{"id":"https://openalex.org/W3016050686","doi":"https://doi.org/10.1001/jamaoncol.2020.0465","title":"Assessment of the Feasibility and Safety of Durvalumab for Treatment of Solid Tumors in Patients With HIV-1 Infection","display_name":"Assessment of the Feasibility and Safety of Durvalumab for Treatment of Solid Tumors in Patients With HIV-1 Infection","publication_year":2020,"publication_date":"2020-04-09","ids":{"openalex":"https://openalex.org/W3016050686","doi":"https://doi.org/10.1001/jamaoncol.2020.0465","mag":"3016050686","pmid":"https://pubmed.ncbi.nlm.nih.gov/32271353","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7146525"},"language":"en","primary_location":{"id":"doi:10.1001/jamaoncol.2020.0465","doi":"https://doi.org/10.1001/jamaoncol.2020.0465","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2020.0465","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2763857/jamaoncology_gonzalezcao_2020_br_200002.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2763857/jamaoncology_gonzalezcao_2020_br_200002.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Maria Gonzalez-Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095200","display_name":"Instituto Oncol\u00f3gico Dr. Rosell","ror":"https://ror.org/00r9kn296","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095200"]},{"id":"https://openalex.org/I4210096255","display_name":"Hospital Universitario Dexeus","ror":"https://ror.org/00scfzf83","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096255"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Maria Gonzalez-Cao","raw_affiliation_strings":["Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095200","https://openalex.org/I4210096255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111775281","display_name":"Teresa Mor\u00e1n","orcid":"https://orcid.org/0000-0001-9172-0035","observed_orcids":["https://orcid.org/0000-0001-9172-0035"]},"institutions":[{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Teresa Mor\u00e1n","raw_affiliation_strings":["Medical Oncology Department, Catalan Institute of Oncology (ICO), Germans Trias i Pujol Hospital, Badalona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Catalan Institute of Oncology (ICO), Germans Trias i Pujol Hospital, Badalona, Spain","institution_ids":["https://openalex.org/I4210107147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050335754","display_name":"Judith Dalmau","orcid":"https://orcid.org/0000-0001-7513-3711","observed_orcids":["https://orcid.org/0000-0001-7513-3711"]},"institutions":[{"id":"https://openalex.org/I4210086361","display_name":"IrsiCaixa","ror":"https://ror.org/001synm23","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210086361","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Judith Dalmau","raw_affiliation_strings":["IrsiCaixa AIDS Research Institute, University Hospital Germans Trias i Pujol, Badalona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IrsiCaixa AIDS Research Institute, University Hospital Germans Trias i Pujol, Badalona, Spain","institution_ids":["https://openalex.org/I4210086361","https://openalex.org/I4210153460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Javier Garcia-Corbacho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Garcia-Corbacho","raw_affiliation_strings":["ICMHO, Hospital Clinic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMHO, Hospital Clinic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009827598","display_name":"Jillian Wilhelmina Paulina Bracht","orcid":"https://orcid.org/0000-0001-9552-3960","observed_orcids":["https://orcid.org/0000-0001-9552-3960"]},"institutions":[{"id":"https://openalex.org/I4210095200","display_name":"Instituto Oncol\u00f3gico Dr. Rosell","ror":"https://ror.org/00r9kn296","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095200"]},{"id":"https://openalex.org/I4210096255","display_name":"Hospital Universitario Dexeus","ror":"https://ror.org/00scfzf83","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096255"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jillian W. P. Bracht","raw_affiliation_strings":["Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095200","https://openalex.org/I4210096255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066986444","display_name":"Reyes Bernab\u00e9","orcid":"https://orcid.org/0000-0003-0312-9195","observed_orcids":["https://orcid.org/0000-0003-0312-9195"]},"institutions":[{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Reyes Bernabe","raw_affiliation_strings":["Hospital Universitario Virgen del Roc\u00edo, Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Virgen del Roc\u00edo, Sevilla, Spain","institution_ids":["https://openalex.org/I4210153139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008290108","display_name":"\u00d3scar