"age":[38],"76.22":[39],"\u00b1":[40],"6.42":[41],"years,":[42],"68":[43],"women":[44],"[53.5%])":[45],"with":[46,103,137,183],"a":[47,54,58,64,208,238],"Clinical":[48],"Dementia":[49],"Rating":[50],"score":[51],"0,":[53],"flortaucipir":[55],"tau-PET":[56],"scan,":[57,63,67],"Pittsburgh":[59],"compound":[60],"B":[61],"amyloid-PET":[62],"structural":[65],"MRI":[66],"cognitive":[69],"testing":[70],"were":[71],"included.":[72],"From":[73],"these":[74],"images,":[75],"we":[76],"calculated":[77],"neocortical,":[78],"hippocampal,":[79],"entorhinal":[81,84,130,150],"pathology;":[83,88],"volumes":[91],"6":[93],"volume.":[99,203],"Memory":[100],"was":[101,147,156,169],"assessed":[102],"selective":[105],"reminding":[106],"test.":[107],"Mediation":[108],"moderation":[110],"analyses":[111],"modeled":[112],"associations":[113],"between":[114,142,222],"regional":[115],"markers":[116],"memory.":[118],"Analyses":[119],"included":[120],"covariates":[121],"for":[122],"age,":[123],"sex,":[124],"education.":[126],"RESULTS:":[127],"Neocortical":[128],"amyloid,":[129],"tau,":[131],"presubiculum":[133,153,167,190],"volume":[134,168,205],"univariately":[135],"associated":[136],"performance.":[139,228],"The":[140,189,229],"relationship":[141],"neocortical":[143],"mediated":[148],"by":[149,158,231],"volume,":[154],"which":[155],"modified":[157],"burden.":[161,187],"With":[162],"other":[163],"biomarkers":[164],"held":[165],"constant,":[166],"only":[171],"marker":[172,210],"predicting":[173],"sample":[179],"elevated":[184],"CONCLUSIONS:":[188],"captures":[191],"unique":[192],"AD-related":[193,224],"biological":[194],"variation":[195],"that":[196,235],"is":[197,237],"not":[198,241],"reflected":[199],"Presubiculum":[204],"may":[206],"be":[207],"promising":[209],"imminent":[212],"problems":[214],"can":[216],"contribute":[217],"understanding":[219],"interaction":[221],"incipient":[223],"pathologies":[225],"modulation":[230],"suggests":[234],"necessary,":[239],"but":[240],"sufficient,":[242],"process":[243],"drive":[245],"neurodegeneration":[246],"memory-related":[248],"regions.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-04-17T00:00:00"}