Juan","orcid":"https://orcid.org/0000-0002-7772-9030","observed_orcids":["https://orcid.org/0000-0002-7772-9030"]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Oscar Juan","raw_affiliation_strings":["Hospital Universitario la Fe de Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario la Fe de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081814994","display_name":"Javier de Castro","orcid":"https://orcid.org/0000-0002-3622-6306","observed_orcids":["https://orcid.org/0000-0002-3622-6306"]},"institutions":[{"id":"https://openalex.org/I2800562746","display_name":"Hospital Universitario La Paz","ror":"https://ror.org/01s1q0w69","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800562746"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier de Castro","raw_affiliation_strings":["Hospital Universitario La Paz, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario La Paz, Madrid, Spain","institution_ids":["https://openalex.org/I2800562746"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Remei Blanco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098336","display_name":"Consorci Sanitari de Terrassa","ror":"https://ror.org/01239b432","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210098336"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Remei Blanco","raw_affiliation_strings":["Consorci Sanitari de Terrassa, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consorci Sanitari de Terrassa, Barcelona, Spain","institution_ids":["https://openalex.org/I4210098336"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ana Drozdowskyj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095200","display_name":"Instituto Oncol\u00f3gico Dr. Rosell","ror":"https://ror.org/00r9kn296","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095200"]},{"id":"https://openalex.org/I4210096255","display_name":"Hospital Universitario Dexeus","ror":"https://ror.org/00scfzf83","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096255"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Drozdowskyj","raw_affiliation_strings":["Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095200","https://openalex.org/I4210096255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029661828","display_name":"Jordi M. Argilaguet","orcid":"https://orcid.org/0000-0001-5924-2774","observed_orcids":["https://orcid.org/0000-0001-5924-2774"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi Argilaguet","raw_affiliation_strings":["Infection Biology Laboratory, University Pompeu Fabra, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Biology Laboratory, University Pompeu Fabra, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029705489","display_name":"Andreas Meyerhans","orcid":"https://orcid.org/0000-0003-0620-5317","observed_orcids":["https://orcid.org/0000-0003-0620-5317"]},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andreas Meyerhans","raw_affiliation_strings":["Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain","Infection Biology Laboratory, University Pompeu Fabra, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain","institution_ids":["https://openalex.org/I11932220"]},{"raw_affiliation_string":"Infection Biology Laboratory, University Pompeu Fabra, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084391105","display_name":"Juli\u00e0 Blanco","orcid":"https://orcid.org/0000-0002-2225-0217","observed_orcids":["https://orcid.org/0000-0002-2225-0217"]},"institutions":[{"id":"https://openalex.org/I115304662","display_name":"Universitat de Vic - Universitat Central de Catalunya","ror":"https://ror.org/006zjws59","country_code":"ES","type":"education","lineage":["https://openalex.org/I115304662"]},{"id":"https://openalex.org/I4210086361","display_name":"IrsiCaixa","ror":"https://ror.org/001synm23","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210086361","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210137002","display_name":"Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol","ror":"https://ror.org/03bzdww12","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210137002","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julia Blanco","raw_affiliation_strings":["Germans Trias i Pujol Research Institute and Hospital (IGTP), Badalona, Spain","IrsiCaixa AIDS Research Institute, University Hospital Germans Trias i Pujol, Badalona, Spain","University of Vic\u2013Central University of Catalonia (UVic-UCC), Vic, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Germans Trias i Pujol Research Institute and Hospital (IGTP), Badalona, Spain","institution_ids":["https://openalex.org/I4210137002"]},{"raw_affiliation_string":"IrsiCaixa AIDS Research Institute, University Hospital Germans Trias i Pujol, Badalona, Spain","institution_ids":["https://openalex.org/I4210086361","https://openalex.org/I4210153460"]},{"raw_affiliation_string":"University of Vic\u2013Central University of Catalonia (UVic-UCC), Vic, Spain","institution_ids":["https://openalex.org/I115304662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056187765","display_name":"J\u00falia G. Prado","orcid":"https://orcid.org/0000-0002-5439-4645","observed_orcids":["https://orcid.org/0000-0002-5439-4645"]},"institutions":[{"id":"https://openalex.org/I4210086361","display_name":"IrsiCaixa","ror":"https://ror.org/001synm23","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210086361","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210137002","display_name":"Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol","ror":"https://ror.org/03bzdww12","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210137002","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julia G. Prado","raw_affiliation_strings":["Germans Trias i Pujol Research Institute and Hospital (IGTP), Badalona, Spain","IrsiCaixa AIDS Research Institute, University Hospital Germans Trias i Pujol, Badalona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Germans Trias i Pujol Research Institute and Hospital (IGTP), Badalona, Spain","institution_ids":["https://openalex.org/I4210137002"]},{"raw_affiliation_string":"IrsiCaixa AIDS Research Institute, University Hospital Germans Trias i Pujol, Badalona, Spain","institution_ids":["https://openalex.org/I4210086361","https://openalex.org/I4210153460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086724117","display_name":"Jorge Carrillo","orcid":"https://orcid.org/0000-0003-0221-5948","observed_orcids":["https://orcid.org/0000-0003-0221-5948"]},"institutions":[{"id":"https://openalex.org/I4210086361","display_name":"IrsiCaixa","ror":"https://ror.org/001synm23","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210086361","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jorge Carrillo","raw_affiliation_strings":["IrsiCaixa AIDS Research Institute, University Hospital Germans Trias i Pujol, Badalona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IrsiCaixa AIDS Research Institute, University Hospital Germans Trias i Pujol, Badalona, Spain","institution_ids":["https://openalex.org/I4210086361","https://openalex.org/I4210153460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028130303","display_name":"Bonaventura Clotet","orcid":"https://orcid.org/0000-0003-3232-4598","observed_orcids":["https://orcid.org/0000-0003-3232-4598"]},"institutions":[{"id":"https://openalex.org/I115304662","display_name":"Universitat de Vic - Universitat Central de Catalunya","ror":"https://ror.org/006zjws59","country_code":"ES","type":"education","lineage":["https://openalex.org/I115304662"]},{"id":"https://openalex.org/I4210086361","display_name":"IrsiCaixa","ror":"https://ror.org/001synm23","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210086361","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Bonaventura Clotet","raw_affiliation_strings":["IrsiCaixa AIDS Research Institute, University Hospital Germans Trias i Pujol, Badalona, Spain","University of Vic\u2013Central University of Catalonia (UVic-UCC), Vic, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IrsiCaixa AIDS Research Institute, University Hospital Germans Trias i Pujol, Badalona, Spain","institution_ids":["https://openalex.org/I4210086361","https://openalex.org/I4210153460"]},{"raw_affiliation_string":"University of Vic\u2013Central University of Catalonia (UVic-UCC), Vic, Spain","institution_ids":["https://openalex.org/I115304662"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bartomeu Massuti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137674","display_name":"Hospital General Universitario de Alicante Doctor Balmis","ror":"https://ror.org/02ybsz607","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210137674"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Bartomeu Massuti","raw_affiliation_strings":["Alicante University Hospital, Alicante, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alicante University Hospital, Alicante, Spain","institution_ids":["https://openalex.org/I4210137674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085499011","display_name":"Mariano Provencio","orcid":"https://orcid.org/0000-0001-9053-9197","observed_orcids":["https://orcid.org/0000-0001-9053-9197","https://orcid.org/0000-0002-2826-656X"]},"institutions":[{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mariano Provencio","raw_affiliation_strings":["Puerta de Hierro Hospital, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Puerta de Hierro Hospital, Madrid, Spain","institution_ids":["https://openalex.org/I4210105637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056676096","display_name":"Miguel \u00c1ngel Molina\u2010Vila","orcid":"https://orcid.org/0000-0001-8866-9881","observed_orcids":["https://orcid.org/0000-0001-8866-9881"]},"institutions":[{"id":"https://openalex.org/I4210095200","display_name":"Instituto Oncol\u00f3gico Dr. Rosell","ror":"https://ror.org/00r9kn296","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095200"]},{"id":"https://openalex.org/I4210096255","display_name":"Hospital Universitario Dexeus","ror":"https://ror.org/00scfzf83","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096255"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel A. Molina-Vila","raw_affiliation_strings":["Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095200","https://openalex.org/I4210096255"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Clara Mayo de las Casa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095200","display_name":"Instituto Oncol\u00f3gico Dr. Rosell","ror":"https://ror.org/00r9kn296","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095200"]},{"id":"https://openalex.org/I4210096255","display_name":"Hospital Universitario Dexeus","ror":"https://ror.org/00scfzf83","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096255"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Clara Mayo de las Casa","raw_affiliation_strings":["Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095200","https://openalex.org/I4210096255"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Monica Garzon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095200","display_name":"Instituto Oncol\u00f3gico Dr. Rosell","ror":"https://ror.org/00r9kn296","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095200"]},{"id":"https://openalex.org/I4210096255","display_name":"Hospital Universitario Dexeus","ror":"https://ror.org/00scfzf83","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096255"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Monica Garzon","raw_affiliation_strings":["Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095200","https://openalex.org/I4210096255"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peng Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Cao","raw_affiliation_strings":["Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China","Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chung-Ying Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099129","display_name":"Nanostring Technologies (United States)","ror":"https://ror.org/00xzdzk88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210099129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung-Ying Huang","raw_affiliation_strings":["NanoString Technologies, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NanoString Technologies, Seattle, Washington","institution_ids":["https://openalex.org/I4210099129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080704945","display_name":"Javier Mart\u00ednez\u2010Picado","orcid":"https://orcid.org/0000-0002-4916-2129","observed_orcids":["https://orcid.org/0000-0002-4916-2129"]},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I4210086361","display_name":"IrsiCaixa","ror":"https://ror.org/001synm23","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210086361","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210137002","display_name":"Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol","ror":"https://ror.org/03bzdww12","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210137002","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Javier Martinez-Picado","raw_affiliation_strings":["Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain","Germans Trias i Pujol Research Institute and Hospital (IGTP), Badalona, Spain","IrsiCaixa AIDS Research Institute, University Hospital Germans Trias i Pujol, Badalona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain","institution_ids":["https://openalex.org/I11932220"]},{"raw_affiliation_string":"Germans Trias i Pujol Research Institute and Hospital (IGTP), Badalona, Spain","institution_ids":["https://openalex.org/I4210137002"]},{"raw_affiliation_string":"IrsiCaixa AIDS Research Institute, University Hospital Germans Trias i Pujol, Badalona, Spain","institution_ids":["https://openalex.org/I4210086361","https://openalex.org/I4210153460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044887899","display_name":"Rafael Rosell","orcid":"https://orcid.org/0000-0003-0817-3400","observed_orcids":["https://orcid.org/0000-0003-0817-3400"]},"institutions":[{"id":"https://openalex.org/I4210095200","display_name":"Instituto Oncol\u00f3gico Dr. Rosell","ror":"https://ror.org/00r9kn296","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095200"]},{"id":"https://openalex.org/I4210096255","display_name":"Hospital Universitario Dexeus","ror":"https://ror.org/00scfzf83","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096255"]},{"id":"https://openalex.org/I4210137002","display_name":"Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol","ror":"https://ror.org/03bzdww12","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210137002","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rafael Rosell","raw_affiliation_strings":["Germans Trias i Pujol Research Institute and Hospital (IGTP), Badalona, Spain","Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Germans Trias i Pujol Research Institute and Hospital (IGTP), Badalona, Spain","institution_ids":["https://openalex.org/I4210137002"]},{"raw_affiliation_string":"Translational Cancer Research Unit, Instituto Oncol\u00f3gico Dr Rosell, Dexeus University Hospital, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095200","https://openalex.org/I4210096255"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5080704945"],"corresponding_institution_ids":["https://openalex.org/I11932220","https://openalex.org/I4210086361","https://openalex.org/I4210095200","https://openalex.org/I4210096255","https://openalex.org/I4210137002","https://openalex.org/I4210153460"],"apc_list":null,"apc_paid":null,"fwci":6.3404,"has_fulltext":true,"cited_by_count":110,"citation_normalized_percentile":{"value":0.977385,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"6","issue":"7","first_page":"1063","last_page":"1063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/durvalumab","display_name":"durvalumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pd-l1-blockade","display_name":"PD-L1 blockade","score":0.7699999809265137},{"id":"https://openalex.org/keywords/pd-1-pd-l1-inhibitors","display_name":"PD-1/PD-L1 inhibitors","score":0.7549999952316284},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8259999752044678},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.5759999752044678},{"id":"https://openalex.org/keywords/drug-related-adverse-events","display_name":"drug-related adverse events","score":0.7599999904632568},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9700999855995178},{"id":"https://openalex.org/C2777742743","wikidata":"https://www.wikidata.org/wiki/Q19904005","display_name":"Durvalumab","level":5,"score":0.8579000234603882},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4171000123023987},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39259999990463257},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3919000029563904},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37220001220703125},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3357999920845032},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.33500000834465027},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3025999963283539},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.2612999975681305},{"id":"https://openalex.org/C3018130915","wikidata":"https://www.wikidata.org/wiki/Q1752284","display_name":"Neoplasm staging","level":3,"score":0.25529998540878296}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1001/jamaoncol.2020.0465","doi":"https://doi.org/10.1001/jamaoncol.2020.0465","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2020.0465","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2763857/jamaoncology_gonzalezcao_2020_br_200002.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},{"id":"pmid:32271353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32271353","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA oncology","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:pubmedcentral.nih.gov:7146525","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7146525/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncol","raw_type":"Text"},{"id":"pmh:oai:www.repositoriosalud.es:10668/15347","doi":null,"is_oa":true,"landing_page_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2763857/jamaoncology_gonzalezcao_2020_br_200002.pdf","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2763857/jamaoncology_gonzalezcao_2020_br_200002.pdf","source":{"id":"https://openalex.org/S4377196114","display_name":"RISalud Institutional Health Repository of Andaluc\u00eda","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"},{"id":"pmh:oai:digital.csic.es:10261/238739","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/238739","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1001/jamaoncol.2020.0465","doi":"https://doi.org/10.1001/jamaoncol.2020.0465","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2020.0465","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2763857/jamaoncology_gonzalezcao_2020_br_200002.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3016050686.pdf","grobid_xml":"https://content.openalex.org/works/W3016050686.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W2035852466","https://openalex.org/W2043223046","https://openalex.org/W2131695868","https://openalex.org/W2156353875","https://openalex.org/W2166662937","https://openalex.org/W2572174216","https://openalex.org/W2763133656","https://openalex.org/W2763963251","https://openalex.org/W2791290180","https://openalex.org/W2890205877","https://openalex.org/W2901185593","https://openalex.org/W2911264428","https://openalex.org/W2913946693","https://openalex.org/W2946998144","https://openalex.org/W2988652721","https://openalex.org/W2991022191","https://openalex.org/W6762559840"],"related_works":["https://openalex.org/W3087985896","https://openalex.org/W2947168188","https://openalex.org/W4386895910","https://openalex.org/W4378783799","https://openalex.org/W2946998144","https://openalex.org/W3038002763","https://openalex.org/W2890487472","https://openalex.org/W4410805259","https://openalex.org/W2922844043","https://openalex.org/W4362458422"],"abstract_inverted_index":{"Importance:":[0],"Therapies":[1],"targeting":[2],"the":[3,16,33,46,60,164,167,184,209,298],"programmed":[4],"cell":[5],"death":[6],"1":[7,251],"(PD-1)":[8],"receptor":[9],"or":[10,102,108,151],"its":[11],"ligand":[12],"(PD-L1),":[13],"such":[14],"as":[15],"humanized":[17],"monoclonal":[18],"antibody":[19],"durvalumab,":[20],"have":[21,43,105,328],"shown":[22],"durable":[23,278],"clinical":[24,52,90],"responses":[25],"in":[26,40,67,92,99,188,243,309],"several":[27],"tumor":[28,97],"types.":[29],"However,":[30],"concerns":[31],"about":[32],"safety":[34,63],"and":[35,62,72,79,157,217,247,252,257,287,291,301,307],"feasibility":[36,61],"of":[37,48,64,114,138,141,166,196,230,234,245,260,284],"PD-1/PD-L1":[38],"blockade":[39],"HIV-1-infected":[41,198,310,318],"individuals":[42],"led":[44],"to":[45,330],"exclusion":[47],"these":[49],"patients":[50,68,93,124,199,263,270,311,319],"from":[51],"trials":[53],"on":[54,320],"cancer":[55,71,202,224,313,326,331],"immunotherapies.":[56],"Objective:":[57],"To":[58],"evaluate":[59],"durvalumab":[65,142,235],"treatment":[66,225,304],"with":[69,94,117,163,200,222,277,312,324],"advanced":[70,201,325],"virologically":[73],"controlled":[74],"HIV-1":[75,293],"infection.":[76],"Design,":[77],"Setting,":[78],"Participants:":[80],"The":[81],"DURVAST":[82],"study":[83],"was":[84,181,213,305],"a":[85,266],"nonrandomized,":[86],"open-label,":[87],"phase":[88],"2":[89,253],"trial":[91],"any":[95],"solid":[96],"type":[98],"which":[100,110],"anti-PD-1":[101],"anti-PD-L1":[103],"antibodies":[104],"approved":[106],"indications":[107],"for":[109,174],"there":[111],"are":[112],"data":[113],"antitumoral":[115],"activity":[116],"no":[118],"other":[119],"available":[120],"curative":[121],"therapy.":[122,134,317],"All":[123],"had":[125,220,265,272],"basal":[126],"undetectable":[127],"plasma":[128,292],"viremia":[129,294],"while":[130],"undergoing":[131],"combination":[132,315],"antiretroviral":[133,316,322],"Interventions:":[135],"Treatment":[136],"consisted":[137],"intravenous":[139],"infusion":[140],"(1500":[143],"mg":[144],"every":[145],"4":[146,231,276],"weeks)":[147],"until":[148],"disease":[149,280],"progression":[150],"unacceptable":[152],"toxic":[153],"effects.":[154],"Main":[155],"Outcomes":[156],"Measures:":[158],"Adverse":[159,175],"events":[160,240],"were":[161,203,207,236,241,249],"graded":[162],"use":[165],"National":[168],"Cancer":[169],"Institute":[170],"Common":[171],"Terminology":[172],"Criteria":[173,187],"Events,":[176],"version":[177,191],"4.03.":[178],"Tumor":[179],"response":[180],"evaluated":[182],"using":[183],"Response":[185],"Evaluation":[186],"Solid":[189],"Tumors":[190],"1.1.":[192],"Results:":[193],"A":[194,227],"total":[195],"20":[197],"enrolled;":[204],"16":[205,261],"(80%)":[206],"male,":[208],"median":[210,228],"(range)":[211,229],"age":[212],"54":[214],"(30-73)":[215],"years,":[216],"12":[218],"(60%)":[219],"progressed":[221],"previous":[223],"lines.":[226],"(1-16)":[232],"cycles":[233],"administered.":[237],"Drug-related":[238],"adverse":[239],"observed":[242],"50%":[244],"patients,":[246],"all":[248],"grade":[250],"(mainly":[254],"diarrhea,":[255],"asthenia,":[256],"arthromyalgia).":[258],"Four":[259],"response-evaluable":[262],"(25%)":[264],"partial":[267],"response.":[268],"Five":[269],"(31%)":[271],"stable":[273,279,296],"disease,":[274],"including":[275],"(disease":[281],"control":[282],"rate":[283],"50%).":[285],"CD4+":[286],"CD8+":[288],"T-cell":[289],"counts":[290],"remained":[295],"throughout":[297],"study.":[299],"Conclusions":[300],"Relevance:":[302],"Durvalumab":[303],"feasible":[306],"safe":[308],"receiving":[314],"suppressive":[321],"therapy":[323],"should":[327],"access":[329],"immunotherapy":[332],"treatments.":[333],"Trial":[334],"Registration:":[335],"ClinicalTrials.gov":[336],"Identifier:":[337],"NCT03094286.":[338]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-04-17T00:00:00"}